Nature is the foremost international weekly scientific journal in the world and is the flagship journal for Nature Portfolio. It publishes the finest peer-reviewed research in all fields of science and technology on the basis of its originality, importance, interdisciplinary interest, timeliness, accessibility, elegance and surprising conclusions. Nature publishes landmark papers, award winning news, leading comment and expert opinion on important, topical scientific news and events that enable readers to share the latest discoveries in science and evolve the discussion amongst the global scientific community. http://feeds.nature.com/nature/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nature/rss.png http://feeds.nature.com/nature/rss/current https://www.nature.com/articles/d41586-026-01014-9 Nature, Published online: 18 April 2026; doi:10.1038/d41586-026-01014-9

This year’s winners include hundreds of physicists across more than 30 institutions.]]> Zeeya Merali doi:10.1038/d41586-026-01014-9 Nature, Published online: 2026-04-18; | doi:10.1038/d41586-026-01014-9 2026-04-18 Nature 10.1038/d41586-026-01014-9 https://www.nature.com/articles/d41586-026-01014-9 https://www.nature.com/articles/d41586-026-01263-8 Nature, Published online: 17 April 2026; doi:10.1038/d41586-026-01263-8

Nature staff discuss some of the week's top science news.]]> Benjamin ThompsonShamini BundellMaren Hunsberger doi:10.1038/d41586-026-01263-8 Nature, Published online: 2026-04-17; | doi:10.1038/d41586-026-01263-8 2026-04-17 Nature 10.1038/d41586-026-01263-8 https://www.nature.com/articles/d41586-026-01263-8 https://www.nature.com/articles/d41586-026-01245-w Nature, Published online: 17 April 2026; doi:10.1038/d41586-026-01245-w

Study in mice suggests that B cells help regulate muscle performance.]]> Claudia Steiner doi:10.1038/d41586-026-01245-w Nature, Published online: 2026-04-17; | doi:10.1038/d41586-026-01245-w 2026-04-17 Nature 10.1038/d41586-026-01245-w https://www.nature.com/articles/d41586-026-01245-w https://www.nature.com/articles/d41586-026-01067-w Nature, Published online: 17 April 2026; doi:10.1038/d41586-026-01067-w

A welcome change.]]> Robert Blasiak doi:10.1038/d41586-026-01067-w Nature, Published online: 2026-04-17; | doi:10.1038/d41586-026-01067-w 2026-04-17 Nature 10.1038/d41586-026-01067-w https://www.nature.com/articles/d41586-026-01067-w https://www.nature.com/articles/d41586-026-01251-y Nature, Published online: 17 April 2026; doi:10.1038/d41586-026-01251-y

A congressional hearing covered the rise of paper mills and the costs of open-access publishing — but there was little agreement on what reform would entail.]]> Max Kozlov doi:10.1038/d41586-026-01251-y Nature, Published online: 2026-04-17; | doi:10.1038/d41586-026-01251-y 2026-04-17 Nature 10.1038/d41586-026-01251-y https://www.nature.com/articles/d41586-026-01251-y https://www.nature.com/articles/d41586-026-01212-5 Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01212-5

Modelling suggests that the layer beneath the planet’s acidic clouds is comprised of particles from outer space.]]> doi:10.1038/d41586-026-01212-5 Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01212-5 2026-04-16 Nature 10.1038/d41586-026-01212-5 https://www.nature.com/articles/d41586-026-01212-5 https://www.nature.com/articles/d41586-026-01210-7 Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01210-7

Most of the individuals in a seventeenth-century-Switzerland burial site had performed strenuous manual labour and died before the age of 20.]]> doi:10.1038/d41586-026-01210-7 Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01210-7 2026-04-16 Nature 10.1038/d41586-026-01210-7 https://www.nature.com/articles/d41586-026-01210-7 https://www.nature.com/articles/d41586-026-01213-4 Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01213-4

Study of gene expression also finds age-related increases in men’s vulnerability to certain cancers.]]> doi:10.1038/d41586-026-01213-4 Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01213-4 2026-04-16 Nature 10.1038/d41586-026-01213-4 https://www.nature.com/articles/d41586-026-01213-4 https://www.nature.com/articles/d41586-026-01134-2 Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01134-2

Many Democrats making the switch to politics are motivated by the Trump administration’s cuts to science — whereas energy and AI are a pull for some Republicans.]]> Edward ChenMax Kozlov doi:10.1038/d41586-026-01134-2 Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01134-2 2026-04-16 Nature 10.1038/d41586-026-01134-2 https://www.nature.com/articles/d41586-026-01134-2 https://www.nature.com/articles/d41586-026-00509-9 Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-00509-9

Can you squeeze your graduate programme into a 40-hour working week? These 13 current and former PhD candidates reveal their top time-management tips.]]> Laura Woodrow doi:10.1038/d41586-026-00509-9 Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-00509-9 2026-04-16 Nature 10.1038/d41586-026-00509-9 https://www.nature.com/articles/d41586-026-00509-9 https://www.nature.com/articles/d41586-026-01236-x Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01236-x

Quantum machines are making inroads into biology but have no ‘advantage’ over classical machines yet.]]> Elizabeth Gibney doi:10.1038/d41586-026-01236-x Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01236-x 2026-04-16 Nature 10.1038/d41586-026-01236-x https://www.nature.com/articles/d41586-026-01236-x https://www.nature.com/articles/d41586-026-01227-y Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01227-y

Variations in gene expression could help to explain why brain-disease risks differ according to sex.]]> Miryam Naddaf doi:10.1038/d41586-026-01227-y Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01227-y 2026-04-16 Nature 10.1038/d41586-026-01227-y https://www.nature.com/articles/d41586-026-01227-y https://www.nature.com/articles/d41586-026-01265-6 Nature, Published online: 16 April 2026; doi:10.1038/d41586-026-01265-6

Data generated by AI ‘teachers’ can subliminally pass on particular traits to ‘student’ models. Plus, sperm-whale communication is structured similarly to some human languages and the success of China’s ‘Great Green Wall’.]]> Jacob Smith doi:10.1038/d41586-026-01265-6 Nature, Published online: 2026-04-16; | doi:10.1038/d41586-026-01265-6 2026-04-16 Nature 10.1038/d41586-026-01265-6 https://www.nature.com/articles/d41586-026-01265-6 https://www.nature.com/articles/s41586-026-10513-8 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10513-8

Cytoplasmic lattices are megadalton storage complexes in mammalian oocytes]]> Zeynep Ilgın KılıçJoyce van LoenhoutMarten ChailletRobert M. van EsPaula Sobrevals AlcarazHarmjan R. VosWillem E. M. NotebornMiguel Ricardo Leung doi:10.1038/s41586-026-10513-8 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10513-8 2026-04-15 Nature 10.1038/s41586-026-10513-8 https://www.nature.com/articles/s41586-026-10513-8 https://www.nature.com/articles/s41586-026-10483-x Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10483-x

Retraction Note: The hidden fitness of the male zebra finch courtship song]]> Danyal AlamFayha ZiaTodd F. Roberts doi:10.1038/s41586-026-10483-x Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10483-x 2026-04-15 Nature 10.1038/s41586-026-10483-x https://www.nature.com/articles/s41586-026-10483-x https://www.nature.com/articles/s41586-026-10504-9 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10504-9

Editorial Expression of Concern: Creation of human tumour cells with defined genetic elements]]> William C. HahnChristopher M. CounterAnte S. LundbergRoderick L. BeijersbergenMary W. BrooksRobert A. Weinberg doi:10.1038/s41586-026-10504-9 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10504-9 2026-04-15 Nature 10.1038/s41586-026-10504-9 https://www.nature.com/articles/s41586-026-10504-9 https://www.nature.com/articles/s41586-026-10519-2 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10519-2

Author Correction: HER2 expression identifies dynamic functional states within circulating breast cancer cells]]> Nicole Vincent JordanAditya BardiaBen S. WittnerCyril BenesMatteo LigorioYu ZhengMin YuTilak K. SundaresanJoseph A. LicausiRushil DesaiRyan M. O’KeefeRichard Y. EbrightMyriam BoukhaliSrinjoy SilMaristela L. OnozatoAnthony J. IafrateRavi KapurDennis SgroiDavid T. TingMehmet TonerSridhar RamaswamyWilhelm HaasShyamala MaheswaranDaniel A. Haber doi:10.1038/s41586-026-10519-2 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10519-2 2026-04-15 Nature 10.1038/s41586-026-10519-2 https://www.nature.com/articles/s41586-026-10519-2 https://www.nature.com/articles/s41586-026-10508-5 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10508-5

Carbonyl swapping converts cyclic ketones to saturated heterocycles]]> Zisheng XueZhengzhao LouXiang LouPeimiao HeJianbo WangYan Xu doi:10.1038/s41586-026-10508-5 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10508-5 2026-04-15 Nature 10.1038/s41586-026-10508-5 https://www.nature.com/articles/s41586-026-10508-5 https://www.nature.com/articles/d41586-026-01241-0 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01241-0

Genomics-guided trial could increase options for people undergoing cancer therapy — plus, a landmark ancient-genome study reveals natural selection in hundreds of human genes.]]> Benjamin Thompson doi:10.1038/d41586-026-01241-0 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01241-0 2026-04-15 Nature 10.1038/d41586-026-01241-0 https://www.nature.com/articles/d41586-026-01241-0 https://www.nature.com/articles/s41586-026-10379-w Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10379-w

Monolithic three-dimensional (3D) integration of tantalum pentoxide on a lithium niobate substrate enables scalable, multifunctional photonic systems and the incorporation of nonlinear optics directly into existing and emerging photonics infrastructure.]]> Grant M. BrodnikGrisha SpektorLindell M. WilliamsJizhao ZangAlexa R. CarolloAtasi DanJennifer A. BlackDavid R. CarlsonScott B. Papp doi:10.1038/s41586-026-10379-w Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10379-w 2026-04-15 Nature 10.1038/s41586-026-10379-w https://www.nature.com/articles/s41586-026-10379-w https://www.nature.com/articles/s41586-026-10362-5 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10362-5

Studies explaining the secondary Igk recombination mechanism are described and Cer/Sis deletion and/or displacement is implicated as a developmental switch converting the rearrangement mechanisms from two-loop-based diffusional primary Igk into one-loop-based linear scanning secondary mechanisms.]]> Xiang LiHongli HuYiwen ZhangTammie ZhuYing GuanKai XuXin LinCamille HebertHimanshu BatraJenny ZhouZhaoqing BaDuane R. WesemannAdam Yongxin YeFrederick W. Alt doi:10.1038/s41586-026-10362-5 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10362-5 2026-04-15 Nature 10.1038/s41586-026-10362-5 https://www.nature.com/articles/s41586-026-10362-5 https://www.nature.com/articles/s41586-026-10381-2 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10381-2

Shelves rather than shorelines may be better topographic indicators of oceans on Earth and Mars.]]> Abdallah S. ZakiMichael P. Lamb doi:10.1038/s41586-026-10381-2 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10381-2 2026-04-15 Nature 10.1038/s41586-026-10381-2 https://www.nature.com/articles/s41586-026-10381-2 https://www.nature.com/articles/s41586-026-10350-9 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10350-9

Combined functional ultrasound imaging and Neuropixels recording of mouse brains identify two neuronal populations with opposing arousal-related activity and distinct haemodynamic response functions, that occur throughout the brain.]]> Agnès LandemardMichael KruminKenneth D. HarrisMatteo Carandini doi:10.1038/s41586-026-10350-9 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10350-9 2026-04-15 Nature 10.1038/s41586-026-10350-9 https://www.nature.com/articles/s41586-026-10350-9 https://www.nature.com/articles/s41586-026-10358-1 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10358-1

Analysis of 15,836 ancient West Eurasian genomes reveals hundreds of instances of directional selection, showing that sustained changes in allele frequency were widespread, rather than being rare over this period as previously assumed.]]> Ali AkbariAnnabel PerryAlison R. BartonMohammadreza KariminejadSteven GazalZheng LiYating ZengAlissa MittnikNick PattersonMatthew MahXiang ZhouAlkes L. PriceEric S. LanderRon PinhasiNadin RohlandSwapan MallickDavid Reich doi:10.1038/s41586-026-10358-1 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10358-1 2026-04-15 Nature 10.1038/s41586-026-10358-1 https://www.nature.com/articles/s41586-026-10358-1 https://www.nature.com/articles/s41586-026-10386-x Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10386-x

This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable environmental and endogenous factors to expand tumorigenic clones.]]> Nuria Lopez-BigasEve KandybaAbel Gonzalez-PerezPaul BrennanAllan Balmain doi:10.1038/s41586-026-10386-x Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10386-x 2026-04-15 Nature 10.1038/s41586-026-10386-x https://www.nature.com/articles/s41586-026-10386-x https://www.nature.com/articles/s41586-026-10353-6 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10353-6

mRNA–lipid-nanoparticle vaccines do not require type 1 conventional dendritic (cDC1) cells or the WDFY4-dependent cross-presentation pathway for CD8+ T cell priming but, instead, engage both cDC1 and cDC2 cells redundantly.]]> + T cell priming]]> Suin JoLijin LiChandrani ThakurKevin A. TelferHussein SultanRay A. OharaMichelle HeGiri NamJing ChenFeiya OuMonia DraghiNicholas M. ValianteRobert D. SchreiberGwendalyn J. RandolphNaresha SaligramaTheresa L. MurphyWilliam E. GillandersKenneth M. Murphy doi:10.1038/s41586-026-10353-6 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10353-6 2026-04-15 Nature 10.1038/s41586-026-10353-6 https://www.nature.com/articles/s41586-026-10353-6 https://www.nature.com/articles/s41586-026-10405-x Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10405-x

Evaluation by the Drug Rediscovery Protocol of off-label use of 37 approved cancer drugs on 1,610 patients showed modest activities overall, although subgroups of responders suggest that off-label drug use could be beneficial in tandem with more stringent biomarker selection.]]> K. VerkerkA. C. SpiekmanS. F. Haj MohammadF. A. J. VerbeekH. TimmerM. A. van MarenL. J. ZeverijnB. S. GeurtsV. van der NoortP. RoepmanA. M. L. JansenW. W. J. de LengH. GelderblomH. M. W. VerheulE. E. VoestH. H. NienhuisJ. M. van Dodewaard-de JongM. LabotsD. J. A. de GrootC. van HerpenA. HoebenH. GelderblomL. V. BeerepootE. D. KerverH. M. WestgeestA. D. BinsA. P. HambergE. BoonG. VreugdenhilG. J. de KlerkT. van VoorthuizenA. VulinkF. van den BerkmortelM. van RooijenD. HoutsmaA. L. T. ImholzH. P. van den BergJ. A. J. DoumaP. de MolS. HovengaM. P. HendriksJ. W. B. de GrootM. LosS. BoudewijnsE. N. Klein HesselinkE. SiemerinkS. C. S. TrompM. A. Davidis-van SchoonhovenF. Jeurissen doi:10.1038/s41586-026-10405-x Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10405-x 2026-04-15 Nature 10.1038/s41586-026-10405-x https://www.nature.com/articles/s41586-026-10405-x https://www.nature.com/articles/s41586-026-10391-0 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10391-0

MitoCatch is a cell-type-specific mitochondrion-targeting system that links mitochondria and the cell surface by protein binders and delivers mitochondria into the target cell.]]> Temurkhan AyupovVerónica Moreno-JuanSerena CurtoniAlex FratzlUpnishad SharmaSusana Posada-CéspedesRamona RatiuRei MorikawaAlexandra Graff MeyerMargherita PezzoliGlenn BantugMorgan ChevalierYanyan HouSarah A. NadeauÁlvaro Herrero-NavarroVikram AyinampudiElizabeth KastanakiNatasha WhiteheadRebecca A. SiwickiMariana M. RibeiroJi Hoon HanAnnalisa BucciChristoph HessSimone PicelliMagdalena RennerDaniel J. MüllerCameron S. CowanSimon HansenBotond Roska doi:10.1038/s41586-026-10391-0 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10391-0 2026-04-15 Nature 10.1038/s41586-026-10391-0 https://www.nature.com/articles/s41586-026-10391-0 https://www.nature.com/articles/s41586-026-10377-y Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10377-y

A human spatial atlas of gene expression in liver based on live donors shows marked porto–central zonation of hepatocytes and non-parenchymal cells, and transcriptomic changes in early steatosis.]]> Oran YakubovskyKeren Bahar HalpernSapir ShirRoy NovoselskyAmichay AfriatAdi EgoziTal BarkaiYotam HarnikRouven HoefflinYael Korem KohanimOfra GolaniInna GoliandYoseph AddadiMerav KedmiHadas Keren-ShaulLiat Fellus-AlyagorLena PrichislovDana HirschChen MayerRon PeryNiv PencovichTimucin TanerIdo NachmanyShalev Itzkovitz doi:10.1038/s41586-026-10377-y Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10377-y 2026-04-15 Nature 10.1038/s41586-026-10377-y https://www.nature.com/articles/s41586-026-10377-y https://www.nature.com/articles/s41586-026-10269-1 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10269-1

In this Perspective article, a theoretical framework for how the AP-1 family of transcription factors mediates cellular adaptation in cancer drug resistance is proposed.]]> Gustavo S. FrançaItai Yanai doi:10.1038/s41586-026-10269-1 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10269-1 2026-04-15 Nature 10.1038/s41586-026-10269-1 https://www.nature.com/articles/s41586-026-10269-1 https://www.nature.com/articles/s41586-026-10384-z Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10384-z

ThermoCas9, a genome-editing enzyme that is sensitive to the DNA methylation status of the target locus, is characterized and shows promise for targeting hypomethylated DNA regions in cancer cells.]]> Mitchell O. RothYuerong ShuYu ZhaoDespoina TrasanidouRenee D. HoffmanChristian SüdfeldEugenios BouzetosNikolaos TrasanidisMichael ZawrotnyMary K. GelascoMegan L. MedinaAnuska DasJay RaiHemant N. GoswamiBing WangJohn van der OostHong Li doi:10.1038/s41586-026-10384-z Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10384-z 2026-04-15 Nature 10.1038/s41586-026-10384-z https://www.nature.com/articles/s41586-026-10384-z https://www.nature.com/articles/s41586-026-10344-7 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10344-7

Metastasis-associated oncofetal cell states emerge at the earliest stages of colorectal cancer and spatial profiling shows stereotypic patterning of fibroblast subtypes resembling normal tissue architecture, resulting in distinct regional microenvironments that dictate the timing and positioning of oncofetal plasticity.]]> Julian R. Buissant des AmorieJoris H. HagemanSascha R. BrunnerSuzanne E. M. van der HorstMaria C. PuschhofArne van HoeckInge van LieropSjors MiddelkampLisa van der ScheeSven van KempenFolkert MorsinkRobin GeeneSander MertensDavid S. CavigelliIngrid Verlaan-KlinkLianne J. KraaierJorieke SalijRenate BezemerOnno KranenburgMiangela M. LacléLeon M. G. MoonsHugo J. G. Snippert doi:10.1038/s41586-026-10344-7 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10344-7 2026-04-15 Nature 10.1038/s41586-026-10344-7 https://www.nature.com/articles/s41586-026-10344-7 https://www.nature.com/articles/s41586-026-10368-z Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10368-z

The E3 ligase SCFFBXO42 degrades holoenzyme-free PP2Ac in complex with the coiled-coil protein CCDC6 to maintain cancer cell fitness]]> FBXO42 regulates PP2A degradation]]> Sebastien CoassoloNairie MichaelianTimurs MaculinsCaleigh M. AzumayaTommy K. CheungJianping YinInna ZilberleybKanika Bajaj PahujaThomas GarnerTed LauDavis MauMatthew GrimmerJean-Philippe FortinMike CostaYoana N. DimitrovaChristopher M. RosePeter L. HsuRobert L. Yauch doi:10.1038/s41586-026-10368-z Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10368-z 2026-04-15 Nature 10.1038/s41586-026-10368-z https://www.nature.com/articles/s41586-026-10368-z https://www.nature.com/articles/s41586-026-10387-w Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10387-w

A monolithic mode-locked semiconductor laser with a continuously and widely tunable repetition rate is achieved by using a microwave driving signal that induces a spatiotemporal gain modulation along the entire laser cavity.]]> Urban SenicaMichael A. SchreiberMarco RaffaPaolo MichelettiMattias BeckChristian JirauschekJérôme FaistGiacomo Scalari doi:10.1038/s41586-026-10387-w Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10387-w 2026-04-15 Nature 10.1038/s41586-026-10387-w https://www.nature.com/articles/s41586-026-10387-w https://www.nature.com/articles/s41586-026-10354-5 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10354-5

In mice, female aggression is governed by an amygdala–to–medial hypothalamus circuit that is strengthened during pregnancy and is dynamically amplified by oxytocin during lactation.]]> Takashi YamaguchiRongzhen YanMashrur KhanSota KunoKanishk TewatiaTakuya OsakadaSrinivas ParthasarathyMichael E. PacoldNirao M. ShahDayu Lin doi:10.1038/s41586-026-10354-5 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10354-5 2026-04-15 Nature 10.1038/s41586-026-10354-5 https://www.nature.com/articles/s41586-026-10354-5 https://www.nature.com/articles/s41586-026-10319-8 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10319-8

During model distillation, large language models can subtly transmit traits unrelated to the training data.]]> Alex CloudMinh LeJames ChuaJan BetleyAnna Sztyber-BetleySören MindermannJacob HiltonSamuel MarksOwain Evans doi:10.1038/s41586-026-10319-8 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10319-8 2026-04-15 Nature 10.1038/s41586-026-10319-8 https://www.nature.com/articles/s41586-026-10319-8 https://www.nature.com/articles/s41586-026-10392-z Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10392-z

Scalable fabrication of ordered perovskite quantum dot superlattices enables high-efficiency, ultrahigh-resolution LEDs and active-matrix displays with greatly improved brightness, stability and device lifetime.]]> Chengxi ZhangQingsen ZengHui LiRenjun GuoYue YuLinjie DaiLyudmila TuryanskaZirui LiuJun DaiYingguo YangYue ZhaoJun LuLin WangLingmei KongTze Chien SumYuchen WuTae-Woo LeeXuyong Yang doi:10.1038/s41586-026-10392-z Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10392-z 2026-04-15 Nature 10.1038/s41586-026-10392-z https://www.nature.com/articles/s41586-026-10392-z https://www.nature.com/articles/s41586-026-10369-y Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10369-y

This work demonstrates industrial-scale roll-to-roll fabrication of high-efficiency visible metalenses using nanoimprinting and TiO2 coating, achieving low cost, high throughput and uniform performance, enabling commercialization of metasurfaces.]]> Trung HoangYujin ParkJoohoon KimHan TruongSajjan ParajuliBeniel Jones RajasekaranKyungtae KimDohyun KangGyoseon JeonKyung-il LeeDong Hyun YoonInki KimJunsuk RhoGyoujin Cho doi:10.1038/s41586-026-10369-y Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10369-y 2026-04-15 Nature 10.1038/s41586-026-10369-y https://www.nature.com/articles/s41586-026-10369-y https://www.nature.com/articles/s41586-026-10324-x Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10324-x

In situ microscopic single-particle imaging demonstrates the significance of rationally engineered metal–support interfaces for activating the oxygen in bulk catalyst, helping elucidate reaction pathways in catalytic conversions.]]> Weijue WangHongbin XuShuhui LiuXiaofeng YangWei LiuYang-Gang WangYanqiang HuangTao Zhang doi:10.1038/s41586-026-10324-x Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10324-x 2026-04-15 Nature 10.1038/s41586-026-10324-x https://www.nature.com/articles/s41586-026-10324-x https://www.nature.com/articles/s41586-026-10367-0 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10367-0

PerturbFate is a high-throughput, cost-effective, single-cell platform that systematically profiles CRISPR interference perturbations to reveal common regulatory nodes and convergent phenotypic states across diverse genetic alterations linked to vemurafenib resistance in melanoma cells.]]> Zihan XuZiyu LuAileen UgurbilAbdulraouf AbdulraoufAndrew LiaoJianxiang ZhangWei ZhouJunyue Cao doi:10.1038/s41586-026-10367-0 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10367-0 2026-04-15 Nature 10.1038/s41586-026-10367-0 https://www.nature.com/articles/s41586-026-10367-0 https://www.nature.com/articles/s41586-026-10416-8 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10416-8

A genome-to-genome association study identifies host and viral risk factors that interact to drive nasopharyngeal carcinoma endemicity in southern China.]]> Yanhong ChenJingtong LiangWanlin ZhangXinyu ZhangXinyi ZhangChing-Yuan WangFei YaoShanshan ZhangXiang ZhouWeimin YeRuimei FengYonglin CaiZhe ZhangMingfang JiQian CuiXihong LinJiesen LiJialei XuQiuting ZhangQinyao HuangYingying ChengYanran LuoXiaoping YeQisheng FengMinzhong TangMu-Sheng ZengYi-Xin ZengZhonghua LiuWeiwei ZhaiJianjun LiuMiao Xu doi:10.1038/s41586-026-10416-8 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10416-8 2026-04-15 Nature 10.1038/s41586-026-10416-8 https://www.nature.com/articles/s41586-026-10416-8 https://www.nature.com/articles/s41586-026-10223-1 Nature, Published online: 15 April 2026; doi:10.1038/s41586-026-10223-1

A composable neural network emulator is described for speeding up thermoelectric generator design, demonstrating the ability to predict generator performance with >99% accuracy while taking only 0.01% of the time compared with commercial finite-element solvers.]]> Airan LiXinzhi WuLongquan WangGang WuJiankang LiZhao HuXinyuan WangTakao Mori doi:10.1038/s41586-026-10223-1 Nature, Published online: 2026-04-15; | doi:10.1038/s41586-026-10223-1 2026-04-15 Nature 10.1038/s41586-026-10223-1 https://www.nature.com/articles/s41586-026-10223-1 https://www.nature.com/articles/d41586-026-01195-3 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01195-3

Efforts to boost tree cover and restore degraded land globally need stable funding and time to learn from failure.]]> doi:10.1038/d41586-026-01195-3 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01195-3 2026-04-15 Nature 10.1038/d41586-026-01195-3 https://www.nature.com/articles/d41586-026-01195-3 https://www.nature.com/articles/d41586-026-00688-5 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00688-5

Meet the creative minds that aim to improve cancer detection and treatment.]]> Sandy OngAmanda Heidt doi:10.1038/d41586-026-00688-5 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00688-5 2026-04-15 Nature 10.1038/d41586-026-00688-5 https://www.nature.com/articles/d41586-026-00688-5 https://www.nature.com/articles/d41586-026-00907-z Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00907-z

An artificial-intelligence system bypasses complex equations to predict the performance of thermoelectric generators.]]> Jing CaoAdy Suwardi doi:10.1038/d41586-026-00907-z Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00907-z 2026-04-15 Nature 10.1038/d41586-026-00907-z https://www.nature.com/articles/d41586-026-00907-z https://www.nature.com/articles/d41586-026-00690-x Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00690-x

A breakdown of publications in the database also reveals the cancer types with the highest output.]]> doi:10.1038/d41586-026-00690-x Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00690-x 2026-04-15 Nature 10.1038/d41586-026-00690-x https://www.nature.com/articles/d41586-026-00690-x https://www.nature.com/articles/d41586-026-00403-4 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00403-4

Through flexibility, problem-solving and the generosity of colleagues, I shepherded students through fieldwork remotely.]]> Mayank Chugh doi:10.1038/d41586-026-00403-4 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00403-4 2026-04-15 Nature 10.1038/d41586-026-00403-4 https://www.nature.com/articles/d41586-026-00403-4 https://www.nature.com/articles/d41586-026-00686-7 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00686-7

Integrated care and prevention strategies are key, but without careful planning — and sustainable funding — they risk falling short.]]> Alexia Austin doi:10.1038/d41586-026-00686-7 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00686-7 2026-04-15 Nature 10.1038/d41586-026-00686-7 https://www.nature.com/articles/d41586-026-00686-7 https://www.nature.com/articles/d41586-026-01181-9 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01181-9

A platform for tracking the changes in gene expression and chromatin accessibility that follow interference with specific genes has been developed. The platform, called PerturbFate, was applied to skin-cancer cells and showed that different genetic perturbations associated with tumour resistance push cells into a shared dedifferentiated state.]]> doi:10.1038/d41586-026-01181-9 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01181-9 2026-04-15 Nature 10.1038/d41586-026-01181-9 https://www.nature.com/articles/d41586-026-01181-9 https://www.nature.com/articles/d41586-026-01189-1 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01189-1

A type of activity in the brain’s cortex, called high gamma, is widely used in studies of brain function, but its origin has long been debated. An experiment using a brain–machine interface now shows that high-gamma activity is generated mainly by synchronized neuronal inputs, rather than outputs, which has implications for the interpretation of neuroscientific studies.]]> doi:10.1038/d41586-026-01189-1 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01189-1 2026-04-15 Nature 10.1038/d41586-026-01189-1 https://www.nature.com/articles/d41586-026-01189-1 https://www.nature.com/articles/d41586-026-01224-1 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01224-1

Using artificial-intelligence to teach other models can be cheaper and faster than building them from scratch, but this approach can introduce dangerous traits.]]> Mohana Basu doi:10.1038/d41586-026-01224-1 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01224-1 2026-04-15 Nature 10.1038/d41586-026-01224-1 https://www.nature.com/articles/d41586-026-01224-1 https://www.nature.com/articles/d41586-026-00689-4 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00689-4

Denmark and South Korea stand out for their strong cancer strategies while England seeks to get back on track.]]> Benjamin Plackett doi:10.1038/d41586-026-00689-4 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00689-4 2026-04-15 Nature 10.1038/d41586-026-00689-4 https://www.nature.com/articles/d41586-026-00689-4 https://www.nature.com/articles/d41586-026-00691-w Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00691-w

A description of the terminology and methodology used in this supplement, and a guide to the functionality that is available free online at natureindex.com.]]> doi:10.1038/d41586-026-00691-w Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00691-w 2026-04-15 Nature 10.1038/d41586-026-00691-w https://www.nature.com/articles/d41586-026-00691-w https://www.nature.com/articles/d41586-026-00910-4 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00910-4

A system of protein binders directs energy-generating organelles to targeted cells, potentially improving ways to treat mitochondrial dysfunction.]]> Samantha J. KrysaJonathan R. Brestoff doi:10.1038/d41586-026-00910-4 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00910-4 2026-04-15 Nature 10.1038/d41586-026-00910-4 https://www.nature.com/articles/d41586-026-00910-4 https://www.nature.com/articles/d41586-026-01248-7 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01248-7

Looking at a childlike version of your face might help you see childhood memories more clearly. Plus, some AI disease-prediction models are trained on suspect data and how thermal imaging can reveal night-flying birds.]]> Flora Graham doi:10.1038/d41586-026-01248-7 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01248-7 2026-04-15 Nature 10.1038/d41586-026-01248-7 https://www.nature.com/articles/d41586-026-01248-7 https://www.nature.com/articles/d41586-026-00906-0 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00906-0

A large language model that is trained using AI outputs can inherit undesirable behaviours, even if they are not directly referenced in the training data.]]> Oskar J. HollinsworthSamuel Bauer doi:10.1038/d41586-026-00906-0 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00906-0 2026-04-15 Nature 10.1038/d41586-026-00906-0 https://www.nature.com/articles/d41586-026-00906-0 https://www.nature.com/articles/d41586-026-01187-3 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01187-3

A high-resolution atlas of the healthy human liver has been assembled using gene-expression profiling and spatial mapping of cells in samples from living donors. The atlas reveals human-specific patterns of gene expression in different zones and uncovers spatially resolved adaptations in liver cells from individuals with the disease steatosis.]]> doi:10.1038/d41586-026-01187-3 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01187-3 2026-04-15 Nature 10.1038/d41586-026-01187-3 https://www.nature.com/articles/d41586-026-01187-3 https://www.nature.com/articles/d41586-026-01102-w Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01102-w

Grand anti-desertification schemes often fail when trees die and funding dries up — yet one project has broken the mould.]]> Lilin ZhengAnnah Lake ZhuQiuxia DongMichael E. MeadowsDavid S. G. ThomasXin GaoJiaojun ZhuXiaobo WangZilong XiaAlex De SherbininRuishan Chen doi:10.1038/d41586-026-01102-w Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01102-w 2026-04-15 Nature 10.1038/d41586-026-01102-w https://www.nature.com/articles/d41586-026-01102-w https://www.nature.com/articles/d41586-026-00687-6 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00687-6

As some countries lower the screening age for breast, colorectal and other cancers, scientists warn that it could cause more harm than good.]]> Roxanne Khamsi doi:10.1038/d41586-026-00687-6 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00687-6 2026-04-15 Nature 10.1038/d41586-026-00687-6 https://www.nature.com/articles/d41586-026-00687-6 https://www.nature.com/articles/d41586-026-01197-1 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01197-1

Climate-friendly technologies are the best way to stymie rising inflation — and will get better and cheaper over time.]]> Gernot Wagner doi:10.1038/d41586-026-01197-1 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01197-1 2026-04-15 Nature 10.1038/d41586-026-01197-1 https://www.nature.com/articles/d41586-026-01197-1 https://www.nature.com/articles/d41586-026-00911-3 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00911-3

If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?]]> Funda Meric-Bernstam doi:10.1038/d41586-026-00911-3 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00911-3 2026-04-15 Nature 10.1038/d41586-026-00911-3 https://www.nature.com/articles/d41586-026-00911-3 https://www.nature.com/articles/d41586-026-00697-4 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-00697-4

The models are designed to predict someone’s risk of diabetes or stroke. A few might already have been used on patients.]]> Mohana Basu doi:10.1038/d41586-026-00697-4 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-00697-4 2026-04-15 Nature 10.1038/d41586-026-00697-4 https://www.nature.com/articles/d41586-026-00697-4 https://www.nature.com/articles/d41586-026-01065-y Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01065-y

Nothing beside remains.]]> Bryce Saputo doi:10.1038/d41586-026-01065-y Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01065-y 2026-04-15 Nature 10.1038/d41586-026-01065-y https://www.nature.com/articles/d41586-026-01065-y https://www.nature.com/articles/d41586-026-01204-5 Nature, Published online: 15 April 2026; doi:10.1038/d41586-026-01204-5

Data from more than 15,000 ancient people reveal natural selection of hundreds of genes linked to immunity, skin tone, behaviour and other traits.]]> Ewen Callaway doi:10.1038/d41586-026-01204-5 Nature, Published online: 2026-04-15; | doi:10.1038/d41586-026-01204-5 2026-04-15 Nature 10.1038/d41586-026-01204-5 https://www.nature.com/articles/d41586-026-01204-5 https://www.nature.com/articles/s41586-026-10493-9 Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10493-9

Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity]]> Pantelis A. NicolaAndrew R. J. LawsonAlexandra TiddJuliette ImbertYoshihiro IshidaLuke A. WyliePaul A. ScottKenny RobertsLuke M. R. HarveyStefanie V. LensingWei ChengFederico AbascalDaniel LeongamornlertYvette HooksMatthew MayhoNicole Müller-SienerthSara WidaaLaura MincarelliJames IllingFlavia PeciBee Ling NgGeorgeina L. JarmanAndrew J. C. RussellKrishnaa T. A. MahbubaniKourosh Saeb-ParsyAnna L. PatersonKrishna ChatterjeeRaheleh RahbariOmer Ali BayraktarMichael R. StrattonPeter J. CampbellJohn A. TadrossNadia SchoenmakersIñigo Martincorena doi:10.1038/s41586-026-10493-9 Nature, Published online: 2026-04-14; | doi:10.1038/s41586-026-10493-9 2026-04-14 Nature 10.1038/s41586-026-10493-9 https://www.nature.com/articles/s41586-026-10493-9 https://www.nature.com/articles/s41586-026-10482-y Nature, Published online: 14 April 2026; doi:10.1038/s41586-026-10482-y

Autonomous closed-loop framework for reproducible perovskite solar cells]]> Danpeng GaoShuaihua LuChunlei ZhangNing WangZexin YuXianglang SunRebecca MartinFrancesco VaninLiangchen QianNicholas LongLarry LüerBo LiMartin StolterfohtJunhui HouJun YinYen-Hung LinHaipeng LuNan LiNicola GaspariniChristoph Joseph BrabecSamuel D. StranksXiao Cheng ZengZonglong Zhu doi:10.1038/s41586-026-10482-y Nature, Published online: 2026-04-14; | doi:10.1038/s41586-026-10482-y 2026-04-14 Nature 10.1038/s41586-026-10482-y https://www.nature.com/articles/s41586-026-10482-y https://www.nature.com/articles/d41586-026-00914-0 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-00914-0

The quest to make fire-lighting less dangerous, and a proposal for smallest unit of information worth photocopying, in our weekly dip into Nature’s archive.]]> doi:10.1038/d41586-026-00914-0 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-00914-0 2026-04-14 Nature 10.1038/d41586-026-00914-0 https://www.nature.com/articles/d41586-026-00914-0 https://www.nature.com/articles/d41586-026-01217-0 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01217-0

Stop overlooking librarians’ expertise]]> Jamie E. BlossKerry A. SewellJoseph G. L. Lee doi:10.1038/d41586-026-01217-0 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01217-0 2026-04-14 Nature 10.1038/d41586-026-01217-0 https://www.nature.com/articles/d41586-026-01217-0 https://www.nature.com/articles/d41586-026-01215-2 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01215-2

Deep-sea mining mustn’t go ahead until there are baseline data]]> Lixin LiZeming Shi doi:10.1038/d41586-026-01215-2 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01215-2 2026-04-14 Nature 10.1038/d41586-026-01215-2 https://www.nature.com/articles/d41586-026-01215-2 https://www.nature.com/articles/d41586-026-01218-z Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01218-z

AI agents replicate human social dynamics in days]]> Sam IllingworthKaren Spinner doi:10.1038/d41586-026-01218-z Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01218-z 2026-04-14 Nature 10.1038/d41586-026-01218-z https://www.nature.com/articles/d41586-026-01218-z https://www.nature.com/articles/d41586-026-01201-8 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01201-8

Storms that cross exceptionally warm ocean waters intensify more quickly and do more damage than storms that do not.]]> doi:10.1038/d41586-026-01201-8 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01201-8 2026-04-14 Nature 10.1038/d41586-026-01201-8 https://www.nature.com/articles/d41586-026-01201-8 https://www.nature.com/articles/d41586-026-01216-1 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01216-1

China discontinues prominent journal ranking list]]> Zheng Liu doi:10.1038/d41586-026-01216-1 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01216-1 2026-04-14 Nature 10.1038/d41586-026-01216-1 https://www.nature.com/articles/d41586-026-01216-1 https://www.nature.com/articles/d41586-025-04132-y Nature, Published online: 14 April 2026; doi:10.1038/d41586-025-04132-y

Services that track researcher profiles can splinter people’s online identities — but there are ways to keep them consistent.]]> Junjie ShenSarah Ormes doi:10.1038/d41586-025-04132-y Nature, Published online: 2026-04-14; | doi:10.1038/d41586-025-04132-y 2026-04-14 Nature 10.1038/d41586-025-04132-y https://www.nature.com/articles/d41586-025-04132-y https://www.nature.com/articles/d41586-026-01099-2 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01099-2

Airborne genetic material can be used to paint a picture of ecosystem health, watch for invasive species and even identify humans.]]> Aisling Irwin doi:10.1038/d41586-026-01099-2 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01099-2 2026-04-14 Nature 10.1038/d41586-026-01099-2 https://www.nature.com/articles/d41586-026-01099-2 https://www.nature.com/articles/d41586-026-01238-9 Nature, Published online: 14 April 2026; doi:10.1038/d41586-026-01238-9

Researchers are using airborne DNA to get snapshots of the make up of ecosystems. Plus, what scientists in Hungary think about the end of Viktor Orbán’s government and the penguins helping to monitor ‘forever chemicals’.]]> Flora Graham doi:10.1038/d41586-026-01238-9 Nature, Published online: 2026-04-14; | doi:10.1038/d41586-026-01238-9 2026-04-14 Nature 10.1038/d41586-026-01238-9 https://www.nature.com/articles/d41586-026-01238-9