Not satisfied with just being Queen of Constance Billard, Jenny sets her sights on becoming the Queen of all the Upper East Side by landing the hottest escort for Cotillion.

Claire is determined to get to the bottom of the Sorority Rush attacks on her own, until H.R.G. intervenes only to realize he may be the source of her troubles. Meanwhile, Peter’s new ability is a perfect fit for his job and gives him the opportunity to help Emma accept her new life. Elsewhere, Sylar’s battle at gaining full control over Matt’s body escalates –with potentially dangerous implications at stake.

House, Cuddy, and Wilson go to a medical conference and meet an old friend, while the team deal with a girl whose appendages have swollen but she refuses to tell them the truth about the events leading up to her illness.

Episode Synopsis: Brooke gets some shocking news that threatens her relationship with Julian. Meanwhile, Nathan finds out that Dan’s back in town as he prepares to sign a new NBA contract; Millicent heads for a big fall; and Haley returns to the stage. Sophia Bush directed the episode.

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It’s the first day of school at Constance Billard which means it’s also time for Jenny to take her rightful place as the new Queen Bee. Unfortunately for Jenny, Blair is more than happy to intervene when news reaches her that she may be needed back at Constance. Lily returns home to Rufus and her family to find that things are definitely not as she left them. A famous movie actress, Olivia Burke (Hilary Duff), enrolls at NYU – and is assigned to be Vanessa’s roommate – hoping for a somewhat normal college experience. Tyra Banks guest stars as Ursula, an actress co-starring in Olivia’s movie and someone who Serena befriends.

As Hiro’s life continues to hang in the balance, he distracts himself with saving the lives of others. Meanwhile, Angela tries to help the new “Nathan” remember his past, at the risk of his remembering too much. Elsewhere, Tracy is determined to get her old job back, but soon realizes that she needs to make more of an impact.

Nathan’s life begins to unravel as the scandal goes public; Haley encourages Quinn to talk to David, her estranged husband; Mouth makes a career-threatening decision.

House’s team struggles with an African politician who falls ill and decide if they want to help him after he’s charged for crimes against humanity in his country.

In the sixth-season finale, Vince reluctantly answers a charity call from Matt Damon and LeBron James. Meanwhile, Ari tries to sell his business deal with Terrance to his wife; Drama considers a drastic career change; and Eric plans a rendezvous with Sloan.

As the citizens of Fairview try to make sense of a recent attack in their neighborhood, Lynette withholds a secret from Susan. Gabrielle gives niece Ana advice on how to get a guy’s attention, whereas Bree worries how her affair with Karl will affect her friendship with Susan, and Angie is determined to protect her son and her family’s past.