JCB Journal Clubtag:typepad.com,2003:weblog-868450677060789882018-06-04T09:58:00-04:00The Journal of Cell Biology’s Journal Club packs are designed to enhance discussion of the latest research published in the JCB. Each month, we select an outstanding recent paper from the journal and provide links to download the manuscript pdf, a PowerPoint file of the paper’s figures, supplementary videos, and an accompanying biosights video, featuring interviews with the paper’s authors.TypePadLymphatic exosomes enhance directional migrationtag:typepad.com,2003:post-6a01053615ed00970c0223c8506941200c2018-06-04T09:58:00-04:002018-06-04T09:59:20-04:00Under inflammatory conditions, antigen-presenting dendritic cells are attracted to lymphatic vessels by chemokines secreted from the basolateral surface of lymphatic endothelial cells. Brown et al. reveal that lymphatic endothelial cells also release exosomal vesicles that, by inducing the formation of cellular protrusions, improve the ability of dendritic cells to detect...RUPress
<div xmlns="http://www.w3.org/1999/xhtml"><p>Under inflammatory conditions, antigen-presenting dendritic cells are attracted to lymphatic vessels by chemokines secreted from the basolateral surface of lymphatic endothelial cells. <a href="http://jcb.rupress.org/content/217/6/2205.abstract">Brown et al.</a> reveal that lymphatic endothelial cells also release exosomal vesicles that, by inducing the formation of cellular protrusions, improve the ability of dendritic cells to detect guidance cues and navigate their way through complex tissue environments.</p>
<video width="480" height="290" controls> <source src=" http://traffic.libsyn.com/rupress/biosights_jun_04_2018.m4v" type='video/mp4; codecs="avc1.42E01E, mp4a.40.2"'> <source src="path/to/myvideo.ogv" type='video/ogg; codecs="theora, vorbis"'> <object width="640" height="384" type="application/x-shockwave-flash" data="path/to/swf/player.swf?image=placeholder.jpg&file=path/to/myvideo.mp4"> <param name="movie" value="path/to/swf/player.swf?image=placeholder.jpg&file=path/to/myvideo.mp4" /> </object> </video>
<p><span class="asset asset-generic at-xid-6a01053615ed00970c0224df381aab200b img-responsive"><a href="http://rupress.typepad.com/files/jcb_jc_jun_04_2018_pack.zip">Download our Journal Club pack</a></span> to aid your discussion of Brown et al.'s study and its implications for inflammation and metastasis. The pack includes a complete PDF of the paper, supplemental videos, and the latest biosights video podcast, which features an interview with one of the paper's senior authors, Dontscho Kerjaschki (Medical University of Vienna).</p></div>