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Is the Combination of GLP-1s and Clozapine Safe?

Tue, 18 Aug 2026 01:15:39 EDT

Gastrointestinal hypomotility is the most lethal adverse event linked to clozapine use. GLP-1s slow the gut too. Clinicians are combining the two, with little safety data to guide them.

Four Signs You Should Biopsy a Skin Lesion, Not Freeze It

Mon, 17 Aug 2026 17:11:12 EDT

Before you freeze a skin lesion, ask yourself whether you really know what it is. Here are four signs you should biopsy instead of freeze.

Primary Care Guidance for Mohs Surgery Referrals

Mon, 17 Aug 2026 17:09:12 EDT

Learn which skin cancers in primary care may be better managed with Mohs surgery and when referral to a specialist is appropriate.

US Kindergarten Vaccine Coverage Continues Downward Trend, Falling 0.1%

Mon, 17 Aug 2026 14:40:37 EDT

U.S. kindergarten vaccination coverage fell 0.1% during the 2025-2026 school year, continuing a downward trend that has seen declines every year except one since the onset...

Adolescent Sleep: Burning the Candle at Both Ends

Mon, 17 Aug 2026 12:22:42 EDT

Dr. Wilkoff argues that sleep is an underprioritized aspect of health in adolescents.

The Expanding Use of CGM for Diabetes

Mon, 17 Aug 2026 10:22:59 EDT

Dr Anne Peters discusses the expanding use of continuous glucose monitoring in people with diabetes.

Cannabis Use May Increase Fall Risk in Adults With HIV

Mon, 17 Aug 2026 10:17:10 EDT

Among adults living with HIV, cannabis use is associated with an increased risk for falls — but the link weakens after accounting for other substance use and medications.

Understanding the 'Wait Time Paradox' in Ovarian Cancer

Mon, 17 Aug 2026 10:06:55 EDT

Dr Maurie Markman examines new registry data on ovarian cancer diagnostic timing, showing how disease biology can complicate the link between early detection and survival.

Semaglutide and Depression: No Clear Link Found

Mon, 17 Aug 2026 09:52:44 EDT

A meta-analysis finds no significant association between use of semaglutide and risk for depression, although with limited certainty of evidence.

Adrenal Incidentalomas: When to Worry and What to Test

Mon, 17 Aug 2026 09:51:25 EDT

Not all adrenal incidentalomas need the same workup. The Curbsiders break down when to worry, what to test, and why MACS may be behind your patient's hard-to-control metabolic disease.

Adapting Approaches in the Fibromyalgia Landscape

Mon, 17 Aug 2026 09:43:53 EDT

Dr Andrea Chadwick describes how the shift from tender points to symptom-based criteria has improved fibromyalgia diagnosis, understanding, and patient-centered care.

How Early Experiences Shaped an Approach to Fibromyalgia

Mon, 17 Aug 2026 09:39:16 EDT

Dr Andrea Chadwick describes gradually recognizing patterns of widespread pain on body maps, which led her to take a bird’s eye view and better identify fibromyalgia.

VNS for RA a Year After Approval: Where Do Things Stand?

Mon, 17 Aug 2026 09:27:10 EDT

A year after approval of the first VNS device for rheumatoid arthritis, many patients are interested and providers in eight states are able to offer the device, but insurers are hesitating.

Mastectomy Preserves Ventriculoperitoneal Shunt in Woman

Mon, 17 Aug 2026 09:01:56 EDT

A woman with breast cancer underwent mastectomy near a ventriculoperitoneal shunt, which was preserved through careful imaging, planning, and sharp dissection.

Obesity Class III Linked to Death Risk in Younger Adults

Mon, 17 Aug 2026 08:53:01 EDT

Younger adults with severe obesity face significantly increased risk for mortality, while older adults show minimal differences across obesity classes.

Ca10H Linked to Improved Colorectal Cancer Outcomes

Mon, 17 Aug 2026 08:40:16 EDT

In a Spanish study of nearly 450 people, an atypical biomarker rose with adenomas and early disease — yet patients with higher levels had better long-term outcomes.

Early Dietitian Visits Linked to Successful Weight Loss

Mon, 17 Aug 2026 08:37:44 EDT

Routine primary care dietetic treatment achieves clinically relevant weight loss in one-third of adults with overweight or obesity, a Dutch study shows.

Diabetes Drug Curbs Weight Gain in Older People With HIV

Mon, 17 Aug 2026 08:00:00 EDT

Metformin, a common diabetes drug, curbs weight gain in older people with HIV over 96 weeks, but the effect reverses after treatment stops, a trial finds.

Cigars, Pipes Up Lung Cancer Risk, Raise Screening Needs

Mon, 17 Aug 2026 08:00:00 EDT

Current or former use of cigars, cigarillos, or pipes increases the risk for lung cancer and may make more people eligible for low-dose CT screening, a study shows.

Need for Best Practices in Pediatric M pneumoniae Testing

Mon, 17 Aug 2026 06:41:01 EDT

Ongoing variability in M pneumoniae testing highlights the need for diagnostic best practices in kids hospitalized with respiratory illnesses and for a national surveillance system for the infection.