Cholesterol is carried in blood by three major carriers or lipo-proteins : High Density Lipo-proteins (HDL) which means that they contain a lot of the protein portion, which means also that they have high affinity to carry fat, which makes them the good guys who are able to carry fat to the liver away from blood vessels. The second carriers are the Low Density Lipo-proteins (LDL), which means – unlike above - that they are not able to carry much fat away from blood vessels, so their abundance in blood is dangerous and harmful and associated with deposition under the internal linings of blood vessels. The third class of carriers are the Very Low Density Lipo-proteins (VLDL). Most laboratories measure the total cholesterol, total triglycerides (TG) and the HDL fraction, leaving the measurement of the rest of your lipid profile to your doctor, based on the fact that the amount of cholesterol found in the VLDL fraction can be estimated by dividing the triglyceridesby 5, and also based on the fact that LDL fraction can by calculated by subtracting HDL and VLDL from the total cholesterol value.

Total cholesterol is relatively stable over time, and doesn’t depend on whether the patient is fasting. However, the TG fraction and HDL vary considerably depending on the fasting status of the patient. That’s why the National Cholesterol Education Program (NCEP), Adult Treatment Panel (ATP III) guidelines recommend that only fasting measurements be used to guide management decisions.

Two persons with the same total cholesterol level of 275 mg/dl may have very different lipid profiles. One may have a HDL cholesterol of 110 mg/dl, with a TG of 150 mg/dl, giving an estimated LDL cholesterol of 135 mg/dl. The other may have a HDL cholesterol of 25 mg/dl, with a TG level of 200 mg/dl, giving a LDL cholesterol of 210 mg/dl. Given all other risk factors are equal , the second person would have more than 10-fold higher risk to develop coronary heart disease than the first.

Basic science studies have shown that deposition of cholesterol in arteries is an inflammatory disease. One of the key factors triggering this inflammation is LDL. When LDL is taken up by certain cells in the blood stream, it triggers the release of certain signals, the end results of which is thickening or rupture of a plaque lining the vessel walls, which in turn leads to the events of coronary artery blockade leading to angina , or carotid artery blockade leading to stroke. So, cholesterol lowering via diet or drugs can therefore be thought of as an anti-inflammatory and plaque stabilizing therapy.

Since the advent of statin drugs ( a group of drugs used to lower cholesterol and the most recent of which is crestor ) around 1980s, several studies highlighted their role in reducing the risk of development of cholesterol related diseases on the heart, blood vessels and brain. Five of these studies were specifically significant.

In 1994, the Scandinavian Simvastatin Survival Study (4S) studied 4444 patients for 5.4 years after treating them with 20-40 mg/day of simvastatin. The patients were high risk in terms of both presence of diseases and unfavourable cholesterol profile. The results were a decrease of coronary artery disease deaths by 34%, a decrease in revascularization procedures by 37%, and all-cause death rate by 30%.

In 1995, the West Of Scotland Coronary Prevention Study (WOSCOPS), treated 6569 patients with markedly elevated cholesterol levels with 40 mg/day of pravastatin for 5 years. Coronary events were reduced by 31%. Coronary artery disease deaths were reduced by 28%. Coronary revascularization reduced by 37%, and all-cause deaths reduced by 22%.

In 1996 and 1998, the Cholesterol And Recurrent Events (CARE) study, and the Long term Intervention with Pravastatin in Ischemic Disease (LIPID) study, respectively, showed reduced incidences of bad clinical outcomes too.

Another later study was done in 1998. The Air Force / Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TEXCAPS) treated 6605 patients with the usual range of cholesterol for the US population with 20-40 mg/day of lovastatin. Remarkably even in this low risk group of patients, after 5 years of therapy, there was reduced coronary artery disease and death rate by 25%, reduced myocardial infarction events by 40% and decreased revascularization by 33%.

Non-favourable fat profiles are usually detected by routine laboratory screening in an asymptomatic person. That’s because except for rare patients whose high cholesterol may present with yellowish skin lesions called xanthomas especially related to eye lids or deposited in tendon bodies like the patellar tendon over the knee joint or the Achilles tendon behind the ankle, the majority of patients have no signs or symptoms of diseae.

So, the NCEP guidelines advise that screening for non-favourable lipid profile be done in adults aged 20 years or older with a fasting lipo-protein levels once every 5 years. The profile is categorized based on the LDL, HDL, and total cholesterol values:
LDL Cholesterol (mg/dl)
< 100 Optimal.
100-129 Near optimal.
130-159 Borderline high.
160-189 High.
>190 Very high.

HDL Cholesterol (mg/dl)
< 40 Low.
> 60 High.

Total cholesterol (mg/dl)
< 200 Desirable.
200-239 Borderline high
> 240 High.

After putting yourself in a category, you’ve already started yourself on the right track to prevent the unwanted effects of high cholesterol – if present - or to maintain your current healthy cholesterol status, also if present.

On the next post ( 2 of 9 ), we’ll continue our advice to you on what to do to save yourself from being pulled into the ever growing maze of not knowing what to do with my lipid profile. Stay tuned.

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• July 29, 2009 — Compelling information about Avandia side effects (1)

Since its approval in 1999, several attempts have been done to study Avandia’s side effects. As early as September 2005, Avandia has been suspected of causing macular edema, which causes partial blindness in various spots of the angle of vision. While blindness is also a possible effect of diabetes, which Avandia is intended to prevent, an article in the Canadian Journal CMAJ has documented several occurences and recommended discontinuation at the first sign of vision problems.

A press release by GlaxoSmithKline in February 2007 noted that there is a greater incidence of fractures of the upper arms, hands and feet in female diabetics given Avandia compared with those given metformin or glyburide. The information was based on data from the ADOPT trial.

A meta-analysis reported in May 2007 that the use of Avandia was associated with significantly increased risk of heart attack, and an even higher risk of death from all cardiovascular diseases. The US Food and Drug Administration (FDA) issued an alert on May 21, 2007. On July 30 of the same year, and advisory Committee of the FDA concluded that the use of Avandia for the treatment of type 2 diabetes was associated with a greater risk of myocardial ischemic events including heart attacks, than placebo.

In 2009, the RECORD study, an open label trial published in the Lancet, found that there was no increase in cardiovascular hospitalization or death with Avandia compared to metformin plus sulfonylurea, but the rate of heart failure causing admission to hospital or death was significantly increased.

Endocrine side effects have included the resumption of ovulation in premenopausal anovulatory women with insulin resistance . These patients may be at risk for pregnancy if adequate contraception is not used.

Metabolic side effects have included increase in total cholesterol, LDL, HDL and decrease in free fatty acids. These changes were statistically different from placebo or glyburide controls. Dose related weight gain has been reported in patients treated with Avandia alone and in combination with other hypoglycemic agents.

Avandia is structurally related to troglitazone , a similar member of the same therapeutic family no longer marketed in the united states, which was associated with toxicity to the liver and rarely caused liver failure and death during use. It is recommended that liver enzymes to be checked in all patients prior to initiation of therapy, and every two months for the first 12 months and periodically thereafter.

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• EXCUSE : “Sunscreens breaks me out″

The truth is that fear of aggravating acne is the number one reason women shun sunscreens, says Robert A. Weiss, MD, president of the American Society for Dermatologic Surgery. But guess what? Protecting skin from UV light curtails future breakouts. “The sun stimulates oil glands and thickens skin, so pores become blocked,” explains Weiss.

So keep breakouts at bay with a lightweight, non-oily lotion like Coppertone NutraShield Faces 70+ SPF with Dual Defence, which is proven not to clog pores.

• EXCUSE : “It’s messy to reapply sunscreen over makeup”

The truth is that not freshening your sunscreen is akin to committing skin suicide. Here’s why: The potency of sunscreen decreases after just a couple of hours, and a mere 10 minutes of daily exposure to aging UVA rays is known to cause changes that lead to wrinkles and brown spots within a few months.

So, a brush-on tinted mineral sunscreen powder such as BareMinerals SPF 30 Natural Sunscreen is perfect for quick touch-ups before dashing out to lunch or running errands midday. Besides helping to even out your skin tone, the minerals naturally diffuse light, so your complexion looks smoother and more luminous.

• EXCUSE : “I sweat ot off so quickly”

The truth is that this lament, common among outdoor athletes, has merit:  Sweating decreases the effectiveness of sunscreen, and so does wiping the skin to remove the sweat, says James Spencer, MD, associate clinical professor of Dermatology at Mount Sinai School of Medicine. Look for a sport sunscreen labeled very water resistant or very water/sweat resistant - that means it’s proven to protect for 80 minutes. Still, to be safe, reapply often.

So, in addition to being very water/sweat resistant, Banana Boat UltraMist Performance Continuous Spray SPF 85 sprays on clear, so hands don’t get greasy rubbing it in ( a boon for golf and tennis players ). A nozzle that works at any angle makes coating hard-to-reach places a breeze.

• EXCUSE : “My skin is sensitive”.

The truth is that chemical sunscreens, which absorb UV light, can be irritating. Instead, opt for a physical sunblock that reflects UV rays; these products contain zinc oxide or titanium dioxide, which rarely upset sensitive skin. Even better, because sunblocks don’t allow skin to get as hot as sunscreens do, they’re less likely  to aggravate redness from conditions such as rosacea,  says Weiss.

So,  some sunblocks create a whitish cast , but the ultrafine zinc and titanium in Neutrogena Sensitive Skin Sunblock Lotion SPF 60+ with Purescreen quickly vanish into skin. It’s also fragrance free, further reducing the chance of irritation.

• EXCUSE : “Sunscreens make my face shiny”

The truth is that even some oil-free formulas leave skin looking (and feeling) like a grease slick. They are often too heavy to apply under makeup as well. As a result, many women rely on the SPF in makeup, a habit worth breaking: A study did show that even under typical office or home conditions, foundation can shift and wear off after a few hours.

So - thanks to its ultra-airy texture, La Roche-Posay Anthelios 60 Ultra Light Sunscreen Fluid for Face absorbs quickly and dries to a matte finish, so foundation glides on smoothly and doesn’t slide off. Skip-a-step bonus: It’s moisturizing, so you don’t need a separate day cream.

• EXCUSE: “It’s too late; the damage is already done”

The truth is that if you still think most sun damage occurs before you hit age 20, here’s news: You get less than 25% of your total sun exposure by the age of 18, not the 80% experts used to believe. In fact, by age 40, you’ve soaked up only about half your total lifetime exposure. And no matter what your age, daily sunscreen use reduces damage and allows skin to repair itself, says Weiss.

So, Protect skin and boost its natural repair abilities  with NIA 24 Sun Damage Prevention 100% Mineral Sunscreen SPF 30. It contains Pro-Niacin, a form of vitamin B3 that helps erase past sun sins by improving skin hydration and minimizing dark spots.

And whatever your complaints about UV protectors, I’ve got you covered.

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Clinical trials have demonstrated that (My Reductil) sibutramine can produce and sustain weight reduction in subjects who have failed to lose and maintain weight loss through diet and exercise alone. That study shows that benifits associated with (My Reductil) sibutramine treatment could be considered as a viable option for pharmacotherapy alongside  diet and exercise.

They estimated the costs and quality of life benefits directly associated with the reduced incidences of coronary heart disease and diabetes. The health costs directly attributable to obesity have been estimated to be as high as  8% of the overall health budgets.

That 54 week study conducted in a primary care setting, explored the effect of a standardized non pharmacological treatment program and (My Reductil) sibutramine treatment or placebo on long term weight reduction in obese subjects with body mass index  equal to or greater than 30 kilograms / square meters. The mean weight loss at the end of study was 8.1 plus or minus 8.2 kg for the (My Reductil) sibutramine group versus 5.1 plus or minus 6.5 kg for patients receiving placebo.

Responders to treatment experienced a mean weight loss of 12 kg at 12 months compared with 6.5 kg for the placebo group. Patients who withdrew because of lack of efficacy returned to their natural history levels immediately, while patients responding to treatment, and those in the placebo arm , reached their original weights  by months 57 and 39 respectively.

The results also showed a significant reduction in coronary heart disease risk after (My Reductil) sibutramine. Also, published evidence suggests that a reduction in body mass index (BMI) from 42 kg/sq. meters to 33 kg/sq. meters give a corresponding reduction in diabetes incidences of 6.1% over a 2-year period.

For a group of 1000 patients, the total number of coronary heart disease events avoided through 12 months of sibutramine treatment is estimated to range from 1.96 for the UK evaluation to 4.08 for the Swiss evaluation. The model also estimates that the number of cases of diabetes that will be avoided will be in the region of 3 for the German evaluation to 3.28 for the Swiss evaluation.

So, the above facts demonstrate that 1 year of (My Reductil) sibutramine 10 or 15 mg tablets treatment  is cost-effective  compared with diet and life style interventions currently received by obese patients in all the countries.

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And since anyone’s ability to try (My Reductil) sibutramine can extend for a year or more, so it is therefore likely that alcohol will be taken concomittantly, so I think it is out of relevant practical importance that I consider writing about the dynamics of (My Reductil) sibutramine when given in combination with alcohol.

In 1991, a group of english scientists from Cognitive Drug Research Limited, investigated the effects of sibutramine, the active ingredient of (My Reductil) in combination alcohol on 20 healthy volunteers.

All 20 volunteers completed 4 (study days) or (treatment periods) of 1 day separated by a minimum of 7 day wash-out period. The volunteers were assigned randomly to receive oral doses of each of 4 treatment combinations on a single occasion. In the morning of the 4 study days, volunteers received either two sibutramine 10 mg capsules plus 0.5 g/kg alcohol, two sibutramine 10 mg capsules plus placebo alcohol, two placebo capsules plus 0.5 g/kg alcohol, or two placebo capsules plus placebo alcohol. The alcohol was diluted in ginger ale, the glass was covered with cling-film, and the mixture (400 ml) was administered through a straw 2 hours after ingestion of the study capsules, so that the peak alcohol concentration would coincide with the peak sibutramine concentration at 3 hours. The volunteers received a standardized breakfast 30 minutes after taking their sibutramine capsules. Lunch was provided following the 4.5 hour cognitive test session.

Assessments were made before, and 3, 4.5, 6, and 10 hours after sibutramine administration. The assessments were performed in the following sequence: blood alcohol concentration, cognitive performance tests ( like the ones they use to test attention, alertness, and memory ), and adverse effects recordings. I’ll cut to the chase here and mention the results of that interesting experiment.

As for the blood alcohol levels, as expected, the average breath alcohol concentration was greatest at the 3 hour assessment. The mean alcohol level following alcohol alone at this time was 53.2 mg/dl. this declined steadily thereafter. At 4.5 hours, it was 36.5 mg/dl, at 6 hours, it was 8.1 mg/dl, and was not detectable by 10 hours.

As for the results of the cognitive tests, the overall picture was that sibutramine, the active ingredient of (My Reductil) improved the speed of carrying out the majority of these tests, in contrast to alcohol which impaired speech. Sibutramine also reduced some errors in visual tracking tasks and reduced body sway. Alcohol impaired picture recognition sensitivity, the speed of word recognition, and increased body sway. Subjective alertness was also lowered following alcohol. There was statistically significant interaction effect shown by the picture recognition sensitivity, and the performance  was less impaired when alcohol was given in combination with sibutramine.

The number of adverse effects reported was highest in the treatment groups in which alcohol was taken. In the alcohol plus placebo treatment group, 16 (80%) volunteers reported 25 events, and in the sibutramine plus alcohol treatment groups, 12 (60%) volunteers reported 18 events. Of these reports, the highest number were in the “nervous” category including very mild weakness, dizziness, or stupor that no volunteer required withdrawal from the study because of such adverse effects. Following sibutramine and placebo, five volunteers (25%) reported 8 events, and in the placebo group, five volunteers (26%) reported 5 events.

So, to conclude, alcohol has long been found to disrupt attention, verbal and non-verbal aspects of memory, to increase body sway, and to lower alertness. Co-administration of sibutramine, the active ingredient of (My Reductil) with alcohol reduced the impairments observed when alcohol was administered alone. In fact, sibutramine improved performance on several tests, and the improvements with sibutramine were generally comparable with the impairments produced by alcohol.

The real reason why I posted this article was to ask the questionwhich I made the headline for my post : Why sibutramine, the active ingredient of (My Reductil)  hasn’t been used sice 1991 - in addition to its weight reduction capability -  to reduce the cognitive impairments done by drinking alcohol ?? It somhow works, but the authers mention at the end of this study that  the data given hasn’t yet justified that use, but I really think it may be a whole new locked  door for sibutramine, the active ingredient of (My Reductil)to try to unlock.

For any of you readers out there who wants the full text article of this study, e-mail me, and I’ll  be happy to send it to you FREE OF CHARGE.

My e-mail is : 

amebied@gmail.com

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• August 30, 2008 — How to make your own weight losing meals for breakfast (0)

“ My Reductil “ What really works …

Mechanisms for regulating food intake are still not clearly established. That the hypothalamus plays a part in these mechanisms, however, seems certain. Numerous studies seem to indicate that a cluster of neurons in the lateral hypothalamus function as an appetite center (meaning that impulses from them bring about increased appetite). Other data suggest that a group of neurons in the ventral medial nucleus of the hypothalamus functions as a satiety center (meaning that impulses from these neurons decrease appetite so that we feel sated, or satisfied. What acts directly on these centers to stimulate or depress them is still a matter of theory rather than a fact.

One theory ( the thermostat theory ) holds that it is the temperature of the blood circulating to the hypothalamus that influences the centers. A moderate decrease in blood temperature stimulates the appetite center (and inhibits the satiety center). Result : the individual has an appetite, wants to eat, and probably does. An increase in blood temperature produces the opposite effect, a depressed appetite (anorexia). One well-known instance of this is the loss of appetite in persons who have a fever.

Another theory ( the glucostat theory ) says that it is the glucose concentration and rate of glucose use that influences the hypothalamic feeding centers. A low blood glucose concentration and rate of glucose use stimulates the appetite center, whereas high blood glucose concentration inhibits it.

The use of (My Reductil) as a drug for weight loss is highly linked to the body’s own appetite control mechanisms, where it suppresses appetite an stimulates the body to use its own energy resources.

The active ingredient of (My Reductil) is sibutramine. Sibutramine was originally developed as an antidepressant ( fights depression ), and it exerts its effect by helping two other substances: noradrenaline and serotonin stay as long as possible in the brain. Noradrenaline is the hormone of stress. It gushes through our blood at times of fight or fear moments to help us use all our bodily capabilities to either fight or run away from the stress at hand. I don’t think anyone who might be reading that article ever had the desire to eat when faced by any threat. Serotonin is a local hormone that controls the release of another local hormone called leptin whose receptors are in the brain and their activation by leptin inhibits impulses that increase appetite, and stimulates impulses that decrease appetite.

This drug is rapidly absorbed from the gut, and it is extensively metabolized ( broken down ) in the liver, and its resulting substances have a half life ( time for the body to breakdown half of the substance ) is 14 – 16 hours, and is responsible for its effects. That’s why (My Reductil) should be taken early in the morning, so that it doesn’t make you awake and disturb your sleeping time, especially on the first day of taking the drug.

(My Reductil) shouldn’t be taken carelessly by patients. It should be prescribed only for people with Body Mass Index (BMI) of 27 or more who have other heart or blood vessel risk factors, or 30 or more in their absence. It should be stopped if weight lost after 3 months is less than 5% of the initial weight. It should be stopped also if weight lost stabilizes at less than 5% of the initial weight thereafter ( despite increase in concentration of My Reductil ), or if users regain more than 3 kg after previous weight loss. It should not be given for more than 1 year.

If one wanna calculate one’s own BMI, Divide your weight in kilograms by the square of your height in meters. So for example, if your weight is 115 kg, and your height is 180 centimeters ( i.e. 1.8 meters ), so your BMI can be calculated as 115/(1.8)² = 115/3.24 = 35.4, so, if you have no other contraindications to use (My Reductil), you’ll definitely be able to use it.

Being part of the antidepressant family, (My Reductil) is not the drug which you might be drinking alcohol during its course of treatment, because both will exert a depressing effect on brain function. So try to be more conservative at birthday parties or celebrations please. The dose of (My Reductil) is 10-15 mg per day by mouth.

One of the most reported side effects experienced by users of (My Reductil), and which - at the same time – are self-limited with continued use or – sometimes – symptomatic treatment, is lack of sleep especially in the first night or two of taking (My Reductil), and the best way to handle that is by taking the pill very early in the morning.

Another very popular side effect, dry mouth, which occurs in more than 10% of users, but it’s nothing to worry about. It may require the user to consume 2-3 litres of water a day, and always carry an extra bottle of water around, but to look at it from another optimistic view, drinking a lot of water daily actually fills the stomach and decreases appetite, so it’s helpful anyway.

There is a famous forum on Yahoo about how good (My Reductil) is as an anti-obesity drug. I’ve been to that forum reading people’s feedback on that drug, and how it really helped most of them with their weight loss battles. Here are some of the remarkable quotes people said after sing that drug: “ With My Reductil, I just have no interest in food “. One guy with inactive thyroid gland said: “ My Reductil is the only thing that helped me “. Another one quoted: “ My Reductil stops you needing to eat. It gets rid of the hunger, but willpower needs to be strong “. A last one: “ Food is not my God anymore “.

There is also one last relation between (My Reductil), blood pressure and headache. That relation needs to be understood by patients in order not to be confused to the extent of quitting treatment for no reason. As I notified earlier, (My Reductil) depends on noradrenaline and serotonin inside the brain to do what it does. As all would know, noradrenaline narrows blood vessels everywhere in the body which contributes to raising the blood pressure alittle, while serotonin, dilates blood vessels, and in the brain, may cause the headaches that (My Reductil) users may experience especially on the first days of treatment. The point is : Don’t just quit (My Reductil) if your blood pressure rises a little bit. You can stop it if the rise in blood pressure is severe ( more than 180/110 ), so that’s why doctors recommend that (My Reductil) users should check their blood pressure closely throughout its use ( twice weekly during the first 3 months ). You shouldn’t worry much about the headache because it goes away later, and as far as your blood pressure is fine, take a panadol or something or the headache and life will go on.

In fact, you should benefit from the 3 months that you start your (My Reductil) in, and not rush losing weight too fast. Losing weight so fast may let you get saggy skin, or let your kidney fall off inside your abdomen due to quick loss of the fat pad attaching it to the wall of the abdomen, so those first 3 months should be used by you wisely. The first month is all about surviving the changes that taking (My Reductil) will have on your life. The second month should be all about trying to establish an eating pattern. The third month should be all about introducing a more extensive exercise program.

The last thing to be mentioned here is that (My Reductil) should not be used in ( severe ) increase in blood pressure. It should not be used at all with peripheral occlusive arterial or coronary heart disease, arrhythmias, enlarged prostate condition, and in severe liver or kidney disease. It shouldn’t also be used to treat obesity of endocrine origin, or those with a major eating disorder or a psychiatric disease. It also shouldn’t be taken together with a tricyclic antidepressant, because both may lead to central nervous system toxicity.

• January 4, 2009 — Why haven’t they promoted (My Reductil) to decrease the cognitive impairments done by alcohol ??! It somehow WORKS !!! (0)
• August 30, 2008 — How to make your own weight losing meals for breakfast (0)
• September 12, 2008 — 4 wonderful dinner recipes for losing weight (0)
• September 4, 2008 — 4 easy lunch recipes to help you lose weight (0)

2-    How long does it take you to fall asleep after getting into bed ?

3-    Do you wake up in the night ? How often does this occur ?

4-    What time do you wake up ? How often do you get up this early ?

5-    How do you feel when you get up ? Do you feel rested ?

6-    Do you nap during the day ?

7-    Do you dream at night ? Do your dreams ever wake you ?

8-    Has anyone ever told you that you grind your teeth in your sleep ?

9-    Has anyone ever told you that you walk in your sleep ?

10- What kind of work do you do ?

11- What hours do you work ?

12- What kind of activity is involved in your work ?

13- What do you do for fun ?

14- Are you engaged in any exercise ?

15- Do you work at home ? What kind of work do you do at home ?

16- Do you need any special bedding to help you sleep ?

17- How many pillows do you use ?

18- Do you sleep with the lighs off ?

19- Do you have to have it very quiet to sleep ?

20- Do you open the window at night ?

21- Do you need the bedroom to be cold ( warm ) to sleep well ?

22- What do you do just before going to bed ?

23- Do you eat before you go to bed ?

24- Do you like a drink before you go to bed ?

25- Do you take any medicine to help you sleep ?

26- Are you taking anything to keep you awake in the daytime ?

27- How much sleep do you think you should have to stay healthy ?

28- How does the way you sleep affect your family ?

29- Have you had a lot of worries lately ?

30- How have you been sleeping ?

• October 7, 2008 — 6 reasons why you need a good night’s sleep (1)

Sleep deprivation compromises immune function and makes you more vulnerable to disease.

2- It slows aging:

Too little sleep elevates the levels of stress hormones and lowers levels of growth hormone, necessary for cell repair. In one study, young, healthy sleep-deprived subjects had the hormonal profiles of much older people.

3- It prevents diabetes :

Sleeplessness increases insulin resistance, a precursor to type 2 diabetes.

4- It keeps you slim:

When you’re sleep deprived, you have more of the appetite-stimulating hormone ghrelin in your blood and less appetite-curbing leptin, a combo that leaves you longing for junk food.

5- It helps maintain a sharp memory :

Even one sleepless night impairs concentration and memory and can affect job performance.

6- It can make you happier:

Insomiacs face a higher risk of depression, alcoholism, and suicide.

• January 4, 2009 — Why haven’t they promoted (My Reductil) to decrease the cognitive impairments done by alcohol ??! It somehow WORKS !!! (0)
• November 16, 2008 — 30 Questions you need to answer if you have trouble sleeping (0)

 Today, while I was going to work, I stopped by the newspaper man to buy my usual daily papers, when I caught the attractive cover of “PREVENTION” magazine, issue October 2008. Not only the cover seized my eyes, but its smart design and pocket size, plus its catchy ads that really provides smart ways to live well. That month’s issue was concentrating on tips to lose weight, and on page 187, it concluded its marvelous work by presenting “Nutrisystem”, as the complete, real life solution to losing weight. I think the magazine is right, for the following reasons:

1-     Perfect portions : as its plan features low glycemic index ” good carbs ” and low fat to avoid increasing your cholesterol levels, together with providing you with optimal amounts of proteins to help keep satisfied , and blood sugar stable.

2-    Heart Healthy : The Nutrisystem TM advanced program also protects your heart because :

·        It is low in fat, low in saturated fats,  and low in cholesterol.

·        It contains heart healthy Omega-3 fatty acids.

·        It also includes an exercise DVD for losing weight that would also improve heart health.*************

3-    Fights hunger : You won’t feel hungry on the Nutrisystem advanced program because of :

·        Added OmegaSol^TM.

·        They add in controlling your appetite, reducing hunger and cravings between meals.

·        Using low glycemic index “Good Carbs” aids in lasting that feeling of fullness.

·        On Nutrisystem, you eat often throughout the day to help keep hunger at bay and your body burning strong.

4-    Glycemic index “Good Carbs”:

·        It measures the quality of carbohydrates and its impact on your blood sugar level.

·        Good carbs are carbohydrates that break down slowly in the body, thus encouraging stable blood sugar levels,
is good, so they rate well or “low” on the glycemic index.

·        On the other hand, carbs that break down more quickly cause your insulin levels to spike, and high insulin levels can cause  your body to store fat. These “bad carbs” are given higher glycemic values and most often leave you hungry soon after a meal.

·        So, if you’re looking to lose weight, you should stay away from “bad carbs” and seek to incorporate more “good carbs” into your diet to help keep your blood sugar level stable and your appetite in check.

5-    Balanced meal plan : So you never need any weighing , measuring or calories or points to count, just great tasting food that’s ready to go when you are.*****************************************************

6-    5 meals a day : You get to eat often throughout the day to help keep you feeling full between meals.

7-     Variety of programs :

·        Women’s program.

·        Men’s program.

·        Women’s silver program.

·        Men’s silver program.

·        Women’s type II diabetic program.

·        Men’s type II diabetic program.

·        Vegetarian program.*********************************************************************************

8-    Very easy to get started :

·        You simply choose which 28-Day program is right for you.

·        Then, you choose the foods you’d like to eat from more than 120 great tasting, pre-packaged entrees, snacks and desserts.

·        You’ll select one perfectly-portioned breakfast, lunch, dinner and dessert for each day ( for 28 days ), or you can simply order their 28-Day ” Favourite Package ” featuring a pre-selected assortment of their most popular foods.

·        Eitherway, anything will arrive together on your doorstep, ready for you to begin losing weight.

9-    Interactive website : Your membership will include :

·        Free sign up.

·        Unlimited counceling and support services.

·        The daily dose motivational message.

·        Online newsletter, bulletin boards and chat rooms.

·        Online weight loss classes.

·        Online fitness diaries.

10-  Each 28-Day Nurisystem advanced order comes with a FREE results kit ( a $50 value ) featuring the following items :

·        Personalized meal planner.

·        Mindset Makeover^TM behaviour modification guide created with the help of renowned weight management expert, Gary Foster, PH.D.

·        Exercise DVD by fitness expert Leslie Sansone, or NFL star Vaughn Hebron.

·        Complete
account and community access guide.***********************************************

Most Commented Posts

• November 29, 2008 — Food is not your God anymore (5)
• September 26, 2008 — 10 reasons to why choose Nutrisystem TM advanced program (2)
• August 24, 2008 — Hello world! (1)
• October 7, 2008 — 6 reasons why you need a good night’s sleep (1)
• September 19, 2008 — Blood proteins alarming lung cancer a whole year before it happens (1)
• June 7, 2009 — Why should you pay more when you can pay less for your weight loss dream ?! READ IT HERE FIRST !! (1)
• June 11, 2009 — Finally, Sunscreens you’ll love to wear ! (1)
• July 29, 2009 — Compelling information about Avandia side effects (1)

The researchers, whose study has been published in a journal for cancer treatment, stated that a workup for blood samples taken from smokers, revealed the presence of 3 proteins in the blood of more than half of the individuals that had lung cancer in a later time.

Dr. Samir Hanash, researcher at Fred Hutchinson Center for cancer research in Seattle quoted: ” If we can increase the number of that research comittee by adding a few more scientists, then we can be able of creating a new blood test that is sensitive and accurate enough to detect lung cancer more early than what the nowadays conventional methods offer based on radiological scanning “.

The test in question uses immune system markers in the same way they are used in the traditional blood tests employed for detection of human immunodeficiency virus ( HIV ) that causes AIDS ( Acquired Immuno Deficiency Syndrome ). ” What happens in cancer is that the immune system identifies carcinogenic antigens as foreign proteins, and although these antigens are formed through cancer cells, it is - in fact - present inside the human body ” , added Hanash.

The study was conducted upon blood samples from 85 individuals ( active and used to be smokers ) within a year from being diagnosed with lung cancer, in addition to another 85 samples from individuals ( active and used to be smokers ) but not having lung cancer, and it was found that the 3 alarming proteins were detected in about 51% of the samples from the lung cancer patients.

Most Commented Posts

• November 29, 2008 — Food is not your God anymore (5)
• September 26, 2008 — 10 reasons to why choose Nutrisystem TM advanced program (2)
• August 24, 2008 — Hello world! (1)
• October 7, 2008 — 6 reasons why you need a good night’s sleep (1)
• September 19, 2008 — Blood proteins alarming lung cancer a whole year before it happens (1)
• June 7, 2009 — Why should you pay more when you can pay less for your weight loss dream ?! READ IT HERE FIRST !! (1)
• June 11, 2009 — Finally, Sunscreens you’ll love to wear ! (1)
• July 29, 2009 — Compelling information about Avandia side effects (1)