In Sequence from GenomeWeb News

Halcyon Molecular Develops Threading Method to Sequence DNA by Transmission EM

Fri, 19 Mar 2010 18:16:19 +0000

At the National Human Genome Research Institute's Advanced Sequencing Technology Development meeting in Chapel Hill, NC, last week, J. Provine, Halcyon's director of nanofabrication, talked about the progress the company has made over the last several years.

Illumina Launches HiScanSQ, Hoping to Lure Microarray Users to Sequencing

Fri, 19 Mar 2010 18:14:15 +0000

The instrument consists of the HiScan Reader, a high-performance array scanner with sub-micron resolution, and the SQ Module, an add-on fluidics device for sequencing.

NIH Developing Genetic Testing Registry to Go Online in 2011

Thu, 18 Mar 2010 16:59:42 +0000

Genetic test providers will be encouraged to voluntarily submit information about the availability, validity, and utility of their tests to the registry, which will serve as an information resource for researchers, healthcare providers, and patients. In addition, the registry will function to facilitate genomic data sharing for research.

Ambry Genetics Adopts RainDance Platform for DNA Enrichment, Sequencing Services

Wed, 17 Mar 2010 19:26:39 +0000

Ambry Genetics, which has a CAP-accredited and CLIA-certified laboratory, is using RainDance's RDT 1000 for micro-droplet PCR-based enrichment of target DNA for sequencing.

Two Studies Highlight Ability of Whole-Genome Sequencing to ID Causative Genes in Mendelian Disease

Tue, 16 Mar 2010 20:21:25 +0000

The researchers from both studies said that their approaches will be useful for studying not only Mendelian diseases, but also more complex diseases.

At NHGRI Meeting, Nanopore Groups Report First Successes in Reading DNA

Tue, 16 Mar 2010 20:21:23 +0000

Researchers from the University of Washington, Nabsys, and Boston University reported advances in electronic and optical approaches to nanopore sequencing last week, including one group's first sequence read.

GE Researchers Plan to Sequence Single DNA Molecules Using “Closed Complex” Chemistry Soon

Tue, 16 Mar 2010 20:15:24 +0000

At the NHGRI Advanced DNA Sequencing Technology Development meeting last week, a GE researcher reported forming stable closed complexes between primed single DNA molecules, polymerase, and nucleotides on a solid support in a microfluidic system.

Plummeting Cost of Whole-Genome Sequencing Raises Questions about Longevity of Exome Sequencing

Tue, 16 Mar 2010 20:03:21 +0000

Participants at a recent conference agreed that the cost of whole-genome sequencing will eventually reach a point that makes exome sequencing obsolete, but there was little agreement over what that crossover price might be, or when it will be attainable.

Q&A: Henk Postma on Graphene Nanogaps for Electronic Single-Molecule Sequencing

Tue, 16 Mar 2010 19:25:22 +0000

Postma, an assistant professor in the department of physics and astronomy at California State University Northridge, recently proposed to sequence DNA using graphene nanogaps, measuring the transverse conductance of the bases.

New Products

Tue, 16 Mar 2010 19:07:21 +0000

Diagenode Bioruptor, CLC Bio De Novo Assembler, SoftGenetics Mutation Surveyor

Paired Ends

Tue, 16 Mar 2010 18:45:32 +0000

David Botstein, Francis Collins, Eric Lander, Leena Peltonen-Palotie, Carl Fuller, Fredrik Dahl

At AGBT, Complete Genomics Sketches Route to 1M Human Genomes; Discusses Early Customer Projects

Tue, 09 Mar 2010 21:27:23 +0000

The company's CSO presented a number of early customer projects, including rare disease studies of a family and an individual, and the firm's first analysis of a primary tumor. In addition, Complete Genomics recently provided details about its commercial service.

Illumina Demonstrates 350 Gb Run on HiSeq 2000; Shows Sequencing Apps for New Instrument

Tue, 09 Mar 2010 21:27:23 +0000

During a company workshop at the Advances in Genome Biology and Technology conference this month, Illumina representatives and a customer showed results from early projects in which they used the HiSeq 2000 for whole-genome sequencing and gene expression analysis and compared its performance to that of the GAIIx.