https://jamanetwork.com/journals/jama en-us Tue, 19 May 2026 00:00:00 GMT Tue, 19 May 2026 11:43:23 GMT Silverchair jamams@jamanetwork.org support@jamanetwork.com https://jamanetwork.com/journals/jama/fullarticle/2849020 Tue, 19 May 2026 00:00:00 GMT 335 19 1649 1650 10.1001/jama.2025.15778 2849020 https://jamanetwork.com/journals/jama/fullarticle/2848410 Tue, 19 May 2026 00:00:00 GMT Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA. 335 19 e2515779 10.1001/jama.2025.15779 2848410 https://jamanetwork.com/journals/jama/fullarticle/2848366 Tue, 19 May 2026 00:00:00 GMT A new bill would cap US insulin costs under private insurance. 335 19 1655 1655 10.1001/jama.2026.2117 2848366 https://jamanetwork.com/journals/jama/fullarticle/2848365 Tue, 19 May 2026 00:00:00 GMT Poor sense of smell was associated with physical function decline in older adults, according to research published in JAMA Otolaryngology − Head & Neck Surgery. 335 19 1655 1655 10.1001/jama.2026.2118 2848365 https://jamanetwork.com/journals/jama/fullarticle/2848364 Tue, 19 May 2026 00:00:00 GMT The US Centers for Disease Control and Prevention (CDC) issued an advisory about growing reports of medetomidine in the illegal fentanyl supply, which has increased the risk of overdose and severe withdrawal syndrome. 335 19 1655 1655 10.1001/jama.2026.2119 2848364 https://jamanetwork.com/journals/jama/fullarticle/2848363 Tue, 19 May 2026 00:00:00 GMT The US Food and Drug Administration (FDA) approved the first generics of the sodium-glucose cotransporter 2 (SGLT2) inhibitor dapagliflozin, marketed as Farxiga. 335 19 1655 1655 10.1001/jama.2026.2120 2848363 https://jamanetwork.com/journals/jama/fullarticle/2848362 Tue, 19 May 2026 00:00:00 GMT For people with certain apolipoprotein E (APOE) genotypes at increased risk of Alzheimer disease, higher meat consumption may be associated with reduced cognitive decline, a study of a cohort in Sweden found. 335 19 1655 1656 10.1001/jama.2026.2121 2848362 https://jamanetwork.com/journals/jama/fullarticle/2848361 Tue, 19 May 2026 00:00:00 GMT Oral semaglutide was associated with sustained improvements in multiple cardiovascular disease (CVD) risk factors, according to research published in JAMA Cardiology. 335 19 1656 1656 10.1001/jama.2026.2123 2848361 https://jamanetwork.com/journals/jama/fullarticle/2848360 Tue, 19 May 2026 00:00:00 GMT This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder. 335 19 1653 1654 10.1001/jama.2026.5755 2848360 https://jamanetwork.com/journals/jama/fullarticle/2848359 Tue, 19 May 2026 00:00:00 GMT This Medical News article discusses the American Heart Association’s new scientific statement on dietary guidance to improve cardiovascular health. 335 19 1651 1652 10.1001/jama.2026.5654 2848359 https://jamanetwork.com/journals/jama/fullarticle/2848121 Tue, 19 May 2026 00:00:00 GMT JAMA and JAMA+ AI Associate Editor Yulin Hswen, ScD, MPH, spoke with Viktor H. Ahlqvist, PhD, a postdoctoral fellow in the Unit of Integrative Epidemiology of the Institute of Environmental Medicine at Karolinska Institutet, for JAMA+ AI Conversations. 335 19 e2524562 10.1001/jama.2025.24562 2848121 https://jamanetwork.com/journals/jama/fullarticle/2848067 Tue, 19 May 2026 00:00:00 GMT Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, with an estimated 150 000 new cases annually worldwide. Patients with DLBCL typically require treatment at the time of diagnosis, and more than 60% of patients are currently cured with front-line immunochemotherapy such as R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone). However, DLBCL is highly heterogeneous, and subsets of patients who progress after front-line treatment have a substantially poorer clinical outcome. Therapeutic progress to improve the outcome of the patients with lymphoma destined to progress after initial chemotherapy has proven very difficult, with very few trials showing superiority of an experimental group over standard R-CHOP. 335 19 1669 1671 10.1001/jama.2026.4291 2848067 https://jamanetwork.com/journals/jama/fullarticle/2848066 Tue, 19 May 2026 00:00:00 GMT This study uses data from the National Vital Statistics System to examine quarterly suicide mortality among individuals aged 15 to 34 years. 335 19 1721 1723 10.1001/jama.2026.5157 2848066 https://jamanetwork.com/journals/jama/fullarticle/2848061 Tue, 19 May 2026 00:00:00 GMT JAMA Senior Editor Derek C. Angus, MD, MPH, spoke with Dost Öngür, MD, PhD, JAMA Psychiatry Editor, and Jeremy Veenstra-VanderWeele, MD, a professor of developmental neuropsychiatry at Columbia University, about autism spectrum disorder for the Healthy Dialogue podcast. 335 19 e263415 10.1001/jama.2026.3415 2848061 https://jamanetwork.com/journals/jama/fullarticle/2848060 Tue, 19 May 2026 00:00:00 GMT This randomized clinical trial conducted in China evaluates the efficacy and safety of the histone deacetylase inhibitor tucidinostat plus R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) vs R-CHOP alone as first-line treatment for patients with MYC/BCL2 double-expressor lymphoma. 335 19 1684 1693 10.1001/jama.2026.4199 2848060 https://jamanetwork.com/journals/jama/fullarticle/2848057 Tue, 19 May 2026 00:00:00 GMT This study aimed to assess whether adding the histone deacetylase inhibitor tucidinostat to rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) improves clinical outcomes in patients with newly diagnosed MYC/BCL2 double-expressor lymphoma. 335 19 e264329 10.1001/jama.2026.4329 2848057 https://jamanetwork.com/journals/jama/fullarticle/2847986 Tue, 19 May 2026 00:00:00 GMT This study analyzes US state actions taken in 2025 that strengthened or weakened COVID-19 vaccination infrastructure and access. 335 19 1719 1721 10.1001/jama.2026.5148 2847986 https://jamanetwork.com/journals/jama/fullarticle/2847985 Tue, 19 May 2026 00:00:00 GMT To the Editor A recent study that used a propensity score and 1:3 matching provided valuable insight into the potential effect of glucagon-like peptide 1 receptor agonists (GLP-1RAs) during pregnancy. Nevertheless, several limitations warrant careful consideration. 335 19 1727 1728 10.1001/jama.2026.2648 2847985 https://jamanetwork.com/journals/jama/fullarticle/2847984 Tue, 19 May 2026 00:00:00 GMT To the Editor A recent study examining gestational weight gain and pregnancy outcomes after discontinuation of GLP-1RAs before conception provided timely evidence in a rapidly evolving therapeutic landscape. However, several methodological and clinical aspects warrant clarification to avoid premature conclusions regarding safety. 335 19 1728 1729 10.1001/jama.2026.2651 2847984 https://jamanetwork.com/journals/jama/fullarticle/2847983 Tue, 19 May 2026 00:00:00 GMT In Reply In their Letters, Dr Boujenah and Dr Hnid detail unmeasured variables that may have influenced the exposures and outcomes in our recent electronic health record–based study of GLP-1RA use and discontinuation before and in early pregnancy. 335 19 1729 1729 10.1001/jama.2026.2654 2847983 https://jamanetwork.com/journals/jama/fullarticle/2847982 Tue, 19 May 2026 00:00:00 GMT This randomized clinical trial compares the effects of a theory-based serious game (a purpose-driven video game) vs usual education on emergency physician adherence to trauma triage guidelines for older adults. 335 19 1672 1683 10.1001/jama.2026.4079 2847982 https://jamanetwork.com/journals/jama/fullarticle/2847981 Tue, 19 May 2026 00:00:00 GMT The study aimed to determine whether a theory-based serious game could improve emergency physician adherence to trauma triage guidelines for severely injured older adults in nontrauma centers. 335 19 e264133 10.1001/jama.2026.4133 2847981 https://jamanetwork.com/journals/jama/fullarticle/2847980 Tue, 19 May 2026 00:00:00 GMT This Review summarizes the current evidence for prepregnancy care and counseling with a primary care focus. 335 19 1706 1716 10.1001/jama.2026.2888 2847980 https://jamanetwork.com/journals/jama/fullarticle/2847972 Tue, 19 May 2026 00:00:00 GMT This retrospective cohort study examines treatment failure and adverse events in standard-dose amoxicillin compared with amoxicillin-clavulanate in adults with acute sinusitis. 335 19 1694 1705 10.1001/jama.2025.26902 2847972 https://jamanetwork.com/journals/jama/fullarticle/2847651 Tue, 19 May 2026 00:00:00 GMT Ray Lyman Wilbur, M.D., Stanford University, Calif. 335 19 1731 1731 10.1001/jama.2025.15780 2847651 https://jamanetwork.com/journals/jama/fullarticle/2847649 Tue, 19 May 2026 00:00:00 GMT To the Editor We write in response to a recent Viewpoint, which contained false statements and misunderstandings about restorative reproductive medicine (RRM) that need to be corrected. 335 19 1726 1727 10.1001/jama.2026.2475 2847649 https://jamanetwork.com/journals/jama/fullarticle/2847648 Tue, 19 May 2026 00:00:00 GMT In Reply We appreciate the Letter from Dr Minjeur and colleagues regarding our Viewpoint, as well as the opportunity for clarifications. 335 19 1727 1727 10.1001/jama.2026.2478 2847648 https://jamanetwork.com/journals/jama/fullarticle/2847581 Tue, 19 May 2026 00:00:00 GMT Cleaning out her bedside stand unused back-rub gift certificates. 335 19 1730 1730 10.1001/jama.2026.2609 2847581 https://jamanetwork.com/journals/jama/fullarticle/2847580 Tue, 19 May 2026 00:00:00 GMT Naming is essential in medicine. Medical terminology allows clinicians to document and communicate and, most importantly, make diagnoses. A feeling of control can come from arriving at that perfect word that unifies each of a patient’s specific medical findings. However, even the most skilled clinician may still be left speechless when confronting the enormity of at once obvious, and yet unspeakable, mortality. The esteemed poet W. H. Auden famously asserted, “…poetry makes nothing happen” in his 1939 poem “In Memory of W. B. Yeats.” “On Mortality” reminds us of the same insufficiency of language, not just medical language but even poetry, as the speaker grasps at the right words to describe the end of life. The chastened clinician relies on found objects and simple observations to convey what even the most astute diagnosis cannot. As moving as these are—the back massage never received, the routinization of intensive care unit deaths—by the last stanza, the speaker finally relinquishes the attempt to explain mortality, surrendering to the realization that “too many words” only defeat such efforts. This ironically lapidary poem offers an interesting reflection for clinicians—what do we say when we feel but cannot fully describe something we witness? Thus poetry, with its comfort with silences and concision, arises in addition to medical vernacular. Poetry, by eliciting pure feeling, can allow the reader to experience awe at the human condition when accurate diagnosis, or even just the right word, seems elusive. 335 19 1730 1730 10.1001/jama.2026.2612 2847580 https://jamanetwork.com/journals/jama/fullarticle/2847576 Tue, 19 May 2026 00:00:00 GMT To the Editor The DESIGNATION trial compared driving pressure–guided high PEEP with standard low PEEP. We seek clarification on 2 methodological aspects of the intervention to better interpret its null result. 335 19 1725 1725 10.1001/jama.2026.2332 2847576 https://jamanetwork.com/journals/jama/fullarticle/2847575 Tue, 19 May 2026 00:00:00 GMT To the Editor In the DESIGNATION randomized clinical trial, individualized driving pressure–guided high PEEP with recruitment maneuvers did not reduce postoperative pulmonary complications compared with standard low PEEP in adults at increased risk for postoperative pulmonary complications (Assess Respiratory Risk in Surgical Patients in Catalonia [ARISCAT] score ≥26) undergoing open abdominal surgery. As anesthesiologists frequently managing the treatment of such patients, we would like to highlight 2 aspects that may further inform bedside practice. 335 19 1724 1725 10.1001/jama.2026.2334 2847575 https://jamanetwork.com/journals/jama/fullarticle/2847574 Tue, 19 May 2026 00:00:00 GMT To the Editor Positive end-expiratory pressure (PEEP) titration has long been proposed as a strategy to reduce postoperative pulmonary complications. Large randomized trials, including PROVHILO and PROBESE, failed to demonstrate benefit from standardized higher intraoperative PEEP, highlighting the limitations of fixed approaches. In the recent Driving Pressure During General Anesthesia for Open Abdominal Surgery (DESIGNATION) trial, the investigators tested an individualized, driving pressure–guided PEEP strategy (driving pressure = plateau pressure − PEEP) during open abdominal surgery. A small but measurable separation of pulmonary mechanics was achieved between groups, although no reduction in postoperative pulmonary complications was observed. 335 19 1723 1724 10.1001/jama.2026.2336 2847574 https://jamanetwork.com/journals/jama/fullarticle/2847573 Tue, 19 May 2026 00:00:00 GMT In Reply The Letters from Dr Mietto and colleagues, Drs Qi and Zhang, and Mr Yang and colleagues question our findings from the DESIGNATION trial, arguing that intermittently scheduled PEEP titration may not reflect dynamic intraoperative physiology, high PEEP may impose hemodynamic harm in the highest-risk patients, and the recruitment maneuver and driving pressure measurement may have been methodologically or physiologically inadequate. 335 19 1725 1726 10.1001/jama.2026.2338 2847573 https://jamanetwork.com/journals/jama/fullarticle/2847330 Tue, 19 May 2026 00:00:00 GMT In this narrative medicine essay, an obstetrician discusses the way in which it is not only the joy of patients, but also the grief, that keeps her going. 335 19 1667 1668 10.1001/jama.2026.2239 2847330 https://jamanetwork.com/journals/jama/fullarticle/2847277 Tue, 19 May 2026 00:00:00 GMT This Viewpoint discusses the chasm between current US health care and a vision of more comprehensive, equitable, and patient-centered care and proposes actionable strategies to bridge that chasm. 335 19 1657 1658 10.1001/jama.2026.4353 2847277 https://jamanetwork.com/journals/jama/fullarticle/2847013 Tue, 19 May 2026 00:00:00 GMT This Perspective discusses the use of bayesian methods in clinical trials and the importance of having US Food and Drug Administration (FDA) guidance that provides substantive insights about the methods’ proper role. 335 19 1659 1661 10.1001/jama.2026.4175 2847013 https://jamanetwork.com/journals/jama/fullarticle/2847012 Tue, 19 May 2026 00:00:00 GMT This Perspective discusses the draft guidance for industry that the US Food and Drug Administration released on the use of bayesian methods in testing therapeutics. 335 19 1662 1663 10.1001/jama.2026.4178 2847012 https://jamanetwork.com/journals/jama/fullarticle/2847011 Tue, 19 May 2026 00:00:00 GMT This Perspective discusses the importance of the US Food and Drug Administration’s draft guidance on the use of bayesian methods in clinical trials because it underscores its commitment to modernizing clinical research. 335 19 1664 1666 10.1001/jama.2026.4179 2847011 https://jamanetwork.com/journals/jama/fullarticle/2846882 Tue, 19 May 2026 00:00:00 GMT This JAMA Clinical Guidelines Synopsis summarizes the 2024 recommendations from the American Heart Association and American College of Cardiology on perioperative cardiovascular medication management for noncardiac surgery. 335 19 1717 1718 10.1001/jama.2026.0067 2846882 https://jamanetwork.com/journals/jama/fullarticle/2846724 Tue, 19 May 2026 00:00:00 GMT Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA. 335 19 e2526408 10.1001/jama.2025.26408 2846724 https://jamanetwork.com/journals/jama/fullarticle/2845582 Tue, 19 May 2026 00:00:00 GMT This JAMA Patient Page describes metabolic dysfunction–associated steatotic liver disease (MASLD) and its risk factors, symptoms and complications, diagnosis, and treatment. 335 19 1734 1734 10.1001/jama.2025.26689 2845582