Amino Acid Catabolism

christoff — Sun, 16 Oct 2011 14:59:10 +0000

This page specifically goed over the various transamination reactions and glutamate deamination which make substrates for the urea cycle. I find this page to be fairly complete and well written with the usual chemical structures on the side.

Interactive animation on inhibitors

christoff — Sat, 10 Sep 2011 04:22:50 +0000

This is a neat animation that gives a better understanding about the effects of inhibitors on enzymes.

MALDI-TOF Spectrometer

christoff — Tue, 06 Sep 2011 03:13:17 +0000

Another great animation that explains the basic workings of a Matrix Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) spectrometer.These are high resolution spectrometers that are useful in determining the mass of atoms all the way to proteins.

HPLC videos and instructions by Sigma-Aldrich

josh — Wed, 31 Aug 2011 19:05:25 +0000

A little product-centric but a good introduction to HPLC techniques and equipment

HPLC Column Fundamentals
Introduction to how solutes can interact with columns containing porous particles and stationary phases to result in separation. I'm listing the most helpful ones below

Nick the Hero: Boost HPLC Productivity
Key features and benefits of Ascentis Express columns and how to use them to boost HPLC lab productivity.

Ultra-high Performance using Fused-Core^® HPLC Columns (28 min)
Reviews the use of Ascentis Express columns with traditional instruments and with ultra-high pressure systems.

The Use of Alternate Selectivity in Reversed-Phase HPLC (43 min)
Chemical structure of various types of bonded phases.

Introduction to Ascentis HPLC Columns (23 min)
Provides an overview of the family of columns.

HPLC Instrument bandwidth and optimizing systems for high-performance (14 min)
Discusses sample dispersion in a HPLC system, and how it can be measured for a given flow rate. Lowering the instrument bandwidth is necessary to achieve the best performance from a high-efficiency column.

High-performance HPLC Fittings and Interconnects
Demonstrates the proper use of our exclusive fittings designed for use with ultra-high pressure and narrow-bore HPLC columns.

Big Picture of signal transduction

christoff — Wed, 31 Aug 2011 05:58:19 +0000

This is a great animation by the university of Pittsburg. It is not only short and concise but it is complete as well. From the main picture you can learn about apoptosis, caspase cascade, apoptosomes, tyrosine kinases, DNA transcription factors and so many more. This might be more geared towards a molecular biologist but it is a great review for a biochemist.

A great animation tutorial on Tyrosine Kinase Receptors

christoff — Wed, 31 Aug 2011 03:36:20 +0000

This is a short and sweet animation that fairly thoroughly reviews tyrosine kinase receptors, autophosphorylation and the signal pathway.

Relationship of inhibitors to Michaelis-Menten Parameters

christoff — Tue, 30 Aug 2011 00:47:04 +0000

Basically remember the following two statements and then derive which type of inhibitor is being expressed.

If one could overcome inhibitor by increase in [Substrate] then Vmax does not change
If inhibitor changes affinity of enzyme to substrate then Km is changed (usually increased)

Competative inhibitor

competes for active site
can be overcome by increase in [S]

Uncompetative inhibitor

Binds Enzyme-Substrate complex
increases apparant Km (enzyme affinity to substrate)
Decreases Vmax (cannot be overcome by additional [S])

Mixed inhibitor

Has affinity to both free enzyme and ES complex
Some have equal affinity = Non-competative inhibitor(rare)
Cannot be overcome by increase in [S] so Vmax decrease
For the most part affinity to substrate changes little to none(non-competative)

X-Ray Diffraction lecture

josh — Sat, 27 Aug 2011 17:30:31 +0000

This lecture covers electron distribution as seen by light diffraction (X-ray diffraction).

The roles of molecular pattern and crystal lattice repetition are illustrated by shining laser light through diffraction masks to generate patterns reminiscent of those encountered in x-ray studies of ordered solids.

This lecture is from the Yale Open Course series.

Earnshaw's Theorem and Double Minima lecture

josh — Sat, 27 Aug 2011 17:21:21 +0000

This lecture covers the "double-well potential of the ozone molecule," "stable arrangements of charged particles" as prescribed by Earnshaw's Theorem, and the all-to-familiar "plum-pudding" atom. Also talks about Coulomb's law.

This is part of the Open Yale courses series.

Force Laws, Lewis Structures, Resonance lecture

josh — Fri, 26 Aug 2011 15:54:55 +0000

This lecture covers the basics of chemical bonding and molecular structure.

After discussing Lewis-dot notation and formal charge, Professor McBride shows that in some "single-minimum" cases the Lewis formalism is inadequate and salvaging it required introducing the confusing concept of "resonance."

This is part of the Open Yale courses series.

First Organic Chemistry Lecture at Yale

josh — Fri, 26 Aug 2011 15:51:14 +0000

A bit of an introduction to chemistry in general and how we get to the important conclusions that add to our body of knowledge. The title is "how do we know," an important question, indeed!

He illustrates the fruitfulness of experiment and logic using the rise of science in the seventeenth century. London's Royal Society and the "crucial" experiment on light by Isaac Newton provide examples. In his correspondence with Newton Samuel Pepys, diarist and naval purchasing officer, illustrates the attitudes and habits which are most vital for budding scientists - especially those who would like to succeed in this course.

This is part of the Open Yale courses series.

Complete Organic Chemistry textbook resources

josh — Wed, 03 Aug 2011 01:59:11 +0000

This is an on-line learning component to a Carey organic chemistry textbook. Truly covers every topic out of a good O-chem textbook. Definitely worth a look if you need parts of this course explained in a different way.

Organic Chemistry IUPAC Nomenclature

josh — Wed, 03 Aug 2011 00:54:15 +0000

Complete explanation of IUPAC organic nomenclature for all organic molecules. Also includes practice drills, interactive animations, and a simplified high school version.

Organic Chemistry Exams

josh — Wed, 03 Aug 2011 00:50:04 +0000

HUGE store of PDF organic chemistry exams! There are midterms and finals for the first and second semester of upper division organic chemistry. Awesome resource, with I had this when I was in these classes...

Organic Chemistry Concepts

josh — Wed, 03 Aug 2011 00:47:01 +0000

Fantastic group of organic chemistry concepts online. There are images, text explanations, several interactive molecule animations, and so much more. Concepts explained:

Organic Chemistry Sample Problems

josh — Wed, 03 Aug 2011 00:42:08 +0000

All of these problems are in PDF so they're easy to print out, try out, and share. List of problem sets:

Chem 351 Wk 4 [PDF]

Chem 351 Wk 6 [PDF]

Chem 351 Wk 7 [PDF]

Chem 351 Wk 9 [PDF] (solving spectroscopy problems, worked example)

Chem 351 Wk 10 [PDF]

Chem 351 Wk 11 [PDF]

Chem 351 Wk 12 [PDF]

Chem 351 Wk 13 [PDF]

Organic Chemistry Podcasts

josh — Wed, 03 Aug 2011 00:39:16 +0000

Great little resource for anyone taking upper division organic chemistry classes. Listen to them while running/biking or just as another method to learn the material. Covers bonding, hybridization, resonance, acidity, alkanes, isomers, conformational analysis, mass spec, NMR, and reactions. Clearly a lot of work went into these!

Organic Laboratory Experiments

josh — Thu, 28 Jul 2011 06:03:25 +0000

First year organic chemistry preparations, including:

Inorganic Laboratory Experiments - Complex Coordination Compounds

josh — Thu, 28 Jul 2011 05:59:44 +0000

The Department of Chemistry, University of the West Indies gives us 5 2nd year inorganic chemistry experiments. Here is the full list:

The preparation of some chromium(III) complexes
The preparation of Potassium tris(oxalato)ferrate(III) trihydrate
The Mechanism of Aquation of trans-dichlorobis(1,2-diaminoethane)cobalt(III) chloride
Preparation of trans-[CoCl2(en)2]Cl
Preparation of Ferrocene

They show the structures, equations, rates, and experiment steps. Great for anyone looking to recreate these compounds or for professors who need a few inorganic lab activites.

Inorganic Chemistry Class Syllabus Examples (PDF, HTML, DOC)

josh — Wed, 27 Jul 2011 04:15:26 +0000

We've been using several different resources online to help us categorize the site so we thought we'd share a few of the resources we found. This is a list of syllabi found across the web for inorganic chemistry classes all over the world.

Chemistry 511 at University of Wisconsin Madison - PDF or Google Docs
Chemistry 462 at Texas A&M - PDF or Google Docs
Chemistry 418/512 (Practical Crystallography) at the University at Buffalo - PDF
Chemistry 423 (Chemical Applications of Group Theory) at the University at Buffalo - PDF
Chemistry 348 (Inorganic Chemistry) at Carnegie Mellon - HTML
Chemistry 1311 (Inorganic Chemistry I) at Georgia Tech - HTML
Chemistry 305 at The College of William & Mary - PDF or Google Docs
Chemistry 414 at Virginia State University - DOC
Chemistry 320 at Nothern Kentucky University - PDF or Google Docs
Chemistry 311 at Dordt College - PDF or Google Docs
Inorganic Chemistry at St. Xavier's College - PDF or Google Docs

Have any to add? Stick them in the comments below!

Recent posts for Chemistry

Amino Acid Catabolism

Interactive animation on inhibitors

MALDI-TOF Spectrometer

HPLC videos and instructions by Sigma-Aldrich

Big Picture of signal transduction

A great animation tutorial on Tyrosine Kinase Receptors

Relationship of inhibitors to Michaelis-Menten Parameters

X-Ray Diffraction lecture

Earnshaw's Theorem and Double Minima lecture

Force Laws, Lewis Structures, Resonance lecture

First Organic Chemistry Lecture at Yale

Complete Organic Chemistry textbook resources

Organic Chemistry IUPAC Nomenclature

Organic Chemistry Exams

Organic Chemistry Concepts

Organic Chemistry Sample Problems

Organic Chemistry Podcasts

Organic Laboratory Experiments

Inorganic Laboratory Experiments - Complex Coordination Compounds

Inorganic Chemistry Class Syllabus Examples (PDF, HTML, DOC)