This Week in Virology - MP3 Edition

TWiV #72 - Bucket of bolts

twiv@twiv.tv — Sun, 07 Mar 2010 21:20:00 -0400

This week the TWiV team explains CRISPR/Cas, the immune system of bacteria and archaea, how novel viruses are discovered by deep sequencing of small RNAs, and the relationship between dry weather and outbreaks of West Nile virus infection.

TWiV #71 - Please Mr. Postman

twiv@twiv.tv — Sun, 28 Feb 2010 19:30:00 -0400

Vincent, Dickson, Alan, and Rich answer listener questions on maternal infection, viral gene therapy, eyeglasses and flu, filtering prions from blood, rinderpest, Tamiflu, the human microbiome, H1N1 vaccine, tumor viruses, RNA interference, and junk DNA.

TWiV #70 - Hacking aphid behavior

twiv@twiv.tv — Sun, 21 Feb 2010 19:00:00 -0400

Vincent, Dickson, and Alan consider a broad spectrum antiviral against enveloped viruses, how a plant virus induces chemical signals in the host to maximize its spread, a new way to preserve viral vaccines at tropical temperatures, and the continuing story of XMRV and chronic fatigue syndrome.

TWiV #69 - They're all safecrackers

twiv@twiv.tv — Sun, 07 Feb 2010 22:00:00 -0400

Vincent, Alan, and Rich review recent outbreaks of mumps in the UK, US, and Israel, protection of mice against 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 vaccines, and a virus-like particle vaccine for chikungunya virus.

TWiV #68 - Ode to a plaque

twiv@twiv.tv — Sun, 31 Jan 2010 23:00:00 -0400

Vincent, Alan, and Rich are enthralled by movies of vaccinia virus plaque formation, then consider how repulsion of superinfection virions leads to rapid virus spread, and a therapeutic prostate cancer vaccine.

TWiV #67 - Wasting deer and the Hulk rabbit

twiv@twiv.tv — Sun, 24 Jan 2010 09:30:00 -0400

Vincent, Alan, and Marc talk about chronic wasting disease of deer caused by prions, blocking the semen-derived enhancer of HIV infection with surfen, and making green transgenic rabbits using a lentiviral vector.

TWiV #66 - Reverse transcription

twiv@twiv.tv — Sun, 17 Jan 2010 20:00:00 -0400

Vincent and Dickson continue virology 101 with a discussion of reverse transcription, the flow of information from RNA to DNA, which occurs in cells infected with retroviruses, hepatitis B virus, cauliflower mosaic virus, foamy viruses, and even in uninfected cells.

TWiV #65 - Matt's bats

twiv@twiv.tv — Sun, 10 Jan 2010 18:30:00 -0400

Vincent, Alan, and Matt discuss a project to study the RNA virome of seven Northeastern American bats, failure to detect XMRV in UK chronic fatigue syndrome patients, and DNA of bornavirus, an RNA virus, in mammalian genomes.

TWiV #64 - Ten virology stories of 2009

twiv@twiv.tv — Sun, 03 Jan 2010 11:30:00 -0400

Vincent, Alan, and Rich discuss ten compelling virology stories of 2009.

TWiV #63 - Melting pot virus

twiv@twiv.tv — Sun, 20 Dec 2009 09:00:00 -0400

Vincent, Alan, and Rich talk about US government contract for freeze-dried smallpox vaccine, red squirrels in the UK threatened by poxvirus, and Marseillevirus, another DNA virus from amoebae built for comfort and speed.

TWiV #62 - Persistence of West Nile virus

twiv@twiv.tv — Sun, 13 Dec 2009 09:00:00 -0400

Vincent, Dickson, and Alan discuss HIV-1 vaccine failure caused by adenovirus vector, presence of West Nile virus in kidneys for years, adaptation of influenza viral RNA polymerase to human cells, and significance of D225G change in influenza HA.

TWiV #61 - Original antigenic sin

twiv@twiv.tv — Sun, 06 Dec 2009 09:00:00 -0400

Vincent and Dick muse about the symbiotic bacterium, Wolbachia, that protects flies from viral infection, the origin of 2009 influenza H1N1 virus, and the lure of original antigenic sin.

TWiV #60 - Making viral RNA

twiv@twiv.tv — Sun, 29 Nov 2009 11:00:00 -0400

Vincent and Dick continue Virology 101 with a discussion of how RNA viruses produce mRNA and replicate their genomes.

TWiV #59 - Dog bites virus

twiv@twiv.tv — Sun, 22 Nov 2009 09:20:00 -0400

A TWiV panel of five considers the finding of Streptococcus pneumoniae in fatal H1N1 cases in Argentina, hysteria in the Ukraine over pandemic influenza, and human vaccinia infection after contact with a raccoon rabies vaccine bait.

TWiV #58 - Nipah virus in ferrets

twiv@twiv.tv — Sun, 15 Nov 2009 09:00:00 -0400

Vincent, Dick, Alan and emergency medicine physician Dr. Joshua Stillman talk about passive antibody therapy for Nipah infection in ferrets, immunization and facemasks to prevent influenza, dengue, and the amazing viral communities in an Antarctic lake.

TWiV #57 - Virology in high school

twiv@twiv.tv — Sun, 08 Nov 2009 08:30:00 -0400

Vincent visited Scotch Plains - Fanwood High School and talked about viruses with high school biology students.

TWiV #56 - Perspicuously perspicacious

twiv@twiv.tv — Sun, 01 Nov 2009 11:00:00 -0400

Vincent, Dick, Alan, and Cliff answer questions from listeners on swine influenza origins, transmission, virulence, and vaccines, HIV and AIDS, and more.

TWiV #55 - Mice lie, monkeys exaggerate

twiv@twiv.tv — Sun, 25 Oct 2009 10:30:00 -0400

The largest TWiV panel ever takes on XMRV and chronic fatigue, chemistry Nobel prizes for ribosome structure, new poxvirus vaccine candidates, brouhaha over leaked Canadian data on flu susceptibility, and transmission of H1N1 influenza to a pet ferret.

TWiV #54 - Professor Lynn Enquist, virology luminary

twiv@twiv.tv — Sun, 18 Oct 2009 11:30:00 -0400

Vincent speaks with Lynn Enquist about his career in virology, moving from academia to industry and back. Along the way he did pioneering research on bacteriophage, participated in the birth of recombinant DNA technology, and studied herpesviruses.

TWiV #53 - The ends justify the means

twiv@twiv.tv — Sun, 11 Oct 2009 11:30:00 -0400

Vincent, Dick, and Alan talk about Nobel prizes for telomere research, bacteriophages that protect aphids from wasps, salicylates and pandemic influenza mortality, and hand washing.

TWiV #52 - Scott Hammer, MD on AIDS vaccines

twiv@twiv.tv — Sun, 04 Oct 2009 18:30:00 -0400

Vincent and Dr. Scott Hammer talk about different types of AIDS vaccines and how they are tested in clinical trials.

TWiV #51 - ALVAC-HIV and AIDSVAX BE

twiv@twiv.tv — Sun, 27 Sep 2009 09:30:00 -0400

Vincent, Dick, and Alan (cameo appearance by Rich Condit) review world’s largest Phase III study of an HIV vaccine candidate in Thailand, immunization of salmon against infectious salmon anemia virus, and an outbreak of blueberry shock virus in Michigan.

TWiV #50 - XMRV

twiv@twiv.tv — Sun, 20 Sep 2009 09:30:00 -0400

Vincent and Jason review influenza 2009 H1N1 vaccine trials and protection against the virus conferred by the 1976 swine flu vaccine, then move on to a virus called XMRV and its possible role in prostate cancer.

TWiV #49 - Viral genomes

twiv@twiv.tv — Sun, 13 Sep 2009 14:00:00 -0400

Vincent and Dick continue Virology 101 with a discussion of the seven different types of viral genomes, and how to use the pathway to mRNA to understand viral replication.

TWiV #48 - Outbreaks near you

twiv@twiv.tv — Sun, 06 Sep 2009 11:30:00 -0400

Vincent, Dick, Alan and Rich revisit a vaccinia virus lab accident and viral vaccines produced in plants, then talk about an iPhone app to track infectious diseases, flying foxes, and an inhaled measles vaccine.

TWiV #47 - Vertical vaccine farm

twiv@twiv.tv — Sun, 30 Aug 2009 10:00:00 -0400

Vincent and Dick discuss influenza virus-like particle vaccines produced in insect and plant cells, rapid sharing of influenza research, and answer listener questions about cytomegalovirus, viral evolution and symbiosis and much more.

TWiV #46 - Virus entry into cells

twiv@twiv.tv — Sun, 23 Aug 2009 11:00:00 -0400

Vincent and Dick continue virology 101 with a discussion of virus entry into cells, then answer reader email on colony collapse disorder and viruses that confer a benefit to their host.

TWiV #45 - Hendra and polio are back

twiv@twiv.tv — Sun, 16 Aug 2009 09:30:00 -0400

Vincent, Dick, Alan, and Jennifer tackle the Hendra virus disease outbreak in Australia, AIDS-like disease in wild chimps, return of polio type 2 in Nigeria, the influenza pandemic wave, and rabies in three countries.

TWiV #44 - No hysteria

twiv@twiv.tv — Sun, 09 Aug 2009 09:30:00 -0400

Vincent, Dick, Alan, and Jennifer on Marburg virus in fruit bats, citrus pathogen in shipping site, canine parvovirus, Relenza-resistant influenza virus, new HIV from gorillas, and public engagement on H1N1 immunization program.

TWiV #43 - Virus classification

twiv@twiv.tv — Sun, 02 Aug 2009 22:30:00 -0400

Vincent and Dick explain virus classification, and revisit the 1976 swine flu immunization campaign and Guillain-Barré syndrome.

TWiV #42 - Bats and ticks

twiv@twiv.tv — Fri, 24 Jul 2009 23:00:00 -0400

Vincent, Dick, Alan, and Delthia Ricks discuss a new influenza virus-like particle vaccine, dog flu, ultrasensitive pen-sized virus detector, imported rabies in the US, Crimean-Congo hemorrhagic fever, and next season's flu vaccines.

TWiV #41 - Fish flu

twiv@twiv.tv — Sun, 19 Jul 2009 09:00:00 -0400

Vincent, Dick, Alan and Rich Condit chat about infectious salmon anemia virus, virus-resistant grapevines, virulence of pandemic H1N1 influenza virus, origin of 1918 influenza virus, holy water ban to halt influenza, human WU and KI polyomavirus infection, rabies in China, and hosts of sin nombre virus.

TWiV #40 - Tamiflu in the water

twiv@twiv.tv — Sun, 12 Jul 2009 09:00:00 -0400

Vincent, Dick, and Alan consider Reston ebolavirus in swine, history of H1N1 influenza virus, Tamiflu-resistant H1N1, Tamiflu in Japanese river waters, H1N1 virus in ferrets, and pneumonia and respiratory failure from H1N1 in Mexico.

TWiV #39 - Virus structure

twiv@twiv.tv — Sun, 05 Jul 2009 23:00:00 -0400

Vincent and Dick discuss virus structure and answer listener questions.

TWiV #38 - Measles

twiv@twiv.tv — Sun, 28 Jun 2009 07:00:00 -0400

Vincent and Glenn Rall chat about koi herpesvirus, H1N1 influenza vaccine produced in insect cells, attack by a rabid raccoon, and measles.

TWiV #37 - Open access

twiv@twiv.tv — Sun, 21 Jun 2009 09:00:00 -0400

Vincent, Alan, and Eric Freed talk about vesivirus contamination of bioreactors, pandemic influenza, maximizing the effect of vaccination by targeting children, chikungunya virus, and open access scientific journals.

TWiV #36 - Pandemic

twiv@twiv.tv — Mon, 15 Jun 2009 01:00:00 -0400

Vincent, Alan, Dick, and Hamish Young discuss the 2009 influenza pandemic, first 2009 H1N1 vaccine, hunting mosquitoes with midges, vaccine-associated polio in India, and adenoviruses.

TWiV #35 - Much achoo about nothing

twiv@twiv.tv — Sun, 07 Jun 2009 09:00:00 -0400

Vincent, Alan, Dick, and Richard Kessin talk about Lujo virus, a new arenavirus, influenza, WHO rewriting pandemic rules, adjuvants, and a brief history of microbiology.

TWiV #34 - Arsenic and facemasks

twiv@twiv.tv — Sun, 31 May 2009 14:00:00 -0400

Vincent, Alan, and Stephen Morse discuss progressive vaccinia in a smallpox vaccinee, arsenic and influenza in mice, facemasks and flu transmission, and antigenic and genetic analyses of the new H1N1 influenza virus.

TWiV #33 - Live in Philly

twiv@twiv.tv — Sun, 24 May 2009 08:00:00 -0400

Vincent, Alan, Dick, and Raul Andino live at ASM discussed cytomegalovirus infection and blood pressure, restriction of avian influenza viral replication at low temperature, first isolation of West Nile virus in PA, and current status of influenza.

TWiV #32 - Influenza in silico

twiv@twiv.tv — Sun, 17 May 2009 16:00:00 -0400

Vincent, Alan, and Raul Rabadan converse about polio survivors in iron lungs, bocavirus, structure of mimivirus, and genome sequence analysis of influenza H1N1 viruses.

TWiV #31 - Fever plus cough or sore throat

twiv@twiv.tv — Sun, 10 May 2009 10:00:00 -0400

Vincent, Dick, Alan, and Marc Pelletier summarize the past week's influenza H1N1 activity, and discuss parvovirus infection of dogs and humans.

TWiV Special - Dr. Peter Palese

twiv@twiv.tv — Wed, 6 May 2009 05:00:00 -0400

Vincent and Dr. Peter Palese, noted influenza expert, discuss the origin and pandemic potential of the new H1N1 influenza virus.

TWiV #30 - A/Mexico/4108/2009 (H1N1)

twiv@twiv.tv — Sun, 3 May 2009 12:00:00 -0400

Vincent, Dick, Alan, and Hamish Young focus on the new H1N1 influenza virus, which originated in swine and is likely to be the next pandemic strain.

TWiV #29 - Swine flu returns

twiv@twiv.tv — Mon, 27 Apr 2009 00:00:00 -0400

Vincent, Dick, and Alan talk about insect and human dengue virus host proteins, equine vaccine for WNV and EEEV, return of swine flu to humans, spread of polio in Africa, and listener email.

TWiV #28 - SARS

twiv@twiv.tv — Sun, 19 Apr 2009 11:00:00 -0400

Vincent, Dick, Alan, and Eric F. Donaldson discuss a new test for influenza H5N1, poliovirus in Minnesota, Koala retrovirus, batteries made from viruses, and SARS.

TWiV #27 - Leaving latency

twiv@twiv.tv — Sat, 4 Apr 2009 13:00:00 -0400

Vincent, Dick, Alan, and Saul Silverstein revisit ebolavirus needlestick accident, and discuss the role of TLR3 in Negri body formation, New England college closed by norovirus gastroenteritis, hand, foot, and mouth disease in China, and exit of herpes simplex virus from latency by synthesis of VP16.

TWiV #26 - Poxviruses

twiv@twiv.tv — Sat, 28 Mar 2009 22:00:00 -0400

Vincent, Alan, and Rich Condit converse about MS drug Tysabri, polyomaviruses, and mefloquine, influenza vaccines for next season, and poxviruses.

TWiV #25 - Viral evolution

twiv@twiv.tv — Sun, 22 Mar 2009 13:00:00 -0400

Vincent, Alan, and Luis Villarreal talk about rabies in Viet Nam and Angola, needle-stick infections with ebolavirus and West Nile virus, and viral evolution.

TWiV #24 - Viroids

twiv@twiv.tv — Sun, 15 Mar 2009 08:00:00 -0400

Vincent, Alan, and Hamish Young discuss bacteriophages in viral vaccines, enteroviruses and diabetes, inhibition of Hendra and Nipah virus replication by the malaria drug chloroquine, and viroids.

TWiV #23 - Extreme virology

twiv@twiv.tv — Sat, 7 Mar 2009 20:30:00 -0400

Vincent, Dick, and Alan review a new macaque model for HIV-1 infection, Epstein-Barr virus and multiple sclerosis, accidental release of H5N1 by a vaccine company, resistance of frogs to virus infection, and the biggest and smallest viruses.

TWiV #22 - Viral bioinformatics

twiv@twiv.tv — Sat, 28 Feb 2009 17:30:00 -0400

Vincent and Chris Upton converse about hepatitis B in India, ribozyme-based AIDS gene therapy, antibodies that neutralize many influenza virus strains, killing tumors with vaccinia virus, rabbit myxoma virus, and the Viral Bioinformatics Resource Center.

TWiV #21 - Viruses of bacteria

twiv@twiv.tv — Sun, 22 Feb 2009 08:30:00 -0400

Vincent, Dick, Alan, and Max Gottesman discuss an unusual wasp-virus symbiosis, influenza transmission and absolute humidity, how mosquitoes survive Dengue virus infection, and viruses of bacteria.

TWiV #20 - Hepatitis C virus

twiv@twiv.tv — Sat, 14 Feb 2009 21:30:00 -0400

Vincent, Dick, Alan, and Matt Evans converse about TED, the Wakefield autism controversy, 99 rhinovirus sequences, Marburg in the USA, and hepatitis C virus.

TWiV #19 - Cap-snatching

twiv@twiv.tv — Sat, 7 Feb 2009 22:30:00 -0400

Vincent and Alan discuss cap-snatching by the hantavirus N protein and the influenza virus endonuclease, HIV-1 and Ebola virus antagonism of tetherin, and influenza pneumonia.

TWiV #18 - Can a virus make you fat?

twiv@twiv.tv — Sat, 31 Jan 2009 18:30:00 -0400

Vincent, Dick, and Alan discuss adenovirus and obesity, new influenza antiviral drugs, VHS virus of fish, and Ebola virus in pigs and pig farmers in the Phillipines.

TWiV #17 - Seminal discoveries in virology

twiv@twiv.tv — Sat, 24 Jan 2009 18:00:00 -0400

Vincent, Dick, and Saul talk about discoveries in virology that have had a major impact on the field.

TWiV #16 - Virology in Saanen, HIV origins

twiv@twiv.tv — Sun, 18 Jan 2009 13:00:00 -0400

Vincent and Jeremy review the Saanen virology meeting and the implications of a new HIV-1 sequence for the origins of AIDS.

TWiV #15 - Deer mice, Spanish flu, measles, antiviral resistance

twiv@twiv.tv — Mon, 12 Jan 2009 23:00:00 -0400

Vincent, Dick, and Alan converse about hantavirus spread by large deer mice, why the 1918 influenza virus replicates in the lower respiratory tract, measles in Europe, and the growing resistance of influenza virus to antivirals.

TWiV #14 - Common cold, H5N1 transmission, HIV denial, Ebola

twiv@twiv.tv — Sun, 4 Jan 2009 23:00:00 -0400

Vincent and Alan discuss a viral upper respiratory tract infection, transmission of H5N1 influenza virus, death of an HIV denialist, and the Ebola outbreak in the Democratic Republic of the Congo.

TWiV #13 - Top 10 virology stories of 2008

twiv@twiv.tv — Sun, 28 Dec 2008 18:00:00 -0400

Vincent and Alan talk about President-elect Obama's choices for his science advisors, SARS sensationalism, a new enteric picornavirus, and the top 10 virology stories of 2008.

TWiV #12 - Prions, lemur lentiviruses, RS virus vaccine, H5N1

twiv@twiv.tv — Sun, 21 Dec 2008 11:00:00 -0400

Vincent, Alan, and Angela converse on Kuru, prions in milk, ancient lentiviruses found in the chromosomes of lemurs, a respiratory syncytial virus vaccine failure in the 1960s, and recent outbreaks of H5N1 influenza in chickens.

TWiV #11 - Elite controllers, mosquitoes, and winter vomiting

twiv@twiv.tv — Fri, 12 Dec 2008 23:00:00 -0400

Vincent, Alan, and Jeremy discuss why certain AIDS patients, called 'elite controllers', do not develop disease, why mosquitoes infected with Sindbis virus remain healthy, and the continuing outbreaks of norovirus gastroenteritis.

TWiV #10 - Bats, elephants, and AIDS

twiv@twiv.tv — Thu, 4 Dec 2008 18:15:00 -0400

Vincent, Dick, and guest Alan Dove chat about reconstruction of a bat SARS-like coronavirus, herpesviruses that are killing elephants in zoos, and a plan to eradicate AIDS in ten years.

TWiV #9 - Fever! The Discovery of Lassa Virus

twiv@twiv.tv — Fri, 21 Nov 2008 23:00:00 -0400

Vincent and Dick recall the first outbreak of Lassa fever in 1969.

TWiV #8 - HIV resistance, Google flu, measles in Gibraltar, viral batteries

twiv@twiv.tv — Fri, 14 Nov 2008 12:00:00 -0400

Vincent and Dick converse about warfare preventing immunization of 120,000 children in Afghanistan, bone marrow transplant curing AIDS patient, Google tracking flu, measles outbreak in Gibraltar, using viruses to make batteries.

TWiV #7 - Viruses in video games

twiv@twiv.tv — Fri, 7 Nov 2008 12:00:00 -0400

How virus infections play prominent roles in notable video games

TWiV #6 - Latest outbreaks

twiv@twiv.tv — Wed, 29 Oct 2008 22:00:00 -0400

Vincent and Dick discuss outbreaks of polio, west Nile and eastern equine encephalitis, Hendra, and norovirus

TWiV #5 - Herpesviruses

twiv@twiv.tv — Thu, 23 Oct 2008 22:45:00 -0400

Vincent and guest Saul Silverstein on herpes simplex and varicella zoster viruses

TWiV #4 - Rabies

twiv@twiv.tv — Fri, 17 Oct 2008 13:45:00 -0400

Vincent and Dickson discuss rabies in humans and animals

TWiV #3 - Dengue

twiv@twiv.tv — Thu, 2 Oct 2008 13:45:00 -0400

Vincent and Dickson talk about the problem of Dengue

TWiV #2 - Polio is not dead

twiv@twiv.tv — Fri, 26 Sep 2008 11:00:00 -0400

Vincent and Dickson discuss the current state of poliomyelitis

TWiV #1 - West Nile Virus

twiv@twiv.tv — Wed, 24 Sep 2008 03:00:00 -0400

Vincent and Dickson discuss the arrival of West Nile Virus into the U.S.