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	<title>UNC Research Stories</title>
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	<link>https://endeavors.unc.edu/</link>
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		<title>AI Insights</title>
		<link>https://endeavors.unc.edu/ai-insights/</link>
		
		<dc:creator><![CDATA[Megan Mendenhall]]></dc:creator>
		<pubDate>Tue, 17 Jun 2025 13:15:09 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Invention]]></category>
		<category><![CDATA[Society]]></category>
		<category><![CDATA[AI]]></category>
		<category><![CDATA[Artificial Intelligence]]></category>
		<category><![CDATA[chatbots]]></category>
		<category><![CDATA[digital learning technology]]></category>
		<category><![CDATA[education]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[highway safety]]></category>
		<category><![CDATA[North Carolina]]></category>
		<category><![CDATA[nutrition for precision health]]></category>
		<category><![CDATA[Precision Nutrition]]></category>
		<category><![CDATA[RENCI]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[The University of North Carolina at Chapel Hill]]></category>
		<category><![CDATA[UNC]]></category>
		<category><![CDATA[UNC Gillings School of Global Public Health]]></category>
		<category><![CDATA[UNC Highway Research Safety Center]]></category>
		<category><![CDATA[UNC Nutrition Research Institute]]></category>
		<category><![CDATA[UNC Research]]></category>
		<category><![CDATA[UNC School of Education]]></category>
		<category><![CDATA[UNC-Chapel Hill]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14341</guid>

					<description><![CDATA[<p><em>Carolina researchers leverage artificial intelligence across various fields to enhance their studies, build on existing knowledge, and drive discoveries for a brighter future.</em></p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/ai-insights/">AI Insights</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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										<content:encoded><![CDATA[<p><iframe style="border-radius:12px" src="https://open.spotify.com/embed/episode/4KwwM9cdUKe6o4rPDUbHQ7?utm_source=generator&#038;t=0" width="100%" height="152" frameBorder="0" allowfullscreen="" allow="autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture" loading="lazy"></iframe></p>
<p>Artificial intelligence (AI) is quietly working behind the scenes in many aspects of everyday life — from personalized recommendations on apps like Netflix and Spotify to predictive text and autocorrect features on smartphones.</p>
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<p>And while it feels like AI has only existed for the last few years thanks to the emergence and growing popularity of agents like ChatGPT, the technology has a long and exciting past, stemming back to the 1950s when scientists wondered if machines could think and learn like humans.Early work focused on creating programs to solve problems, play simple games, and understand language. By the 1980s, scientists developed systems mimicking human expertise in specific fields. But the big breakthrough happened in the 2000s and 2010s with the rise of machine learning, a subfield of AI that enables computers to learn and improve from data without requiring explicit programming.</p>
<p>Instead of being given specific instructions on how to perform a task, machine learning algorithms learn from data to identify patterns. There are generally two types: supervised learning, which is trained on data to make predictions, and unsupervised learning, which isn’t.</p>
<p>These advances use AI to analyze vast amounts of data — and the technology keeps getting smarter. AI has the potential to serve as the foundation for the iterative process, allowing users to build on existing knowledge and gain new insights. Because of this, it is also revolutionizing research across various fields.</p>
<p>UNC-Chapel Hill researchers are leveraging AI in a variety of ways. Some are harnessing its power to advance health care by creating innovative diagnostics and personalized treatment plans that improve patient outcomes. Others are using it to analyze vast data sets, decode complex problems, and unlock new ways of understanding.</p>
<p>&#8220;As someone who&#8217;s always seen technology as a potential solution, AI is another advancement that can help us find answers,&#8221; says <a href="https://sph.unc.edu/adv_profile/deborah-tate-phd/">Deborah Tate</a>, a nutrition professor in the UNC Gillings School of Global Public Health and interim director of the <a href="https://uncnri.org/">UNC Nutrition Research Institute</a>. &#8220;It provides the opportunity to make extremely rapid advances. But while it’s exciting, it&#8217;s only as good as you train it to be.&#8221;</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/grad-globe-light-sidebar_Globe2.png" alt="Old Well Icon" width="40" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">Carolina is a leader in the use of artificial intelligence (AI). From health sciences to journalism, sports to social work, researchers are applying AI to solve the world&#8217;s problems.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_Old-Well2.png" alt="Old Well Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">Since January 2023, Carolina researchers have submitted more than 900 AI-related research proposals. The AI Committee at UNC-Chapel Hill is dedicated to equipping students and faculty with the skills to harness this technology by encouraging responsible AI use, fostering innovation, advancing AI research, and providing AI learning experiences.</p>
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<h3><strong>Creating personalized food plans</strong></h3>
			<div class="media-credit-container alignnone"  style="max-width: 1010px">
			<img decoding="async" fetchpriority="high" class="wp-image-14345 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_06102025_deborah_tate_0002.jpg" alt="A women stands in a kitchen with stainles steel appliances while smiling at the camera." width="1000" height="667" /><span class="media-credit">Deborah Tate (photo by Megan Mendenhall)</span>		</div>
	
<p>Imagine a future where a person’s diet can be customized to align perfectly with their body&#8217;s unique makeup, helping to prevent the effects of chronic and progressive diseases like obesity, diabetes, and cardiovascular disease.</p>
<p>This vision is the driving force behind <a href="https://uncnri.org/2024/11/05/the-nutrition-for-precision-health-study/">Nutrition for Precision Health</a>, powered by the All of Us Research Program. This $170 million investment from the National Institutes of Health Common Fund aims to explore how genetics, gut bacteria, environment, and lifestyle influence our responses to food. What makes this initiative particularly innovative is its use of AI.</p>
<p>&#8220;Historically, we&#8217;ve been looking at the average effects. For every intervention we’ve tried, half the people have succeeded, and half the people haven’t,&#8221; explains Deborah Tate, who is co-leading the study with nutrition professor <a href="https://sph.unc.edu/adv_profile/elizabeth-mayer-davis-phd/">Elizabeth Mayer-Davis</a>. &#8220;We&#8217;re trying to move away from what works best on average to what works best for the individual.&#8221;</p>
<p>The goal is to develop algorithms to retreat from one-size-fits-all diets and instead personalize nutrition for each person&#8217;s unique needs. These algorithms look at weight, age, blood sugar levels, and other health information to predict a food regimen that can meet specific health goals like controlling blood sugar or lowering blood pressure. These advances provide unprecedented opportunities to generate new data offering insight into <a href="https://uncnri.org/precision-nutrition-sept-2019/">precision nutrition.</a></p>
<p>&#8220;Many of these lifestyle changes have profound impacts on health, and it&#8217;s been undersold because we have not been personalizing,” Tate shares. “So, imagine our ability to use AI to help personalize in real-time to find the right intervention and support so that prevention reaches its full potential and people live healthier lives.&#8221;</p>
<h3><strong>Mapping safer roads</strong></h3>
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			<img decoding="async" class="wp-image-14343 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_05232025_raghavan_srinivasan_0028.jpg" alt="A man sits on a couch in front of a wall filled with maps." width="1000" height="667" /><span class="media-credit">Raghavan Srinivasan (photo by Megan Mendenhall)</span>		</div>
	
<p>Behind every safe road trip lies significant but often unseen effort: research, innovation, and collaboration. Researchers like <a href="https://www.hsrc.unc.edu/team/srinivasan/">Raghavan &#8220;Srini&#8221; Srinivasan</a>, a senior transportation research engineer at the <a href="https://www.hsrc.unc.edu/">UNC Highway Safety Research Center</a>, play a crucial role in this process by studying how drivers behave, analyzing traffic data, and developing solutions to prevent crashes and injuries on the road.</p>
<p>Many state agencies have information about their roads, like the number of lanes, their width, traffic volume, and features like shoulders and curves.</p>
<p>“But gaps come in when you&#8217;re talking about the roadside beyond the shoulder, like if guardrails, poles, or other objects are present,” Srinivasan explains. “Many state agencies do not have the information about poles and other objects that are beyond the shoulder.”</p>
<p>Inserting guardrails can prevent vehicles from straying too far off the road, while strategically placing utility poles in areas where runaway cars are less likely to collide with them can help reduce the severity of accidents.</p>
<p>“If state agencies have this information, they could be proactive in trying to mitigate any potential issues,” he says.</p>
<p>To address this, Srinivasan and his colleagues at the HSRC partnered with <a href="https://renci.org/">RENCI</a>, Carolina’s computing institute, to use AI to assist in identifying these objects.</p>
<p>The RENCI team created an annotation tool to help N.C. Department of Transportation personnel review video logs of North Carolina roadways to identify the presence of guardrails or utility poles along the roadside. This process generated a dataset to train AI models to detect these objects. In the next phase of the project, the team is developing an AI model that can pinpoint the exact coordinates of these objects and is using a mapping technology called LiDAR to verify it.</p>
<p>&#8220;Traditionally, research in transportation safety was focused on analyzing data that could be collected within the confines of budgets and schedules,” Srinivasan says. “Over the next few years, I hope researchers will have access to data that were not available earlier.”</p>
<h3><strong>Improving science education</strong></h3>
			<div class="media-credit-container alignnone"  style="max-width: 1010px">
			<img decoding="async" class="wp-image-14344 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_05292025_nguyen_ha_0008.jpg" alt="A women sits at a desk infront of a projected image of a text conversation." width="1000" height="667" /><span class="media-credit">Ha Nguyen (photo by Megan Mendenhall)</span>		</div>
	
<p>AI is helping educators and researchers create innovative ways to support student learning.</p>
<p><a href="https://ed.unc.edu/people/ha-nguyen/">Ha Nguyen,</a> a professor in the UNC School of Education, focuses on the intersection of education and technology, especially how students learn in science classes. Her work explores how chatbots and other digital learning technology can help promote collaborative learning, critical thinking, and understanding of scientific concepts.</p>
<p>Nguyen thinks through how chatbots can help students identify with scientists and construct their own scientific identity. For her current project, she’s interviewing local residents and students about topics like sustainability, the values they associate with their sense of place, and the effects of severe weather on these values to train chatbots to create more relatable and realistic responses.</p>
<p>While ethical considerations like trust and privacy are important, Nguyen wants to create interactions that support students and build their understanding. Instead of simply providing facts, the chatbots ask follow-up questions and offer resources, giving students more control and encouraging active learning.</p>
<p>Another strand of Nguyen&#8217;s work is designing AI technology to help researchers analyze and understand data more effectively. Some of this involves using models that can handle non-textual data, like images and audio, to process science assessment outcomes and other information that teachers already collect from the classroom. The goal is to provide students with tailored feedback and follow-up questions related to their performance.</p>
<p>&#8220;That level of teasing out student thinking and their responses is really important,&#8221; Nguyen says. &#8220;But teachers don&#8217;t always have the time to do it.&#8221;</p>
<p>Her work also explores how researchers can use AI to help them analyze challenging educational data like interviews and survey responses.</p>
<p>&#8220;Education is going to change, and the way we support learning is going to change,&#8221; Nguyen shares. &#8220;It’s important to think about how these technologies can support and transform people&#8217;s learning.&#8221;</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/ai-insights/">AI Insights</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>RUNC: Tianlong Chen</title>
		<link>https://endeavors.unc.edu/runc-tianlong-chen/</link>
		
		<dc:creator><![CDATA[UNC Research Stories]]></dc:creator>
		<pubDate>Wed, 11 Jun 2025 15:36:56 +0000</pubDate>
				<category><![CDATA[Invention]]></category>
		<category><![CDATA[Research UNCovered]]></category>
		<category><![CDATA[Society]]></category>
		<category><![CDATA[AI]]></category>
		<category><![CDATA[apps]]></category>
		<category><![CDATA[Artificial Intelligence]]></category>
		<category><![CDATA[biological sciences]]></category>
		<category><![CDATA[Computer Science]]></category>
		<category><![CDATA[health care]]></category>
		<category><![CDATA[health care apps]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[Tianlong Chen]]></category>
		<category><![CDATA[UNC College of Arts and Sciences]]></category>
		<category><![CDATA[UNC-Chapel Hill]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14316</guid>

					<description><![CDATA[<p>Tianlong Chen creates AI tools to improve biological science and health care.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/runc-tianlong-chen/">RUNC: Tianlong Chen</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
]]></description>
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<p><a href="https://cs.unc.edu/person/tianlong-chen/">Tianlong Chen</a> is an assistant professor in the Department of Computer Science within the UNC College of Arts and Sciences. He builds accurate, trustworthy, and efficient machine learning systems for using advanced artificial intelligence (AI) algorithms for biological science and health care. Some of his current projects include using AI to improve the diagnosis of lupus and other autoimmune diseases and to create an app for sexual and reproductive health education.</p>
<p><span style="color: #4b9cd3;"><b>Q: How did you discover your specific field of study?</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>During my undergraduate studies in 2016, I founded a startup and worked on custom behavior analysis based on visual machine learning. It brought in decent revenue and opened the door to machine learning — a branch of AI focused on teaching computers to identify patterns in data and adapt their behavior accordingly.</p>
<p>But the reason why I put 50% of my efforts into researching machine learning for biological science and health care is my experience during COVID. The pandemic brought significant changes to my life and my family. I want to do public health research that has the potential to serve human beings.</p>
<p><span style="color: #4b9cd3;"><b>Q: Academics are problem-solvers. Describe a research challenge you’ve faced and how you overcame it.</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>I needed to gain more domain knowledge in biological science, since my bachelor’s degree is in applied mathematics and my PhD is in electrical and computer engineering. I took a gap year from 2023-2024 after my PhD to pursue a postdoc at MIT and Harvard University in the field of computational biology. I expanded my communications with biologists and doctors to learn more. I also extended my reading scope to include more articles and books on science.</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14015" style="margin: 10px; margin-top: 18px;" src="https://endeavors.unc.edu/wp-content/uploads/RUNC-sidebar_NC-state2.png" alt="Icon of North Carolina" width="60" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">North Carolina has the second-highest AI usage rate in the nation, according to the N.C. Department of Commerce. Over 5% of businesses are currently using the technology and that number is expected to increase.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/US-dollar-sidebar_Dollar-Sign.png" alt="Dollar Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">Projects like Tianlong Chen’s are funded by grants from the National Institutes of Health. This funding supports vital research, advancing treatments for the people of North Carolina and beyond.</p>
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<p><span style="color: #4b9cd3;"><b>Q: Describe your research in five words.</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>AI agents enable scientific discoveries.</p>
<p><span style="color: #4b9cd3;"><b>Q: Who or what inspires you? Why?</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>Research for human beings. The world faces many threats in terms of food, energy, climate, health, and more. Some of these issues seems far away from us, but they actually impact everyone’s day-to-day lives. One of my dreams is that my research benefits more people.</p>
<p><span style="color: #4b9cd3;"><b>Q: If you could pursue any other career, what would it be and why?</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>Working for a startup focused on AI for science that would affect a lot of people.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/runc-tianlong-chen/">RUNC: Tianlong Chen</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Rooted: George “Rick” Stouffer</title>
		<link>https://research.unc.edu/2025/06/04/rooted-george-rick-stouffer/</link>
		
		<dc:creator><![CDATA[Corina]]></dc:creator>
		<pubDate>Wed, 04 Jun 2025 15:16:03 +0000</pubDate>
				<category><![CDATA[Rooted]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14310</guid>

					<description><![CDATA[<p>George “Rick” Stouffer has been contributing to research at Carolina for 25 years.</p>
<p>The post <a rel="nofollow" href="https://research.unc.edu/2025/06/04/rooted-george-rick-stouffer/">Rooted: George “Rick” Stouffer</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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										<content:encoded><![CDATA[&hellip;<p>The post <a rel="nofollow" href="https://research.unc.edu/2025/06/04/rooted-george-rick-stouffer/">Rooted: George “Rick” Stouffer</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Science in Every Step</title>
		<link>https://endeavors.unc.edu/science-in-every-step/</link>
		
		<dc:creator><![CDATA[Maggie McIntyre]]></dc:creator>
		<pubDate>Wed, 28 May 2025 12:42:12 +0000</pubDate>
				<category><![CDATA[Invention]]></category>
		<category><![CDATA[Video]]></category>
		<category><![CDATA[aging]]></category>
		<category><![CDATA[aging research]]></category>
		<category><![CDATA[Biomedical Engineering]]></category>
		<category><![CDATA[fall prevention]]></category>
		<category><![CDATA[Jason Franz]]></category>
		<category><![CDATA[Lampe Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University]]></category>
		<category><![CDATA[Professor]]></category>
		<category><![CDATA[rehabilitation]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[UNC Research]]></category>
		<category><![CDATA[UNC-Chapel Hill]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14263</guid>

					<description><![CDATA[<p>Jason Franz is helping older adults stay on their feet as they age by creating solutions to prevent falls and maintain independence.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/science-in-every-step/">Science in Every Step</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><iframe style="border-radius:12px" src="https://open.spotify.com/embed/episode/3iVrLJqHmPozQgfZEyy9cz?utm_source=generator&#038;t=0" width="100%" height="152" frameBorder="0" allowfullscreen="" allow="autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture" loading="lazy"></iframe></p>
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<p>The treadmill hums as bright lights from a wraparound virtual reality screen flicker on the walls, casting moving shadows across Elizabeth Christopher’s face. Small silver sensors dot her joints, measuring her movement. And behind a computer monitor nearby sits <a href="https://bme.unc.edu/bme-person/jason-franz/">Jason Franz</a>, a professor of biomedical engineering at UNC-Chapel Hill.</p>
<p>Franz is the director of the Applied Biomechanics Lab in the Lampe Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University. His mission is simple: find solutions to help people age gracefully. In a world where nearly <a href="https://www.prb.org/resources/elderly-americans/">one in five Americans will be over 65 by 2030</a>, that goal is more urgent than ever.</p>
<p>Franz has spent the past two decades investigating how age-related changes in muscle strength, joint flexibility, and balance impact mobility, especially as people enter their later years. Falls among older adults are the leading cause of injury and death, yet they are often preventable with the right interventions.</p>
<p>“I am 61, almost 62 years old,” Christopher, a participant in one of Franz’s studies, shares. “I&#8217;m much more aware of the fear of falling. I’m much more aware of trying to challenge myself in different ways to stay active both mentally and physically. It’s part of getting older and not having the flexibility [or] the stability we take for granted until it’s not there anymore.”</p>
<p>In Franz’s state-of-the-art lab, participants walk, move, and even slip — all under carefully controlled scenarios designed to simulate the unpredictable nature of daily life.</p>
<p>“Young people fall all the time,” he says. “The difference between a fall that you might see in a toddler and a fall that we view in our older community is the consequences. The risk of fracture, risk of injury, and the economic costs of a fall can be devastating.”</p>
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<div style="margin: 5px; color: black; padding-top: 10px; padding-bottom: 20px;">
<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14015" style="margin: 10px; margin-top: 18px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_NC-state2.png" alt="Icon of North Carolina" width="60" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">Each year, one in four older adults report falling, which is the leading cause of injury in the aging population. Nearly 20% of North Carolina’s population is above 65 years old, making aging a critical research focus for the state.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_Old-Well2.png" alt="Old Well Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">Since 2003, the Lampe Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University has been a significant contributor to education and research on important topics like aging. With approximately 600 students and 50 faculty members, the department boasts a wide variety of expertise and impact.</p>
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<h3><strong>Mapping mechanics</strong></h3>
<p>Growing up, Franz spent his summers on the eastern shore of Maryland with his grandfather. Over time, he saw the toll that aging could take on a man that had once been active.</p>
<p>“I watched him go from being the most physically capable person that I knew to becoming frail,” Franz says.  “He had difficulty with walking and standing up out of a chair and eventually started falling. And it struck me that we could probably do better as engineers in coming up with solutions to meet the needs of those in our rapidly aging communities.”</p>
<p>His lab’s research has led to important findings about how aging impacts walking and mobility. Older adults experience changes in how the body moves and how the nervous system controls movement — changes that can make someone more likely to feel tired or to fall.</p>
<p>One key finding is that older adults often exhibit less vigor when pushing off the ground, which leads to shorter, shuffling steps and slower walking speeds. This change is primarily due to muscle redistribution. Older adults rely more on their hip and thigh muscles, which cost us more energy than the ankle muscles used by younger adults.</p>
<p>Franz’s team also found that the Achilles tendon, which plays a critical role in pushing off the ground during walking, loses its stiffness with age. As the tendon loosens, it doesn’t stretch and recoil as effectively. This change means the muscles attached to it, mainly those in the calf, must contract more to produce the same movement, leading to higher muscle activation, increased energy consumption, and more fatigue.</p>
<p>This makes older adults more vulnerable to losing their balance, especially during longer walks or on uneven terrain. The lab’s work is focused on developing interventions to mitigate this.</p>
<p>They use tools like wearable sensors, 3D motion capture cameras, force sensors on a treadmill, and video X-ray to provide real-time biofeedback or inform assistive technologies. That data can help individuals adjust their gait and walking patterns, making them more dynamic and less prone to falls.</p>
<h3><strong>Lasting balance</strong></h3>
<p>Franz meets with study participants, physical therapists, and members of the older population regularly to ensure his work is having the impact he intends and to address their needs directly.</p>
<p>“We want to have genuine impact when we&#8217;re doing a study, and the only way we can do that is by speaking the language of the individuals who might make use of the work we&#8217;re doing,” he explains.</p>
<p>“I find that I do kind of trip on my foot every now and then just walking outside,” Christopher says. “My mother has experienced a couple of falls, and she&#8217;s 90 now. And so I want to avoid that in my future.</p>
<p>Franz also prioritizes mentoring and teaching in his lab. The curiosity and tenacity that postdoctoral scholars, graduate students, and undergraduate researchers bring to his research gives him hope for the future of the field.</p>
<p>“As we advocate for the fields of rehabilitation engineering and biomechanics more broadly, I would love to see a greater understanding of the impact we&#8217;re having on the world,” he says.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/science-in-every-step/">Science in Every Step</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Rewriting the Prescription</title>
		<link>https://endeavors.unc.edu/rewriting-the-prescription/</link>
		
		<dc:creator><![CDATA[Maggie McIntyre]]></dc:creator>
		<pubDate>Tue, 27 May 2025 11:53:02 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Society]]></category>
		<category><![CDATA[aging]]></category>
		<category><![CDATA[aging research]]></category>
		<category><![CDATA[medications]]></category>
		<category><![CDATA[North Carolina]]></category>
		<category><![CDATA[pharmacy]]></category>
		<category><![CDATA[prescribing]]></category>
		<category><![CDATA[prescription]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[UNC Eshelman School of Pharmacy]]></category>
		<category><![CDATA[UNC Research]]></category>
		<category><![CDATA[UNC School of Medicine]]></category>
		<category><![CDATA[UNC-Chapel Hill]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14237</guid>

					<description><![CDATA[<p>Joshua Niznik is blending data and empathy to shift the culture of prescribing medications in older adults — starting with when to stop.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/rewriting-the-prescription/">Rewriting the Prescription</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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										<content:encoded><![CDATA[<p><iframe style="border-radius:12px" src="https://open.spotify.com/embed/episode/4GORsXMOkQboTeK3EkKjzK?utm_source=generator&#038;t=0" width="100%" height="152" frameBorder="0" allowfullscreen="" allow="autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture" loading="lazy"></iframe></p>
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<p>Every night around the same time, <a href="https://www.med.unc.edu/medicine/geriatrics/people/joshua-niznik/">Joshua Niznik’s</a> grandmother, like many older adults, would sit down with a glass of water and a plastic organizer brimming with pills. She was in her late 70s, living with dementia, and taking almost a dozen medications. Some of them were meant to ease her confusion; others might have been making it worse.“I remember thinking, <em>Are all these prescriptions actually beneficial?</em>” Niznik recalls.</p>
<p>That quiet question sparked a research career now shaping the way Niznik thinks about aging, medicine, and what it means to live well, especially toward the end of life.</p>
<p>Within the UNC School of Medicine and Eshelman School of Pharmacy, Niznik studies medication use in older adults. Specifically, he focuses on deprescribing: the supervised process of reducing or discontinuing drugs that may no longer be necessary — or may be doing more harm than good. In a health care system that often adds more pills than it subtracts, his work asks a deceptively simple question: What if less is more?</p>
<p>Before he was a researcher, Niznik was just a curious kid growing up in Pennsylvania. He liked chemistry class and lived across the street from a woman who worked as a pharmacist. For a career project in eighth grade, he decided to shadow her and was struck by the unique way pharmacists combined science and real-world impact.</p>
<p>Upon entering pharmacy school at the University of Pittsburgh, he imagined himself working in clinical settings, helping patients manage their prescriptions. But as he moved through his coursework, he found himself drawn to the bigger picture: Why are certain medications prescribed in the first place? How do decisions made in clinical settings affect people long after they’ve left the doctor’s office?</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14015" style="margin: 10px; margin-top: 18px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_NC-state2.png" alt="Icon of North Carolina" width="60" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">Nearly 20% of North Carolinians are over the age of 65 — a number that continues to grow as the state’s population ages. Many live in rural or medically underserved areas where access to geriatric care is limited, making thoughtful care critical.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/US-dollar-sidebar_Dollar-Sign.png" alt="Dollar Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">Joshua Niznik’s research is funded by the National Institute on Aging, part of the National Institutes of Health. This federal support enables high-impact studies using Medicare and Veterans Affairs data, helping to inform guidelines for safer, more personalized care in older adults.</p>
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<p>He eventually pivoted to research in pharmaceutical outcomes and policy, driven by a deeper desire to understand — not just treat.</p>
<h3><strong>Decoding deprescribing </strong></h3>
<p>If prescribing is an action — something a doctor does — then deprescribing is more of a question. It asks: Is this still the right medication for this person at this stage of their life?</p>
<p>Deprescribing doesn’t mean cutting corners or taking people off meds just for the sake of it. It means zooming out, seeing the full picture of someone’s health, and reconsidering the long list of prescriptions that may have accumulated over years, even decades. It means choosing quality over quantity. Relief over routine.</p>
<p>“The ultimate goal is to reduce the number of pills someone takes, making it easier for them to manage their prescriptions,” Niznik explains. “I mean, it&#8217;s a lot to take 10 pills. It&#8217;s more about personalizing the goals of each of the treatments that they&#8217;re receiving so that it&#8217;s more aligned with maximizing safety and minimizing risk.”</p>
<p>Take diabetes, for example. For younger adults, the focus is often strict blood sugar control and keeping glucose levels in a tight range. But for an 85-year-old with a history of falls, memory issues, or other chronic conditions, the risks of that aggressive control — like low blood sugar or dizziness — can outweigh the benefits. In that case, backing off the medication can actually be the safer choice.</p>
<p>And then there are over-the-counter drugs, like Benadryl. It’s easy to grab from a pharmacy shelf, but for older adults, the active ingredient — diphenhydramine — can cause confusion and memory problems.</p>
<p>“As we age, we get more vulnerable to the negative side effects of medications,” Niznik says. “Our bodies don&#8217;t process or eliminate medications as well. And so what would be a normal dose for a younger, healthier person can end up being a really high systemic exposure.”</p>
<p>And older adults are vastly underrepresented in research. Although he is no longer a practicing clinical pharmacist, Niznik is driven to encourage a sense of agency and purpose in patients as they age, with support from their caregivers and providers.</p>
<h3><strong>Purposeful pills</strong></h3>
<p>Niznik’s research may be driven by patient stories and interactions, but that is only part of the work he does. He interviews patients, caregivers, and health care providers to gather insights that don’t always show up in lab results or charts. These conversations often reveal the emotional terrain of deprescribing, like the fear of change.</p>
<p>The other side of his work is rooted in data — and lots of it. Niznik analyzes enormous health care datasets like Medicare records, electronic health records, and databases from the Veterans Health Administration.</p>
<p>Thanks to Carolina’s robust hospital system, access to this information is much easier. Niznik uses their anonymous data to look for patterns over time, like who is on what prescriptions, when their medications get discontinued, and what happens after. He hopes to connect the dots between medication use and real-world health outcomes, especially for older adults with complex needs.</p>
<p>“I try to identify groups of people who would be targets for deprescribing,” he clarifies. “So often it&#8217;s people with dementia or with a prognosis of less than six months, and people who are near end-of-life. We look at their prescription refill records and basically try to piece it together like a daily diary.”</p>
<p>In one <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7456032/">study</a>, Niznik found that people who take 10 or more medications are less likely to discontinue or have doctors deprescribe any of their prescriptions. While these patients seem like logical candidates for deprescribing, Niznik and his team realized they need a more nuanced approach for identifying candidates for medication reduction.</p>
<p>Even though this research might start with interviews and spreadsheets, it is helping reshape how health care systems think about prescribing in older adults.</p>
<p>Niznik is also using data from electronic health care records to compare documents that list patient goals with their medications and determine if those two factors are aligned. For example, if a patient prioritizes staying mentally sharp enough to play with their grandkids, that value should guide how doctors approach drugs that might impact cognition.</p>
<p>“Patient awareness and engagement are what our field needs to drive deprescribing,” Niznik says. “Patients have access to more information, they can ask more questions, and they should ask questions. They should feel empowered to check the decisions that are being made.”</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/rewriting-the-prescription/">Rewriting the Prescription</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Trial and Discovery</title>
		<link>https://endeavors.unc.edu/trial-and-discovery/</link>
		
		<dc:creator><![CDATA[Megan Mendenhall]]></dc:creator>
		<pubDate>Tue, 20 May 2025 12:16:50 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Brain Cancer]]></category>
		<category><![CDATA[breast cancer]]></category>
		<category><![CDATA[clinical trials]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[Lampe Joint Department of Biomedical Engineering]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[North Carolina]]></category>
		<category><![CDATA[Parkinson's disease]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[The University of North Carolina at Chapel Hill]]></category>
		<category><![CDATA[UNC]]></category>
		<category><![CDATA[UNC College of Arts and Sciences]]></category>
		<category><![CDATA[UNC Gillings School of Global Public Health]]></category>
		<category><![CDATA[UNC Lineberger Comprehensive Cancer Center]]></category>
		<category><![CDATA[UNC School of Medicine]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14244</guid>

					<description><![CDATA[<p><em>Carolina researchers are pushing the boundaries of medicine through clinical trials — driving innovation, uncovering new therapies, and shaping a future where science transforms lives.</em></p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/trial-and-discovery/">Trial and Discovery</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p><iframe style="border-radius:12px" src="https://open.spotify.com/embed/episode/7HfORyVU1ZEvrwZruMCXPP?utm_source=generator&#038;t=0" width="100%" height="152" frameBorder="0" allowfullscreen="" allow="autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture" loading="lazy"></iframe></p>
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<p>UNC-Chapel Hill draws people from across the state and nation to participate in its nearly 1,200 clinical trials. These studies are vital for medical innovation, helping us understand which treatments are most effective and safe.</p>
<p>For some participants, clinical trials provide access to cutting-edge treatments, offering new hope for those struggling with conditions that fail to respond to traditional therapies. Others are driven by a desire to contribute to research that has the potential to change countless lives.</p>
<p>Engaging in clinical trials also empowers patients, placing them at the center of their health journey and encouraging meaningful discussions about their treatment options. These studies give people a sense of hope, community, and purpose.</p>
<p>&#8220;Our patients rely on us to provide the best care possible, and this care needs to be informed by evidence,&#8221; explains <a href="https://www.med.unc.edu/healthsciences/physical/directory/dr-michael-lewek-pt/">Mike Lewek</a>, a physical therapy professor at UNC-Chapel Hill. &#8220;Clinical trials allow us to test new and developing treatments and to verify that what we think has an impact on outcomes actually does.&#8221;</p>
<p>In honor of Clinical Trials Day, researchers from around the university unpack the trials they&#8217;re working on and how they could benefit people in North Carolina and beyond.</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14015" style="margin: 10px; margin-top: 18px;" src="https://endeavors.unc.edu/wp-content/uploads/health-care-sidebar.png" alt="Icon of North Carolina" width="45" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">Clinical trials at UNC-Chapel Hill promote advancements in health care and economic growth while improving health outcomes and informing effective health policies for North Carolinians.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_Old-Well2.png" alt="Old Well Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">5,700 participants are actively enrolled in clinical trials at Carolina.</p>
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<h3><strong>Boosting mobility for people with Parkinson’s disease</strong></h3>
			<div class="media-credit-container alignleft"  style="max-width: 1010px">
			<img decoding="async" loading="lazy" class="alignleft wp-image-14248 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_04092025_mike_lewek_0004.jpg" alt="A man smiles with his arms crossed while standing in front of a tread mill in a research lab." width="1000" height="667" /><span class="media-credit">photo by Megan Mendenhall</span>		</div>
	
<p>UNC School of Medicine researcher <a href="https://www.med.unc.edu/healthsciences/physical/directory/dr-michael-lewek-pt/">Mike Lewek</a> is running a clinical trial with colleagues <a href="https://www.med.unc.edu/radiology/people/eran-dayan/">Eran Dayan</a> and <a href="https://www.med.unc.edu/neurology/directory/nina-m-browner-md/">Nina Browner</a> to improve walking for people with Parkinson’s disease.</p>
<p><strong>What is your research focus?</strong></p>
<p>We work with people who have Parkinson&#8217;s disease (PD), a brain disorder impacting movement, balance, and coordination. These individuals often walk with slow, short, shuffling steps. As part of our rehabilitation process, we help them take longer steps by synchronizing their steps to a metronome, a tool used to maintain tempo in music.</p>
<p>Metronomes provide timing cues that aid in learning to move more effectively. Our practice facilitates use-dependent learning, repeating desired movements over and over to change movement patterns.</p>
<p><strong>Tell us about the clinical trial you’re running.</strong></p>
<p>We are examining how we can use various forms of motor learning to create durable, long-term effects on walking for people with PD. My lab has developed a unique method of using a metronome that addresses both the timing and the distance of the steps that people take, parameters that are important to improving walking.</p>
<p>In our clinical trial we are comparing walking with and without this cueing to improve long-term retention of walking. Participants do a series of baseline tests and then complete 12 training visits over a month. They then repeat the walking tests after we complete training, and again three months later to determine how much of the changes they have retained.</p>
<p>Participants also undergo an MRI of their brains to see how the brain changes as it learns. This information will help us understand how to structure interventions that make use of intact pathways, connections, and subsections of the brain. Ultimately, we hope to make our walking changes more durable for longer-term impacts.</p>
<p><strong>What would you like to see happen in the future for your research in the clinical trials space?</strong></p>
<p>I would like to expand my clinical trials to multiple sites and move into community settings. Currently, our work is done in a research lab due to specific data collection needs, but training can be done anywhere with a treadmill. I’d like to partner with outpatient facilities to replicate our findings on a larger scale and measure longer-term outcomes. Just because something works well in a research setting doesn’t mean that it will work everywhere, so translating those findings is critical.</p>
<h3><strong>Expanding life expectancy for people with brain cancer</strong></h3>
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			<img decoding="async" loading="lazy" class="alignnone wp-image-14249 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_04162025_soma_sengupta_0008.jpg" alt="A woman in a white lab coat smiles while standing at a lab bench." width="1000" height="667" /><span class="media-credit">photo by Megan Mendenhall</span>		</div>
	
<p>UNC School of Medicine researcher <a href="https://www.med.unc.edu/neurology/directory/soma-sengupta-md-phd-frcp-faan-fana/">Soma Sengupta</a> is running clinical trials to develop new treatments for an aggressive type of brain cancer called glioblastoma.</p>
<p><strong>What is your research focus? </strong></p>
<p>I’m a physician-scientist specializing in brain tumor treatment and research, and my primary focus is to improve treatment outcomes for patients with brain cancer. The standard approach for treating glioblastoma does not significantly extend the survival outcomes of patients. The journeys of the patients and their families are so hard that I feel my colleagues and I need to shift treatment paradigms to make a difference.</p>
<p><strong>Tell us about the clinical trials you’re running.</strong></p>
<p>My team, which consists of scientists, research coordinators, and regulatory personnel, is currently running over nine trials.</p>
<p>An example of one of these clinical trials is for patients with a new diagnosis of unmethylated MGMT promoter glioblastomas — a type of aggressive, malignant brain tumor.  Participants will be randomly assigned to two different doses of a new cancer drug called ropidoxuridine during six weeks of radiation therapy.</p>
<p>We also have an expanded access program for patients who have exhausted available treatments. They will try a new oral therapy called gallium maltolate, which has proven effective for patients with various cancers.</p>
<p><strong>Have you made any discoveries thus far? </strong></p>
<p>I have discovered how a neurotransmitter receptor in the brain, called GABA-A, works in cancer and immune cells and have established how it can be targeted with a new class of molecules for treatment. GABA-A receptors are a therapeutic target for drugs like benzodiazepines, which can help alleviate anxiety, insomnia, and nausea.</p>
<p>GABA is also found throughout nature. Plants and insects need it to survive. It helps transport metabolites — small molecules that break down substances — into cells. For example, if you go into a field of lavender, you’ll start to feel relaxed because the fragrance is acting on your GABA-A receptor.</p>
<p>The same receptor is present in cancer cells, but it acts differently in non-cancerous cells. We have identified a class of drugs that can kill the cancer cells through this receptor, without affecting normal cells in the same way.</p>
<p><strong>What are your hopes for the future of clinical trials?</strong></p>
<p>A huge part of my research is centered on advocating for patients and caregivers and advancing technologies that have the potential to improve patient quality of life through art, music, and creative writing.</p>
<p>I’m currently collaborating on a study assessing an app for young adults who have survived cancer. It provides them with digital art therapy through weekly prompts to improve their moods. The app was created by a team of designers, artists, art therapists, and clinicians working together to find new ways to help patients.</p>
<p>Whether I’m advocating for the patient, working in the lab, or studying apps, my focus is on improving the quality of life for these patients and improving their outcomes.</p>
<h3><strong>Preventing and treating diseases with omega-3s</strong></h3>
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			<img decoding="async" loading="lazy" class="alignnone wp-image-14250 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_05012025_raz_shaihk_0011.jpg" alt="A man with his hands in his pocket smiles at the camera while standing in front of a brick building on a university campus." width="1000" height="667" /><span class="media-credit">photo by Megan Mendenhall</span>		</div>
	
<p>UNC Gillings School of Global Public Health researcher <a href="https://sph.unc.edu/adv_profile/raz-shaikh-phd/">Saame “Raz” Shaikh</a> is running clinical trials to test how omega-3 fatty acids may prevent and treat various diseases.</p>
<p><strong>What is your research focus? </strong></p>
<p>Long chain omega-3 fatty acids, which are found in oily fish and as dietary supplements, are poorly consumed in the Western diet. In fact, some argue that we are highly deficient in omega-3s, which may help prevent and treat various diseases.</p>
<p>I am focused on understanding how increased dietary consumption of omega-3 fatty acids can improve differing aspects of human health. For example, I am interested in understanding the mechanisms by which long chain omega-3 fatty acids lower chronic inflammation in obesity and other diseases.</p>
<p>Thus far, select omega-3s are clinically approved for lowering elevated triglycerides — a type of fat — and lowering the risk of cardiovascular diseases. Data also suggests they may have a role in infant development, preventing pre-term births, and treating select aspects of depression.</p>
<p><strong>Tell us about the clinical trials you’re running.</strong></p>
<p>We recently completed a clinical trial with a unique fish oil that is high in a fatty acid known as omega-7 to treat inflammation in healthy adults. We are also starting a study with a unique omega-3-enriched fish oil in adults with obesity. Our work is being conducted at the <a href="https://uncnri.org/">UNC Nutrition Research Institute</a> in Kannapolis, N.C.</p>
<p><strong>Have you made any discoveries thus far? </strong></p>
<p>We are studying how metabolites made from omega-3s, which we think are critical for inflammation, increase upon omega-3 consumption. Thus far, we have found that some metabolites increase in the blood after a month of dietary supplementation in adults with obesity. Our goal now is to test a long-term, 12-week intervention to determine if key molecules made from omega-3s are increased in the blood.</p>
<p><strong>What would you like to see happen in the future for your research in the clinical trials space?</strong></p>
<p>Our immediate goal of the research program is to further test the effects of omega-3 fatty acids for improving inflammation by establishing mechanisms and efficacy in the adult population with obesity. The proof-of-concept efficacy part will require placebo-controlled clinical trials focused on inflammation in select patient populations based upon their genetic background and other variables. We also aim to increase consumption of omega-3s in North Carolinians with increased consumption of fish off our own coast.</p>
<h3><strong>Transforming care for people with breast cancer</strong></h3>
			<div class="media-credit-container alignnone"  style="max-width: 1010px">
			<img decoding="async" loading="lazy" class="alignnone wp-image-14247 size-full" src="https://endeavors.unc.edu/wp-content/uploads/sized_04082025_lisa_carey_0003.jpg" alt="A woman in a white lab coat smiles while standing in a hallway of a medical office building." width="1000" height="667" /><span class="media-credit">photo by Megan Mendenhall</span>		</div>
	
<p>UNC School of Medicine researcher <a href="https://www.med.unc.edu/medicine/oncology/people/lisa-a-carey-md/">Lisa Carey</a> is running clinical trials to improve breast cancer treatments.</p>
<p><strong>What is your research focus?</strong></p>
<p>In addition to being a breast cancer doctor, I design and run clinical trials, either testing treatment approaches or examining biologic features as predictors of treatment effectiveness or survival. Those trials are based on clinical challenges I see my patients struggle with every day.</p>
<p><strong>Tell us about the clinical trials you’re running.</strong></p>
<p>There are many trials at Carolina — we have a very engaged group of researchers! I have two that I am particularly involved with. One is testing whether knowledge of the underlying biology of breast cancer helps oncologists make better treatment decisions for incurable or metastatic disease, when cancer cells have spread to other parts of the body. The other trial is examining features of antibody-drug conjugates, a type of cancer treatment that combines a monoclonal antibody — a protein made in a lab to mimic a part of the immune system — with a chemotherapy drug.</p>
<p>Beyond my work at UNC-Chapel Hill, I co-chair the breast cancer committee for a national clinical trials network that runs National Cancer Institute-sponsored clinical trials in the U.S. and Canada. In this setting, I have helped develop and run several trials, including two that are designed to evaluate if therapy can be safely shortened to improve patient comfort. A third trial is testing a lower dose of a common drug to see if it is as effective as a higher dose in order to reduce side effects. Another trial is examining whether adding more medications for high-risk breast cancer can improve the cure rate.</p>
<p><strong>Have you made any discoveries thus far? </strong></p>
<p>The work that I did at Carolina, along with multiple international collaborators, led to the development of a test that may allow us to tailor therapy safely and effectively in a particular kind of breast cancer.</p>
<p>For the national clinical trials network, trials that I oversee have demonstrated that:</p>
<ul>
<li>aspirin does not help prevent breast cancer recurrence;</li>
<li>combining two antiestrogen therapies together does not provide additional benefits compared to using just one;</li>
<li>adding a targeted drug to metastatic treatment of a particular kind of breast cancer doubled the amount of time that the cancer was controlled; and</li>
<li>you can safely perform lumpectomies, instead of a mastectomy, in patients diagnosed with multiple breast cancers.</li>
</ul>
<p><strong>What would you like to see happen in the future for your research in the clinical trials space?</strong></p>
<p>I think there is a huge challenge in supporting young physician scientists getting started in research. We also need to simplify clinical trials so that they can be less expensive and easier to run.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/trial-and-discovery/">Trial and Discovery</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Aging with Care</title>
		<link>https://endeavors.unc.edu/aging-with-care/</link>
		
		<dc:creator><![CDATA[Alyssa LaFaro]]></dc:creator>
		<pubDate>Mon, 19 May 2025 12:16:11 +0000</pubDate>
				<category><![CDATA[Society]]></category>
		<category><![CDATA[aging]]></category>
		<category><![CDATA[aging research]]></category>
		<category><![CDATA[assisted living]]></category>
		<category><![CDATA[dementia]]></category>
		<category><![CDATA[North Carolina]]></category>
		<category><![CDATA[nursing homes]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[Sheryl Zimmerman]]></category>
		<category><![CDATA[Social Work]]></category>
		<category><![CDATA[Social Work Research]]></category>
		<category><![CDATA[UNC Research]]></category>
		<category><![CDATA[UNC School of Social Work]]></category>
		<category><![CDATA[UNC-Chapel Hill]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14234</guid>

					<description><![CDATA[<p>Sheryl Zimmerman has transformed Carolina into a national leader in nursing home and assisted living research.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/aging-with-care/">Aging with Care</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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<p>When <a href="https://ssw.unc.edu/employees/sheryl-zimmerman/">Sheryl Zimmerman</a> started her PhD in social work at the University of Illinois in the early 1980s, dementia care was a new topic in her field.Dementia has been in the vernacular for about 300 years, first described in the mid-1700s as “madness or melancholia” and eventually recognized as a brain disease by the end of that century. In 1910, after engaging in numerous case studies on people with dementia, German psychiatrists Emil Kraelin and Alois Alzheimer became the first to identify Alzheimer’s disease, a type of dementia that started earlier in life and progressed over time.</p>
<p>So while the term was not new in the 1980s, research on the care of people with dementia living in nursing homes and assisted living was. And Zimmerman saw this as an opportunity to dive into the field and uncover best practices for working with this community of people.</p>
<p>“I heard a presentation about it at a national conference, and I thought, <em>That’s where I can make a difference,</em>” she shares. “People weren’t talking about it like they were talking about patients with cancer or rheumatoid arthritis and how they can still have quality of life. Dementia wasn&#8217;t even on people&#8217;s radar screens in terms of having quality of life.”</p>
<p>Today, dementia is an umbrella term for a collection of symptoms —memory loss, language decline, and reduced problem-solving ability — that are severe enough to impede daily activities. The most common cause of dementia is Alzheimer’s disease, a progressive disorder that causes these symptoms to worsen over time.</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14015" style="margin: 10px; margin-top: 18px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_NC-state2.png" alt="Icon of North Carolina" width="60" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">In 2024, 1.8 million North Carolinians were over age 65 — a number that’s expected to double by 2040, according to the N.C. Office of State Budget and Management. Sheryl Zimmerman’s research on how to better support people in nursing homes and assisted living communities helps protect this population.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/US-dollar-sidebar_Dollar-Sign.png" alt="Dollar Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">Federal funding propels projects like this forward. Most of Zimmerman’s funding for this work comes from the National Institutes of Health.</p>
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<p>Now at Carolina, Zimmerman is the nation’s top-ranked social work scholar on aging and long-term care. She is a distinguished professor in the UNC School of Social Work; co-director of the Program on Aging, Chronic Illness, and Long-Term Care at the Cecil G. Sheps Center for Health Services Research; and executive director of <a href="https://theceal.org/">CEAL@UNC</a> — a national center advancing the well-being of people who work and live in assisted living communities.</p>
<p>She has written five books and published over 450 peer-reviewed studies, and her work has been cited nearly 31,000 times. In 2022, she was recognized for her incredible contributions to the field with the Kleemeier Award from the Gerontological Society of America, and in 2024, she received the Distinguished Career Achievement Award from the Society for Social Work and Research.</p>
<p>“The welfare of older adults affects everyone,” Zimmerman says. “We’re all growing older, and we all have someone in our family who already is older, from parents to aunts and uncles. And in the next 10 years, the number of older adults is going to exceed the number of people aged 18 and younger.”</p>
<h3><strong>A researcher at heart</strong></h3>
<p>Growing up as a middle child in the suburbs of Chicago, Zimmerman would watch her family’s daily interactions. She’s always been tuned into how people affect each other within systems.</p>
<p>“In some ways, having a psychosocial perspective was the core of who I was from a young age,” she says.</p>
<p>Psychosocial research explores the intersection of psychological and social conditions — and how those factors impact behavior, physical health, and well-being.</p>
<p>Inspired by her intro to psychology class at the University of Illinois Urbana-Champaign and her older brother’s research with police departments, Zimmerman decided to major in social work and minor in criminal justice. She began conducting research as a first-year undergraduate student and went on to earn a master’s and PhD in social work. Her dissertation assessed interactions between police officers and social workers affiliated with police departments.</p>
<p>When Zimmerman landed her first faculty position in the epidemiology department at the University of Maryland in 1989, she attended a gerontological conference that provided insight about the huge gap in research in assisted living, now the largest residential long-term care provider overall and for people with dementia.</p>
<p>“At that point, I was a strong psychosocial and health services researcher — and I think someone who&#8217;s a researcher at heart can find passion to study almost anything,” she says. “As soon as I started getting involved in research with older adults, I realized it&#8217;s a population where so much could be done and where a little would go a long way. And so from the beginning, I saw it as a place where I could make the most impact.”</p>
<h3><strong>Life-saving interventions</strong></h3>
<p>With 40 years in the field and hundreds of studies to her name, Zimmerman has worked on countless projects, from the impact of reducing antibiotic prescribing in nursing homes to dementia prevalence in assisted living to how this demographic was affected by the COVID pandemic.</p>
<p>One of her most impactful projects to date is an oral health intervention.</p>
<p>“You can tell the quality of care in a nursing home by looking at someone&#8217;s mouth,” she says.</p>
<p>Consider what happens sometimes while eating dinner with friends. While talking and chewing, food might go down “the wrong pipe,” meaning it enters the lungs and we, in response, cough until it comes out. That’s called aspiration.</p>
<p>Older adults who experience coughing or trouble breathing can aspirate bacteria from their mouth into their lungs, which could lead to an infection like pneumonia — which affects more than 250,000 nursing home residents annually, according to Zimmerman. The likelihood of pneumonia is higher when the teeth and gums harbor bacteria, and people who have experienced stroke or are living with Alzheimer’s disease or other cognitive impairments may not be able to brush their teeth.</p>
<p>In response, Zimmerman and Carolina colleagues Philip Sloane, John Preisser, and Patricia Poole developed an evidence-based training program for people with cognitive and physical impairment called “<a href="https://www.mouthcarewithoutabattle.org/">Mouth Care Without a Battle</a>.” In a 2020 study, they found that training nursing home staff to provide daily mouth care using this program reduced pneumonia by 26%.</p>
<p>This toolkit provides information about cleaning older people’s teeth — like gentle brushing for broken teeth, dentures, and sensitive gums — and has been provided free of charge to nursing homes across North Carolina, Connecticut, Florida, and West Virginia.</p>
<p>“It&#8217;s not rocket science, but someone with dementia might back away and close their mouth when someone approaches them with a toothbrush,” Zimmerman says. “So staff need to learn sensitive care practices, like approach from the front and go slow.”</p>
<p>Zimmerman is equally proud of her <a href="https://www-clinicalkey-com.libproxy.lib.unc.edu/#!/content/playContent/1-s2.0-S1525861024006492?returnurl=null&amp;referrer=null">research on a lighting system for doorframes</a> that’s reduced falls at night by 34%. Falls are the leading cause of injury for adults 65 and older, according to the Centers for Disease Control. They can lead to muscle strains, bone breaks, and even death.</p>
<p>Not only was Zimmerman’s intervention successful, but it’s low-cost and easy to implement.</p>
<p>“I told my friend about it, and she decided to string Christmas lights around her mom&#8217;s bedroom door,” she shares with a laugh. “It’s a good start. Our lighting system is more fine-tuned than that.”</p>
<h3><strong>A center of aging expertise</strong></h3>
<p>For hundreds of years, families have taken care of older adults themselves. It wasn’t until the mid-1900s when private and public nursing homes started to develop nationwide, partially due to a shift in hospital rehabilitative care after World War II. As Medicare and Medicaid expanded coverage for care, more and more nursing homes were built.</p>
<p>By the 1980s, it became clear that not everyone needing supportive care required nursing care, and so assisted living — a model more focused on person-centered care rather than medical care — mushroomed. Assisted living communities help people with housekeeping, medications, and other daily tasks, but don’t provide nursing care. Between 1990 and 2002, the number of assisted living beds grew by 97%.</p>
<p>In the early 2000s, the U.S. Senate Special Committee on Aging convened a hearing on assisted living to better understand this burgeoning industry, resulting in a workgroup to address guidelines for policy, regulation, and operations. One recommendation was to create a national Center for Excellence in Assisted Living (CEAL). Founded in 2003, the center brought together experts from across the country to inform care practices — from medication management to information disclosure — and policies for the people who work and live in these communities.</p>
<p>Zimmerman has been involved with CEAL since its founding, and in 2023, oversaw its transition to Carolina. Today, she leads CEAL@UNC, which strives to bridge the gap between academic research, practice, policy, and public understanding; develops tools for medical and mental health care in assisted living; confers with legislative representatives to inform policy; and works with more than 100 organizational representatives and researchers involved in assisted living.</p>
<p>“I&#8217;ve never done research solely to publish papers,” Zimmerman says. “I do research because I want to inform practice and policy — and CEAL is all about that.”</p>
<p>Real-world application is key for Zimmerman. She wants to supply caregivers with knowledge they can implement immediately. We all know someone who is aging and needs care, even if they’re not dealing with decline from dementia.</p>
<p>After four decades of working with these communities, and taking care of her own parents, Zimmerman offers advice to anyone who might benefit from it.</p>
<p>“First, take a deep breath, and take stock of your capacity and well-being,” she advises. “If you over-tax yourself, no one wins. Second, learn about the issues affecting your family member or friend, which can inform how you interact on a day-to-day basis. Third, learn about and take advantage of the resources that are available. As the population has grown, so too have the resources to support their care and yours.”</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/aging-with-care/">Aging with Care</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>RUNC: Elizabeth Kwong</title>
		<link>https://endeavors.unc.edu/runc-elizabeth-kwong/</link>
		
		<dc:creator><![CDATA[UNC Research Stories]]></dc:creator>
		<pubDate>Wed, 14 May 2025 12:30:15 +0000</pubDate>
				<category><![CDATA[Health]]></category>
		<category><![CDATA[Research UNCovered]]></category>
		<category><![CDATA[Society]]></category>
		<category><![CDATA[burnout]]></category>
		<category><![CDATA[Elizabeth Kwong]]></category>
		<category><![CDATA[Graduate Student]]></category>
		<category><![CDATA[health]]></category>
		<category><![CDATA[health care]]></category>
		<category><![CDATA[health care worker]]></category>
		<category><![CDATA[medicine]]></category>
		<category><![CDATA[PhD Student]]></category>
		<category><![CDATA[physician burnout]]></category>
		<category><![CDATA[The Graduate School at UNC-Chapel Hill]]></category>
		<category><![CDATA[UNC Health]]></category>
		<category><![CDATA[UNC Research]]></category>
		<category><![CDATA[UNC School of Medicine]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14253</guid>

					<description><![CDATA[<p>Elizabeth Kwong studies physician burnout and how to improve their well-being.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/runc-elizabeth-kwong/">RUNC: Elizabeth Kwong</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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<p>Elizabeth Kwong is a recently graduated PhD student of the Carolina Health Informatics Program, which is supported by nine academic units across the UNC-Chapel Hill campus. She researches and identifies factors contributing to clinician burnout and looks for areas of improvement to improve well-being.</p>
<p><span style="color: #4b9cd3;"><b>Q: How did you discover your specific field of study?</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>In 2021, I started my PhD in the UNC Healthcare Engineering Division because I was interested in improving care and safety for patients. Led by Dr. Lukasz Mazur, the division and team members have had a huge impact on my research. More recently, I have been studying clinician burnout and well-being, especially after the pandemic, when health care professionals were inundated in the clinic. We need to take care of the clinicians that take care of others, first and foremost.</p>
<p><span style="color: #4b9cd3;"><b>Q: Academics are problem-solvers. Describe a research challenge you’ve faced and how you overcame it.</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>Assessing clinician well-being is not new. Most health care professionals complete yearly surveys that ask them what can be done to improve their welfare. The problem is clinicians often don’t see any substantial change. The data gets collected and ends up as a metric somewhere.</p>
<p>That’s why I wanted to be comprehensive and holistic with my data collection methods. I too started with a survey, but also conducted focus groups so participants could provide contextual information for their top-rated stressors. Then, we followed up with them individually to shadow them, see issues in real life, and conduct interviews. We used this information to identify key problem areas, which participants rated from the least to most impactful. This was used to create a visual report that was presented back to their departments and hospital leadership.</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/US-dollar-sidebar_United-States.png" alt="Icon of USA" width="35" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">Burnout directly impacts physicians’ well-being, patient safety, and the overall quality of health care delivery. More than 45% of U.S. physicians reported at least one symptom of burnout in 2023, according to the American Medical Association.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/RUNC-sidebar_Old-Well2.png" alt="Old Well Icon" width="35" /></p>
<p style="padding-bottom: 5px; line-height: 150%;">Elizabeth is one of more than 9,000 graduate students at Carolina. Some will become the next generation of professors and researchers. Others will pursue private sector jobs, fueling fields like technology, science, health care, art, and music.</p>
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<p>During my project, multiple clinicians told me that not only did they feel like they were being heard, but that they hoped this would bring about some of the changes they have been wanting to see. Our next challenge is living up to that promise and ensuring those improvements are implemented.</p>
<p><span style="color: #4b9cd3;"><b>Q: Describe your research in five words.</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>Contextual clues uncover burnout blues.</p>
<p><span style="color: #4b9cd3;"><b>Q: Who or what inspires you? Why?</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>Women scientists and leaders. My mentors. My family. My partner. They have all impacted and inspired me in different ways at different time periods of my life and motivated me to get to where I am today. They also give me inspiration when things in the world don’t seem great.</p>
<p>I also can’t forget my cat Billie Jean and dog Eleanor Rigby, who inspire me to keep working hard so I can continue feeding them fancy food.</p>
<p><span style="color: #4b9cd3;"><b>Q: If you could pursue any other career, what would it be and why?</b></span></p>
<p><span style="color: #b72177;"><b>A: </b></span>I think it would be cool to be a food and travel journalist. I love to eat, travel, and eat while I travel, so to be paid to do that would be amazing.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/runc-elizabeth-kwong/">RUNC: Elizabeth Kwong</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Rooted: Sandra B. Greene</title>
		<link>https://research.unc.edu/2025/05/07/rooted-sandra-b-greene/</link>
		
		<dc:creator><![CDATA[Corina]]></dc:creator>
		<pubDate>Wed, 07 May 2025 15:26:23 +0000</pubDate>
				<category><![CDATA[Rooted]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14229</guid>

					<description><![CDATA[<p>Sandra B. Greene has been contributing to research at Carolina for 45 years.</p>
<p>The post <a rel="nofollow" href="https://research.unc.edu/2025/05/07/rooted-sandra-b-greene/">Rooted: Sandra B. Greene</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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										<content:encoded><![CDATA[&hellip;<p>The post <a rel="nofollow" href="https://research.unc.edu/2025/05/07/rooted-sandra-b-greene/">Rooted: Sandra B. Greene</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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		<title>Cap to Career</title>
		<link>https://endeavors.unc.edu/cap-to-career/</link>
		
		<dc:creator><![CDATA[Maggie McIntyre]]></dc:creator>
		<pubDate>Wed, 23 Apr 2025 13:05:54 +0000</pubDate>
				<category><![CDATA[Society]]></category>
		<category><![CDATA[college graduation]]></category>
		<category><![CDATA[graduation]]></category>
		<category><![CDATA[Philosophy]]></category>
		<category><![CDATA[politics]]></category>
		<category><![CDATA[Research]]></category>
		<category><![CDATA[student]]></category>
		<category><![CDATA[Student Research]]></category>
		<category><![CDATA[UNC College of Arts and Sciences]]></category>
		<category><![CDATA[undergraduate]]></category>
		<category><![CDATA[undergraduate research]]></category>
		<category><![CDATA[Willow Taylor Chiang Yang]]></category>
		<guid isPermaLink="false">https://endeavors.unc.edu/?p=14138</guid>

					<description><![CDATA[<p>Willow Taylor Chiang Yang explores how socioeconomic status predicts career values and decisions among graduating seniors.</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/cap-to-career/">Cap to Career</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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										<content:encoded><![CDATA[<p><iframe style="border-radius:12px" src="https://open.spotify.com/embed/episode/6dyPytLFsRYrwmlI1QL3cF?utm_source=generator&#038;t=0" width="100%" height="152" frameBorder="0" allowfullscreen="" allow="autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture" loading="lazy"></iframe></p>
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<p>Graduation, at its core, is a celebration. A turning of tassels and tossing of caps, signifying an end to academic pursuits.</p>
<p>But for many seniors, graduation brings a torrent of pressure and uncertainty. Balancing personal interests, financial security, and family expectations is a delicate dance — one that makes it incredibly hard to answer the question everyone is asking: What’s next?</p>
<p>As Willow Taylor Chiang Yang aptly describes it: &#8220;It&#8217;s both confusing and totally understandable at the same time.&#8221;</p>
<p>This paradox lies at the heart of her research, which explores how socioeconomic status predicts career decisions among college seniors. As a graduating senior at UNC-Chapel Hill, Chiang Yang isn’t just studying this phenomenon — she’s living it.</p>
<h3><strong>Shaping her interests</strong></h3>
<p>In 2017, at the age of 14, Chiang Yang knew she wanted to change the world — and decided that politics was the best way to make her mark. She quickly became involved in political campaigns and journalism, fueling her interests in activism and economics, curiosities that would shape her academic experiences.</p>
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<h3>Impact Report</h3>
<p><img decoding="async" class="alignleft size-full wp-image-14016" style="margin: 10px;" src="https://endeavors.unc.edu/wp-content/uploads/RUNC-sidebar_Old-Well2.png" alt="Old Well Icon" width="35" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">16,000+ undergraduate students are engaged in research at Carolina, from humanities to health care.</p>
<p><img decoding="async" class="alignleft size-full wp-image-14015" style="margin: 10px; margin-top: 18px;" src="https://research.unc.edu/wp-content/uploads/2025/03/RUNC-sidebar_NC-state2.png" alt="Icon of North Carolina" width="60" /></p>
<p style="padding-bottom: 20px; line-height: 150%;">Support from programs like the Morehead-Cain Scholars Program encourage the next generation of leaders to use their education to positively impact the university, state, nation, and world.</p>
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<p style="margin-top: 3px;">When she began studying at The Nueva School outside San Francisco, Chiang Yang took a seventh-grade elective on game theory and economics — her first academic introduction to the subject. Her teacher in that class became a key mentor, inspiring her interest in the intersection of economics, philosophy, and social justice. Years later, Chiang Yang was a student in his high school economics class. Now, she fondly recalls his support.</p>
<p>“He said to me, ‘I knew you as a seventh grader, and you were going to absolutely annihilate all those eighth-grade boys in the class,’” she says with a smile. ”At that moment, I thought economics was something that I could potentially do.”</p>
<p>Chiang Yang explored these interests outside the classroom, too. She founded her high school’s newspaper and began writing for a magazine. Through these experiences, she deepened her understanding of social issues and began to see the connections between media, activism, and the power structures that shape our lives.</p>
<p>Because of her diligent work in high school, Chiang Yang was awarded the <a href="https://www.moreheadcain.org/">Morehead-Cain scholarship</a> at UNC-Chapel Hill, which focuses on developing the next generation of leaders. She knew that Carolina was the place to continue exploring meaningful ways to engage with the world.</p>
<h3><strong>Finding her focus</strong></h3>
<p>When Chiang Yang started her undergraduate studies in 2021, she studied philosophy and created her own major in American political economy. Her academic path set the stage for her evolving research focus, which began to take shape during the aftermath of the COVID-19 pandemic.</p>
<p>As the pandemic reshaped labor markets, particularly with an increase in voluntary resignations, Chiang Yang became intrigued by the idea of a “values reorientation” in the workforce. She initially wanted to analyze long-term trends in work values, comparing shifts in the U.S. and China, even traveling to Shanghai to explore the cultural landscape. Faced with limited access to data, she pivoted her research to focus more narrowly on college-age students at UNC-Chapel Hill.</p>
<p>This pivot was influenced in part by her own experiences as a graduating senior, grappling with the same career anxieties and uncertainties she aimed to explore. She saw that college seniors were at a critical crossroads, making significant decisions about their futures, and recognized that their perspectives could offer invaluable insights into the evolving landscape of work values.</p>
<p>“When we talk about labor and the thing that we spend over a third of our lives doing, of course this is going to be a huge part of how you derive value, how you identify, how you explain living to other people,” she says.</p>
<p>With a clear focus in mind, Willow designed a survey that asked participants to rate 10 key work considerations — from job stability to reputation to personal interest — by placing each into one of three categories: “value it,” “don’t consider it,” or “actively try to reject it/avoid it.” Then, she had them rank the values by importance, providing insight into the magnitude of their preferences.</p>
<p>After hundreds of emails and numerous in-person surveys, Chiang Yang gathered responses from over 240 graduating seniors at Carolina.</p>
<p>“I&#8217;ve been lucky to have known and been friends with a lot of different kinds of people from different backgrounds,” she says. “And I’ve heard the variety of things that they&#8217;re thinking about.”</p>
<p>So far, Chiang Yang has uncovered some interesting results. For example, participants from lower and middle socioeconomic backgrounds are more likely to place higher value on job stability and social impact compared to people from more affluent families. And people of all backgrounds rank their desire for personal fulfillment the same: It’s important.</p>
<p>Her thesis also examines the concept of &#8220;economic self-realization,&#8221; which explores whether people from different socioeconomic backgrounds truly have sufficient access to the career opportunities that align with their values.</p>
<h3><strong>Exploring divides</strong></h3>
<p>Outside of her thesis, Chiang Yang has found other ways to engage in research.</p>
<p>After taking a class with Carolina philosophy professor <a href="https://philosophy.unc.edu/people/luc-bovens/">Luc Bovens</a>, she began learning a programming language for data analysis. For the last three years, they’ve been analyzing data from the American National Election Survey and the General Social Survey to understand ideological differences between democrats and republicans with and without a bachelor&#8217;s degree or higher.</p>
<p>Their preliminary results indicate that, over the past few decades, preferences have become more strongly aligned with party affiliation rather than education level — a flip-flop from an earlier trend where educational level had a more significant correlation with political views. But Chiang Yang and Bovens have yet to run tests of statistical significance.</p>
<p>“It seems like our hypotheses are holding up, which is super cool,” Chiang Yang reflects.</p>
<p>While she hopes to continue contributing to this project after she graduates, she’d also like to spend a year traveling and then a few years working before pursuing a PhD. She’s enjoyed the research process so much that she knows she wants to do more of it in the future.</p>
<p>That’s because her research isn’t just an academic pursuit — it’s a lens through which she’s examining the world around her. She’s not just asking important questions about career values; she’s considering how to reshape the systems that influence those values.</p>
<p>“I think work has always been a really big part of my identity and a part of how I choose to interact with the world,” she reflects. “And it will continue to be so.”</p>
<p>The post <a rel="nofollow" href="https://endeavors.unc.edu/cap-to-career/">Cap to Career</a> appeared first on <a rel="nofollow" href="https://endeavors.unc.edu">UNC Research Stories</a>.</p>
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