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	<title>Pharma Strategy Blog</title>
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		<title>Developing a predictive biomarker for PARP inhibition</title>
		<link>https://pharmastrategyblog.com/2014/02/developing-a-predictive-biomarker-for-parp-inhibition.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Fri, 07 Feb 2014 15:24:54 +0000</pubDate>
				<category><![CDATA[Basic Research]]></category>
		<category><![CDATA[Biomarkers]]></category>
		<category><![CDATA[Breast Cancer]]></category>
		<category><![CDATA[Ovarian Cancer]]></category>
		<category><![CDATA[Pipeline]]></category>
		<category><![CDATA[Translational Research]]></category>
		<category><![CDATA[Abbott]]></category>
		<category><![CDATA[astrazeneca]]></category>
		<category><![CDATA[Biomarin]]></category>
		<category><![CDATA[BMN 673]]></category>
		<category><![CDATA[BRCA1]]></category>
		<category><![CDATA[BRCA2]]></category>
		<category><![CDATA[breast cancer]]></category>
		<category><![CDATA[Clovis Oncology]]></category>
		<category><![CDATA[iniparib]]></category>
		<category><![CDATA[olaparib]]></category>
		<category><![CDATA[PARP inhibitors]]></category>
		<category><![CDATA[rucaparib]]></category>
		<category><![CDATA[serous ovarian cancer]]></category>
		<category><![CDATA[veliparib]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6273</guid>

					<description><![CDATA[Today’s Science Friday post looks at the identification of a potential new biomarker and possible strategies for expanding use of&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Update on RAF resistance in metastatic melanoma</title>
		<link>https://pharmastrategyblog.com/2014/01/update-on-raf-resistance-in-metastatic-melanoma.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Fri, 31 Jan 2014 17:38:39 +0000</pubDate>
				<category><![CDATA[Basic Research]]></category>
		<category><![CDATA[Mechanism of Action]]></category>
		<category><![CDATA[Melanoma]]></category>
		<category><![CDATA[New products]]></category>
		<category><![CDATA[Pathways]]></category>
		<category><![CDATA[Pipeline]]></category>
		<category><![CDATA[Skin cancer]]></category>
		<category><![CDATA[Strategy]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[Translational Research]]></category>
		<category><![CDATA[AKT]]></category>
		<category><![CDATA[BRAF V600E]]></category>
		<category><![CDATA[cobimetinib]]></category>
		<category><![CDATA[dabrafenib]]></category>
		<category><![CDATA[Genentech]]></category>
		<category><![CDATA[GSK]]></category>
		<category><![CDATA[intermittent dosing]]></category>
		<category><![CDATA[MEK]]></category>
		<category><![CDATA[Novartis]]></category>
		<category><![CDATA[PI3K]]></category>
		<category><![CDATA[Roche]]></category>
		<category><![CDATA[trametinib]]></category>
		<category><![CDATA[vemurafenib]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6259</guid>

					<description><![CDATA[“RAF inhibitors (vemurafenib and dabrafenib) have profound clinical activity in patients with BRAF-mutant melanoma, but their therapeutic effects are limited&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Red and Green Flags in cancer research and development</title>
		<link>https://pharmastrategyblog.com/2014/01/red-and-green-flags-in-cancer-research-and-development.html/</link>
					<comments>https://pharmastrategyblog.com/2014/01/red-and-green-flags-in-cancer-research-and-development.html/#comments</comments>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Fri, 24 Jan 2014 17:26:06 +0000</pubDate>
				<category><![CDATA[Biomarkers]]></category>
		<category><![CDATA[Drugs]]></category>
		<category><![CDATA[Market Trends]]></category>
		<category><![CDATA[Mechanism of Action]]></category>
		<category><![CDATA[Random musings]]></category>
		<category><![CDATA[Strategy]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[Translational Research]]></category>
		<category><![CDATA[Tumour Types]]></category>
		<category><![CDATA[Biotech red and green flags]]></category>
		<category><![CDATA[Cancer Biomarker Strategy]]></category>
		<category><![CDATA[Cancer Clinical Research Strategy]]></category>
		<category><![CDATA[Cancer Drug Targets]]></category>
		<category><![CDATA[cancer research]]></category>
		<category><![CDATA[Oncogenic Targets]]></category>
		<category><![CDATA[Oncology Drug Development Strategy]]></category>
		<category><![CDATA[oncology research strategy]]></category>
		<category><![CDATA[Pharma Commercial Strategy]]></category>
		<category><![CDATA[Pharma red and green flags]]></category>
		<category><![CDATA[R&D]]></category>
		<category><![CDATA[targeted therapies]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6240</guid>

					<description><![CDATA[Recently, there was a red flags meme going around the biosphere started by Xconomy’s Luke Timmerman on 21 Red Flags&#8230;]]></description>
		
					<wfw:commentRss>https://pharmastrategyblog.com/2014/01/red-and-green-flags-in-cancer-research-and-development.html/feed/</wfw:commentRss>
			<slash:comments>2</slash:comments>
		
		
			</item>
		<item>
		<title>Will intermittent dosing transform TKI therapy in cancer research?</title>
		<link>https://pharmastrategyblog.com/2014/01/will-intermittent-dosing-transform-tki-therapy-in-cancer-research.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Fri, 17 Jan 2014 19:09:22 +0000</pubDate>
				<category><![CDATA[Basic Research]]></category>
		<category><![CDATA[Mechanism of Action]]></category>
		<category><![CDATA[New products]]></category>
		<category><![CDATA[Pathways]]></category>
		<category><![CDATA[Pipeline]]></category>
		<category><![CDATA[Strategy]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[Translational Research]]></category>
		<category><![CDATA[intermittent dosing]]></category>
		<category><![CDATA[MEK]]></category>
		<category><![CDATA[PI3K]]></category>
		<category><![CDATA[PI3K Drug Development Strategy]]></category>
		<category><![CDATA[PI3K-AKT-mTOR pathway]]></category>
		<category><![CDATA[RAS-RAF-MEK-ERK pathway]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6232</guid>

					<description><![CDATA[At AACR last year, one of the most revealing presentations was on metastatic melanoma, specifically, some elegant research by Meghna&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Making a difference in NHL and CLL: an interview with Dr Carol Gallagher</title>
		<link>https://pharmastrategyblog.com/2014/01/making-a-difference-in-nhl-and-cll-an-interview-with-dr-carol-gallagher.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Fri, 10 Jan 2014 18:09:49 +0000</pubDate>
				<category><![CDATA[Biomarkers]]></category>
		<category><![CDATA[Cancer Patients]]></category>
		<category><![CDATA[Hematology]]></category>
		<category><![CDATA[Leukemia]]></category>
		<category><![CDATA[New products]]></category>
		<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[AbbVie]]></category>
		<category><![CDATA[ABT-199]]></category>
		<category><![CDATA[ASH 2013]]></category>
		<category><![CDATA[Calistoga]]></category>
		<category><![CDATA[Carol Gallagher]]></category>
		<category><![CDATA[CLL]]></category>
		<category><![CDATA[Frazier Healthcare]]></category>
		<category><![CDATA[Gazyva]]></category>
		<category><![CDATA[Genentech]]></category>
		<category><![CDATA[Gilead]]></category>
		<category><![CDATA[ibrutnib]]></category>
		<category><![CDATA[idelalisib]]></category>
		<category><![CDATA[NHL]]></category>
		<category><![CDATA[obinutuzumab]]></category>
		<category><![CDATA[Pharmacyclics]]></category>
		<category><![CDATA[Roche]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6220</guid>

					<description><![CDATA[For as long as anyone can remember, humanity has wondered, &#8220;Why do we do things even when we know we&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Medivation announce interim results of PREVAIL in pre-chemotherapy CRPC</title>
		<link>https://pharmastrategyblog.com/2013/10/medivation-announce-interim-results-of-prevail-in-pre-chemotherapy-crpc.html/</link>
					<comments>https://pharmastrategyblog.com/2013/10/medivation-announce-interim-results-of-prevail-in-pre-chemotherapy-crpc.html/#comments</comments>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Tue, 22 Oct 2013 20:21:23 +0000</pubDate>
				<category><![CDATA[News]]></category>
		<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Prostate Cancer]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[enzalutamide]]></category>
		<category><![CDATA[MDV3100]]></category>
		<category><![CDATA[medivation]]></category>
		<category><![CDATA[pre-chemotherapy CRPC]]></category>
		<category><![CDATA[PREVAIL trial]]></category>
		<category><![CDATA[Xtandi]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6183</guid>

					<description><![CDATA[This morning Medivation and Astellas announced the interim results of the PREVAIL trial in the pre-chemotherapy castrate resistant prostate cancer&#8230;]]></description>
		
					<wfw:commentRss>https://pharmastrategyblog.com/2013/10/medivation-announce-interim-results-of-prevail-in-pre-chemotherapy-crpc.html/feed/</wfw:commentRss>
			<slash:comments>2</slash:comments>
		
		
			</item>
		<item>
		<title>Can Merck make an impact in pancreatic cancer?</title>
		<link>https://pharmastrategyblog.com/2013/10/can-merck-make-an-impact-in-pancreatic-cancer.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Tue, 22 Oct 2013 10:22:39 +0000</pubDate>
				<category><![CDATA[Conferences]]></category>
		<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Pancreatic Cancer]]></category>
		<category><![CDATA[Pipeline]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[AACR Molecular Targets]]></category>
		<category><![CDATA[AKT]]></category>
		<category><![CDATA[CDK5]]></category>
		<category><![CDATA[dinaciclib]]></category>
		<category><![CDATA[ERK]]></category>
		<category><![CDATA[Merck]]></category>
		<category><![CDATA[MK-2206]]></category>
		<category><![CDATA[pancreatic cancer]]></category>
		<category><![CDATA[PI3K]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6177</guid>

					<description><![CDATA[There were a number of interesting posters at the AACR-NCI-EORTC Molecular Targets meeting today. Specifically, two on metastatic pancreatic cancer&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>Removing the PD-1 brake enhances the effect on adoptive CAR T cells</title>
		<link>https://pharmastrategyblog.com/2013/10/removing-the-pd-1-brake-enhances-the-effect-on-adoptive-car-t-cells.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Wed, 16 Oct 2013 15:47:34 +0000</pubDate>
				<category><![CDATA[Basic Research]]></category>
		<category><![CDATA[Breast Cancer]]></category>
		<category><![CDATA[Immunology]]></category>
		<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Pipeline]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[breast cancer]]></category>
		<category><![CDATA[CAR T cells]]></category>
		<category><![CDATA[CART]]></category>
		<category><![CDATA[HER2]]></category>
		<category><![CDATA[PD-1]]></category>
		<category><![CDATA[PD-L1]]></category>
		<category><![CDATA[solid tumors]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6166</guid>

					<description><![CDATA[Someone in my Twitter stream kindly shared a link to an article this morning on how removing the PD-1 brake&#8230;]]></description>
		
		
		
			</item>
		<item>
		<title>The CLL Landscape is rapidly a’changing…</title>
		<link>https://pharmastrategyblog.com/2013/10/the-cll-landscape-is-rapidly-achanging.html/</link>
					<comments>https://pharmastrategyblog.com/2013/10/the-cll-landscape-is-rapidly-achanging.html/#comments</comments>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Thu, 10 Oct 2013 13:05:31 +0000</pubDate>
				<category><![CDATA[Leukemia]]></category>
		<category><![CDATA[Lymphoma]]></category>
		<category><![CDATA[Pathways]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[Abbott]]></category>
		<category><![CDATA[ABT-199]]></category>
		<category><![CDATA[CLL]]></category>
		<category><![CDATA[GA-101]]></category>
		<category><![CDATA[Gilead 116 Study]]></category>
		<category><![CDATA[GS9973]]></category>
		<category><![CDATA[ibrutinib]]></category>
		<category><![CDATA[idelalisib]]></category>
		<category><![CDATA[Infinity]]></category>
		<category><![CDATA[IPI-145]]></category>
		<category><![CDATA[NHL]]></category>
		<category><![CDATA[obinutuzumab]]></category>
		<category><![CDATA[Roche]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6155</guid>

					<description><![CDATA[Yesterday evening, Gilead announced that the Data Monitoring Committee (DMC) had recommended early stoppage of the 116 trial, which looks&#8230;]]></description>
		
					<wfw:commentRss>https://pharmastrategyblog.com/2013/10/the-cll-landscape-is-rapidly-achanging.html/feed/</wfw:commentRss>
			<slash:comments>1</slash:comments>
		
		
			</item>
		<item>
		<title>Update on KRAS and NRAS mutations in colorectal cancer</title>
		<link>https://pharmastrategyblog.com/2013/09/update-on-kras-and-nras-mutations-in-colorectal-cancer.html/</link>
		
		<dc:creator><![CDATA[MaverickNY]]></dc:creator>
		<pubDate>Thu, 19 Sep 2013 16:07:51 +0000</pubDate>
				<category><![CDATA[Biomarkers]]></category>
		<category><![CDATA[Colorectal Cancer]]></category>
		<category><![CDATA[Oncology]]></category>
		<category><![CDATA[Targeted Therapies]]></category>
		<category><![CDATA[cetuximab]]></category>
		<category><![CDATA[colorectal cancer]]></category>
		<category><![CDATA[EGFR antibodies]]></category>
		<category><![CDATA[KRAS]]></category>
		<category><![CDATA[NRAS]]></category>
		<category><![CDATA[panitumumab]]></category>
		<guid isPermaLink="false">http://pharmastrategyblog.com/?p=6146</guid>

					<description><![CDATA[A new NEJM article on KRAS and metastatic colorectal cancer (CRC) caught my eye last week. One of the challenges&#8230;]]></description>
		
		
		
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