Sounds Physiological

Viewing things the way the channel does: Karl Magleby

Rockefeller University Press — Mon, 26 Oct 2015 13:00:07 +0000

A conversation with Karl Magleby on short-term synaptic plasticity, discovering BK, and viewing things the way a channel does. Download PDF transcript Key words: synaptic plasticity, facilitation, augmentation, potentiation, BK, calcium-activated K channel

A well-channeled journey from heart to brain: Dick Tsien

Rockefeller University Press — Mon, 28 Sep 2015 13:00:15 +0000

A conversation with Dick Tsien on moving from cardiac physiology to LTP in a half-dozen years, conformational signaling by channels, and being a physiologist in the UK when Hodgkin, Huxley, and Katz were all doing experiments Download PDF transcript Key words: cardiac physiology, neuroscience, LTP, calcium channels, N-type channels, Denis Noble, Alan Hodgkin

Why we don’t twitch when we smoke: Henry Lester

Rockefeller University Press — Mon, 24 Aug 2015 13:05:29 +0000

A conversation with Henry Lester on nicotinic acetylcholine receptors, inside-out pharmacology, teaching MOOCs, and Richard Feynman’s thoughts about single-channel recording. Download PDF transcript Key words: nicotine, nAChR, nicotinic receptor, inside-out pharmacology, MOOCs

Calcium signaling in the heart: Don Bers

Rockefeller University Press — Mon, 27 Jul 2015 13:00:07 +0000

A conversation with Don Bers on calcium signaling and compartmentation in cardiac myocytes. Download PDF transcript Key words: calcium, cardiomyocytes, cardiac contractility, calcium compartmentation, arrhythmias, CaM kinase

Did Alan Hodgkin dream of calcium sparks? Eduardo Ríos

Rockefeller University Press — Mon, 25 May 2015 13:00:51 +0000

A conversation with Eduardo Ríos on post-Hodgkin thought, the voltage sensor in EC coupling, calcium sparks, and the university system in Uruguay. Download PDF transcript Key words: dihydropyridine receptor, ryanodine receptor, calcium sparks, cardiac muscle, skeletal muscle, calcium sparks, excitation-contraction coupling, calsequestrin

Getting from “This can’t be right” to “Of course”: Paul Greengard

Rockefeller University Press — Mon, 27 Apr 2015 13:00:00 +0000

A conversation with Paul Greengard on “hormonal” communication between nerve cells, the biochemical bases by which antidepressants work, and the Pearl Meister Greengard Prize for outstanding women in biomedical research. Download PDF transcript Key words: second messengers, protein phosphorylation, slow synaptic transmission, protein kinases, cGMP, cAMP, synapsin I, serotonin, dopamine, p11, annexin A2, SMARCA3

Fleeing complexity: Chris Miller

Rockefeller University Press — Mon, 30 Mar 2015 13:00:00 +0000

A conversation with Chris Miller on channels, transporters, radical reductionism, and trusting your sense of scientific aesthetics. Download PDF Transcript Key words: ion channels, ion transporters, biophysics, ClC, chloride, fluoride, Fluc, lipid bilayers

Jumping into the unknown: Rich Lewis

Rockefeller University Press — Mon, 23 Feb 2015 14:16:37 +0000

A conversation with Richard Lewis on electrical resonance in hair cells, channels and signals in T cells, papayas in the lab, and following your nose. Download PDF transcript Key words: calcium, T cell, Hair cell, Papain, Orai, STIM, CRAC channels

Molecular hermeneutics and unusual sorbets: Barbara Ehrlich

Rockefeller University Press — Mon, 26 Jan 2015 14:00:30 +0000

A conversation with Barbara Ehrlich on calcium signaling, interpreting Truth, and what’s wrong with green apple-wasabi sorbet. Download PDF transcript Key words: calcium, IP3 receptor, ryanodine receptor, polycystin-2, paramecium, molecular hermeneutics, taxol, lithium, NCS-1, peripheral neuropathy

In search of the unexpected: David Clapham

Rockefeller University Press — Mon, 29 Dec 2014 14:00:42 +0000

A conversation with David Clapham, on where scientific curiosity can take you. Download PDF transcript Key words: calcium, sperm, mitochondria, cilia, TRPM7, GPCRs, CRAC, noise analysis, patch clamp, channels

Investigating calcium compartmentation and dynamics: Tullio Pozzan

Rockefeller University Press — Mon, 24 Nov 2014 14:00:00 +0000

A conversation with Tullio Pozzan on calcium compartmentation and dynamics, and signaling between the mitochondria and the ER. Download PDF transcript Key words: calcium, cAMP, mitochondria, endoplamic reticulum, calcium indicators

Shedding light on the action potential: Brian Salzberg

Rockefeller University Press — Mon, 27 Oct 2014 13:00:00 +0000

A conversation with Brian Salzberg on using optical methods to measure membrane voltage, calcium, and neuropeptide secretion. Download PDF transcript Key Words: Potentiometric dyes; voltage-sensitive dyes; arsenazo III, merocyanine-540, posterior pituitary, neurohypophysis, exocytosis, birefringence, secretion, chlorophyll, phototoxicity; squid

Peering Into the Black Box: Bertil Hille

Rockefeller University Press — Mon, 29 Sep 2014 11:00:20 +0000

A conversation with Bertil Hille, who has devoted many years to investigating ion channel regulation, and permeability mechanisms. Download PDF Transcript Key Words: Ion channel, permeability, frog, nerve, muscle, GPCRs, local anesthetics

Taking a thermodynamic approach: Baron Chanda

Rockefeller University Press — Mon, 28 Jul 2014 16:38:00 +0000

A conversation with Baron Chanda, winner of the 2013 Paul F. Cranefield Award Download PDF transcript Key Words: Ion channel, gating, voltage-clamp fluorimetry, thermodynamics, allosteric linkage

Friends of Physiology: Clay Armstrong and Clara Franzini Armstrong

Rockefeller University Press — Mon, 28 Oct 2013 15:00:00 +0000

A conversation with Clay Armstrong, who has devoted many years to investigating ion channel permeability mechanisms and gating processes, and Clara Franzini Armstrong, who has spent many years investigating the structural bases of excitation–contraction coupling. Download PDF transcript Key words: Ion channel, gating, neuroscience, squid, TEA, muscle, excitation-contraction coupling, electron microscopy