Does Not Equal is a webcomic by Sarah Ennals – check out the pre-Futurismic archives, and the strips that have been published here previously.

[ Be sure to check out the Does Not Equal Cafepress store for webcomic merchandise featuring Canadians with geometrically-shaped heads! ]

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Rather than having their cellular clocks fully reset and reverting to an embryonic state, cells in the salamanders’ stumps became slightly less mature versions of the cells they’d been before. The findings could inspire research into human tissue regeneration.

“The cells don’t have to step as far back as we thought they had to, in order to regenerate a complicated thing like a limb,” said study co-author Elly Tanaka, a Max Planck Institute cell biologist. “There’s a higher chance that human or mammalian cells can be induced into doing the same thing.”

[...]

They found that salamander regeneration begins when a clump of cells called a blastema forms at the tip of a lost limb. From the blastema come skin, muscle, bone, blood vessels and neurons, ultimately growing into a limb virtually identical to the old one.

Researchers, many of whom hoped their findings could someday be used to heal people, hypothesized that as cells joined blastemas, they “de-differentiated” and became pluripotent — able to become any type of tissue. Embryonic stem cells are also pluripotent, as are cells that have been genetically reprogrammed through a process called induced pluripotency.

Such cells have raised hopes of replacing lost or diseased tissue. They’re also difficult to control and prone to turning cancerous. These problems may well be the inevitable growing pains of early-stage research, but could also represent more fundamental limits in cellular plasticity.

If Tanaka’s right that blastema cells don’t become pluripotent, then the findings raise another possibility — not just for salamanders, but for people. Rather than pushing cellular limits, perhaps researchers could work within nature’s parameters.

Another step towards transhuman immortality, perhaps? It’s fun seeing such science fictional subjects in ‘regular’ news venues, if only to watch journalists asking the sort of questions science fiction has always hinged on – like Khaled Diab at The Guardian, for example, trying to imagine what the world would be like if Aubrey De Grey is right about the immortality singularity:

Should people’s lives be extended indefinitely? If not, should society or the individual choose when to pull the plug? Should a 250-year-old physical teen be treated as an adult and served alcohol or not? Would society take long-term threats, such as the environment, more seriously because people will actually live to see the consequences? Does living so long rob future generations of their right to life? Would you like to live in a society without death?

I figure that, if it happens, we’ll work out a way to cope during the journey – much like Jamais Cascio suggests we’ll cope fine with intelligence augmentation, because it’s an iterative process rather than a momentary leap of change.

Of course, De Grey has already secured himself one form of immortality – the only form of it in which I’d be interested, anyway. I’m sympathetic to the transhumanist project, but the thought of living forever just doesn’t appeal to me. I’ve always theorised that without the ticking clock of mortality we’d have very little to motivate us to create anything new or unique; you struggle to produce a legacy to fill the void of your leaving, if you will. Of course, my attitudes may change as I get older… but even so, if offered the choice right now I’d settle for a standard lifespan minus the gradual decline into senescence and frailty at the end. Death doesn’t scare me, but dying slowly sure does.

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Hawking says that we have entered a new phase of evolution. “At first, evolution proceeded by natural selection, from random mutations. This Darwinian phase, lasted about three and a half billion years, and produced us, beings who developed language, to exchange information.”

But what distinguishes us from our cave man ancestors is the knowledge that we have accumulated over the last ten thousand years, and particularly, Hawking points out, over the last three hundred.

“I think it is legitimate to take a broader view, and include externally transmitted information, as well as DNA, in the evolution of the human race,” Hawking said.

This point has echos of Jack Cohen and Ian Stewarts ideas of extelligence, Richard Dawkins‘ notion of the meme, and Kevin Kelly’s concept of the Technium. What is special about humans is as much about what happens outside and between our minds as any other intrinsic properties of homo sapiens sapiens

[via George Dvorsky, from The Daily Galaxy][image from Peter Kaminski on flickr]

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Through The Extraordinaries, you might be able to use your smart phone — while waiting in the dentist’s office or standing in the Dept. of Motor Vehicles line — to:

• translate a foreign-language document into English

• add identifying tags to photos and videos for a museum

• give advice to a college applicant

During your lunch break you could snap a picture of a pothole that needs patching and zap it to the proper authorities. You could report a dying elm to the parks-and-recreation department or spot a rare woodpecker for the Audubon Society.

“This is an organization that changes the paradigm,” says Jacob Colker, 26, co-founder of the San Francisco-based Extraordinaries. “We hope people might look differently at that ride on the bus and not just play video games.”

Skepticism is healthy, too, of course. I’m still on crowdsourcing 101, myself, but unintended consequences can sometimes be positive.

[What are you doing? by wharman]

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Ornithopters – which feature heavily in the Dune series – are aircraft that are propelled by flapping their wings like a bird rather than using rotors, propellors or jets. Check out the Mercury prototype in action:

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