Nature Neuroscience provides the international neuroscience community with a highly visible forum in which the most exciting developments in all areas of neuroscience can be communicated to a broad readership. A lively front half, including News & Views, Reviews, Perspectives and editorials, helps place the primary research in context, providing readers with a broad perspective on the entire field. Nature Neuroscience aims to provide readers with authoritative, accessible and timely information on the most important advances in understanding the nervous system. Areas covered include molecular, cellular, systems, behavioral, cognitive and computational studies. http://feeds.nature.com/neuro/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Neuroscience © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/neuro/rss.gif http://feeds.nature.com/neuro/rss/current https://www.nature.com/articles/s41593-026-02339-4 Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02339-4

Simultaneous voltage imaging of soma and dendrites in layer 2/3 cortical neurons in live mice reveals rich dynamics of spike back-propagation, with amplitude shaped by spiking history, dendrite location and behavioral state.]]> J. David Wong-CamposPojeong ParkByung Hun LeeHunter C. DavisYitong QiHe TianDaniel G. ItkisDoyeon KimJonathan B. GrimmSarah E. PlutkisLuke D. LavisAdam E. Cohen doi:10.1038/s41593-026-02339-4 Nature Neuroscience, Published online: 2026-06-19; | doi:10.1038/s41593-026-02339-4 2026-06-19 Nature Neuroscience 10.1038/s41593-026-02339-4 https://www.nature.com/articles/s41593-026-02339-4 https://www.nature.com/articles/s41593-026-02341-w Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02341-w

Erucamide, a fatty acid amide reduced in degenerating retinas, activates myeloid cells via TMEM19 to release neurotrophic and angiogenic factors, rescuing photoreceptors and vasculature in mouse models of retinal degeneration.]]> Guoqin WeiShreyosree ChatterjeeQinglin YangSanahan VijayakumarDaisuke OgasawaraSarah GilesKatie BiscochoPeter WestenskowJunhua WangRuhan FanHelena PhamEdith AguilarJacob RobinsonAyumi Usui-OuchiRoberto BonelliKevin EadeGary SiuzdakBenjamin CravattMichael J. SailorDale BogerMartin Friedlander doi:10.1038/s41593-026-02341-w Nature Neuroscience, Published online: 2026-06-19; | doi:10.1038/s41593-026-02341-w 2026-06-19 Nature Neuroscience 10.1038/s41593-026-02341-w https://www.nature.com/articles/s41593-026-02341-w https://www.nature.com/articles/s41593-026-02332-x Nature Neuroscience, Published online: 19 June 2026; doi:10.1038/s41593-026-02332-x

Cao et al. identify tryptamine as a sleep signal in mice. Wake-active monoaminergic neurons release tryptamine, which binds to GPR139 in POA neurons that suppress wake-promoting neurons. GPR139 agonists could be a new class of sleep medication.]]> Huateng CaoKui WangJin ZhaoZhong-Hua ZhaQian ZhangYijin XiuBangsheng WuShajin HuangXiao-Na ZhuXiaoting LiJianan ChenHan WenSiwen PanKe-Xin YangJi HuJin-tai YuZhi-Jie LiuTian HuaYu MuZhian HuPeng YuanZhe Zhang doi:10.1038/s41593-026-02332-x Nature Neuroscience, Published online: 2026-06-19; | doi:10.1038/s41593-026-02332-x 2026-06-19 Nature Neuroscience 10.1038/s41593-026-02332-x https://www.nature.com/articles/s41593-026-02332-x https://www.nature.com/articles/s41593-026-02325-w Nature Neuroscience, Published online: 16 June 2026; doi:10.1038/s41593-026-02325-w

The authors develop red fluorescent GRAB acetylcholine (ACh) sensors and highlight rACh1h as a robust tool for multiplex recording together with various green sensors. Using fiber photometry, mesoscopic imaging and two-photon imaging, rACh1h is shown to reliably report ACh dynamics in vivo.]]> Shu XieXiaolei MiaoGuochuan LiYu ZhengMengyao LiEn JiJinxu WangShaochuang LiRuyi CaiLan GengJiesi FengChangwei WeiYulong Li doi:10.1038/s41593-026-02325-w Nature Neuroscience, Published online: 2026-06-16; | doi:10.1038/s41593-026-02325-w 2026-06-16 Nature Neuroscience 10.1038/s41593-026-02325-w https://www.nature.com/articles/s41593-026-02325-w https://www.nature.com/articles/s41593-026-02351-8 Nature Neuroscience, Published online: 15 June 2026; doi:10.1038/s41593-026-02351-8

Author Correction: Shared receptors in axon guidance: SAX-3/Robo signals via UNC-34/Enabled and a Netrin-independent UNC-40/DCC function]]> Timothy W. YuJoe C. HaoWendell LimMarc Tessier-LavigneCornelia I. Bargmann doi:10.1038/s41593-026-02351-8 Nature Neuroscience, Published online: 2026-06-15; | doi:10.1038/s41593-026-02351-8 2026-06-15 Nature Neuroscience 10.1038/s41593-026-02351-8 https://www.nature.com/articles/s41593-026-02351-8 https://www.nature.com/articles/s41593-026-02361-6 Nature Neuroscience, Published online: 15 June 2026; doi:10.1038/s41593-026-02361-6

Publisher Correction: TGFβ signaling mediates microglial resilience to spatiotemporally restricted myelin degeneration]]> Keying ZhuYun LiuJin-Hong MinVijay JoshuaJianing LinYue LiJudith C. KreutzmannYuxi GuoWenlong XiaElyas MohammadiMelanie PieberValerie SuerthYiming XiaZaneta AndrusivovaJean-Philippe HugnotShigeaki KanataniPer UhlénJoakim LundebergXiaofei LiStephen P. J. FancyHeela SarlusRobert A. HarrisHarald Lund doi:10.1038/s41593-026-02361-6 Nature Neuroscience, Published online: 2026-06-15; | doi:10.1038/s41593-026-02361-6 2026-06-15 Nature Neuroscience 10.1038/s41593-026-02361-6 https://www.nature.com/articles/s41593-026-02361-6 https://www.nature.com/articles/s41593-026-02355-4 Nature Neuroscience, Published online: 15 June 2026; doi:10.1038/s41593-026-02355-4

The 2026 closure of the Strait of Hormuz exposed a structural dependency that the neuroimaging community has rarely discussed openly.]]> Mohammad Hadi Aarabi doi:10.1038/s41593-026-02355-4 Nature Neuroscience, Published online: 2026-06-15; | doi:10.1038/s41593-026-02355-4 2026-06-15 Nature Neuroscience 10.1038/s41593-026-02355-4 https://www.nature.com/articles/s41593-026-02355-4 https://www.nature.com/articles/s41593-026-02346-5 Nature Neuroscience, Published online: 15 June 2026; doi:10.1038/s41593-026-02346-5

Neuroscientists have an ever-expanding array of tools for measuring brain activity at multiple scales, motivating efforts to integrate diverse datasets and capitalize on their complementary strengths. The new Triple-N dataset introduced by Li et al. tackles this challenge by conducting large-scale macaque electrophysiology in an experimental paradigm matched to the human 7T fMRI Natural Scenes Dataset.]]> Ammar I. MarviJacob S. PrinceKendrick Kay doi:10.1038/s41593-026-02346-5 Nature Neuroscience, Published online: 2026-06-15; | doi:10.1038/s41593-026-02346-5 2026-06-15 Nature Neuroscience 10.1038/s41593-026-02346-5 https://www.nature.com/articles/s41593-026-02346-5