NCI Featured Clinical Trials

Combination Therapy for Patients with Myelodysplastic Syndromes

Tue, 17 Nov 2009 05:00:00 GMT

In this trial, patients with myelodysplatic syndrome and symptomatic anemia who have a low or intermediate-1 risk of progression to leukemia will be treated with lenalidomide, and some will randomly assigned to receive epoetin alfa (Procrit).

Combining Chemotherapy and a PARP Inhibitor for Advanced Solid Tumors

Tue, 03 Nov 2009 05:00:00 GMT

In this clinical trial, patients who have solid tumors that cannot be removed by surgery or that have spread to other areas of the body will be treated with the PARP inhibitor AZD2281 and chemotherapy drugs cisplatin and gemcitabine.

Testing Satraplatin in Advanced Prostate Cancer

Tue, 20 Oct 2009 04:00:00 GMT

In this clinical trial, men with androgen-independent metastatic prostate cancer that has progressed after first-line chemotherapy will be treated with satraplatin and prednisone.

Targeting HER2 in the Treatment of Ductal Carcinoma in Situ

Tue, 06 Oct 2009 04:00:00 GMT

In this clinical trial, women with HER2-positive DCIS will be treated with lumpectomy followed by whole-breast radiation therapy; half of the women will also receive two doses of trastuzumab during their radiation treatment.

Comparing Drug Regimens for Diffuse Large B-cell Lymphoma

Tue, 22 Sep 2009 04:00:00 GMT

In this trial, patients with previously untreated diffuse large B-cell lymphoma will be randomly assigned to receive either the R-CHOP regimen or EPOCH-R regimen for 6 to 8 cycles.

Testing a New Drug in Advanced BRCA-related Cancer

Tue, 08 Sep 2009 04:00:00 GMT

In this clinical trial, women with advanced breast or ovarian cancer who carry a known BRCA gene mutation or who have a strong family history of these diseases (and are, therefore, likely to carry such a mutation) will be treated with a new drug called AZD2281 (olaparib) together with the chemotherapy drug carboplatin.

Refining Treatment for High-risk Early Stage Endometrial Cancer

Fri, 14 Aug 2009 04:00:00 GMT

In this clinical trial, women with high-risk early stage endometrial cancer will be randomly assigned following surgery to receive one of two types of adjuvant therapy: brachytherapy targeted to the vaginal cuff in combination with chemotherapy or standard pelvic external-beam radiotherapy.

Comparing Second-Line Therapies for Advanced Lung Cancer

Tue, 28 Jul 2009 04:00:00 GMT

In this trial, patients with advanced non-small cell lung cancer that has recurred or progressed after initial chemotherapy will be tested for EGFR gene amplification and then randomly assigned to receive either pemetrexed or erlotinib.

Combining Immunotoxin and Chemotherapy for Pleural Mesothelioma

Tue, 14 Jul 2009 04:00:00 GMT

In this trial, patients with inoperable epithelial pleural mesothelioma will be given SS1P immunotoxin in combination with pemetrexed and cisplatin to determine the maximum tolerated dose of SS1P and side effects profile in these patients.

Testing Trabectedin in Pediatric Patients

Tue, 30 Jun 2009 04:00:00 GMT

In this phase I clinical trial, children with solid tumors that have either recurred or have not responded to previous treatment will be treated with trabectedin.