tag:blogger.com,1999:blog-49886786085359795152025-11-17T17:55:30.540+05:30A Steps Into Freedom From Type 1 Diabetes MellitusDr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.comBlogger32125tag:blogger.com,1999:blog-4988678608535979515.post-73315857257311552352025-11-14T17:13:00.004+05:302025-11-14T17:13:23.817+05:30

Regulatory T-Cells (Tregs) play an important role in preventing and reversing Type 1 Diabetes Mellitus (T1DM). This video explains the scientific mechanisms through which these cells act in preserving pancreatic beta cells.  For more videos and discussions on T1DM, visit: t1dm.org For queries or feedback, email info@t1dm.org or simply leave a comment below.

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com1Hyderabad, Telangana, India17.406498 78.477243899999991-10.903735836178846 43.320993899999991 45.716731836178845 113.63349389999999tag:blogger.com,1999:blog-4988678608535979515.post-52321300120866945722025-02-07T22:52:00.010+05:302025-02-27T23:03:19.988+05:30

Background: Type 1 diabetes mellitus (T1DM) is an autoimmune disease with difficult management, affecting the quality of life. Stem cell therapy has been proven to have regenerative ability. Using the existing stem cell therapy and modifying it, the current study aims to evaluate the effect of umbilical cord-derived mesenchymal stem cells (UCMSC), condition media (CM), and UCMSC and CM

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0tag:blogger.com,1999:blog-4988678608535979515.post-35765442067323386262024-07-07T19:33:00.007+05:302025-11-14T17:07:23.407+05:30

Dr Shivani Desai’s research journey uncovered in a heart-to-heart conversation at ‘Research Cafe’. Video Courtesy: CliMed Academy  For more videos and discussions on T1DM, visit: t1dm.org For queries or feedback, email info@t1dm.org or simply leave a comment below.

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-78045269781677208592024-03-08T08:25:00.024+05:302024-06-16T08:47:47.811+05:30

Background: Type 1 diabetes mellitus (T1DM) is a condition marked by elevated blood sugar levels and primarily recognized by the destruction of beta cells caused by an autoimmune attack, which is a significant characteristic of T1DM. Recent studies have demonstrated the regenerative potential of conditioned medium therapy. In light of this, the current research sought to assess the impact of

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-17910563726344825892023-11-14T10:20:00.002+05:302023-11-14T10:20:21.637+05:30

This video explains the basic immunology involved in the pathophysiology of Type 1 Diabetes Mellitus. It describes the types of immune cells with a special emphasis on Helper T-cells and the imbalance caused between Th-1 and Th-2 responses.  Related article: Seesaw of Th1 and Th2 in Autoimmune Disorders For more videos and discussions on T1DM, visit: https://www.t1dm.org

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Bilimora, Gujarat, India20.7702311 72.9823779-10.987961528876657 37.8261279 52.52842372887666 108.1386279tag:blogger.com,1999:blog-4988678608535979515.post-83359885400863992322023-10-08T22:15:00.009+05:302023-10-10T22:34:03.581+05:30

Dr Shivani Desai’s guest lecture on "Research Advances in Type 1 Diabetes" (टाइप 1 मधुमेह में अनुसंधान प्रगति) as part of Yog Dhyan Foundation's One Virtual Event on 08 October, 2023. The lecture covered ongoing research on the management of Type 1 Diabetes, including: Current therapeutic approaches Vaccine research Stem cell therapy  For more videos,

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-51868976029536557092023-05-22T16:42:00.030+05:302023-05-26T08:09:52.626+05:30

Background: Diabetes occurs due to insulin deficiency or less insulin. To manage this condition, insulin administration as well as increased insulin sensitivity is required, but exogeneous insulin cannot replace the sensitive and gentle regulation of blood glucose levels same as β cells of healthy individuals. By considering the ability of regeneration and differentiation of stem cells, the

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-38285649352521278312023-02-05T18:42:00.026+05:302023-10-10T22:31:33.360+05:30

Dr Shivani Desai’s lecture at the DISCT (Diabetes, Insulin and Stem Cell Therapy) Masterclass, hosted by CliMed Research Solutions on the topic of 'Regenerative Medicine: A Newer Approach For Autoimmune Diabetes'. My special thanks to Dr Ajit Singh for this opportunity! The following video is a deep dive into this approach: For more publications and discussions on T1DM, visit: https://

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-19976734717648308002022-11-23T08:21:00.012+05:302022-11-24T10:07:05.371+05:30

Background and objective: Type 1 diabetes mellitus is a complex disease defined by the loss of pancreatic cells, which leads to complete insulin insufficiency. The Diabetes Control and Problems Trial defines the aims of Type 1 diabetes therapy as achieving adequate glycaemic control and preventing and avoiding recurrent bouts of hypoglycaemia. Despite ongoing efforts to improve insulin therapy

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-32694682381422160522022-09-28T13:38:00.001+05:302022-10-16T13:56:34.695+05:30

Abstract: Insulin is a peptide hormone released by pancreatic beta cells. An autoimmune reaction in diabetes mellitus type 1 causes the beta cells to die, preventing insulin from being produced or released into the bloodstream which impacts 30 million people globally and is linked to shortened lifespan due to acute and chronic repercussions. Insulin therapy aims to replicate normal pancreatic

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-53864714292784300052022-08-23T19:15:00.002+05:302022-08-28T19:31:50.887+05:30

Abstract: Several cellular and molecular therapies such as stem cell therapy, cell replacement therapy, gene modification therapy and tolerance induction therapy have been researched to procure a permanent cure for Type 1 Diabetes. However, due to the induction of undesirable side effects, their clinical utility is questionable. These anti-diabetic therapies can be modified with nanotechnological

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-82305662736480272912022-04-11T19:26:00.001+05:302022-08-05T19:30:39.286+05:30

Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disease, involves the destruction of pancreatic β cells. β cells maintain glucose homeostasis by identifying blood glucose and accordingly releasing insulin in order to maintain normal physiologic glucose levels. Human umbilical cord blood (hUCB) cells posture a lesser risk of viral contamination as there is low placental transmission

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-35653110073176234612022-03-26T20:20:00.007+05:302022-03-27T20:25:25.016+05:30

I recently delivered a lecture at Masters Certificate Course in Diabetic Pharmacotherapy (MCCDP), hosted by CliMed Research Solutions on the topic of 'Pathophysiology and Pharmacology of Type 1 Diabetes Mellitus'. Special thanks to Dr Ajit Singh for this opportunity! Understanding the disease's pathophysiology can help in managing it better. The following video is a deep dive into this

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com1Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-65732098451111316772022-03-12T19:06:00.000+05:302022-03-12T19:06:03.722+05:30

Balanced Th1 and Th2 cytokines are significantly associated to maintain the immunological ecosystem in human physiology. Any imbalance can lead to either autoimmune diseases or immunodeficient diseases. This editorial highlights the immunological mechanism involved in type 1 diabetes (T1DM). Journal: Current Diabetes Reviews Keywords: Cytokines; T1D; T2D; anti-inflammatory; immunological

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-63330422798505251412022-02-20T13:39:00.004+05:302022-02-20T13:41:19.001+05:30

The history of insulin is a 100 years story. This marvel has become a blessing for Type 1 Diabetic Mellitus (T1DM) patients. This video describes the complete journey of insulin from even before its scientific discovery.  Related article: A Century-Long Journey Of Type 1 Diabetes Management: From Insulin To…?? For more videos and discussions on T1DM, visit: https://

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com1Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-82551501940685894012021-12-19T14:17:00.011+05:302022-01-30T21:38:48.894+05:30

Insulin is the only available treatment for Type 1 Diabetes Mellitus (T1DM) for over a century now. Globally, scientists are working on different avenues to find a permanent cure for T1DM. Clinical trials are under process, but with little success so far. So where are we today? A short video: Related article: A Century-Long Journey Of Type 1 Diabetes Management: From Insulin To…?? For

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-27195876173444218262021-11-14T11:09:00.023+05:302022-02-22T19:20:50.490+05:30

The history of type 1 diabetes mellitus (T1DM) is a longstanding story and during this 'Diabetes Month', we have designed this platform to discuss various aspects of this disease. This video is an introduction to T1DM on the occasion of Diabetes Day 2021. For more videos and publications on T1DM, visit www.t1dm.org. For queries or feedback, email info@t1dm.org or simply leave a

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Hyderabad, Telangana, India17.385044 78.486671-10.925189836178845 43.330421 45.695277836178846 113.642921tag:blogger.com,1999:blog-4988678608535979515.post-69141515057065462112021-10-17T13:37:00.004+05:302022-01-30T18:10:41.213+05:30

Autoimmune diseases stem from imbalances within the functioning of the patient’s immune system. This imbalance is witnessed due to many factors, such as stress, malnutrition, vitamin and mineral deficiencies, inappropriate gut flora, and allergies. These are the common etiologies that are considered while diagnosing any autoimmune disease. However, this article describes the basic

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-60935950552090159902021-09-01T16:50:00.063+05:302022-01-30T18:17:55.788+05:30

Survey Objective: Type 1 diabetes mellitus (T1DM) is growing in incidence over a few years. The objective of this short survey is to report the viewpoint of the general population about their belief if type 1 diabetes mellitus (T1DM) can be prevented. This will further motivate the researchers to accelerate their research to develop vaccines for the prevention and reversal of T1DM.Methods: A

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-52303947983777530702021-08-21T18:20:00.022+05:302022-01-30T18:12:33.448+05:30

Coronavirus disease 2019 (COVID-19) has stimulated health concerns globally, especially in diabetes where it has been accompanied by severe outcomes.Type 2 diabetes mellitus (T2DM) is a chief worry; though, there are a considerable population of patients with type 1 diabetes mellitus (T1DM) also, that too with incomparable concerns during the current COVID-19 pandemic. Some children experience

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com2Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-68152476249489823652021-02-23T22:43:00.010+05:302022-01-30T18:14:02.848+05:30

Can you answer this question mark in the title? What is the next product coming in the market for reversing or managing type 1 diabetes? The history of type 1 diabetes (T1DM) is a longstanding story. However, its management became possible only after the discovery of insulin by Frederick Banting and Charles Best in 1921. With this, scientists started developing hopes to cure this disease.

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com5Puducherry, India11.9415915 79.8083133-16.368642336178844 44.652063299999995 40.251825336178847 114.9645633tag:blogger.com,1999:blog-4988678608535979515.post-88280726942819626372021-01-31T12:01:00.026+05:302022-01-30T20:07:27.301+05:30

Abstract: The incidence of type 1 diabetes mellitus (T1DM), an autoimmune disorder, has ascended considerably with around 98,200 and 15,900 incidents in children below 15 years of age, globally and in India, respectively. This is typically due to environmental changes leading to genetic modifications. Also, T1DM encompasses the presence of autoantigens and many other etiologies which can be

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-41715918315917467322020-07-16T16:34:00.008+05:302022-01-30T18:15:54.902+05:30

Abstract: Diabetes mellitus is the 7th leading cause of death worldwide. Diabetes can affect the organ systems and lead to a serious complication, majorly categorized as macrovascular complications, microvascular complications, and diabetic wound. Foot ulcer develops in 15-25% diabetic patient. In diabetic wound, there is impairment in growth factor, neuropeptide, matrix metalloproteinases,

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-23380415581042346902020-07-10T19:42:00.007+05:302022-01-30T18:23:54.935+05:30

Abstract: Type 1 diabetes mellitus (T1DM), an autoimmune disease, leads to obliteration ofpancreatic β-cells, and hence causes insufficient production of insulin. With many other etiological factors, antibiotic use and gut microbiota have a significant role to play in its development. The gut microbiota interacts with the cells involved in innate immunity and has a significant role in determining

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.7898035361788445 38.700493699999996 46.830664136178846 109.0129937tag:blogger.com,1999:blog-4988678608535979515.post-73879938523035616232020-07-03T08:54:00.005+05:302022-01-30T18:24:50.216+05:30

Abstract: Diabetes is a chronic metabolic disorder of the endocrine system characterized by an increase in blood glucose levels. Several factors such as pancreatic damage, oxidative stress, infection, genetic factor, obesity, liver dysfunction play a vital role in the pathogenesis of diabetes which further leads to serious diabetic complications. The diabetic wound is one such complication where

Dr. Shivani Desaihttp://www.blogger.com/profile/15063069639541558528noreply@blogger.com0Pune, Maharashtra, India18.5204303 73.8567437-9.78980558480242 38.700491017790981 46.830666184802425 109.01299638220901