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Shashank Shekhar, Gregory J. Hoeprich, Jeff Gelles, Bruce L. Goode
Shekhar and Hoeprich et al. show that Twinfilin bypasses the normal requirement for actin filament aging (Pi release) and drives barbed end depolymerization of newly formed filaments. This occurs even under assembly-promoting conditions, where actin monomer levels are far above the critical concentration.
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Tara D. Fischer, Chunxin Wang, Benjamin S. Padman, Michael Lazarou, Richard J. Youle
A primordial function of the cGAS/STING pathway may be to induce LC3B lipidation. Fischer et al. show cGAMP-activated STING induces the V-ATPase to recruit ATG16L1 for lipidation of LC3B onto single-membrane perinuclear vesicles. The bacterial effector SopF blocks this pathway, suggesting roles in host defense.
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Pearl V. Ryder, Junnan Fang, Dorothy A. Lerit
Little is known about the functional importance of mRNA localization to centrosomes. Ryder et al. survey RNA localization to centrosomes within Drosophila embryos and show that regulation of centrocortin mRNA by FMRP ensures normal mitosis and embryonic viability.
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Swapnil Rohidas Shinde, Andrew R. Nager, Maxence V. Nachury
Shinde et al. find that activation of G protein–coupled receptors (GPCRs) inside cilia triggers formation of ubiquitin chains onto the receptors via β-arrestin and that ubiquitin chains commit the GPCRs for exit from cilia.
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Jie Liu, Manuel A. Riquelme, Zhen Li, Yuting Li, Yuxin Tong, Yumeng Quan, Cheng Pei, Sumin Gu, Jean X. Jiang
Oxidative stress is a major risk factor for multiple disorders, including cataracts. The current study uncovers a unique mechanism that transports nutrients and antioxidants to maintain lens homeostasis and transparency. This process is fulfilled through a collaboration between integrin molecules and connexin channels.
Article
Sadanori Watanabe, Franz Meitinger, Andrew K. Shiau, Karen Oegema, Arshad Desai
Watanabe et al. show that centrioles and their associated pericentriolar matrix can independently support spindle assembly. They delineate how the pericentriolar matrix acts without centrioles and describe cancer cell lines in which spindles can assemble in the absence of both centrioles and pericentriolar matrix.
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Madison Atkins, Jiří Týč, Shahaan Shafiq, Manu Ahmed, Eloïse Bertiaux, Artur Leonel De Castro Neto, Jack Sunter, Philippe Bastin, Samuel Dale Dean, Sue Vaughan
Stable eukaryotic flagella can maintain their length, and many protists grow new flagella while maintaining existing flagella. Mechanisms regulating this are not well understood. Atkins et al. show that CEP164C is important for this regulation, and these findings provide key novel insights into this process.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 11,
November 2, 2020
Reviews & Opinions
Spotlight
Daniela C. Zarnescu
Zarnescu previews work by the Lerit laboratory highlighting a role for FMRP in ensuring centrocortin mRNA localization to centrosomes, which is needed for cell division and embryonic development.
Spotlight
Samuel J.P. Taylor, Federico Pelisch
Taylor and Pelisch preview work from the McNally group suggesting a new kinetochore-based model of chromosome segregation in C. elegans oocyte meiosis.
Spotlight
Giorgia Benzi, Simonetta Piatti
Benzi and Piatti preview work from Cordeiro and colleagues that describes new insights into the regulation of PLK1 during mitotic checkpoint silencing.

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