

<!DOCTYPE html>
<html dir="ltr" class="ms-isBot" lang="en-US">
    <head>

<script type='text/javascript' data-ot-ignore>const otAllowScripts = ['/init.js']; new MutationObserver(function (d) { Array.prototype.forEach.call(d, function (g) { Array.prototype.forEach.call(g.addedNodes, function (e) { try { if ('script' === e.tagName?.toLowerCase() && otAllowScripts.some(s => e.src?.includes(s))) { e.setAttribute('data-ot-ignore', ''); } } catch (err) { console.error(err); } }) }) }).observe(document.documentElement, { childList: !0, subtree: !0, attributes: !0, attributeFilter: ['src'] });</script>
<!-- OneTrust Cookies Consent Notice start for journals.lww.com -->
<script type="text/javascript" src="https://cdn.cookielaw.org/consent/7537629c-faa0-40ce-a837-f7b14c0d4e70/OtAutoBlock.js"></script>
<script src="https://cdn.cookielaw.org/scripttemplates/otSDKStub.js" type="text/javascript" charset="UTF-8" data-domain-script="7537629c-faa0-40ce-a837-f7b14c0d4e70"></script>

<script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/lww-cookiepro.js?v=05.25.00.229">

</script>
<title>
	Current Opinion in Allergy and Clinical Immunology
</title>
<!--Google Analytics -->

<!-- Google Tag Manager -->
<script>(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start':new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0],j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.setAttributeNode(d.createAttribute('data-ot-ignore'));j.async=true;j.src='https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f);})(window,document,'script','dataLayer','GTM-NLR6H6W');</script>
<!-- End Google Tag Manager -->
<meta name="GENERATOR" content="Microsoft SharePoint" /><meta http-equiv="Content-type" content="text/html; charset=utf-8" /><meta http-equiv="X-UA-Compatible" content="IE=edge" /><script type="text/javascript">window.NREUM||(NREUM={});NREUM.info = {"beacon":"bam.nr-data.net","errorBeacon":"bam.nr-data.net","licenseKey":"NRJS-310e337bbb542715b7f","applicationID":"1029107228","transactionName":"ZgdWMRZUVkVSBUBbCl9NdTY0GltZHgdYXgBDBU1KO1ZZQlIKW1UWHg9VFhBQSkZSAVEdAUgMVQgNVkhXVANYUxxeF0BLBUZITg==","queueTime":1,"applicationTime":1742,"agent":"","atts":""}</script><script type="text/javascript">(window.NREUM||(NREUM={})).init={privacy:{cookies_enabled:true},ajax:{deny_list:["bam.nr-data.net"]},distributed_tracing:{enabled:true}};(window.NREUM||(NREUM={})).loader_config={agentID:"1103305545",accountID:"2792772",trustKey:"1191223",xpid:"VgEOU1FUChABVFNbBgEAVFYJ",licenseKey:"NRJS-310e337bbb542715b7f",applicationID:"1029107228"};;/*! For license information please see nr-loader-spa-1.294.0.min.js.LICENSE.txt */
(()=>{var e,t,r={8122:(e,t,r)=>{"use strict";r.d(t,{a:()=>i});var n=r(944);function i(e,t){try{if(!e||"object"!=typeof e)return(0,n.R)(3);if(!t||"object"!=typeof t)return(0,n.R)(4);const r=Object.create(Object.getPrototypeOf(t),Object.getOwnPropertyDescriptors(t)),o=0===Object.keys(r).length?e:r;for(let a in o)if(void 0!==e[a])try{if(null===e[a]){r[a]=null;continue}Array.isArray(e[a])&&Array.isArray(t[a])?r[a]=Array.from(new Set([...e[a],...t[a]])):"object"==typeof e[a]&&"object"==typeof t[a]?r[a]=i(e[a],t[a]):r[a]=e[a]}catch(e){r[a]||(0,n.R)(1,e)}return r}catch(e){(0,n.R)(2,e)}}},2555:(e,t,r)=>{"use strict";r.d(t,{D:()=>s,f:()=>a});var n=r(384),i=r(8122);const o={beacon:n.NT.beacon,errorBeacon:n.NT.errorBeacon,licenseKey:void 0,applicationID:void 0,sa:void 0,queueTime:void 0,applicationTime:void 0,ttGuid:void 0,user:void 0,account:void 0,product:void 0,extra:void 0,jsAttributes:{},userAttributes:void 0,atts:void 0,transactionName:void 0,tNamePlain:void 0};function a(e){try{return!!e.licenseKey&&!!e.errorBeacon&&!!e.applicationID}catch(e){return!1}}const s=e=>(0,i.a)(e,o)},9324:(e,t,r)=>{"use strict";r.d(t,{F3:()=>i,Xs:()=>o,Yq:()=>a,xv:()=>n});const n="1.294.0",i="PROD",o="CDN",a="^2.0.0-alpha.18"},6154:(e,t,r)=>{"use strict";r.d(t,{A4:()=>s,OF:()=>d,RI:()=>i,WN:()=>h,bv:()=>o,gm:()=>a,lR:()=>f,m:()=>u,mw:()=>c,sb:()=>l});var n=r(1863);const i="undefined"!=typeof window&&!!window.document,o="undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self.navigator instanceof WorkerNavigator||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis.navigator instanceof WorkerNavigator),a=i?window:"undefined"!=typeof WorkerGlobalScope&&("undefined"!=typeof self&&self instanceof WorkerGlobalScope&&self||"undefined"!=typeof globalThis&&globalThis instanceof WorkerGlobalScope&&globalThis),s="complete"===a?.document?.readyState,c=Boolean("hidden"===a?.document?.visibilityState),u=""+a?.location,d=/iPad|iPhone|iPod/.test(a.navigator?.userAgent),l=d&&"undefined"==typeof SharedWorker,f=(()=>{const e=a.navigator?.userAgent?.match(/Firefox[/\s](\d+\.\d+)/);return Array.isArray(e)&&e.length>=2?+e[1]:0})(),h=Date.now()-(0,n.t)()},7295:(e,t,r)=>{"use strict";r.d(t,{Xv:()=>a,gX:()=>i,iW:()=>o});var n=[];function i(e){if(!e||o(e))return!1;if(0===n.length)return!0;for(var t=0;t<n.length;t++){var r=n[t];if("*"===r.hostname)return!1;if(s(r.hostname,e.hostname)&&c(r.pathname,e.pathname))return!1}return!0}function o(e){return void 0===e.hostname}function a(e){if(n=[],e&&e.length)for(var t=0;t<e.length;t++){let r=e[t];if(!r)continue;0===r.indexOf("http://")?r=r.substring(7):0===r.indexOf("https://")&&(r=r.substring(8));const i=r.indexOf("/");let o,a;i>0?(o=r.substring(0,i),a=r.substring(i)):(o=r,a="");let[s]=o.split(":");n.push({hostname:s,pathname:a})}}function s(e,t){return!(e.length>t.length)&&t.indexOf(e)===t.length-e.length}function c(e,t){return 0===e.indexOf("/")&&(e=e.substring(1)),0===t.indexOf("/")&&(t=t.substring(1)),""===e||e===t}},3241:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(6154);const i="newrelic";function o(e={}){try{n.gm.dispatchEvent(new CustomEvent(i,{detail:e}))}catch(e){}}},1687:(e,t,r)=>{"use strict";r.d(t,{Ak:()=>u,Ze:()=>f,x3:()=>d});var n=r(3241),i=r(7836),o=r(3606),a=r(860),s=r(2646);const c={};function u(e,t){const r={staged:!1,priority:a.P3[t]||0};l(e),c[e].get(t)||c[e].set(t,r)}function d(e,t){e&&c[e]&&(c[e].get(t)&&c[e].delete(t),p(e,t,!1),c[e].size&&h(e))}function l(e){if(!e)throw new Error("agentIdentifier required");c[e]||(c[e]=new Map)}function f(e="",t="feature",r=!1){if(l(e),!e||!c[e].get(t)||r)return p(e,t);c[e].get(t).staged=!0,h(e)}function h(e){const t=Array.from(c[e]);t.every((([e,t])=>t.staged))&&(t.sort(((e,t)=>e[1].priority-t[1].priority)),t.forEach((([t])=>{c[e].delete(t),p(e,t)})))}function p(e,t,r=!0){const a=e?i.ee.get(e):i.ee,c=o.i.handlers;if(!a.aborted&&a.backlog&&c){if((0,n.W)({agentIdentifier:e,type:"lifecycle",name:"drain",feature:t}),r){const e=a.backlog[t],r=c[t];if(r){for(let t=0;e&&t<e.length;++t)g(e[t],r);Object.entries(r).forEach((([e,t])=>{Object.values(t||{}).forEach((t=>{t[0]?.on&&t[0]?.context()instanceof s.y&&t[0].on(e,t[1])}))}))}}a.isolatedBacklog||delete c[t],a.backlog[t]=null,a.emit("drain-"+t,[])}}function g(e,t){var r=e[1];Object.values(t[r]||{}).forEach((t=>{var r=e[0];if(t[0]===r){var n=t[1],i=e[3],o=e[2];n.apply(i,o)}}))}},7836:(e,t,r)=>{"use strict";r.d(t,{P:()=>s,ee:()=>c});var n=r(384),i=r(8990),o=r(2646),a=r(5607);const s="nr@context:".concat(a.W),c=function e(t,r){var n={},a={},d={},l=!1;try{l=16===r.length&&u.initializedAgents?.[r]?.runtime.isolatedBacklog}catch(e){}var f={on:p,addEventListener:p,removeEventListener:function(e,t){var r=n[e];if(!r)return;for(var i=0;i<r.length;i++)r[i]===t&&r.splice(i,1)},emit:function(e,r,n,i,o){!1!==o&&(o=!0);if(c.aborted&&!i)return;t&&o&&t.emit(e,r,n);var s=h(n);g(e).forEach((e=>{e.apply(s,r)}));var u=v()[a[e]];u&&u.push([f,e,r,s]);return s},get:m,listeners:g,context:h,buffer:function(e,t){const r=v();if(t=t||"feature",f.aborted)return;Object.entries(e||{}).forEach((([e,n])=>{a[n]=t,t in r||(r[t]=[])}))},abort:function(){f._aborted=!0,Object.keys(f.backlog).forEach((e=>{delete f.backlog[e]}))},isBuffering:function(e){return!!v()[a[e]]},debugId:r,backlog:l?{}:t&&"object"==typeof t.backlog?t.backlog:{},isolatedBacklog:l};return Object.defineProperty(f,"aborted",{get:()=>{let e=f._aborted||!1;return e||(t&&(e=t.aborted),e)}}),f;function h(e){return e&&e instanceof o.y?e:e?(0,i.I)(e,s,(()=>new o.y(s))):new o.y(s)}function p(e,t){n[e]=g(e).concat(t)}function g(e){return n[e]||[]}function m(t){return d[t]=d[t]||e(f,t)}function v(){return f.backlog}}(void 0,"globalEE"),u=(0,n.Zm)();u.ee||(u.ee=c)},2646:(e,t,r)=>{"use strict";r.d(t,{y:()=>n});class n{constructor(e){this.contextId=e}}},9908:(e,t,r)=>{"use strict";r.d(t,{d:()=>n,p:()=>i});var n=r(7836).ee.get("handle");function i(e,t,r,i,o){o?(o.buffer([e],i),o.emit(e,t,r)):(n.buffer([e],i),n.emit(e,t,r))}},3606:(e,t,r)=>{"use strict";r.d(t,{i:()=>o});var n=r(9908);o.on=a;var i=o.handlers={};function o(e,t,r,o){a(o||n.d,i,e,t,r)}function a(e,t,r,i,o){o||(o="feature"),e||(e=n.d);var a=t[o]=t[o]||{};(a[r]=a[r]||[]).push([e,i])}},3878:(e,t,r)=>{"use strict";function n(e,t){return{capture:e,passive:!1,signal:t}}function i(e,t,r=!1,i){window.addEventListener(e,t,n(r,i))}function o(e,t,r=!1,i){document.addEventListener(e,t,n(r,i))}r.d(t,{DD:()=>o,jT:()=>n,sp:()=>i})},5607:(e,t,r)=>{"use strict";r.d(t,{W:()=>n});const n=(0,r(9566).bz)()},9566:(e,t,r)=>{"use strict";r.d(t,{LA:()=>s,ZF:()=>c,bz:()=>a,el:()=>u});var n=r(6154);const i="xxxxxxxx-xxxx-4xxx-yxxx-xxxxxxxxxxxx";function o(e,t){return e?15&e[t]:16*Math.random()|0}function a(){const e=n.gm?.crypto||n.gm?.msCrypto;let t,r=0;return e&&e.getRandomValues&&(t=e.getRandomValues(new Uint8Array(30))),i.split("").map((e=>"x"===e?o(t,r++).toString(16):"y"===e?(3&o()|8).toString(16):e)).join("")}function s(e){const t=n.gm?.crypto||n.gm?.msCrypto;let r,i=0;t&&t.getRandomValues&&(r=t.getRandomValues(new Uint8Array(e)));const a=[];for(var s=0;s<e;s++)a.push(o(r,i++).toString(16));return a.join("")}function c(){return s(16)}function u(){return s(32)}},2614:(e,t,r)=>{"use strict";r.d(t,{BB:()=>a,H3:()=>n,g:()=>u,iL:()=>c,tS:()=>s,uh:()=>i,wk:()=>o});const n="NRBA",i="SESSION",o=144e5,a=18e5,s={STARTED:"session-started",PAUSE:"session-pause",RESET:"session-reset",RESUME:"session-resume",UPDATE:"session-update"},c={SAME_TAB:"same-tab",CROSS_TAB:"cross-tab"},u={OFF:0,FULL:1,ERROR:2}},1863:(e,t,r)=>{"use strict";function n(){return Math.floor(performance.now())}r.d(t,{t:()=>n})},7485:(e,t,r)=>{"use strict";r.d(t,{D:()=>i});var n=r(6154);function i(e){if(0===(e||"").indexOf("data:"))return{protocol:"data"};try{const t=new URL(e,location.href),r={port:t.port,hostname:t.hostname,pathname:t.pathname,search:t.search,protocol:t.protocol.slice(0,t.protocol.indexOf(":")),sameOrigin:t.protocol===n.gm?.location?.protocol&&t.host===n.gm?.location?.host};return r.port&&""!==r.port||("http:"===t.protocol&&(r.port="80"),"https:"===t.protocol&&(r.port="443")),r.pathname&&""!==r.pathname?r.pathname.startsWith("/")||(r.pathname="/".concat(r.pathname)):r.pathname="/",r}catch(e){return{}}}},944:(e,t,r)=>{"use strict";r.d(t,{R:()=>i});var n=r(3241);function i(e,t){"function"==typeof console.debug&&(console.debug("New Relic Warning: https://github.com/newrelic/newrelic-browser-agent/blob/main/docs/warning-codes.md#".concat(e),t),(0,n.W)({agentIdentifier:null,drained:null,type:"data",name:"warn",feature:"warn",data:{code:e,secondary:t}}))}},5701:(e,t,r)=>{"use strict";r.d(t,{B:()=>o,t:()=>a});var n=r(3241);const i=new Set,o={};function a(e,t){const r=t.agentIdentifier;o[r]??={},e&&"object"==typeof e&&(i.has(r)||(t.ee.emit("rumresp",[e]),o[r]=e,i.add(r),(0,n.W)({agentIdentifier:r,loaded:!0,drained:!0,type:"lifecycle",name:"load",feature:void 0,data:e})))}},8990:(e,t,r)=>{"use strict";r.d(t,{I:()=>i});var n=Object.prototype.hasOwnProperty;function i(e,t,r){if(n.call(e,t))return e[t];var i=r();if(Object.defineProperty&&Object.keys)try{return Object.defineProperty(e,t,{value:i,writable:!0,enumerable:!1}),i}catch(e){}return e[t]=i,i}},6389:(e,t,r)=>{"use strict";function n(e,t=500,r={}){const n=r?.leading||!1;let i;return(...r)=>{n&&void 0===i&&(e.apply(this,r),i=setTimeout((()=>{i=clearTimeout(i)}),t)),n||(clearTimeout(i),i=setTimeout((()=>{e.apply(this,r)}),t))}}function i(e){let t=!1;return(...r)=>{t||(t=!0,e.apply(this,r))}}r.d(t,{J:()=>i,s:()=>n})},3304:(e,t,r)=>{"use strict";r.d(t,{A:()=>o});var n=r(7836);const i=()=>{const e=new WeakSet;return(t,r)=>{if("object"==typeof r&&null!==r){if(e.has(r))return;e.add(r)}return r}};function o(e){try{return JSON.stringify(e,i())??""}catch(e){try{n.ee.emit("internal-error",[e])}catch(e){}return""}}},3496:(e,t,r)=>{"use strict";function n(e){return!e||!(!e.licenseKey||!e.applicationID)}function i(e,t){return!e||e.licenseKey===t.info.licenseKey&&e.applicationID===t.info.applicationID}r.d(t,{A:()=>i,I:()=>n})},5289:(e,t,r)=>{"use strict";r.d(t,{GG:()=>o,Qr:()=>s,sB:()=>a});var n=r(3878);function i(){return"undefined"==typeof document||"complete"===document.readyState}function o(e,t){if(i())return e();(0,n.sp)("load",e,t)}function a(e){if(i())return e();(0,n.DD)("DOMContentLoaded",e)}function s(e){if(i())return e();(0,n.sp)("popstate",e)}},384:(e,t,r)=>{"use strict";r.d(t,{NT:()=>o,US:()=>u,Zm:()=>a,bQ:()=>c,dV:()=>s,pV:()=>d});var n=r(6154),i=r(1863);const o={beacon:"bam.nr-data.net",errorBeacon:"bam.nr-data.net"};function a(){return n.gm.NREUM||(n.gm.NREUM={}),void 0===n.gm.newrelic&&(n.gm.newrelic=n.gm.NREUM),n.gm.NREUM}function s(){let e=a();return e.o||(e.o={ST:n.gm.setTimeout,SI:n.gm.setImmediate,CT:n.gm.clearTimeout,XHR:n.gm.XMLHttpRequest,REQ:n.gm.Request,EV:n.gm.Event,PR:n.gm.Promise,MO:n.gm.MutationObserver,FETCH:n.gm.fetch,WS:n.gm.WebSocket}),e}function c(e,t){let r=a();r.initializedAgents??={},t.initializedAt={ms:(0,i.t)(),date:new Date},r.initializedAgents[e]=t}function u(e,t){a()[e]=t}function d(){return function(){let e=a();const t=e.info||{};e.info={beacon:o.beacon,errorBeacon:o.errorBeacon,...t}}(),function(){let e=a();const t=e.init||{};e.init={...t}}(),s(),function(){let e=a();const t=e.loader_config||{};e.loader_config={...t}}(),a()}},2843:(e,t,r)=>{"use strict";r.d(t,{u:()=>i});var n=r(3878);function i(e,t=!1,r,i){(0,n.DD)("visibilitychange",(function(){if(t)return void("hidden"===document.visibilityState&&e());e(document.visibilityState)}),r,i)}},8139:(e,t,r)=>{"use strict";r.d(t,{u:()=>f});var n=r(7836),i=r(3434),o=r(8990),a=r(6154);const s={},c=a.gm.XMLHttpRequest,u="addEventListener",d="removeEventListener",l="nr@wrapped:".concat(n.P);function f(e){var t=function(e){return(e||n.ee).get("events")}(e);if(s[t.debugId]++)return t;s[t.debugId]=1;var r=(0,i.YM)(t,!0);function f(e){r.inPlace(e,[u,d],"-",p)}function p(e,t){return e[1]}return"getPrototypeOf"in Object&&(a.RI&&h(document,f),c&&h(c.prototype,f),h(a.gm,f)),t.on(u+"-start",(function(e,t){var n=e[1];if(null!==n&&("function"==typeof n||"object"==typeof n)){var i=(0,o.I)(n,l,(function(){var e={object:function(){if("function"!=typeof n.handleEvent)return;return n.handleEvent.apply(n,arguments)},function:n}[typeof n];return e?r(e,"fn-",null,e.name||"anonymous"):n}));this.wrapped=e[1]=i}})),t.on(d+"-start",(function(e){e[1]=this.wrapped||e[1]})),t}function h(e,t,...r){let n=e;for(;"object"==typeof n&&!Object.prototype.hasOwnProperty.call(n,u);)n=Object.getPrototypeOf(n);n&&t(n,...r)}},3434:(e,t,r)=>{"use strict";r.d(t,{Jt:()=>o,YM:()=>c});var n=r(7836),i=r(5607);const o="nr@original:".concat(i.W);var a=Object.prototype.hasOwnProperty,s=!1;function c(e,t){return e||(e=n.ee),r.inPlace=function(e,t,n,i,o){n||(n="");const a="-"===n.charAt(0);for(let s=0;s<t.length;s++){const c=t[s],u=e[c];d(u)||(e[c]=r(u,a?c+n:n,i,c,o))}},r.flag=o,r;function r(t,r,n,s,c){return d(t)?t:(r||(r=""),nrWrapper[o]=t,function(e,t,r){if(Object.defineProperty&&Object.keys)try{return Object.keys(e).forEach((function(r){Object.defineProperty(t,r,{get:function(){return e[r]},set:function(t){return e[r]=t,t}})})),t}catch(e){u([e],r)}for(var n in e)a.call(e,n)&&(t[n]=e[n])}(t,nrWrapper,e),nrWrapper);function nrWrapper(){var o,a,d,l;let f;try{a=this,o=[...arguments],d="function"==typeof n?n(o,a):n||{}}catch(t){u([t,"",[o,a,s],d],e)}i(r+"start",[o,a,s],d,c);const h=performance.now();let p=h;try{return l=t.apply(a,o),p=performance.now(),l}catch(e){throw p=performance.now(),i(r+"err",[o,a,e],d,c),f=e,f}finally{const e=p-h,t={duration:e,isLongTask:e>=50,methodName:s,thrownError:f};t.isLongTask&&i("long-task",[t],d,c),i(r+"end",[o,a,l,t],d,c)}}}function i(r,n,i,o){if(!s||t){var a=s;s=!0;try{e.emit(r,n,i,t,o)}catch(t){u([t,r,n,i],e)}s=a}}}function u(e,t){t||(t=n.ee);try{t.emit("internal-error",e)}catch(e){}}function d(e){return!(e&&"function"==typeof e&&e.apply&&!e[o])}},9300:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.ajax},3333:(e,t,r)=>{"use strict";r.d(t,{$v:()=>u,TZ:()=>n,Zp:()=>i,kd:()=>c,mq:()=>s,nf:()=>a,qN:()=>o});const n=r(860).K7.genericEvents,i=["auxclick","click","copy","keydown","paste","scrollend"],o=["focus","blur"],a=4,s=1e3,c=["PageAction","UserAction","BrowserPerformance"],u={MARKS:"experimental.marks",MEASURES:"experimental.measures",RESOURCES:"experimental.resources"}},6774:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.jserrors},993:(e,t,r)=>{"use strict";r.d(t,{A$:()=>o,ET:()=>a,TZ:()=>s,p_:()=>i});var n=r(860);const i={ERROR:"ERROR",WARN:"WARN",INFO:"INFO",DEBUG:"DEBUG",TRACE:"TRACE"},o={OFF:0,ERROR:1,WARN:2,INFO:3,DEBUG:4,TRACE:5},a="log",s=n.K7.logging},3785:(e,t,r)=>{"use strict";r.d(t,{R:()=>c,b:()=>u});var n=r(9908),i=r(1863),o=r(860),a=r(8154),s=r(993);function c(e,t,r={},c=s.p_.INFO,u,d=(0,i.t)()){(0,n.p)(a.xV,["API/logging/".concat(c.toLowerCase(),"/called")],void 0,o.K7.metrics,e),(0,n.p)(s.ET,[d,t,r,c,u],void 0,o.K7.logging,e)}function u(e){return"string"==typeof e&&Object.values(s.p_).some((t=>t===e.toUpperCase().trim()))}},8154:(e,t,r)=>{"use strict";r.d(t,{z_:()=>o,XG:()=>s,TZ:()=>n,rs:()=>i,xV:()=>a});r(6154),r(9566),r(384);const n=r(860).K7.metrics,i="sm",o="cm",a="storeSupportabilityMetrics",s="storeEventMetrics"},6630:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewEvent},782:(e,t,r)=>{"use strict";r.d(t,{T:()=>n});const n=r(860).K7.pageViewTiming},6344:(e,t,r)=>{"use strict";r.d(t,{BB:()=>d,G4:()=>o,Qb:()=>l,TZ:()=>i,Ug:()=>a,_s:()=>s,bc:()=>u,yP:()=>c});var n=r(2614);const i=r(860).K7.sessionReplay,o={RECORD:"recordReplay",PAUSE:"pauseReplay",ERROR_DURING_REPLAY:"errorDuringReplay"},a=.12,s={DomContentLoaded:0,Load:1,FullSnapshot:2,IncrementalSnapshot:3,Meta:4,Custom:5},c={[n.g.ERROR]:15e3,[n.g.FULL]:3e5,[n.g.OFF]:0},u={RESET:{message:"Session was reset",sm:"Reset"},IMPORT:{message:"Recorder failed to import",sm:"Import"},TOO_MANY:{message:"429: Too Many Requests",sm:"Too-Many"},TOO_BIG:{message:"Payload was too large",sm:"Too-Big"},CROSS_TAB:{message:"Session Entity was set to OFF on another tab",sm:"Cross-Tab"},ENTITLEMENTS:{message:"Session Replay is not allowed and will not be started",sm:"Entitlement"}},d=5e3,l={API:"api"}},5270:(e,t,r)=>{"use strict";r.d(t,{Aw:()=>s,CT:()=>c,SR:()=>a,rF:()=>u});var n=r(384),i=r(7767),o=r(6154);function a(e){return!!(0,n.dV)().o.MO&&(0,i.V)(e)&&!0===e?.session_trace.enabled}function s(e){return!0===e?.session_replay.preload&&a(e)}function c(e,t){const r=t.correctAbsoluteTimestamp(e);return{originalTimestamp:e,correctedTimestamp:r,timestampDiff:e-r,originTime:o.WN,correctedOriginTime:t.correctedOriginTime,originTimeDiff:Math.floor(o.WN-t.correctedOriginTime)}}function u(e,t){try{if("string"==typeof t?.type){if("password"===t.type.toLowerCase())return"*".repeat(e?.length||0);if(void 0!==t?.dataset?.nrUnmask||t?.classList?.contains("nr-unmask"))return e}}catch(e){}return"string"==typeof e?e.replace(/[\S]/g,"*"):"*".repeat(e?.length||0)}},3738:(e,t,r)=>{"use strict";r.d(t,{He:()=>i,Kp:()=>s,Lc:()=>u,Rz:()=>d,TZ:()=>n,bD:()=>o,d3:()=>a,jx:()=>l,uP:()=>c});const n=r(860).K7.sessionTrace,i="bstResource",o="resource",a="-start",s="-end",c="fn"+a,u="fn"+s,d="pushState",l=1e3},3962:(e,t,r)=>{"use strict";r.d(t,{AM:()=>o,O2:()=>c,Qu:()=>u,TZ:()=>s,ih:()=>d,pP:()=>a,tC:()=>i});var n=r(860);const i=["click","keydown","submit","popstate"],o="api",a="initialPageLoad",s=n.K7.softNav,c={INITIAL_PAGE_LOAD:"",ROUTE_CHANGE:1,UNSPECIFIED:2},u={INTERACTION:1,AJAX:2,CUSTOM_END:3,CUSTOM_TRACER:4},d={IP:"in progress",FIN:"finished",CAN:"cancelled"}},7378:(e,t,r)=>{"use strict";r.d(t,{$p:()=>x,BR:()=>b,Kp:()=>R,L3:()=>y,Lc:()=>c,NC:()=>o,SG:()=>d,TZ:()=>i,U6:()=>p,UT:()=>m,d3:()=>w,dT:()=>f,e5:()=>A,gx:()=>v,l9:()=>l,oW:()=>h,op:()=>g,rw:()=>u,tH:()=>E,uP:()=>s,wW:()=>T,xq:()=>a});var n=r(384);const i=r(860).K7.spa,o=["click","submit","keypress","keydown","keyup","change"],a=999,s="fn-start",c="fn-end",u="cb-start",d="api-ixn-",l="remaining",f="interaction",h="spaNode",p="jsonpNode",g="fetch-start",m="fetch-done",v="fetch-body-",b="jsonp-end",y=(0,n.dV)().o.ST,w="-start",R="-end",x="-body",T="cb"+R,A="jsTime",E="fetch"},4234:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(7836),i=r(1687);class o{constructor(e,t){this.agentIdentifier=e,this.ee=n.ee.get(e),this.featureName=t,this.blocked=!1}deregisterDrain(){(0,i.x3)(this.agentIdentifier,this.featureName)}}},7767:(e,t,r)=>{"use strict";r.d(t,{V:()=>i});var n=r(6154);const i=e=>n.RI&&!0===e?.privacy.cookies_enabled},1741:(e,t,r)=>{"use strict";r.d(t,{W:()=>o});var n=r(944),i=r(4261);class o{#e(e,...t){if(this[e]!==o.prototype[e])return this[e](...t);(0,n.R)(35,e)}addPageAction(e,t){return this.#e(i.hG,e,t)}register(e){return this.#e(i.eY,e)}recordCustomEvent(e,t){return this.#e(i.fF,e,t)}setPageViewName(e,t){return this.#e(i.Fw,e,t)}setCustomAttribute(e,t,r){return this.#e(i.cD,e,t,r)}noticeError(e,t){return this.#e(i.o5,e,t)}setUserId(e){return this.#e(i.Dl,e)}setApplicationVersion(e){return this.#e(i.nb,e)}setErrorHandler(e){return this.#e(i.bt,e)}addRelease(e,t){return this.#e(i.k6,e,t)}log(e,t){return this.#e(i.$9,e,t)}start(){return this.#e(i.d3)}finished(e){return this.#e(i.BL,e)}recordReplay(){return this.#e(i.CH)}pauseReplay(){return this.#e(i.Tb)}addToTrace(e){return this.#e(i.U2,e)}setCurrentRouteName(e){return this.#e(i.PA,e)}interaction(){return this.#e(i.dT)}wrapLogger(e,t,r){return this.#e(i.Wb,e,t,r)}measure(e,t){return this.#e(i.V1,e,t)}}},4261:(e,t,r)=>{"use strict";r.d(t,{$9:()=>d,BL:()=>c,CH:()=>p,Dl:()=>R,Fw:()=>w,PA:()=>v,Pl:()=>n,Tb:()=>f,U2:()=>a,V1:()=>A,Wb:()=>T,bt:()=>y,cD:()=>b,d3:()=>x,dT:()=>u,eY:()=>g,fF:()=>h,hG:()=>o,hw:()=>i,k6:()=>s,nb:()=>m,o5:()=>l});const n="api-",i=n+"ixn-",o="addPageAction",a="addToTrace",s="addRelease",c="finished",u="interaction",d="log",l="noticeError",f="pauseReplay",h="recordCustomEvent",p="recordReplay",g="register",m="setApplicationVersion",v="setCurrentRouteName",b="setCustomAttribute",y="setErrorHandler",w="setPageViewName",R="setUserId",x="start",T="wrapLogger",A="measure"},5205:(e,t,r)=>{"use strict";r.d(t,{j:()=>S});var n=r(384),i=r(1741);var o=r(2555),a=r(3333);const s=e=>{if(!e||"string"!=typeof e)return!1;try{document.createDocumentFragment().querySelector(e)}catch{return!1}return!0};var c=r(2614),u=r(944),d=r(8122);const l="[data-nr-mask]",f=e=>(0,d.a)(e,(()=>{const e={feature_flags:[],experimental:{marks:!1,measures:!1,resources:!1},mask_selector:"*",block_selector:"[data-nr-block]",mask_input_options:{color:!1,date:!1,"datetime-local":!1,email:!1,month:!1,number:!1,range:!1,search:!1,tel:!1,text:!1,time:!1,url:!1,week:!1,textarea:!1,select:!1,password:!0}};return{ajax:{deny_list:void 0,block_internal:!0,enabled:!0,autoStart:!0},api:{allow_registered_children:!0,duplicate_registered_data:!1},distributed_tracing:{enabled:void 0,exclude_newrelic_header:void 0,cors_use_newrelic_header:void 0,cors_use_tracecontext_headers:void 0,allowed_origins:void 0},get feature_flags(){return e.feature_flags},set feature_flags(t){e.feature_flags=t},generic_events:{enabled:!0,autoStart:!0},harvest:{interval:30},jserrors:{enabled:!0,autoStart:!0},logging:{enabled:!0,autoStart:!0},metrics:{enabled:!0,autoStart:!0},obfuscate:void 0,page_action:{enabled:!0},page_view_event:{enabled:!0,autoStart:!0},page_view_timing:{enabled:!0,autoStart:!0},performance:{get capture_marks(){return e.feature_flags.includes(a.$v.MARKS)||e.experimental.marks},set capture_marks(t){e.experimental.marks=t},get capture_measures(){return e.feature_flags.includes(a.$v.MEASURES)||e.experimental.measures},set capture_measures(t){e.experimental.measures=t},capture_detail:!0,resources:{get enabled(){return e.feature_flags.includes(a.$v.RESOURCES)||e.experimental.resources},set enabled(t){e.experimental.resources=t},asset_types:[],first_party_domains:[],ignore_newrelic:!0}},privacy:{cookies_enabled:!0},proxy:{assets:void 0,beacon:void 0},session:{expiresMs:c.wk,inactiveMs:c.BB},session_replay:{autoStart:!0,enabled:!1,preload:!1,sampling_rate:10,error_sampling_rate:100,collect_fonts:!1,inline_images:!1,fix_stylesheets:!0,mask_all_inputs:!0,get mask_text_selector(){return e.mask_selector},set mask_text_selector(t){s(t)?e.mask_selector="".concat(t,",").concat(l):""===t||null===t?e.mask_selector=l:(0,u.R)(5,t)},get block_class(){return"nr-block"},get ignore_class(){return"nr-ignore"},get mask_text_class(){return"nr-mask"},get block_selector(){return e.block_selector},set block_selector(t){s(t)?e.block_selector+=",".concat(t):""!==t&&(0,u.R)(6,t)},get mask_input_options(){return e.mask_input_options},set mask_input_options(t){t&&"object"==typeof t?e.mask_input_options={...t,password:!0}:(0,u.R)(7,t)}},session_trace:{enabled:!0,autoStart:!0},soft_navigations:{enabled:!0,autoStart:!0},spa:{enabled:!0,autoStart:!0},ssl:void 0,user_actions:{enabled:!0,elementAttributes:["id","className","tagName","type"]}}})());var h=r(6154),p=r(9324);let g=0;const m={buildEnv:p.F3,distMethod:p.Xs,version:p.xv,originTime:h.WN},v={appMetadata:{},customTransaction:void 0,denyList:void 0,disabled:!1,entityManager:void 0,harvester:void 0,isolatedBacklog:!1,isRecording:!1,loaderType:void 0,maxBytes:3e4,obfuscator:void 0,onerror:void 0,ptid:void 0,releaseIds:{},session:void 0,timeKeeper:void 0,jsAttributesMetadata:{bytes:0},get harvestCount(){return++g}},b=e=>{const t=(0,d.a)(e,v),r=Object.keys(m).reduce(((e,t)=>(e[t]={value:m[t],writable:!1,configurable:!0,enumerable:!0},e)),{});return Object.defineProperties(t,r)};var y=r(5701);const w=e=>{const t=e.startsWith("http");e+="/",r.p=t?e:"https://"+e};var R=r(7836),x=r(3241);const T={accountID:void 0,trustKey:void 0,agentID:void 0,licenseKey:void 0,applicationID:void 0,xpid:void 0},A=e=>(0,d.a)(e,T),E=new Set;function S(e,t={},r,a){let{init:s,info:c,loader_config:u,runtime:d={},exposed:l=!0}=t;if(!c){const e=(0,n.pV)();s=e.init,c=e.info,u=e.loader_config}e.init=f(s||{}),e.loader_config=A(u||{}),c.jsAttributes??={},h.bv&&(c.jsAttributes.isWorker=!0),e.info=(0,o.D)(c);const p=e.init,g=[c.beacon,c.errorBeacon];E.has(e.agentIdentifier)||(p.proxy.assets&&(w(p.proxy.assets),g.push(p.proxy.assets)),p.proxy.beacon&&g.push(p.proxy.beacon),function(e){const t=(0,n.pV)();Object.getOwnPropertyNames(i.W.prototype).forEach((r=>{const n=i.W.prototype[r];if("function"!=typeof n||"constructor"===n)return;let o=t[r];e[r]&&!1!==e.exposed&&"micro-agent"!==e.runtime?.loaderType&&(t[r]=(...t)=>{const n=e[r](...t);return o?o(...t):n})}))}(e),(0,n.US)("activatedFeatures",y.B),e.runSoftNavOverSpa&&=!0===p.soft_navigations.enabled&&p.feature_flags.includes("soft_nav")),d.denyList=[...p.ajax.deny_list||[],...p.ajax.block_internal?g:[]],d.ptid=e.agentIdentifier,d.loaderType=r,e.runtime=b(d),E.has(e.agentIdentifier)||(e.ee=R.ee.get(e.agentIdentifier),e.exposed=l,(0,x.W)({agentIdentifier:e.agentIdentifier,drained:!!y.B?.[e.agentIdentifier],type:"lifecycle",name:"initialize",feature:void 0,data:e.config})),E.add(e.agentIdentifier)}},8374:(e,t,r)=>{r.nc=(()=>{try{return document?.currentScript?.nonce}catch(e){}return""})()},860:(e,t,r)=>{"use strict";r.d(t,{$J:()=>d,K7:()=>c,P3:()=>u,XX:()=>i,Yy:()=>s,df:()=>o,qY:()=>n,v4:()=>a});const n="events",i="jserrors",o="browser/blobs",a="rum",s="browser/logs",c={ajax:"ajax",genericEvents:"generic_events",jserrors:i,logging:"logging",metrics:"metrics",pageAction:"page_action",pageViewEvent:"page_view_event",pageViewTiming:"page_view_timing",sessionReplay:"session_replay",sessionTrace:"session_trace",softNav:"soft_navigations",spa:"spa"},u={[c.pageViewEvent]:1,[c.pageViewTiming]:2,[c.metrics]:3,[c.jserrors]:4,[c.spa]:5,[c.ajax]:6,[c.sessionTrace]:7,[c.softNav]:8,[c.sessionReplay]:9,[c.logging]:10,[c.genericEvents]:11},d={[c.pageViewEvent]:a,[c.pageViewTiming]:n,[c.ajax]:n,[c.spa]:n,[c.softNav]:n,[c.metrics]:i,[c.jserrors]:i,[c.sessionTrace]:o,[c.sessionReplay]:o,[c.logging]:s,[c.genericEvents]:"ins"}}},n={};function i(e){var t=n[e];if(void 0!==t)return t.exports;var o=n[e]={exports:{}};return r[e](o,o.exports,i),o.exports}i.m=r,i.d=(e,t)=>{for(var r in t)i.o(t,r)&&!i.o(e,r)&&Object.defineProperty(e,r,{enumerable:!0,get:t[r]})},i.f={},i.e=e=>Promise.all(Object.keys(i.f).reduce(((t,r)=>(i.f[r](e,t),t)),[])),i.u=e=>({212:"nr-spa-compressor",249:"nr-spa-recorder",478:"nr-spa"}[e]+"-1.294.0.min.js"),i.o=(e,t)=>Object.prototype.hasOwnProperty.call(e,t),e={},t="NRBA-1.294.0.PROD:",i.l=(r,n,o,a)=>{if(e[r])e[r].push(n);else{var s,c;if(void 0!==o)for(var u=document.getElementsByTagName("script"),d=0;d<u.length;d++){var l=u[d];if(l.getAttribute("src")==r||l.getAttribute("data-webpack")==t+o){s=l;break}}if(!s){c=!0;var f={478:"sha512-YymwR40CR+J7R4UXDnwksJzIRNxMdpgny+W8Wa7/YR6zs6EwXhn6+KpFLp4uMy30jBpv5+lGTmKQkMSIclh1Nw==",249:"sha512-e0/YJ6Fdh7SXo9ax04BKCmyP4W279fbmeC3BEjjdHoDlh3sGZ2cTyW+a8ZutFDgDcJtqfMUBdf4mDvDZuD58aQ==",212:"sha512-LcvCeEfwiK7ppgjHtPU4FEAu0WS1EVn2PKuPDeApGiov8Pw3uFtTVk+OLQBukXJ+kK3XsnTWji3DzNMUkpunyA=="};(s=document.createElement("script")).charset="utf-8",s.timeout=120,i.nc&&s.setAttribute("nonce",i.nc),s.setAttribute("data-webpack",t+o),s.src=r,0!==s.src.indexOf(window.location.origin+"/")&&(s.crossOrigin="anonymous"),f[a]&&(s.integrity=f[a])}e[r]=[n];var h=(t,n)=>{s.onerror=s.onload=null,clearTimeout(p);var i=e[r];if(delete e[r],s.parentNode&&s.parentNode.removeChild(s),i&&i.forEach((e=>e(n))),t)return t(n)},p=setTimeout(h.bind(null,void 0,{type:"timeout",target:s}),12e4);s.onerror=h.bind(null,s.onerror),s.onload=h.bind(null,s.onload),c&&document.head.appendChild(s)}},i.r=e=>{"undefined"!=typeof Symbol&&Symbol.toStringTag&&Object.defineProperty(e,Symbol.toStringTag,{value:"Module"}),Object.defineProperty(e,"__esModule",{value:!0})},i.p="https://js-agent.newrelic.com/",(()=>{var e={38:0,788:0};i.f.j=(t,r)=>{var n=i.o(e,t)?e[t]:void 0;if(0!==n)if(n)r.push(n[2]);else{var o=new Promise(((r,i)=>n=e[t]=[r,i]));r.push(n[2]=o);var a=i.p+i.u(t),s=new Error;i.l(a,(r=>{if(i.o(e,t)&&(0!==(n=e[t])&&(e[t]=void 0),n)){var o=r&&("load"===r.type?"missing":r.type),a=r&&r.target&&r.target.src;s.message="Loading chunk "+t+" failed.\n("+o+": "+a+")",s.name="ChunkLoadError",s.type=o,s.request=a,n[1](s)}}),"chunk-"+t,t)}};var t=(t,r)=>{var n,o,[a,s,c]=r,u=0;if(a.some((t=>0!==e[t]))){for(n in s)i.o(s,n)&&(i.m[n]=s[n]);if(c)c(i)}for(t&&t(r);u<a.length;u++)o=a[u],i.o(e,o)&&e[o]&&e[o][0](),e[o]=0},r=self["webpackChunk:NRBA-1.294.0.PROD"]=self["webpackChunk:NRBA-1.294.0.PROD"]||[];r.forEach(t.bind(null,0)),r.push=t.bind(null,r.push.bind(r))})(),(()=>{"use strict";i(8374);var e=i(9566),t=i(1741);class r extends t.W{agentIdentifier=(0,e.LA)(16)}var n=i(860);const o=Object.values(n.K7);var a=i(5205);var s=i(9908),c=i(1863),u=i(4261),d=i(3241),l=i(944),f=i(5701),h=i(8154);function p(e,t,i,o){const a=o||i;!a||a[e]&&a[e]!==r.prototype[e]||(a[e]=function(){(0,s.p)(h.xV,["API/"+e+"/called"],void 0,n.K7.metrics,i.ee),(0,d.W)({agentIdentifier:i.agentIdentifier,drained:!!f.B?.[i.agentIdentifier],type:"data",name:"api",feature:u.Pl+e,data:{}});try{return t.apply(this,arguments)}catch(e){(0,l.R)(23,e)}})}function g(e,t,r,n,i){const o=e.info;null===r?delete o.jsAttributes[t]:o.jsAttributes[t]=r,(i||null===r)&&(0,s.p)(u.Pl+n,[(0,c.t)(),t,r],void 0,"session",e.ee)}var m=i(1687),v=i(4234),b=i(5289),y=i(6154),w=i(5270),R=i(7767),x=i(6389);class T extends v.W{constructor(e,t){super(e.agentIdentifier,t),this.abortHandler=void 0,this.featAggregate=void 0,this.onAggregateImported=void 0,this.deferred=Promise.resolve(),!1===e.init[this.featureName].autoStart?this.deferred=new Promise(((t,r)=>{this.ee.on("manual-start-all",(0,x.J)((()=>{(0,m.Ak)(e.agentIdentifier,this.featureName),t()})))})):(0,m.Ak)(e.agentIdentifier,t)}importAggregator(e,t,r={}){if(this.featAggregate)return;let o;this.onAggregateImported=new Promise((e=>{o=e}));const a=async()=>{let a;await this.deferred;try{if((0,R.V)(e.init)){const{setupAgentSession:t}=await i.e(478).then(i.bind(i,2955));a=t(e)}}catch(e){(0,l.R)(20,e),this.ee.emit("internal-error",[e]),this.featureName===n.K7.sessionReplay&&this.abortHandler?.()}try{if(!this.#t(this.featureName,a,e.init))return(0,m.Ze)(this.agentIdentifier,this.featureName),void o(!1);const{Aggregate:n}=await t();this.featAggregate=new n(e,r),e.runtime.harvester.initializedAggregates.push(this.featAggregate),o(!0)}catch(e){(0,l.R)(34,e),this.abortHandler?.(),(0,m.Ze)(this.agentIdentifier,this.featureName,!0),o(!1),this.ee&&this.ee.abort()}};y.RI?(0,b.GG)((()=>a()),!0):a()}#t(e,t,r){switch(e){case n.K7.sessionReplay:return(0,w.SR)(r)&&!!t;case n.K7.sessionTrace:return!!t;default:return!0}}}var A=i(6630),E=i(2614);class S extends T{static featureName=A.T;constructor(e){var t;super(e,A.T),this.setupInspectionEvents(e.agentIdentifier),t=e,p(u.Fw,(function(e,r){"string"==typeof e&&("/"!==e.charAt(0)&&(e="/"+e),t.runtime.customTransaction=(r||"http://custom.transaction")+e,(0,s.p)(u.Pl+u.Fw,[(0,c.t)()],void 0,void 0,t.ee))}),t),this.ee.on("api-send-rum",((e,t)=>(0,s.p)("send-rum",[e,t],void 0,this.featureName,this.ee))),this.importAggregator(e,(()=>i.e(478).then(i.bind(i,1983))))}setupInspectionEvents(e){const t=(t,r)=>{t&&(0,d.W)({agentIdentifier:e,timeStamp:t.timeStamp,loaded:"complete"===t.target.readyState,type:"window",name:r,data:t.target.location+""})};(0,b.sB)((e=>{t(e,"DOMContentLoaded")})),(0,b.GG)((e=>{t(e,"load")})),(0,b.Qr)((e=>{t(e,"navigate")})),this.ee.on(E.tS.UPDATE,((t,r)=>{(0,d.W)({agentIdentifier:e,type:"lifecycle",name:"session",data:r})}))}}var _=i(384);var N=i(2843),O=i(3878),I=i(782);class P extends T{static featureName=I.T;constructor(e){super(e,I.T),y.RI&&((0,N.u)((()=>(0,s.p)("docHidden",[(0,c.t)()],void 0,I.T,this.ee)),!0),(0,O.sp)("pagehide",(()=>(0,s.p)("winPagehide",[(0,c.t)()],void 0,I.T,this.ee))),this.importAggregator(e,(()=>i.e(478).then(i.bind(i,9917)))))}}class j extends T{static featureName=h.TZ;constructor(e){super(e,h.TZ),y.RI&&document.addEventListener("securitypolicyviolation",(e=>{(0,s.p)(h.xV,["Generic/CSPViolation/Detected"],void 0,this.featureName,this.ee)})),this.importAggregator(e,(()=>i.e(478).then(i.bind(i,8351))))}}var k=i(6774),C=i(3304);class L{constructor(e,t,r,n,i){this.name="UncaughtError",this.message="string"==typeof e?e:(0,C.A)(e),this.sourceURL=t,this.line=r,this.column=n,this.__newrelic=i}}function M(e){return K(e)?e:new L(void 0!==e?.message?e.message:e,e?.filename||e?.sourceURL,e?.lineno||e?.line,e?.colno||e?.col,e?.__newrelic)}function H(e){const t="Unhandled Promise Rejection: ";if(!e?.reason)return;if(K(e.reason)){try{e.reason.message.startsWith(t)||(e.reason.message=t+e.reason.message)}catch(e){}return M(e.reason)}const r=M(e.reason);return(r.message||"").startsWith(t)||(r.message=t+r.message),r}function D(e){if(e.error instanceof SyntaxError&&!/:\d+$/.test(e.error.stack?.trim())){const t=new L(e.message,e.filename,e.lineno,e.colno,e.error.__newrelic);return t.name=SyntaxError.name,t}return K(e.error)?e.error:M(e)}function K(e){return e instanceof Error&&!!e.stack}function U(e,t,r,i,o=(0,c.t)()){"string"==typeof e&&(e=new Error(e)),(0,s.p)("err",[e,o,!1,t,r.runtime.isRecording,void 0,i],void 0,n.K7.jserrors,r.ee)}var F=i(3496),W=i(993),B=i(3785);function G(e,{customAttributes:t={},level:r=W.p_.INFO}={},n,i,o=(0,c.t)()){(0,B.R)(n.ee,e,t,r,i,o)}function V(e,t,r,i,o=(0,c.t)()){(0,s.p)(u.Pl+u.hG,[o,e,t,i],void 0,n.K7.genericEvents,r.ee)}function z(e){p(u.eY,(function(t){return function(e,t){const r={};let i,o;(0,l.R)(54,"newrelic.register"),e.init.api.allow_registered_children||(i=()=>(0,l.R)(55));t&&(0,F.I)(t)||(i=()=>(0,l.R)(48,t));const a={addPageAction:(n,i={})=>{u(V,[n,{...r,...i},e],t)},log:(n,i={})=>{u(G,[n,{...i,customAttributes:{...r,...i.customAttributes||{}}},e],t)},noticeError:(n,i={})=>{u(U,[n,{...r,...i},e],t)},setApplicationVersion:e=>{r["application.version"]=e},setCustomAttribute:(e,t)=>{r[e]=t},setUserId:e=>{r["enduser.id"]=e},metadata:{customAttributes:r,target:t,get connected(){return o||Promise.reject(new Error("Failed to connect"))}}};i?i():o=new Promise(((n,i)=>{try{const o=e.runtime?.entityManager;let s=!!o?.get().entityGuid,c=o?.getEntityGuidFor(t.licenseKey,t.applicationID),u=!!c;if(s&&u)t.entityGuid=c,n(a);else{const d=setTimeout((()=>i(new Error("Failed to connect - Timeout"))),15e3);function l(r){(0,F.A)(r,e)?s||=!0:t.licenseKey===r.licenseKey&&t.applicationID===r.applicationID&&(u=!0,t.entityGuid=r.entityGuid),s&&u&&(clearTimeout(d),e.ee.removeEventListener("entity-added",l),n(a))}e.ee.emit("api-send-rum",[r,t]),e.ee.on("entity-added",l)}}catch(f){i(f)}}));const u=async(t,r,a)=>{if(i)return i();const u=(0,c.t)();(0,s.p)(h.xV,["API/register/".concat(t.name,"/called")],void 0,n.K7.metrics,e.ee);try{await o;const n=e.init.api.duplicate_registered_data;(!0===n||Array.isArray(n)&&n.includes(a.entityGuid))&&t(...r,void 0,u),t(...r,a.entityGuid,u)}catch(e){(0,l.R)(50,e)}};return a}(e,t)}),e)}class Z extends T{static featureName=k.T;constructor(e){var t;super(e,k.T),t=e,p(u.o5,((e,r)=>U(e,r,t)),t),function(e){p(u.bt,(function(t){e.runtime.onerror=t}),e)}(e),function(e){let t=0;p(u.k6,(function(e,r){++t>10||(this.runtime.releaseIds[e.slice(-200)]=(""+r).slice(-200))}),e)}(e),z(e);try{this.removeOnAbort=new AbortController}catch(e){}this.ee.on("internal-error",((t,r)=>{this.abortHandler&&(0,s.p)("ierr",[M(t),(0,c.t)(),!0,{},e.runtime.isRecording,r],void 0,this.featureName,this.ee)})),y.gm.addEventListener("unhandledrejection",(t=>{this.abortHandler&&(0,s.p)("err",[H(t),(0,c.t)(),!1,{unhandledPromiseRejection:1},e.runtime.isRecording],void 0,this.featureName,this.ee)}),(0,O.jT)(!1,this.removeOnAbort?.signal)),y.gm.addEventListener("error",(t=>{this.abortHandler&&(0,s.p)("err",[D(t),(0,c.t)(),!1,{},e.runtime.isRecording],void 0,this.featureName,this.ee)}),(0,O.jT)(!1,this.removeOnAbort?.signal)),this.abortHandler=this.#r,this.importAggregator(e,(()=>i.e(478).then(i.bind(i,5928))))}#r(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var q=i(8990);let X=1;function Y(e){const t=typeof e;return!e||"object"!==t&&"function"!==t?-1:e===y.gm?0:(0,q.I)(e,"nr@id",(function(){return X++}))}function J(e){if("string"==typeof e&&e.length)return e.length;if("object"==typeof e){if("undefined"!=typeof ArrayBuffer&&e instanceof ArrayBuffer&&e.byteLength)return e.byteLength;if("undefined"!=typeof Blob&&e instanceof Blob&&e.size)return e.size;if(!("undefined"!=typeof FormData&&e instanceof FormData))try{return(0,C.A)(e).length}catch(e){return}}}var Q=i(8139),ee=i(7836),te=i(3434);const re={},ne=["open","send"];function ie(e){var t=e||ee.ee;const r=function(e){return(e||ee.ee).get("xhr")}(t);if(void 0===y.gm.XMLHttpRequest)return r;if(re[r.debugId]++)return r;re[r.debugId]=1,(0,Q.u)(t);var n=(0,te.YM)(r),i=y.gm.XMLHttpRequest,o=y.gm.MutationObserver,a=y.gm.Promise,s=y.gm.setInterval,c="readystatechange",u=["onload","onerror","onabort","onloadstart","onloadend","onprogress","ontimeout"],d=[],f=y.gm.XMLHttpRequest=function(e){const t=new i(e),o=r.context(t);try{r.emit("new-xhr",[t],o),t.addEventListener(c,(a=o,function(){var e=this;e.readyState>3&&!a.resolved&&(a.resolved=!0,r.emit("xhr-resolved",[],e)),n.inPlace(e,u,"fn-",b)}),(0,O.jT)(!1))}catch(e){(0,l.R)(15,e);try{r.emit("internal-error",[e])}catch(e){}}var a;return t};function h(e,t){n.inPlace(t,["onreadystatechange"],"fn-",b)}if(function(e,t){for(var r in e)t[r]=e[r]}(i,f),f.prototype=i.prototype,n.inPlace(f.prototype,ne,"-xhr-",b),r.on("send-xhr-start",(function(e,t){h(e,t),function(e){d.push(e),o&&(p?p.then(v):s?s(v):(g=-g,m.data=g))}(t)})),r.on("open-xhr-start",h),o){var p=a&&a.resolve();if(!s&&!a){var g=1,m=document.createTextNode(g);new o(v).observe(m,{characterData:!0})}}else t.on("fn-end",(function(e){e[0]&&e[0].type===c||v()}));function v(){for(var e=0;e<d.length;e++)h(0,d[e]);d.length&&(d=[])}function b(e,t){return t}return r}var oe="fetch-",ae=oe+"body-",se=["arrayBuffer","blob","json","text","formData"],ce=y.gm.Request,ue=y.gm.Response,de="prototype";const le={};function fe(e){const t=function(e){return(e||ee.ee).get("fetch")}(e);if(!(ce&&ue&&y.gm.fetch))return t;if(le[t.debugId]++)return t;function r(e,r,n){var i=e[r];"function"==typeof i&&(e[r]=function(){var e,r=[...arguments],o={};t.emit(n+"before-start",[r],o),o[ee.P]&&o[ee.P].dt&&(e=o[ee.P].dt);var a=i.apply(this,r);return t.emit(n+"start",[r,e],a),a.then((function(e){return t.emit(n+"end",[null,e],a),e}),(function(e){throw t.emit(n+"end",[e],a),e}))})}return le[t.debugId]=1,se.forEach((e=>{r(ce[de],e,ae),r(ue[de],e,ae)})),r(y.gm,"fetch",oe),t.on(oe+"end",(function(e,r){var n=this;if(r){var i=r.headers.get("content-length");null!==i&&(n.rxSize=i),t.emit(oe+"done",[null,r],n)}else t.emit(oe+"done",[e],n)})),t}var he=i(7485);class pe{constructor(e){this.agentRef=e}generateTracePayload(t){const r=this.agentRef.loader_config;if(!this.shouldGenerateTrace(t)||!r)return null;var n=(r.accountID||"").toString()||null,i=(r.agentID||"").toString()||null,o=(r.trustKey||"").toString()||null;if(!n||!i)return null;var a=(0,e.ZF)(),s=(0,e.el)(),c=Date.now(),u={spanId:a,traceId:s,timestamp:c};return(t.sameOrigin||this.isAllowedOrigin(t)&&this.useTraceContextHeadersForCors())&&(u.traceContextParentHeader=this.generateTraceContextParentHeader(a,s),u.traceContextStateHeader=this.generateTraceContextStateHeader(a,c,n,i,o)),(t.sameOrigin&&!this.excludeNewrelicHeader()||!t.sameOrigin&&this.isAllowedOrigin(t)&&this.useNewrelicHeaderForCors())&&(u.newrelicHeader=this.generateTraceHeader(a,s,c,n,i,o)),u}generateTraceContextParentHeader(e,t){return"00-"+t+"-"+e+"-01"}generateTraceContextStateHeader(e,t,r,n,i){return i+"@nr=0-1-"+r+"-"+n+"-"+e+"----"+t}generateTraceHeader(e,t,r,n,i,o){if(!("function"==typeof y.gm?.btoa))return null;var a={v:[0,1],d:{ty:"Browser",ac:n,ap:i,id:e,tr:t,ti:r}};return o&&n!==o&&(a.d.tk=o),btoa((0,C.A)(a))}shouldGenerateTrace(e){return this.agentRef.init?.distributed_tracing?.enabled&&this.isAllowedOrigin(e)}isAllowedOrigin(e){var t=!1;const r=this.agentRef.init?.distributed_tracing;if(e.sameOrigin)t=!0;else if(r?.allowed_origins instanceof Array)for(var n=0;n<r.allowed_origins.length;n++){var i=(0,he.D)(r.allowed_origins[n]);if(e.hostname===i.hostname&&e.protocol===i.protocol&&e.port===i.port){t=!0;break}}return t}excludeNewrelicHeader(){var e=this.agentRef.init?.distributed_tracing;return!!e&&!!e.exclude_newrelic_header}useNewrelicHeaderForCors(){var e=this.agentRef.init?.distributed_tracing;return!!e&&!1!==e.cors_use_newrelic_header}useTraceContextHeadersForCors(){var e=this.agentRef.init?.distributed_tracing;return!!e&&!!e.cors_use_tracecontext_headers}}var ge=i(9300),me=i(7295),ve=["load","error","abort","timeout"],be=ve.length,ye=(0,_.dV)().o.REQ,we=(0,_.dV)().o.XHR;const Re="X-NewRelic-App-Data";class xe extends T{static featureName=ge.T;constructor(e){super(e,ge.T),this.dt=new pe(e),this.handler=(e,t,r,n)=>(0,s.p)(e,t,r,n,this.ee);try{const e={xmlhttprequest:"xhr",fetch:"fetch",beacon:"beacon"};y.gm?.performance?.getEntriesByType("resource").forEach((t=>{if(t.initiatorType in e&&0!==t.responseStatus){const r={status:t.responseStatus},i={rxSize:t.transferSize,duration:Math.floor(t.duration),cbTime:0};Te(r,t.name),this.handler("xhr",[r,i,t.startTime,t.responseEnd,e[t.initiatorType]],void 0,n.K7.ajax)}}))}catch(e){}fe(this.ee),ie(this.ee),function(e,t,r,i){function o(e){var t=this;t.totalCbs=0,t.called=0,t.cbTime=0,t.end=A,t.ended=!1,t.xhrGuids={},t.lastSize=null,t.loadCaptureCalled=!1,t.params=this.params||{},t.metrics=this.metrics||{},e.addEventListener("load",(function(r){E(t,e)}),(0,O.jT)(!1)),y.lR||e.addEventListener("progress",(function(e){t.lastSize=e.loaded}),(0,O.jT)(!1))}function a(e){this.params={method:e[0]},Te(this,e[1]),this.metrics={}}function u(t,r){e.loader_config.xpid&&this.sameOrigin&&r.setRequestHeader("X-NewRelic-ID",e.loader_config.xpid);var n=i.generateTracePayload(this.parsedOrigin);if(n){var o=!1;n.newrelicHeader&&(r.setRequestHeader("newrelic",n.newrelicHeader),o=!0),n.traceContextParentHeader&&(r.setRequestHeader("traceparent",n.traceContextParentHeader),n.traceContextStateHeader&&r.setRequestHeader("tracestate",n.traceContextStateHeader),o=!0),o&&(this.dt=n)}}function d(e,r){var n=this.metrics,i=e[0],o=this;if(n&&i){var a=J(i);a&&(n.txSize=a)}this.startTime=(0,c.t)(),this.body=i,this.listener=function(e){try{"abort"!==e.type||o.loadCaptureCalled||(o.params.aborted=!0),("load"!==e.type||o.called===o.totalCbs&&(o.onloadCalled||"function"!=typeof r.onload)&&"function"==typeof o.end)&&o.end(r)}catch(e){try{t.emit("internal-error",[e])}catch(e){}}};for(var s=0;s<be;s++)r.addEventListener(ve[s],this.listener,(0,O.jT)(!1))}function l(e,t,r){this.cbTime+=e,t?this.onloadCalled=!0:this.called+=1,this.called!==this.totalCbs||!this.onloadCalled&&"function"==typeof r.onload||"function"!=typeof this.end||this.end(r)}function f(e,t){var r=""+Y(e)+!!t;this.xhrGuids&&!this.xhrGuids[r]&&(this.xhrGuids[r]=!0,this.totalCbs+=1)}function p(e,t){var r=""+Y(e)+!!t;this.xhrGuids&&this.xhrGuids[r]&&(delete this.xhrGuids[r],this.totalCbs-=1)}function g(){this.endTime=(0,c.t)()}function m(e,r){r instanceof we&&"load"===e[0]&&t.emit("xhr-load-added",[e[1],e[2]],r)}function v(e,r){r instanceof we&&"load"===e[0]&&t.emit("xhr-load-removed",[e[1],e[2]],r)}function b(e,t,r){t instanceof we&&("onload"===r&&(this.onload=!0),("load"===(e[0]&&e[0].type)||this.onload)&&(this.xhrCbStart=(0,c.t)()))}function w(e,r){this.xhrCbStart&&t.emit("xhr-cb-time",[(0,c.t)()-this.xhrCbStart,this.onload,r],r)}function R(e){var t,r=e[1]||{};if("string"==typeof e[0]?0===(t=e[0]).length&&y.RI&&(t=""+y.gm.location.href):e[0]&&e[0].url?t=e[0].url:y.gm?.URL&&e[0]&&e[0]instanceof URL?t=e[0].href:"function"==typeof e[0].toString&&(t=e[0].toString()),"string"==typeof t&&0!==t.length){t&&(this.parsedOrigin=(0,he.D)(t),this.sameOrigin=this.parsedOrigin.sameOrigin);var n=i.generateTracePayload(this.parsedOrigin);if(n&&(n.newrelicHeader||n.traceContextParentHeader))if(e[0]&&e[0].headers)s(e[0].headers,n)&&(this.dt=n);else{var o={};for(var a in r)o[a]=r[a];o.headers=new Headers(r.headers||{}),s(o.headers,n)&&(this.dt=n),e.length>1?e[1]=o:e.push(o)}}function s(e,t){var r=!1;return t.newrelicHeader&&(e.set("newrelic",t.newrelicHeader),r=!0),t.traceContextParentHeader&&(e.set("traceparent",t.traceContextParentHeader),t.traceContextStateHeader&&e.set("tracestate",t.traceContextStateHeader),r=!0),r}}function x(e,t){this.params={},this.metrics={},this.startTime=(0,c.t)(),this.dt=t,e.length>=1&&(this.target=e[0]),e.length>=2&&(this.opts=e[1]);var r,n=this.opts||{},i=this.target;"string"==typeof i?r=i:"object"==typeof i&&i instanceof ye?r=i.url:y.gm?.URL&&"object"==typeof i&&i instanceof URL&&(r=i.href),Te(this,r);var o=(""+(i&&i instanceof ye&&i.method||n.method||"GET")).toUpperCase();this.params.method=o,this.body=n.body,this.txSize=J(n.body)||0}function T(e,t){if(this.endTime=(0,c.t)(),this.params||(this.params={}),(0,me.iW)(this.params))return;let i;this.params.status=t?t.status:0,"string"==typeof this.rxSize&&this.rxSize.length>0&&(i=+this.rxSize);const o={txSize:this.txSize,rxSize:i,duration:(0,c.t)()-this.startTime};r("xhr",[this.params,o,this.startTime,this.endTime,"fetch"],this,n.K7.ajax)}function A(e){const t=this.params,i=this.metrics;if(!this.ended){this.ended=!0;for(let t=0;t<be;t++)e.removeEventListener(ve[t],this.listener,!1);t.aborted||(0,me.iW)(t)||(i.duration=(0,c.t)()-this.startTime,this.loadCaptureCalled||4!==e.readyState?null==t.status&&(t.status=0):E(this,e),i.cbTime=this.cbTime,r("xhr",[t,i,this.startTime,this.endTime,"xhr"],this,n.K7.ajax))}}function E(e,r){e.params.status=r.status;var i=function(e,t){var r=e.responseType;return"json"===r&&null!==t?t:"arraybuffer"===r||"blob"===r||"json"===r?J(e.response):"text"===r||""===r||void 0===r?J(e.responseText):void 0}(r,e.lastSize);if(i&&(e.metrics.rxSize=i),e.sameOrigin&&r.getAllResponseHeaders().indexOf(Re)>=0){var o=r.getResponseHeader(Re);o&&((0,s.p)(h.rs,["Ajax/CrossApplicationTracing/Header/Seen"],void 0,n.K7.metrics,t),e.params.cat=o.split(", ").pop())}e.loadCaptureCalled=!0}t.on("new-xhr",o),t.on("open-xhr-start",a),t.on("open-xhr-end",u),t.on("send-xhr-start",d),t.on("xhr-cb-time",l),t.on("xhr-load-added",f),t.on("xhr-load-removed",p),t.on("xhr-resolved",g),t.on("addEventListener-end",m),t.on("removeEventListener-end",v),t.on("fn-end",w),t.on("fetch-before-start",R),t.on("fetch-start",x),t.on("fn-start",b),t.on("fetch-done",T)}(e,this.ee,this.handler,this.dt),this.importAggregator(e,(()=>i.e(478).then(i.bind(i,3845))))}}function Te(e,t){var r=(0,he.D)(t),n=e.params||e;n.hostname=r.hostname,n.port=r.port,n.protocol=r.protocol,n.host=r.hostname+":"+r.port,n.pathname=r.pathname,e.parsedOrigin=r,e.sameOrigin=r.sameOrigin}const Ae={},Ee=["pushState","replaceState"];function Se(e){const t=function(e){return(e||ee.ee).get("history")}(e);return!y.RI||Ae[t.debugId]++||(Ae[t.debugId]=1,(0,te.YM)(t).inPlace(window.history,Ee,"-")),t}var _e=i(3738);function Ne(e){p(u.BL,(function(t=Date.now()){const r=t-y.WN;r<0&&(0,l.R)(62,t),(0,s.p)(h.XG,[u.BL,{time:r}],void 0,n.K7.metrics,e.ee),e.addToTrace({name:u.BL,start:t,origin:"nr"}),(0,s.p)(u.Pl+u.hG,[r,u.BL],void 0,n.K7.genericEvents,e.ee)}),e)}const{He:Oe,bD:Ie,d3:Pe,Kp:je,TZ:ke,Lc:Ce,uP:Le,Rz:Me}=_e;class He extends T{static featureName=ke;constructor(e){var t;super(e,ke),t=e,p(u.U2,(function(e){if(!(e&&"object"==typeof e&&e.name&&e.start))return;const r={n:e.name,s:e.start-y.WN,e:(e.end||e.start)-y.WN,o:e.origin||"",t:"api"};r.s<0||r.e<0||r.e<r.s?(0,l.R)(61,{start:r.s,end:r.e}):(0,s.p)("bstApi",[r],void 0,n.K7.sessionTrace,t.ee)}),t),Ne(e);if(!(0,R.V)(e.init))return void this.deregisterDrain();const r=this.ee;let o;Se(r),this.eventsEE=(0,Q.u)(r),this.eventsEE.on(Le,(function(e,t){this.bstStart=(0,c.t)()})),this.eventsEE.on(Ce,(function(e,t){(0,s.p)("bst",[e[0],t,this.bstStart,(0,c.t)()],void 0,n.K7.sessionTrace,r)})),r.on(Me+Pe,(function(e){this.time=(0,c.t)(),this.startPath=location.pathname+location.hash})),r.on(Me+je,(function(e){(0,s.p)("bstHist",[location.pathname+location.hash,this.startPath,this.time],void 0,n.K7.sessionTrace,r)}));try{o=new PerformanceObserver((e=>{const t=e.getEntries();(0,s.p)(Oe,[t],void 0,n.K7.sessionTrace,r)})),o.observe({type:Ie,buffered:!0})}catch(e){}this.importAggregator(e,(()=>i.e(478).then(i.bind(i,575))),{resourceObserver:o})}}var De=i(6344);class Ke extends T{static featureName=De.TZ;#n;#i;constructor(e){var t;let r;super(e,De.TZ),t=e,p(u.CH,(function(){(0,s.p)(u.CH,[],void 0,n.K7.sessionReplay,t.ee)}),t),function(e){p(u.Tb,(function(){(0,s.p)(u.Tb,[],void 0,n.K7.sessionReplay,e.ee)}),e)}(e),this.#i=e;try{r=JSON.parse(localStorage.getItem("".concat(E.H3,"_").concat(E.uh)))}catch(e){}(0,w.SR)(e.init)&&this.ee.on(De.G4.RECORD,(()=>this.#o())),this.#a(r)?(this.#n=r?.sessionReplayMode,this.#s()):this.importAggregator(this.#i,(()=>i.e(478).then(i.bind(i,6167)))),this.ee.on("err",(e=>{this.#i.runtime.isRecording&&(this.errorNoticed=!0,(0,s.p)(De.G4.ERROR_DURING_REPLAY,[e],void 0,this.featureName,this.ee))}))}#a(e){return e&&(e.sessionReplayMode===E.g.FULL||e.sessionReplayMode===E.g.ERROR)||(0,w.Aw)(this.#i.init)}#c=!1;async#s(e){if(!this.#c){this.#c=!0;try{const{Recorder:t}=await Promise.all([i.e(478),i.e(249)]).then(i.bind(i,8589));this.recorder??=new t({mode:this.#n,agentIdentifier:this.agentIdentifier,trigger:e,ee:this.ee,agentRef:this.#i}),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording}catch(e){this.parent.ee.emit("internal-error",[e])}this.importAggregator(this.#i,(()=>i.e(478).then(i.bind(i,6167))),{recorder:this.recorder,errorNoticed:this.errorNoticed})}}#o(){this.featAggregate?this.featAggregate.mode!==E.g.FULL&&this.featAggregate.initializeRecording(E.g.FULL,!0):(this.#n=E.g.FULL,this.#s(De.Qb.API),this.recorder&&this.recorder.parent.mode!==E.g.FULL&&(this.recorder.parent.mode=E.g.FULL,this.recorder.stopRecording(),this.recorder.startRecording(),this.abortHandler=this.recorder.stopRecording))}}var Ue=i(3962);function Fe(e){const t=e.ee.get("tracer");function r(){}p(u.dT,(function(e){return(new r).get("object"==typeof e?e:{})}),e);const i=r.prototype={createTracer:function(r,i){var o={},a=this,d="function"==typeof i;return(0,s.p)(h.xV,["API/createTracer/called"],void 0,n.K7.metrics,e.ee),e.runSoftNavOverSpa||(0,s.p)(u.hw+"tracer",[(0,c.t)(),r,o],a,n.K7.spa,e.ee),function(){if(t.emit((d?"":"no-")+"fn-start",[(0,c.t)(),a,d],o),d)try{return i.apply(this,arguments)}catch(e){const r="string"==typeof e?new Error(e):e;throw t.emit("fn-err",[arguments,this,r],o),r}finally{t.emit("fn-end",[(0,c.t)()],o)}}}};["actionText","setName","setAttribute","save","ignore","onEnd","getContext","end","get"].forEach((t=>{p.apply(this,[t,function(){return(0,s.p)(u.hw+t,[(0,c.t)(),...arguments],this,e.runSoftNavOverSpa?n.K7.softNav:n.K7.spa,e.ee),this},e,i])})),p(u.PA,(function(){e.runSoftNavOverSpa?(0,s.p)(u.hw+"routeName",[performance.now(),...arguments],void 0,n.K7.softNav,e.ee):(0,s.p)(u.Pl+"routeName",[(0,c.t)(),...arguments],this,n.K7.spa,e.ee)}),e)}class We extends T{static featureName=Ue.TZ;constructor(e){if(super(e,Ue.TZ),Fe(e),!y.RI||!(0,_.dV)().o.MO)return;const t=Se(this.ee);Ue.tC.forEach((e=>{(0,O.sp)(e,(e=>{a(e)}),!0)}));const r=()=>(0,s.p)("newURL",[(0,c.t)(),""+window.location],void 0,this.featureName,this.ee);t.on("pushState-end",r),t.on("replaceState-end",r);try{this.removeOnAbort=new AbortController}catch(e){}(0,O.sp)("popstate",(e=>(0,s.p)("newURL",[e.timeStamp,""+window.location],void 0,this.featureName,this.ee)),!0,this.removeOnAbort?.signal);let n=!1;const o=new((0,_.dV)().o.MO)(((e,t)=>{n||(n=!0,requestAnimationFrame((()=>{(0,s.p)("newDom",[(0,c.t)()],void 0,this.featureName,this.ee),n=!1})))})),a=(0,x.s)((e=>{(0,s.p)("newUIEvent",[e],void 0,this.featureName,this.ee),o.observe(document.body,{attributes:!0,childList:!0,subtree:!0,characterData:!0})}),100,{leading:!0});this.abortHandler=function(){this.removeOnAbort?.abort(),o.disconnect(),this.abortHandler=void 0},this.importAggregator(e,(()=>i.e(478).then(i.bind(i,4393))),{domObserver:o})}}var Be=i(7378);const Ge={},Ve=["appendChild","insertBefore","replaceChild"];function ze(e){const t=function(e){return(e||ee.ee).get("jsonp")}(e);if(!y.RI||Ge[t.debugId])return t;Ge[t.debugId]=!0;var r=(0,te.YM)(t),n=/[?&](?:callback|cb)=([^&#]+)/,i=/(.*)\.([^.]+)/,o=/^(\w+)(\.|$)(.*)$/;function a(e,t){if(!e)return t;const r=e.match(o),n=r[1];return a(r[3],t[n])}return r.inPlace(Node.prototype,Ve,"dom-"),t.on("dom-start",(function(e){!function(e){if(!e||"string"!=typeof e.nodeName||"script"!==e.nodeName.toLowerCase())return;if("function"!=typeof e.addEventListener)return;var o=(s=e.src,c=s.match(n),c?c[1]:null);var s,c;if(!o)return;var u=function(e){var t=e.match(i);if(t&&t.length>=3)return{key:t[2],parent:a(t[1],window)};return{key:e,parent:window}}(o);if("function"!=typeof u.parent[u.key])return;var d={};function l(){t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,O.jT)(!1)),e.removeEventListener("error",f,(0,O.jT)(!1))}function f(){t.emit("jsonp-error",[],d),t.emit("jsonp-end",[],d),e.removeEventListener("load",l,(0,O.jT)(!1)),e.removeEventListener("error",f,(0,O.jT)(!1))}r.inPlace(u.parent,[u.key],"cb-",d),e.addEventListener("load",l,(0,O.jT)(!1)),e.addEventListener("error",f,(0,O.jT)(!1)),t.emit("new-jsonp",[e.src],d)}(e[0])})),t}const Ze={};function qe(e){const t=function(e){return(e||ee.ee).get("promise")}(e);if(Ze[t.debugId])return t;Ze[t.debugId]=!0;var r=t.context,n=(0,te.YM)(t),i=y.gm.Promise;return i&&function(){function e(r){var o=t.context(),a=n(r,"executor-",o,null,!1);const s=Reflect.construct(i,[a],e);return t.context(s).getCtx=function(){return o},s}y.gm.Promise=e,Object.defineProperty(e,"name",{value:"Promise"}),e.toString=function(){return i.toString()},Object.setPrototypeOf(e,i),["all","race"].forEach((function(r){const n=i[r];e[r]=function(e){let i=!1;[...e||[]].forEach((e=>{this.resolve(e).then(a("all"===r),a(!1))}));const o=n.apply(this,arguments);return o;function a(e){return function(){t.emit("propagate",[null,!i],o,!1,!1),i=i||!e}}}})),["resolve","reject"].forEach((function(r){const n=i[r];e[r]=function(e){const r=n.apply(this,arguments);return e!==r&&t.emit("propagate",[e,!0],r,!1,!1),r}})),e.prototype=i.prototype;const o=i.prototype.then;i.prototype.then=function(...e){var i=this,a=r(i);a.promise=i,e[0]=n(e[0],"cb-",a,null,!1),e[1]=n(e[1],"cb-",a,null,!1);const s=o.apply(this,e);return a.nextPromise=s,t.emit("propagate",[i,!0],s,!1,!1),s},i.prototype.then[te.Jt]=o,t.on("executor-start",(function(e){e[0]=n(e[0],"resolve-",this,null,!1),e[1]=n(e[1],"resolve-",this,null,!1)})),t.on("executor-err",(function(e,t,r){e[1](r)})),t.on("cb-end",(function(e,r,n){t.emit("propagate",[n,!0],this.nextPromise,!1,!1)})),t.on("propagate",(function(e,r,n){this.getCtx&&!r||(this.getCtx=function(){if(e instanceof Promise)var r=t.context(e);return r&&r.getCtx?r.getCtx():this})}))}(),t}const Xe={},Ye="setTimeout",$e="setInterval",Je="clearTimeout",Qe="-start",et=[Ye,"setImmediate",$e,Je,"clearImmediate"];function tt(e){const t=function(e){return(e||ee.ee).get("timer")}(e);if(Xe[t.debugId]++)return t;Xe[t.debugId]=1;var r=(0,te.YM)(t);return r.inPlace(y.gm,et.slice(0,2),Ye+"-"),r.inPlace(y.gm,et.slice(2,3),$e+"-"),r.inPlace(y.gm,et.slice(3),Je+"-"),t.on($e+Qe,(function(e,t,n){e[0]=r(e[0],"fn-",null,n)})),t.on(Ye+Qe,(function(e,t,n){this.method=n,this.timerDuration=isNaN(e[1])?0:+e[1],e[0]=r(e[0],"fn-",this,n)})),t}const rt={};function nt(e){const t=function(e){return(e||ee.ee).get("mutation")}(e);if(!y.RI||rt[t.debugId])return t;rt[t.debugId]=!0;var r=(0,te.YM)(t),n=y.gm.MutationObserver;return n&&(window.MutationObserver=function(e){return this instanceof n?new n(r(e,"fn-")):n.apply(this,arguments)},MutationObserver.prototype=n.prototype),t}const{TZ:it,d3:ot,Kp:at,$p:st,wW:ct,e5:ut,tH:dt,uP:lt,rw:ft,Lc:ht}=Be;class pt extends T{static featureName=it;constructor(e){if(super(e,it),Fe(e),!y.RI)return;try{this.removeOnAbort=new AbortController}catch(e){}let t,r=0;const n=this.ee.get("tracer"),o=ze(this.ee),a=qe(this.ee),u=tt(this.ee),d=ie(this.ee),l=this.ee.get("events"),f=fe(this.ee),h=Se(this.ee),p=nt(this.ee);function g(e,t){h.emit("newURL",[""+window.location,t])}function m(){r++,t=window.location.hash,this[lt]=(0,c.t)()}function v(){r--,window.location.hash!==t&&g(0,!0);var e=(0,c.t)();this[ut]=~~this[ut]+e-this[lt],this[ht]=e}function b(e,t){e.on(t,(function(){this[t]=(0,c.t)()}))}this.ee.on(lt,m),a.on(ft,m),o.on(ft,m),this.ee.on(ht,v),a.on(ct,v),o.on(ct,v),this.ee.on("fn-err",((...t)=>{t[2]?.__newrelic?.[e.agentIdentifier]||(0,s.p)("function-err",[...t],void 0,this.featureName,this.ee)})),this.ee.buffer([lt,ht,"xhr-resolved"],this.featureName),l.buffer([lt],this.featureName),u.buffer(["setTimeout"+at,"clearTimeout"+ot,lt],this.featureName),d.buffer([lt,"new-xhr","send-xhr"+ot],this.featureName),f.buffer([dt+ot,dt+"-done",dt+st+ot,dt+st+at],this.featureName),h.buffer(["newURL"],this.featureName),p.buffer([lt],this.featureName),a.buffer(["propagate",ft,ct,"executor-err","resolve"+ot],this.featureName),n.buffer([lt,"no-"+lt],this.featureName),o.buffer(["new-jsonp","cb-start","jsonp-error","jsonp-end"],this.featureName),b(f,dt+ot),b(f,dt+"-done"),b(o,"new-jsonp"),b(o,"jsonp-end"),b(o,"cb-start"),h.on("pushState-end",g),h.on("replaceState-end",g),window.addEventListener("hashchange",g,(0,O.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("load",g,(0,O.jT)(!0,this.removeOnAbort?.signal)),window.addEventListener("popstate",(function(){g(0,r>1)}),(0,O.jT)(!0,this.removeOnAbort?.signal)),this.abortHandler=this.#r,this.importAggregator(e,(()=>i.e(478).then(i.bind(i,5592))))}#r(){this.removeOnAbort?.abort(),this.abortHandler=void 0}}var gt=i(3333);class mt extends T{static featureName=gt.TZ;constructor(e){super(e,gt.TZ);const t=[e.init.page_action.enabled,e.init.performance.capture_marks,e.init.performance.capture_measures,e.init.user_actions.enabled,e.init.performance.resources.enabled];var r;if(r=e,p(u.hG,((e,t)=>V(e,t,r)),r),function(e){p(u.fF,(function(){(0,s.p)(u.Pl+u.fF,[(0,c.t)(),...arguments],void 0,n.K7.genericEvents,e.ee)}),e)}(e),Ne(e),z(e),function(e){p(u.V1,(function(t,r){const i=(0,c.t)(),{start:o,end:a,customAttributes:d}=r||{},f={customAttributes:d||{}};if("object"!=typeof f.customAttributes||"string"!=typeof t||0===t.length)return void(0,l.R)(57);const h=(e,t)=>null==e?t:"number"==typeof e?e:e instanceof PerformanceMark?e.startTime:Number.NaN;if(f.start=h(o,0),f.end=h(a,i),Number.isNaN(f.start)||Number.isNaN(f.end))(0,l.R)(57);else{if(f.duration=f.end-f.start,!(f.duration<0))return(0,s.p)(u.Pl+u.V1,[f,t],void 0,n.K7.genericEvents,e.ee),f;(0,l.R)(58)}}),e)}(e),y.RI&&(e.init.user_actions.enabled&&(gt.Zp.forEach((e=>(0,O.sp)(e,(e=>(0,s.p)("ua",[e],void 0,this.featureName,this.ee)),!0))),gt.qN.forEach((e=>{const t=(0,x.s)((e=>{(0,s.p)("ua",[e],void 0,this.featureName,this.ee)}),500,{leading:!0});(0,O.sp)(e,t)}))),e.init.performance.resources.enabled&&y.gm.PerformanceObserver?.supportedEntryTypes.includes("resource"))){new PerformanceObserver((e=>{e.getEntries().forEach((e=>{(0,s.p)("browserPerformance.resource",[e],void 0,this.featureName,this.ee)}))})).observe({type:"resource",buffered:!0})}t.some((e=>e))?this.importAggregator(e,(()=>i.e(478).then(i.bind(i,8019)))):this.deregisterDrain()}}var vt=i(2646);const bt=new Map;function yt(e,t,r,n){if("object"!=typeof t||!t||"string"!=typeof r||!r||"function"!=typeof t[r])return(0,l.R)(29);const i=function(e){return(e||ee.ee).get("logger")}(e),o=(0,te.YM)(i),a=new vt.y(ee.P);a.level=n.level,a.customAttributes=n.customAttributes;const s=t[r]?.[te.Jt]||t[r];return bt.set(s,a),o.inPlace(t,[r],"wrap-logger-",(()=>bt.get(s))),i}class wt extends T{static featureName=W.TZ;constructor(e){var t;super(e,W.TZ),t=e,p(u.$9,((e,r)=>G(e,r,t)),t),function(e){p(u.Wb,((t,r,{customAttributes:n={},level:i=W.p_.INFO}={})=>{yt(e.ee,t,r,{customAttributes:n,level:i})}),e)}(e),z(e);const r=this.ee;yt(r,y.gm.console,"log",{level:"info"}),yt(r,y.gm.console,"error",{level:"error"}),yt(r,y.gm.console,"warn",{level:"warn"}),yt(r,y.gm.console,"info",{level:"info"}),yt(r,y.gm.console,"debug",{level:"debug"}),yt(r,y.gm.console,"trace",{level:"trace"}),this.ee.on("wrap-logger-end",(function([e]){const{level:t,customAttributes:n}=this;(0,B.R)(r,e,n,t)})),this.importAggregator(e,(()=>i.e(478).then(i.bind(i,5288))))}}new class extends r{constructor(e){var t;(super(),y.gm)?(this.features={},(0,_.bQ)(this.agentIdentifier,this),this.desiredFeatures=new Set(e.features||[]),this.desiredFeatures.add(S),this.runSoftNavOverSpa=[...this.desiredFeatures].some((e=>e.featureName===n.K7.softNav)),(0,a.j)(this,e,e.loaderType||"agent"),t=this,p(u.cD,(function(e,r,n=!1){if("string"==typeof e){if(["string","number","boolean"].includes(typeof r)||null===r)return g(t,e,r,u.cD,n);(0,l.R)(40,typeof r)}else(0,l.R)(39,typeof e)}),t),function(e){p(u.Dl,(function(t){if("string"==typeof t||null===t)return g(e,"enduser.id",t,u.Dl,!0);(0,l.R)(41,typeof t)}),e)}(this),function(e){p(u.nb,(function(t){if("string"==typeof t||null===t)return g(e,"application.version",t,u.nb,!1);(0,l.R)(42,typeof t)}),e)}(this),function(e){p(u.d3,(function(){e.ee.emit("manual-start-all")}),e)}(this),this.run()):(0,l.R)(21)}get config(){return{info:this.info,init:this.init,loader_config:this.loader_config,runtime:this.runtime}}get api(){return this}run(){try{const e=function(e){const t={};return o.forEach((r=>{t[r]=!!e[r]?.enabled})),t}(this.init),t=[...this.desiredFeatures];t.sort(((e,t)=>n.P3[e.featureName]-n.P3[t.featureName])),t.forEach((t=>{if(!e[t.featureName]&&t.featureName!==n.K7.pageViewEvent)return;if(this.runSoftNavOverSpa&&t.featureName===n.K7.spa)return;if(!this.runSoftNavOverSpa&&t.featureName===n.K7.softNav)return;const r=function(e){switch(e){case n.K7.ajax:return[n.K7.jserrors];case n.K7.sessionTrace:return[n.K7.ajax,n.K7.pageViewEvent];case n.K7.sessionReplay:return[n.K7.sessionTrace];case n.K7.pageViewTiming:return[n.K7.pageViewEvent];default:return[]}}(t.featureName).filter((e=>!(e in this.features)));r.length>0&&(0,l.R)(36,{targetFeature:t.featureName,missingDependencies:r}),this.features[t.featureName]=new t(this)}))}catch(e){(0,l.R)(22,e);for(const e in this.features)this.features[e].abortHandler?.();const t=(0,_.Zm)();delete t.initializedAgents[this.agentIdentifier]?.features,delete this.sharedAggregator;return t.ee.get(this.agentIdentifier).abort(),!1}}}({features:[xe,S,P,He,Ke,j,Z,mt,wt,We,pt],loaderType:"spa"})})()})();</script><meta charset="utf-8" /><meta name="viewport" content="width=device-width, initial-scale=1" /><meta http-equiv="Expires" content="0" /><meta name="WT.cg_n" content="co-allergy" /><meta name="WT.cg_s" content="Home Page" /><meta name="Description" content="​​​​​Current Opinion in Allergy and Clinical Immunology is a highly regarded journal offering insightful editorials and on-the-mark invited reviews, and covering key subjects such as upper airway disease; food allergy; mechanisms of allergy and adult asthma; drug allergy; and immunotherapy. Published bimonthly, each issue of Current Opinion in Allergy and Clinical Immunology introduces world renowned guest editors and internationally recognized academics within the allergy and clinical immunology field, delivering a widespread selection of expert assessments on the latest developments from the most recent literature." /><meta name="robots" content="index, follow, noarchive" /><meta name="WT.sv" content="ZUSE1PEJPWEB01" /><meta name="Title" content="Current Opinion in Allergy and Clinical Immunology" /><style id="SPThemeHideForms" type="text/css">body {opacity:0 !important}</style>
        
        <!-- Head container delegate control -->
        <link href="https://fonts.googleapis.com/css?family=Arvo:400,400i,700|Fira+Sans:300,300i,400,400i,500,500i,600,600i,700,700i&amp;display=swap" rel="stylesheet" />


		<script>
			// temporary workaround for Bug 316328:[Stage][Registration][Regression 05.04] - Omniture events are not displayed for article viewer page
			// prevents JS exception in Adobe launch.js caused by situation when wkhealth_institution_type meta tag is present while wkhealth_institution_name tag is not in the page head
			// see this check in Adobe launch.js: null != document.querySelector("meta[name='wkhealth_institution_name']") ...
			// TODO: implement proper code fix after release 05.04.00 deployment

			var wkhealth_institution_type = document.querySelector("meta[name='wkhealth_institution_type']");
			var wkhealth_institution_name = document.querySelector("meta[name='wkhealth_institution_name']");
			
			console.warn(wkhealth_institution_type);
			console.warn(wkhealth_institution_name);
			if (wkhealth_institution_type && !wkhealth_institution_name) {
				console.warn('Workaround in release 05.04.00 - removing wkhealth_institution_type meta tag if wkhealth_institution_name is not present');
				wkhealth_institution_type.remove();
			}
		</script>
        <link rel="shortcut icon" href="https://cdn.wolterskluwer.io/wk-logos/1.0.x/favicon.png" type="image/vnd.microsoft.icon" id="favicon" />
        <link id="ctl00_ctl14_wkfavicon_linkFavIcon" rel="shortcut icon" href="/co-allergy/PublishingImages/WKfavicon.ico" type="image/x-icon"></link>

        <meta name="msapplication-TileImage" content="/_layouts/15/images/SharePointMetroAppTile.png" /><meta name="msapplication-TileColor" content="#0072C6" />

        
        <link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/1033/styles/Themable/corev15.css?v=05.25.00.229" media="screen" />
        
        
        <link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/oaks.journals/core/bootstrap.min.css?v=05.25.00.229" media="screen" />
        <link id="ctl00_ctl14_FontAwesomeStylesheet" rel="stylesheet" type="text/css" href="https://unpkg.com/font-awesome@4.4.0/css/font-awesome.min.css"></link>
        
        <link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/1033/styles/oaks.journals/bootstrap-overwrites.css?v=05.25.00.229" media="screen" /><link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/1033/styles/oaks.journals/tachyons.css?v=05.25.00.229" media="screen" /><link rel="stylesheet" type="text/css" href="/co-allergy/_layouts/15/1033/styles/oaks.journals/base-main-header.css?v=05.25.00.229" media="screen" /><link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/oaks.journals/core/lww-core.css?v=05.25.00.229" media="screen" /><link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/oaks.journals/core/ejp.css?v=05.25.00.229" media="screen" /><link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/oaks.journals/core/ejp-print.css?v=05.25.00.229" media="print" /><link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/15/oaks.journals/core/jqueryui.css?v=05.25.00.229" media="screen" />

        <link rel="stylesheet" type="text/css" href="/co-allergy/Style%20Library/journal.css?v=05.25.00.229" media="screen" />
        <link rel="stylesheet" type="text/css" href="/co-allergy/Style%20Library/custom.journal.css?v=05.25.00.229" media="screen" />

        <script>var WebContext = {"EndPoints":{"ArticleMetricsEndpoint":"//services.journals.lww.com/IntegrationServices/ArticleMetricsService.svc","ThirdPartyRSSFeedServiceEndPoint":"https://services.journals.lww.com/IntegrationServices/ThirdPartyRSSFeedService.svc","JwtTokenServiceEndpoint":"https://journals.lww.com/co-allergy/_layouts/15/OAKS.Journals/JsonWebToken.svc"}}</script>
        
        
        <script type="text/javascript">// <![CDATA[ 

var g_SPOffSwitches={};
// ]]>
</script>
<script type="text/javascript" src="/_layouts/15/1033/initstrings.js?rev=94%2F8Pzbtowd6g2cd%2FsOoIg%3D%3DTAG0"></script>
<script type="text/javascript" src="/_layouts/15/init.js?rev=eqiUN2EN5Xn%2F2YyfuJQDtA%3D%3DTAG0"></script>
<script type="text/javascript" src="/_layouts/15/theming.js?rev=SuLUbbwTXcxFWOWLFUsOkw%3D%3DTAG0"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=F7rjznvAP1ZvjwmSYaDR9a3zqrnKFnNGXs7A_cRIg2rplizpOOjwg9eBfW_KxBMLRVN3lzATjzWkisQusj_Iaw7I7xHhM2EsA2p1WTk5lIh-1_uEIMq1sktVYKM3D6Gp5VSqOtDTEnrScqHWTHOzdCPnKDjm2mtJH72pNbP0u4uI_zDnfi9spPAqI_kz3qnF0&amp;t=ffffffffaa493ab8"></script>
<script type="text/javascript" src="/_layouts/15/blank.js?rev=OqEYlnomw4m5X%2FMg2wSuyA%3D%3DTAG0"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=Fr5k7XDliwj7SPEiKSqb-V3uT_yv_Vc0LBq3yd_m1_Ea8vkvI41fPqtWB8rH7kW9D2--SObxiXOCEDDg2Tv5yxNEAylK5ZpV5j9rD03yPUcCPh8w-y9A8MWLSg0jrQ-0kisGzu4Hba8Ct3e6oiiAj5nLa8lUDGLzNSKFrT8wEzRvrGDuqa6AKloxdLDyhLNb6sYlIjtGIn7oUTXlG_HGsg2&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=LXNyktQiaIpbp533FW-c46OHB30ylIqDlrzk7r3HlWeMLy05SwQ7ZZDsPGq7NzzDRSU0tvewepiuVrszZuoio7QLmOYibhCj6dQNfSL2hGpxpyP-E7et27fbWMHpoIuHecopwN8d_b-WR8rimwUGdbN6akitIdX32lXMez7LH7qkG1jVMDvXf2M0_6gdMpGjpPKlEhmMrNGzYuo05_KLRO4TeTkKykcR_5pPB2fyzgk1&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=UozfgYfgcP8g118ZMoKEWz_x5V51ZaIWOeFUe49mdZ8Yy8frQahBfRlFRNNeizXxYfmbtpE1uZMOMW2QeF7QCWjREvRvpNDSCGO5YICh1GalcUtEGJaGvVObluwmGza6-lV8S-wgb9vDF6UYZlWbyLOo-d94ckB8BN1hUlnIdqL9auDE1qR-ddFC7rw_89VZWQ6uTxR6vOlq2jE0iTr3J_6_Q3a7SLOduMua_ZXDgk7k01lBMUodCwi6dm-oTxLE0&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=ZWgxL8bxzPcm3sf7nBtjnXIE2wsAF-izuHnFdkP9YIwhY40NTQZWAMXXd5_I4JNrdCjHASB5kHO0Yp663zuk5AhL_jRl1k_SY5vnpUrSCkFxyolVdXM4FQlXIKn4Vvw31N76GuK5LU06Z_W9PLwfY2Syw-289UtPxVzBx9gVTRruCab2sQxw8wsPzWwQuzodrorJnIINUBwKL_vl4JpUyg2&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=EBaCwkyF6v0hRUf3ae-93ssVmxQ7oIMqv_PPxkqrb9oreHGbb2-nfpYVrHcdp3m-zVM-7IejfExLCflpv83MelmvDxCP_bfWTqE6qeqNKtnJrC6U7f-VSqzDeiqxeFeQcr2gdWPsj6xuQIL9yofEjL-H9aGyCIOqWIpEBJ7whIjP5cINMF1LSl9sjJQ7m8EzvCkRy97Lv87xdtMaOwsPZQua3oe2eRAfQMy5DfH1rBU1&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=wD8VqdUYdbEDwBKpnhKPdzJbzZckynHSZAFSwtw0pb9xBjjkE5QcyWugHeKYmmlr5VSa3nfGB1Xz7jafz_E7BWSKiwSgokhW7jiO928L_QrPFxF6EUuMyF_R_k74O2ZH3Z2j_4YTihok5YYe4jIHNbXew2ICIYicdQ6t5hTNp6rgynp1DalRocxe5znBs87HZLCu8p1QfDK38eKJRZE968HV31IWzfYmG-OLm0YY--COCDBd2W06gq-Q4GGHyVyR0&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=-7EYqBUD5SBnN9GXen_j6q1vUCHCiGsBm9LG-6jUM7Rd46ySBRRKNEzamKwU97Ev4GNWdvuZGqjKPpTco_vaUnZotagIyWjSOr8Y_YpPpCBN41u1qvqUa_Z3KhaMpFpLnBCVAOGXsZBX0gnLdrWl7SPrwgrfSJovgJOyKQNohnCagrVGRS7D0SajjiwZiBwbRFFXzQUODi-UXS4-R3OUE9NEoYmrfX_DvTq3geTEsrQ1&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=1Bz5XD8diaSe1jTYew43lskkqvoOQ7xUk9zYBR9yPfNI5dG64NIPCYkFSKOHNDL_QVi-dGp62xDY0jGHiOTaybK9bApxYHqJLIbzEwEQB4irPiQPiKBzzY5p7N4f-D0FpCNtiMYBBQwavF6nxBbyIVOMdRyTBQ10Hm9Zmj9z2NOmhfNxDVkOcXNQDwO54qpnA74wIl4P7kqB5Ngz9hx4kY3xEadtMKXSX7uqRVTMzso1&amp;t=596f116c"></script>
<script type="text/javascript" src="/ScriptResource.axd?d=2jUlVNSVbehJJ-Lt4PSuX3imkArDDoAUwrw500StXDnRKdoHS2np91egmJiBUG7feIOax9x-3d3eG4JYvatg-8X9LQmJU49eWww19gWY7vSdphyQrCWf_QI352TwlgZkOjBO9SLzCdnP0Rkx2chN2q3GkIbDzjCD2z0q_V19F4FLoBgT9FcKUizcWUqIzBoXhgYN9ZOMKI0YCb0cjcqnIG9l7yUe6eYzolUqVyyoo5k1&amp;t=596f116c"></script>
<script type="text/javascript">RegisterSod("require.js", "\u002f_layouts\u002f15\u002frequire.js?rev=bv3fWJhk0uFGpVwBxnZKNQ\u00253D\u00253DTAG0");</script>
<script type="text/javascript">RegisterSod("strings.js", "\u002f_layouts\u002f15\u002f1033\u002fstrings.js?rev=qTd5Iu3wkfWjQOhKADG18A\u00253D\u00253DTAG0");</script>
<script type="text/javascript">RegisterSod("core.js", "\u002f_layouts\u002f15\u002fcore.js?rev=OuK8lknoOD37VvjQyOsHrw\u00253D\u00253DTAG0");RegisterSodDep("core.js", "strings.js");</script>
<script type="text/javascript">RegisterSod("menu.js", "\u002f_layouts\u002f15\u002fmenu.js?rev=WMbI5XqdDKTzX20rarEQsQ\u00253D\u00253DTAG0");</script>
<script type="text/javascript">RegisterSod("mQuery.js", "\u002f_layouts\u002f15\u002fmquery.js?rev=wdHoEUjBno2g0ULGFwFjAg\u00253D\u00253DTAG0");</script>
<script type="text/javascript">RegisterSod("callout.js", "\u002f_layouts\u002f15\u002fcallout.js?rev=yFnKkBSYasfA2rW6krdVFQ\u00253D\u00253DTAG0");RegisterSodDep("callout.js", "strings.js");RegisterSodDep("callout.js", "mQuery.js");RegisterSodDep("callout.js", "core.js");</script>
<script type="text/javascript">RegisterSod("clienttemplates.js", "\u002f_layouts\u002f15\u002fclienttemplates.js?rev=oZO8iLnMIX278DJXZp9S4A\u00253D\u00253DTAG0");</script>
<script type="text/javascript">RegisterSod("sharing.js", "\u002f_layouts\u002f15\u002fsharing.js?rev=z7dWWrP\u00252FqzzxvtLQKR08Ww\u00253D\u00253DTAG0");RegisterSodDep("sharing.js", "strings.js");RegisterSodDep("sharing.js", "mQuery.js");RegisterSodDep("sharing.js", "clienttemplates.js");RegisterSodDep("sharing.js", "core.js");</script>
<script type="text/javascript">RegisterSod("suitelinks.js", "\u002f_layouts\u002f15\u002fsuitelinks.js?rev=hNe7S\u00252B4EVV83bzPy9U\u00252BEvQ\u00253D\u00253DTAG0");RegisterSodDep("suitelinks.js", "strings.js");RegisterSodDep("suitelinks.js", "core.js");</script>
<script type="text/javascript">RegisterSod("followingcommon.js", "\u002f_layouts\u002f15\u002ffollowingcommon.js?rev=MgAestdI8p64n4UsP1Xeug\u00253D\u00253DTAG0");RegisterSodDep("followingcommon.js", "strings.js");RegisterSodDep("followingcommon.js", "sp.js");RegisterSodDep("followingcommon.js", "userprofile");RegisterSodDep("followingcommon.js", "core.js");RegisterSodDep("followingcommon.js", "mQuery.js");</script>
<script type="text/javascript">RegisterSod("profilebrowserscriptres.resx", "\u002f_layouts\u002f15\u002f1033\u002fprofilebrowserscriptres.js?rev=qwf69WaVc1mYlJLXqmZmVA\u00253D\u00253DTAG0");</script>
<script type="text/javascript">RegisterSod("browserScript", "\u002f_layouts\u002f15\u002fnon_ie.js?rev=KT6LY54Wt0vnHyVV6VVzWw\u00253D\u00253DTAG0");RegisterSodDep("browserScript", "strings.js");</script>
<script type="text/javascript">RegisterSod("inplview", "\u002f_layouts\u002f15\u002finplview.js?rev=ecdG8BqIlGbfoftF0\u00252FIAZA\u00253D\u00253DTAG0");RegisterSodDep("inplview", "strings.js");RegisterSodDep("inplview", "core.js");RegisterSodDep("inplview", "clienttemplates.js");RegisterSodDep("inplview", "sp.js");</script>
<script type="text/javascript">RegisterSod("dragdrop.js", "\u002f_layouts\u002f15\u002fdragdrop.js?rev=h\u00252F2Jd5ursJLUu88iNs\u00252FM2A\u00253D\u00253DTAG0");RegisterSodDep("dragdrop.js", "strings.js");</script>
<script type="text/javascript">RegisterSod("quicklaunch.js", "\u002f_layouts\u002f15\u002fquicklaunch.js?rev=yuA4NhRQlmo9X6TJsaidUg\u00253D\u00253DTAG0");RegisterSodDep("quicklaunch.js", "strings.js");RegisterSodDep("quicklaunch.js", "dragdrop.js");</script>
<script type="text/javascript">RegisterSod("WPAdderClass", "\u002f_layouts\u002f15\u002fwpadder.js?rev=cLi8ZAp2DVY4x\u00252BMDFIRWvQ\u00253D\u00253DTAG0");</script>

        
        
        
        
        
        
        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/jquery.js?v=05.25.00.229">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/bootstrap.bundle.min.js?v=05.25.00.229" defer="true">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/jqueryui.js?v=05.25.00.229">

</script>

        
        <link type="text/xml" rel="alternate" href="/co-allergy/_vti_bin/spsdisco.aspx" />

        <link rel="canonical" href="https://journals.lww.com/co-allergy/pages/default.aspx" />
        
        
        <noscript>
            <meta http-equiv="Refresh" content="3;url=/_layouts/1033/OAKS.Journals/Error/JavaScript.html" />
        </noscript>

        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/lww-core.js?v=05.25.00.229">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/1033/Scripts/wk/journal-navigation.min.js?v=05.25.00.229" defer="true">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/1033/Scripts/wk/journals_master.min.js?v=05.25.00.229">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/manifest.js?v=05.25.00.229" defer="true">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/ejp.js?v=05.25.00.229" defer="true">

</script>
        <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/react-redux-vendors.js?v=05.25.00.229" defer="true">

</script>

            
            
            
        
        <script type="text/javascript">
            var scpl_time = new Date();
            scpl_time = scpl_time.getTime();

            window.A8AJQ = jQuery.noConflict();
            window.$ = jQuery.noConflict();

        </script>
        

<script async type="text/plain" src="https://aim-tag.hcn.health/js/client.js?dl=aimDataLayer&target=ie11" class="optanon-category-C0004"></script>
<script>
    window.aimDataLayer = window.aimDataLayer || [];
    function aimTag() { aimDataLayer.push(arguments); }
    aimTag('2429bf11-c05b-409f-b998-8acef505546e', 'pageview');
    aimTag('2429bf11-c05b-409f-b998-8acef505546e', 'signal', function (err, success) {
        if (err) {
            console.log(err);
        } else {
            console.log(success);
            if (success.identity_type === "AUT") {
            }
        }
    });
</script>
</head>


    <body id="ctl00_BodyTag" class="lww-body ej-home">
        <h1 id="ctl00_PageHeadingTitle" class="visually-hidden">Current Opinion in Allergy and Clinical Immunology</h1>
        <span class="js-custom-event" data-config="{&quot;name&quot;:&quot;omni:page:view&quot;,&quot;detail&quot;:{&quot;uid&quot;:&quot;&quot;,&quot;uid_src&quot;:&quot;None&quot;,&quot;page_loc&quot;:&quot;https://journals.lww.com/co-allergy/pages/default.aspx&quot;,&quot;page_ttl&quot;:&quot;Current Opinion in Allergy and Clinical Immunology&quot;},&quot;order&quot;:2147483647,&quot;config&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false}}"></span>
        <!-- Google Tag Manager (noscript) -->
        <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-NLR6H6W"height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>
        <!-- End Google Tag Manager (noscript) -->

        <div id="imgPrefetch" style="display:none">
<img src="https://cdn.wolterskluwer.io/wk-logos/1.0.x/favicon.png?rev=43" />
<img src="/_layouts/15/images/spcommon.png?rev=43" />
</div>

        <noscript><div class='noindex'>You may be trying to access this site from a secured browser on the server. Please enable scripts and reload this page.</div></noscript>
        
        <form method="post" action="/co-allergy/pages/default.aspx" id="aspnetForm">
<input type="hidden" name="_wpcmWpid" id="_wpcmWpid" value="" />
<input type="hidden" name="wpcmVal" id="wpcmVal" value="" />
<input type="hidden" name="MSOWebPartPage_PostbackSource" id="MSOWebPartPage_PostbackSource" value="" />
<input type="hidden" name="MSOTlPn_SelectedWpId" id="MSOTlPn_SelectedWpId" value="" />
<input type="hidden" name="MSOTlPn_View" id="MSOTlPn_View" value="0" />
<input type="hidden" name="MSOTlPn_ShowSettings" id="MSOTlPn_ShowSettings" value="False" />
<input type="hidden" name="MSOGallery_SelectedLibrary" id="MSOGallery_SelectedLibrary" value="" />
<input type="hidden" name="MSOGallery_FilterString" id="MSOGallery_FilterString" value="" />
<input type="hidden" name="MSOTlPn_Button" id="MSOTlPn_Button" value="none" />
<input type="hidden" name="__REQUESTDIGEST" id="__REQUESTDIGEST" value="noDigest" />
<input type="hidden" name="MSOSPWebPartManager_DisplayModeName" id="MSOSPWebPartManager_DisplayModeName" value="Browse" />
<input type="hidden" name="MSOSPWebPartManager_ExitingDesignMode" id="MSOSPWebPartManager_ExitingDesignMode" value="false" />
<input type="hidden" name="MSOWebPartPage_Shared" id="MSOWebPartPage_Shared" value="" />
<input type="hidden" name="MSOLayout_LayoutChanges" id="MSOLayout_LayoutChanges" value="" />
<input type="hidden" name="MSOLayout_InDesignMode" id="MSOLayout_InDesignMode" value="" />
<input type="hidden" name="_wpSelected" id="_wpSelected" value="" />
<input type="hidden" name="_wzSelected" id="_wzSelected" value="" />
<input type="hidden" name="MSOSPWebPartManager_OldDisplayModeName" id="MSOSPWebPartManager_OldDisplayModeName" value="Browse" />
<input type="hidden" name="MSOSPWebPartManager_StartWebPartEditingName" id="MSOSPWebPartManager_StartWebPartEditingName" value="false" />
<input type="hidden" name="MSOSPWebPartManager_EndWebPartEditing" id="MSOSPWebPartManager_EndWebPartEditing" value="false" />
<input type="hidden" name="listContainerControlstate" id="listContainerControlstate" value="AAEAAAD/////AQAAAAAAAAAEAQAAAA5TeXN0ZW0uQm9vbGVhbgEAAAAHbV92YWx1ZQABAQs=" />
<input type="hidden" name="hiddenDisplayItemView" id="hiddenDisplayItemView" value="Citation" />
<input type="hidden" name="hiddenSortBy" id="hiddenSortBy" value="" />
<input type="hidden" name="listControlstate" id="listControlstate" value="AAEAAAD/////AQAAAAAAAAAMAgAAAGRXS0guUEUuT0FLUy5Kb3VybmFscy5Vc2VyQ29udHJvbHMsIFZlcnNpb249MS4wLjAuMCwgQ3VsdHVyZT1uZXV0cmFsLCBQdWJsaWNLZXlUb2tlbj1kNDJkNDJiYWMzZDZmMDk5BQEAAABIV0tILlBFLk9BS1MuSm91cm5hbHMuVXNlckNvbnRyb2xzLkxpc3RDb250cm9sQmFzZStDb250cm9sU3RhdGVQcm9wZXJ0aWVzAwAAABo8UGFnZUluZGV4PmtfX0JhY2tpbmdGaWVsZBk8UGFnZVNpemU+a19fQmFja2luZ0ZpZWxkGjxQYWdlQ291bnQ+a19fQmFja2luZ0ZpZWxkAAAACAgIAgAAAAEAAABkAAAAAQAAAAs=" />
<input type="hidden" name="__VIEWSTATE" id="__VIEWSTATE" value="/wEPDwULLTIwMjM5MTQ2NzcPZBYCZg9kFgRmDw8WAh4HVmlzaWJsZWhkZAICD2QWBAIBD2QWBAIPD2QWAmYPZBYGAgMPZBYCZg8WAh4EaHJlZgUqL2NvLWFsbGVyZ3kvUHVibGlzaGluZ0ltYWdlcy9XS2Zhdmljb24uaWNvZAILDxYCHwEFPWh0dHBzOi8vdW5wa2cuY29tL2ZvbnQtYXdlc29tZUA0LjQuMC9jc3MvZm9udC1hd2Vzb21lLm1pbi5jc3NkAhMPFgIeBFRleHQF+QI8c2NyaXB0PnZhciBXZWJDb250ZXh0ID0geyJFbmRQb2ludHMiOnsiQXJ0aWNsZU1ldHJpY3NFbmRwb2ludCI6Ii8vc2VydmljZXMuam91cm5hbHMubHd3LmNvbS9JbnRlZ3JhdGlvblNlcnZpY2VzL0FydGljbGVNZXRyaWNzU2VydmljZS5zdmMiLCJUaGlyZFBhcnR5UlNTRmVlZFNlcnZpY2VFbmRQb2ludCI6Imh0dHBzOi8vc2VydmljZXMuam91cm5hbHMubHd3LmNvbS9JbnRlZ3JhdGlvblNlcnZpY2VzL1RoaXJkUGFydHlSU1NGZWVkU2VydmljZS5zdmMiLCJKd3RUb2tlblNlcnZpY2VFbmRwb2ludCI6Imh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9jby1hbGxlcmd5L19sYXlvdXRzLzE1L09BS1MuSm91cm5hbHMvSnNvbldlYlRva2VuLnN2YyJ9fTwvc2NyaXB0PmQCEA9kFgICAw9kFgJmD2QWAmYPPCsABgBkAgMPFgIeBWNsYXNzBRBsd3ctYm9keSBlai1ob21lFggCAQ8WBB4JaW5uZXJodG1sBTJDdXJyZW50IE9waW5pb24gaW4gQWxsZXJneSBhbmQgQ2xpbmljYWwgSW1tdW5vbG9neR8DBQ92aXN1YWxseS1oaWRkZW5kAgUPFgIfAgWfATxub3NjcmlwdD48aWZyYW1lIHNyYz0iaHR0cHM6Ly93d3cuZ29vZ2xldGFnbWFuYWdlci5jb20vbnMuaHRtbD9pZD1HVE0tTkxSNkg2VyJoZWlnaHQ9IjAiIHdpZHRoPSIwIiBzdHlsZT0iZGlzcGxheTpub25lO3Zpc2liaWxpdHk6aGlkZGVuIj48L2lmcmFtZT48L25vc2NyaXB0PmQCDQ8WAh4GYWN0aW9uBR4vY28tYWxsZXJneS9wYWdlcy9kZWZhdWx0LmFzcHgWEgIBD2QWAgIBD2QWCgUmZ19mZGQyMzc2ZV9lMDU0XzRlNTBfOTcyY18yN2RmZjA4MmJiYTYPZBYGZg9kFgYCAQ8PFgIfAmQWAh4Fc3R5bGUFDWRpc3BsYXk6bm9uZTtkAgIPFgIeCkJlaGF2aW9ySUQFKGVtYWlsVG9Db2xsZWFndWVQb3B1cEV4dGVuZGVyXzE5Njk4NTcwMzlkAgMPZBYEAgEPZBYIZg8PFgIfAgUSRW1haWwgdG8gQ29sbGVhZ3VlZGQCAQ9kFgICAQ8PFgIfAgUdQ29sbGVhZ3VlJ3MgRS1tYWlsIGlzIEludmFsaWRkZAIEDw8WAh8CBRJDb2xsZWFndWUncyBFbWFpbDpkZAIIDw8WBB4IQ3NzQ2xhc3MFWWpzLXNlbmQtYnV0dG9uIHByaW1hcnktYnV0dG9uIGdyZWNhcHRjaGEtZW1haWwtY29sbGVhZ3VlLTcxOWE1NDYwNjRlYjQxMzhhZWI0NmJiZjg1NGE4OGEwHgRfIVNCAgJkZAIDD2QWAgIBD2QWAgIBDw8WAh8CBTpZb3VyIG1lc3NhZ2UgaGFzIGJlZW4gc3VjY2Vzc2Z1bGx5IHNlbnQgdG8geW91ciBjb2xsZWFndWUuZGQCAQ9kFgYCAQ8PFgIfAmQWAh8GBQ1kaXNwbGF5Om5vbmU7ZAICDxYCHwcFJU9wZW5FeHBvcnRUb1BvcHVwRXh0ZW5kZXJfXzEyMTg3ODI0MTlkAgMPZBYCZg9kFgICAQ8QZA8WA2YCAQICFgMQBQhFbmQgTm90ZQUHRW5kTm90ZWcQBQdQcm9jaXRlBQdQcm9jaXRlZxAFEVJlZmVyZW5jZSBNYW5hZ2VyBRBSZWZlcmVuY2VNYW5hZ2VyZ2RkAgMPZBYEAgMPZBYCAgEPFgIfAgUYQ3VycmVudCBJc3N1ZSBIaWdobGlnaHRzZAILD2QWBGYPDxYCHwBoZBYIAgEPFgIfAGhkAgMPFgIfAGhkAgUPFgIfAGhkAgcPFgIfAGhkAgIPDxYCHwBoZBYEAgEPDxYCHwBoZBYCAgMPD2QWAh4MYXJpYS1jdXJyZW50BQR0cnVlZAIDD2QWBAIBDxBkZBYAZAIDDxBkZBYAZAUmZ180ZmJlNjhjMV85YzUzXzQ0MzhfODdiNl9jNjcyYzRiMjQwZWQPZBYCZg9kFgICAg8WBB8DBShlai1hZHZlcnRpc2VtZW50IGVqLWFkdmVydGlzZW1lbnQtbWlkZGxlHwBnFgICAQ8WBB8CBf0CPGRpdiBpZD0iZ2FfZDMzYzM1MzEtZjBlNC00NWUxLWIyOTktYzYzYmQwYjM4YjExIiBjbGFzcz0iYWQtc2xvdC1jb250YWluZXIgYWQtc2xvdC1jb250YWluZXItZ2FfZDMzYzM1MzEtZjBlNC00NWUxLWIyOTktYzYzYmQwYjM4YjExIiBkYXRhLXNpemVtYXA9IltbWzAsIDBdLCBbWzMwMCwgMjUwXV1dXSIgZGF0YS1hZHBhdGg9Ii8xNTcyNjcwMjc2MS9EZXNrdG9wL2NvLWFsbGVyZ3kvSG9tZS9SaWdodCIgZGF0YS1hdXRvbG9hZD0ibm8iIGRhdGEtb3V0b2ZwYWdlPSJubyIgZGF0YS1zdGlja3k9Im5vIiBkYXRhLXNsb3R0YXJnZXRpbmc9JycgZGF0YS1kaXNwbGF5c2x1Zz0ieWVzIiBkYXRhLXN0aWNreS1kdXJhdGlvbj0iMCIgZGF0YS1uYW1lPSJSaWdodCI+PC9kaXY+HwBnZAUmZ180OGM4MThkOF9hZmUyXzQ3Y2ZfOTFlYV85Zjk1OTc1OGI5MDcPZBYCZg9kFgJmDxYCHgNzcmMFOGh0dHBzOi8vcGh5c2ljaWFuam9icy5sd3cuY29tL3dpZGdldC9ib290c3RyYXAvam9iLyNpPTE0ZAUmZ19mNDI4MWQzM180OTgxXzRjMDRfYmQxN184NWI0MjZkNmNmOTUPZBYCZg9kFgICAg8WBB8DBS1lai1hZHZlcnRpc2VtZW50IGVqLWFkdmVydGlzZW1lbnQtYmFubmVyY29tYm8fAGcWAgIBDxYEHwIF4wM8ZGl2IGlkPSJnYV81M2IwNzNlYS0wZTM0LTQ5MzAtYWI5NC0wNzgxZTY0MjNkZmMiIGNsYXNzPSJhZC1zbG90LWNvbnRhaW5lciBhZC1zbG90LWNvbnRhaW5lci1nYV81M2IwNzNlYS0wZTM0LTQ5MzAtYWI5NC0wNzgxZTY0MjNkZmMiIGRhdGEtc2l6ZW1hcD0iW1tbMTA1MCwgMjAwXSwgW1szMDAsIDYwMF0sIFszMDAsIDI1MF0sIFsxNjAsIDYwMF1dXSwgW1s3MzAsIDYwMF0sIFtbMzAwLCA2MDBdLCBbMzAwLCAyNTBdXV0sIFsgWyAwLCAwIF0sIFsgWzMwMCwgMjUwXSBdIF0gXSIgZGF0YS1hZHBhdGg9Ii8xNTcyNjcwMjc2MS9EZXNrdG9wL2NvLWFsbGVyZ3kvSG9tZS9SaWdodDEiIGRhdGEtYXV0b2xvYWQ9Im5vIiBkYXRhLW91dG9mcGFnZT0ibm8iIGRhdGEtc3RpY2t5PSJubyIgZGF0YS1zbG90dGFyZ2V0aW5nPScnIGRhdGEtZGlzcGxheXNsdWc9InllcyIgZGF0YS1zdGlja3ktZHVyYXRpb249IjAiIGRhdGEtbmFtZT0iUmlnaHQxIj48L2Rpdj4fAGdkBSZnXzI0YjhkYjZiXzU2YzZfNDU5Nl85ZGIyXzkzMjA0ZTI4MGQxZA9kFgJmD2QWAmYPZBYEAgEPFgIfBAUPTGF0ZXN0IEFydGljbGVzZAIDD2QWAmYPZBYCAgEPZBYCZg9kFgJmDxQrAAIPFgQeC18hRGF0YUJvdW5kZx4LXyFJdGVtQ291bnQCBWRkFgJmD2QWCgIBD2QWBAIBDxYCHwBoZAIDD2QWAgIDD2QWAgIDDxYCHw0C/////w9kAgIPZBYEAgEPFgIfAGhkAgMPZBYCAgMPZBYCAgMPFgIfDQL/////D2QCAw9kFgQCAQ8WAh8AaGQCAw9kFgICAw9kFgICAw8WAh8NAv////8PZAIED2QWBAIBDxYCHwBoZAIDD2QWAgIDD2QWAgIDDxYCHw0C/////w9kAgUPZBYEAgEPFgIfAGhkAgMPZBYCAgMPZBYCAgMPFgIfDQL/////D2QCCQ8WAh8AaBYCAgUPZBYCAgMPFgIfAGgWAmYPZBYEAgIPZBYGAgEPFgIfAGhkAgMPFgIfAGhkAgUPFgIfAGhkAgMPDxYCHglBY2Nlc3NLZXkFAS9kZAIND2QWAgIBD2QWAmYPZBYCZg8PFgIfAGhkZAITD2QWAgIBD2QWAmYPZBYCAgIPFgQfAwUqZWotYWR2ZXJ0aXNlbWVudCBlai1hZHZlcnRpc2VtZW50LXRvcGNvbWJvHwBnFgICAQ8WBB8CBZUDPGRpdiBpZD0iZ2FfYmE0NThjNWQtYzE1My00ZWQwLWFiNjEtNDc2NWU3ZTU3YmRkIiBjbGFzcz0iYWQtc2xvdC1jb250YWluZXIgYWQtc2xvdC1jb250YWluZXItZ2FfYmE0NThjNWQtYzE1My00ZWQwLWFiNjEtNDc2NWU3ZTU3YmRkIiBkYXRhLXNpemVtYXA9IltbWzczMCwgNTAwXSwgW1s3MjgsIDkwXV1dLCBbWzAsIDBdLCBbWzMwMCwgNTBdXV1dIiBkYXRhLWFkcGF0aD0iLzE1NzI2NzAyNzYxL0Rlc2t0b3AvY28tYWxsZXJneS9Ib21lL1RvcCIgZGF0YS1hdXRvbG9hZD0ieWVzIiBkYXRhLW91dG9mcGFnZT0ibm8iIGRhdGEtc3RpY2t5PSJ5ZXMiIGRhdGEtc2xvdHRhcmdldGluZz0nJyBkYXRhLWRpc3BsYXlzbHVnPSJ5ZXMiIGRhdGEtc3RpY2t5LWR1cmF0aW9uPSI1IiBkYXRhLW5hbWU9IlRvcCI+PC9kaXY+HwBnZAIVD2QWAmYPZBYQZg9kFgRmD2QWDAIBDxYCHwBoFgQCAw9kFhACAQ8WAh8AaBYCAgEPDxYCHgtOYXZpZ2F0ZVVybAVvaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvc2VjdXJlL3BhZ2VzL215YWNjb3VudC5hc3B4P0NvbnRleHRVcmw9JTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4ZGQCAw8WAh8AaBYCAgEPDxYCHw8FkAFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9zZWN1cmUvcGFnZXMvbXlhY2NvdW50LmFzcHg/Q29udGV4dFVybD0lMmZjby1hbGxlcmd5JTJmcGFnZXMlMmZkZWZhdWx0LmFzcHgmZWRpdFdlYlBhcnQ9ZWRpdENoYW5nZVBhc3N3b3JkV1BkZAIFDxYCHwBoFgICAQ8PFgIfDwVxaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvc2VjdXJlL3BhZ2VzL215ZmF2b3JpdGVzLmFzcHg/Q29udGV4dFVybD0lMmZjby1hbGxlcmd5JTJmcGFnZXMlMmZkZWZhdWx0LmFzcHhkZAIHD2QWAgIBDw8WAh8PBYoBaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvc2VjdXJlL3BhZ2VzL215ZmF2b3JpdGVzLmFzcHg/Q29udGV4dFVybD0lMmZjby1hbGxlcmd5JTJmcGFnZXMlMmZkZWZhdWx0LmFzcHgmY29sbGVjdGlvbj1TYXZlZFNlYXJjaGVzZGQCCw9kFgICAQ8PFgIfDwVnaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvcGFnZXMvcmVnaXN0ZXIuYXNweD9Db250ZXh0VXJsPSUyZmNvLWFsbGVyZ3klMmZwYWdlcyUyZmRlZmF1bHQuYXNweGRkAg0PZBYCAgEPFgIfAQUZaHR0cDovL2hlYWx0aGpvYnNwbHVzLmNvbWQCDw8WAh8AZxYCAgEPDxYGHw8FhAFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9sb2dpbi5hc3B4P0NvbnRleHRVcmw9JTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4JlJlcXVlc3RGb3I9QWN0aXZhdGVTdWJzY3JpcHRpb24eB0VuYWJsZWRnHwBnZGQCEw8WAh8AaBYCAgEPDxYCHw8FlwFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9fbGF5b3V0cy8xNS9vYWtzLmpvdXJuYWxzL2xvZ291dC5hc3B4P0NvbnRleHRVcmw9aHR0cHMlM2ElMmYlMmZqb3VybmFscy5sd3cuY29tJTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4ZGQCBQ8WAh8AaBYCAgEPFCsAAmRkZAIDDxYCHwBnZAIED2QWAgIBDw8WCB8IBSB1c2VyLW1lbnVfX2xpbmsganMtcmVnaXN0ZXItbGluax8PBWdodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9yZWdpc3Rlci5hc3B4P0NvbnRleHRVcmw9JTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4HwkCAh8AZxYCHgtkYXRhLWNvbmZpZwVUeyJldmVudE5hbWUiOiJSZWdpc3RlciIsImV2ZW50RGV0YWlsIjp7InNvdXJjZSI6Ik1hc3RoZWFkIERyb3Bkb3duIn0sImlzTnVsbCI6ZmFsc2V9ZAIFDxYCHwBnFgICAQ8PFgIfDwUgaHR0cHM6Ly9zaG9wLmx3dy5jb20vcC8xNTI4LTQwNTBkZAIIDxYCHwBoZAILD2QWAgIGD2QWAgIBD2QWAgIFDw8WBB8PBUdodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9fbGF5b3V0cy9vYWtzLmpvdXJuYWxzL3ByaXZhY3kuYXNweB8CBQ5Qcml2YWN5IFBvbGljeWRkAgEPZBYGZg8QDxYGHg1EYXRhVGV4dEZpZWxkBQRUZXh0Hg5EYXRhVmFsdWVGaWVsZAUEVGV4dB8MZ2QQFQYDQWxsCEFydGljbGVzBkltYWdlcwZWaWRlb3MIUG9kY2FzdHMFQmxvZ3MVBgNBbGwIQXJ0aWNsZXMGSW1hZ2VzBlZpZGVvcwhQb2RjYXN0cwVCbG9ncxQrAwZnZ2dnZ2dkZAIFDw8WAh8PBT1odHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9hZHZhbmNlZHNlYXJjaC5hc3B4ZGQCBg8PFgIfEGhkZAIBDw8WAh8PBSBodHRwczovL3Nob3AubHd3LmNvbS9wLzE1MjgtNDA1MGRkAgIPDxYCHw8FZ2h0dHBzOi8vam91cm5hbHMubHd3LmNvbS9jby1hbGxlcmd5L3BhZ2VzL3JlZ2lzdGVyLmFzcHg/Q29udGV4dFVybD0lMmZjby1hbGxlcmd5JTJmcGFnZXMlMmZkZWZhdWx0LmFzcHhkZAIDDw8WBB8PBW9odHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9zZWN1cmUvcGFnZXMvbXlhY2NvdW50LmFzcHg/Q29udGV4dFVybD0lMmZjby1hbGxlcmd5JTJmcGFnZXMlMmZkZWZhdWx0LmFzcHgfAGhkZAIEDw8WAh8AaBYCHwYFImJvcmRlci1yaWdodDoxcHggc29saWQgIWltcG9ydGFudDtkAgYPDxYCHw8FlwFodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9fbGF5b3V0cy8xNS9vYWtzLmpvdXJuYWxzL2xvZ291dC5hc3B4P0NvbnRleHRVcmw9aHR0cHMlM2ElMmYlMmZqb3VybmFscy5sd3cuY29tJTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4FgIfBgUiYm9yZGVyLXJpZ2h0OjFweCBzb2xpZCAhaW1wb3J0YW50O2QCBw8WAh8RBbkBeyJicm93c2luZ0hpc3RvcnkiOnsiaXNFbmFibGVkIjp0cnVlLCJzZXJ2aWNlVXJsIjoiaHR0cHM6Ly9lZS5sd3cuY29tL2VuZ2FnZW1lbnRlbmdpbmUtYXBpL2FwaSIsInBkZkRvd25sb2FkVXJsIjoiL19sYXlvdXRzLzE1L29ha3Muam91cm5hbHMvZG93bmxvYWRwZGYuYXNweD90cmNrbmdfc3JjX3BnPUhpc3RvcnlUYWIifX1kAgoPZBYGZg8QDxYGHxIFBFRleHQfEwUEVGV4dB8MZ2QQFQYDQWxsCEFydGljbGVzBkltYWdlcwZWaWRlb3MIUG9kY2FzdHMFQmxvZ3MVBgNBbGwIQXJ0aWNsZXMGSW1hZ2VzBlZpZGVvcwhQb2RjYXN0cwVCbG9ncxQrAwZnZ2dnZ2dkZAIFDw8WAh8PBT1odHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9hZHZhbmNlZHNlYXJjaC5hc3B4ZGQCBg8PFgIfEGhkZAIhD2QWAmYPZBYcAgEPZBYCZg9kFgJmD2QWCAIBDxYCHwsFV2h0dHBzOi8vaW1hZ2VzLmpvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9YTGFyZ2VUaHVtYi4wMDEzMDgzMi0yMDI1MDgwMDAtMDAwMDAuQ1YuanBlZ2QCAw8WAh8EBRNOZXZlciBNaXNzIGFuIElzc3VlZAIFDxYCHwQFQUdldCBuZXcgam91cm5hbCBUYWJsZXMgb2YgQ29udGVudHMgc2VudCByaWdodCB0byB5b3VyIGVtYWlsIGluYm94ZAIJDxYGHg9kYXRhLWFsZXJ0LXR5cGUFBEV0b2MeE2RhdGEtc3Vic2NyaWJlZC1tc2cFT1lvdSBhcmUgbm93IHN1YnNjcmliZWQgdG8gcmVjZWl2ZSBlVE9DIGFsZXJ0cyB3aGVuZXZlciBuZXcgaXNzdWVzIGFyZSBwdWJsaXNoZWQfBAUUR2V0IE5ldyBJc3N1ZSBBbGVydHNkAgMPZBYIAgEPFCsAAg8WBB8MZx8NAgVkZBYKZg9kFgJmDxUDMS9jby1hbGxlcmd5L3BhZ2VzL3ZpZXdhbGxtb3N0cG9wdWxhcmFydGljbGVzLmFzcHgADE1vc3QgUG9wdWxhcmQCAQ9kFgJmDxUDQi9jby1hbGxlcmd5L19sYXlvdXRzLzEwMzMvb2Frcy5qb3VybmFscy9pbmZvcm1hdGlvbmZvcmF1dGhvcnMuYXNweAALRm9yIEF1dGhvcnNkAgIPZBYCZg8VAyYvY28tYWxsZXJneS9wYWdlcy9hYm91dHRoZWpvdXJuYWwuYXNweAARQWJvdXQgdGhlIEpvdXJuYWxkAgMPZBYCZg8VAyAvY28tYWxsZXJneS9wYWdlcy9pc3N1ZWxpc3QuYXNweAALUGFzdCBJc3N1ZXNkAgQPZBYCZg8VAyEvY28tYWxsZXJneS9wYWdlcy9jdXJyZW50dG9jLmFzcHgADUN1cnJlbnQgSXNzdWVkAgMPZBYCZg8PFgIfDwVnaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvcGFnZXMvcmVnaXN0ZXIuYXNweD9Db250ZXh0VXJsPSUyZmNvLWFsbGVyZ3klMmZwYWdlcyUyZmRlZmF1bHQuYXNweGRkAgUPFgIfAGcWAmYPDxYCHw8FIGh0dHBzOi8vc2hvcC5sd3cuY29tL3AvMTUyOC00MDUwZGQCCQ8WAh8AaBYCAgEPFCsAAmRkZAIFD2QWDAIBD2QWAgIBDxQrAAIPFgQfDGcfDQICZGQWBGYPZBYCZg8VBABFL2NvLWFsbGVyZ3kvX2xheW91dHMvMTUvMTAzMy9vYWtzLmpvdXJuYWxzL2luZm9ybWF0aW9uZm9yYXV0aG9ycy5hc3B4ABFTdWJtaXQgYW4gYXJ0aWNsZWQCAQ9kFgJmDxUEACVodHRwczovL3drYXV0aG9yc2VydmljZXMuZWRpdGFnZS5jb20vBl9ibGFuaxZIb3cgdG8gcHVibGlzaCB3aXRoIHVzZAIFDxYCHw0CBBYIZg9kFgJmDxUEGmVqcC1mb290ZXItLXNob3ctb24tbW9iaWxlZmh0dHBzOi8vbHd3LmNvbS9zZWN1cmUvcGFnZXMvYWN0aXZhdGVzdWJzY3JpcHRpb24uYXNweD9Db250ZXh0VXJsPSUyZmNvLWFsbGVyZ3klMmZwYWdlcyUyZmRlZmF1bHQuYXNweAAiQWN0aXZhdGUgeW91ciBqb3VybmFsIHN1YnNjcmlwdGlvbmQCAQ9kFgJmDxUEGmVqcC1mb290ZXItLWhpZGUtb24tbW9iaWxlZmh0dHBzOi8vbHd3LmNvbS9zZWN1cmUvcGFnZXMvYWN0aXZhdGVzdWJzY3JpcHRpb24uYXNweD9Db250ZXh0VXJsPSUyZmNvLWFsbGVyZ3klMmZwYWdlcyUyZmRlZmF1bHQuYXNweAAdQWN0aXZhdGUgSm91cm5hbCBTdWJzY3JpcHRpb25kAgIPZBYCZg8VBBplanAtZm9vdGVyLS1oaWRlLW9uLW1vYmlsZThodHRwczovL3draGxycC5teS5zaXRlLmNvbS9MaXBwaW5jb3R0T25saW5lSGVscENlbnRlci9zLwAWQnJvd3NlIHRoZSBoZWxwIGNlbnRlcmQCAw9kFgJmDxUEGmVqcC1mb290ZXItLXNob3ctb24tbW9iaWxlWWh0dHBzOi8vd2toZWFsdGguZm9yY2UuY29tL2x3d29ubGluZS9zL3RvcGljLzBUTzBWMDAwMDAxWWdMWldBMC9sd3ctb25saW5lP3RhYnNldC1kZGJmZT0yAARIZWxwZAIHDxYGHwEFIGh0dHBzOi8vd3d3LnRmYWZvcm1zLmNvbS80OTY2NTcwHgZ0YXJnZXQFBl9ibGFuax8EBRhTdWJtaXQgYSBTZXJ2aWNlIFJlcXVlc3RkAg0PFgIfAGhkAg8PFCsAAg8WBB8MZx8NZmRkZAIRDxYCHwBnZAIHDxYCHxEFow57ImxvZ2luQ29uZmlndXJhdGlvbiI6eyJzZXJ2aWNlVXJsIjoiaHR0cHM6Ly9zZXJ2aWNlcy5qb3VybmFscy5sd3cuY29tL0ludGVncmF0aW9uU2VydmljZXMvQWNjb3VudFNlcnZpY2Uuc3ZjL0xvZ2luIiwicmVnaXN0ZXJVcmwiOiJodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9yZWdpc3Rlci5hc3B4P0NvbnRleHRVcmw9JTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4IiwiZm9yZ290UGFzc3dvcmRVcmwiOiJodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9mb3Jnb3RwYXNzd29yZC5hc3B4P0NvbnRleHRVcmw9JTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4IiwicmVkaXJlY3RVcmwiOiJodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9wYWdlcy9sb2dpbi5hc3B4P0NvbnRleHRVcmw9JTJmY28tYWxsZXJneSUyZnBhZ2VzJTJmZGVmYXVsdC5hc3B4IiwidG9rZW5LZXkiOiJBcHBTc29Ub2tlbiIsInNzb0xvZ2luT3B0aW9ucyI6W10sImN1c3RvbWVyU2VydmljZSI6eyJjdXN0b21lclNlcnZpY2VVU1Bob25lIjoiKDgwMCkgNjM4LTMwMzAiLCJjdXN0b21lclNlcnZpY2VJbnRlcm5hdGlvbmFsUGhvbmUiOiIzMDEtMjIzLTIzMDAiLCJjdXN0b21lclNlcnZpY2VFbWFpbCI6ImN1c3RvbWVyc2VydmljZUBsd3cuY29tIn0sInVzZUFsdGVybmF0aXZlQWNjb3VudExpbmtzIjpmYWxzZX0sImNvbW1vbkNvbmZpZ3VyYXRpb24iOnsiY29tbW9uRW5kcG9pbnRzIjp7ImFkZFRvRmF2b3JpdGVzU2VydmljZVVybCI6Imh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9jby1hbGxlcmd5L19sYXlvdXRzLzE1L09BS1MuSm91cm5hbHMvVXNlckNvbGxlY3Rpb25zU2VydmljZS5zdmMvQWRkVG9GYXZvcml0ZXMiLCJzYXZlU2VhcmNoU2VydmljZVVybCI6Imh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9jby1hbGxlcmd5L19sYXlvdXRzLzE1L09BS1MuSm91cm5hbHMvVXNlckNvbGxlY3Rpb25zU2VydmljZS5zdmMvU2F2ZVNlYXJjaCIsImNvdW50ZXJEYXRhU2VydmljZVVybCI6Imh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9jby1hbGxlcmd5L19sYXlvdXRzLzE1L09BS1MuSm91cm5hbHMvRHVhbEFjY2Vzc1NlcnZpY2Uuc3ZjL1NlbmRDb3VudGVyRGF0YVJlcXVlc3RCeUFOIn0sImthbHR1cmEiOnsicGFydG5lcklkIjoiMTMxNTYzMSIsInBsYXllcklkIjoiNTIyNTM4NzIiLCJrYWx0dXJhV2lkZ2V0VXJsIjoiaHR0cHM6Ly9jZG5hcGlzZWMua2FsdHVyYS5jb20vcC8xMzE1NjMxL2VtYmVkUGxheWtpdEpzL3VpY29uZl9pZC81MjI1Mzg3MiJ9LCJicmlnaHRDb3ZlIjp7ImJyaWdodENvdmVTY3JpcHRVcmwiOiJodHRwczovL3BsYXllcnMuYnJpZ2h0Y292ZS5uZXQvMjMyNDk4MjY4NzAwMS9IeVAwSlNBUnhfZGVmYXVsdC9pbmRleC5taW4uanMiLCJkYXRhQWNjb3VudCI6IjIzMjQ5ODI2ODcwMDEiLCJkYXRhUGxheWVyIjoiSHlQMEpTQVJ4In0sIm1hdGgiOnsibGliVXJsIjoiaHR0cHM6Ly9jZG4uanNkZWxpdnIubmV0L25wbS9tYXRoamF4QDMvZXM1L3RleC1tbWwtY2h0bWwuanMifSwicmVjb1dpZGdldCI6eyJqb3VybmFscyI6W3siSWQiOiJjby1hbGxlcmd5IiwiVmVyc2lvbiI6IjA0LjAzIiwiUHJvZHVjdENvZGUiOiJjb2FjaSJ9XSwicHViRmlsdGVyIjp7fSwiY2xpZW50SWQiOiJlanBfdjMiLCJsaWJVcmwiOiJodHRwczovL2Fzc2V0cy5vdmlkLmNvbS93aWRnZXQvdjMvd2lkZ2V0LmpzIn0sInNjaXRlQmFkZ2UiOnsibGliVXJsIjoiaHR0cHM6Ly9jZG4uc2NpdGUuYWkvYmFkZ2Uvc2NpdGUtYmFkZ2UtbGF0ZXN0Lm1pbi5qcyJ9fX1kAgkPZBYCAgEPZBYCAgEPFCsAAg8WBB8MZx8NAgFkZBYCZg9kFgJmDxUIABpodHRwczovL1guY29tL0NPX0FsbGVyZ3lDSQZfYmxhbmsBWAFYDGRpc3BsYXk6bm9uZQAQd2staWNvbi1maWxsZWQteGQCCw8PFgQfDwVHaHR0cHM6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvX2xheW91dHMvb2Frcy5qb3VybmFscy9wcml2YWN5LmFzcHgfAgUOUHJpdmFjeSBQb2xpY3lkZAINDw8WAh8PBUpodHRwczovL2pvdXJuYWxzLmx3dy5jb20vY28tYWxsZXJneS9fbGF5b3V0cy9vYWtzLmpvdXJuYWxzL2Rpc2NsYWltZXIuYXNweGRkAg8PDxYCHw8FRWh0dHBzOi8vam91cm5hbHMubHd3LmNvbS9jby1hbGxlcmd5L19sYXlvdXRzL29ha3Muam91cm5hbHMvdGVybXMuYXNweGRkAhEPDxYCHw8FVWh0dHBzOi8vd3d3LndvbHRlcnNrbHV3ZXIuY29tL2VuL3NvbHV0aW9ucy9saXBwaW5jb3R0LWpvdXJuYWxzL2xpcHBpbmNvdHQtb3Blbi1hY2Nlc3NkZAITDxQrAAIPFgQfDGcfDQIEZGQWCGYPZBYCZg8VBwAmL2NvLWFsbGVyZ3kvU2VjdXJlL1BhZ2VzL2ZlZWRiYWNrLmFzcHgADGRpc3BsYXk6bm9uZQAACEZlZWRiYWNrZAIBD2QWAmYPFQcAS2h0dHA6Ly9qb3VybmFscy5sd3cuY29tL2NvLWFsbGVyZ3kvX2xheW91dHMvMTAzMy9vYWtzLmpvdXJuYWxzL3NpdGVtYXAuYXNweAVibGFuawxkaXNwbGF5Om5vbmUAAAdTaXRlbWFwZAICD2QWAmYPFQcALS9jby1hbGxlcmd5L19sYXlvdXRzL09BS1MuSm91cm5hbHMvZmVlZHMuYXNweAAMZGlzcGxheTpub25lAAAJUlNTIEZlZWRzZAIDD2QWAmYPFQcAEGh0dHBzOi8vbHd3LmNvbS8ADGRpc3BsYXk6bm9uZQAADExXVyBKb3VybmFsc2QCFQ8PFgQfAgUfWW91ciBDYWxpZm9ybmlhIFByaXZhY3kgQ2hvaWNlcx8PBXdodHRwczovL3ByaXZhY3lwb3J0YWwtZGUub25ldHJ1c3QuY29tL3dlYmZvcm0vMjIxN2UxMTctNTI2Yi00Njk2LThhOTgtOGM0MDJmOGYyYjgxLzViMDQ5YmEzLTAxMDYtNGI3Ny1hN2RhLTVkMTIyMzhjOTBhNGRkAhcPFgIfCwU3L19sYXlvdXRzLzEwMzMvSU1BR0VTL09BS1MuSm91cm5hbHMvQ0FQcml2YWN5UG9saWN5LnBuZ2QCGQ8WAh8CBSw8c3Bhbj5Db3B5cmlnaHQmbmJzcDsmY29weTsmbmJzcDsyMDI1PC9zcGFuPmQCGw8WAh8CBe4BPGEgaHJlZj0iaHR0cHM6Ly93d3cud29sdGVyc2tsdXdlci5jb20vZW4vaGVhbHRoIiB0YXJnZXQ9Il9ibGFuayI+V29sdGVycyBLbHV3ZXIgSGVhbHRoLCBJbmMuIGFuZC9vciBpdHMgc3Vic2lkaWFyaWVzLiAgQWxsIHJpZ2h0cyByZXNlcnZlZC4gfCBDb250ZW50IHVzZSBmb3IgdGV4dCBhbmQgZGF0YSBtaW5pbmcgYW5kIGFydGlmaWNpYWwgaW50ZWxsaWdlbmNlIHRyYWluaW5nIGlzIG5vdCBwZXJtaXR0ZWQuPC9hPmQCIw9kFgJmD2QWCGYPDxYCHwBoZGQCAg8PFgIfAGhkZAIED2QWAmYPFgIfAGhkAgYPZBYCZg8WAh8AaGQCJQ9kFgJmD2QWAgICDxYEHwMFSWVqLWFkdmVydGlzZW1lbnQgZWpwLWFkdmVydGlzZW1lbnQtaGlnaGltcGFjdCBqcy1hZHZlcnRpc2VtZW50LWhpZ2hpbXBhY3QfAGcWAgIBDxYEHwIFuwM8ZGl2IGlkPSJnYV9kOWI3MTEwZS0xNWU3LTRhODctYmMxMS0xZDYyNTUwZDBjZDQiIGNsYXNzPSJhZC1zbG90LWNvbnRhaW5lciBhZC1zbG90LWNvbnRhaW5lci1nYV9kOWI3MTEwZS0xNWU3LTRhODctYmMxMS0xZDYyNTUwZDBjZDQiIGRhdGEtc2l6ZW1hcD0iW1tbOTkyLCA1MDBdLCBbWzMwMCwgMjUwXV1dLCBbWzc2OCwgMTgwXSwgW1s3MjgsIDkwXV1dLCBbWzAsIDBdLCBbWzMwMCwgNTBdXV1dIiBkYXRhLWFkcGF0aD0iLzE1NzI2NzAyNzYxL0Rlc2t0b3AvY28tYWxsZXJneS9IaWdoSW1wYWN0IiBkYXRhLWF1dG9sb2FkPSJ5ZXMiIGRhdGEtb3V0b2ZwYWdlPSJubyIgZGF0YS1zdGlja3k9InllcyIgZGF0YS1zbG90dGFyZ2V0aW5nPScnIGRhdGEtZGlzcGxheXNsdWc9InllcyIgZGF0YS1zdGlja3ktZHVyYXRpb249IjEwIiBkYXRhLW5hbWU9IkhpZ2hJbXBhY3QiPjwvZGl2Ph8AZ2QCKQ9kFgJmDxYCHwBoZAITD2QWAmYPZBYEZg8WCB4NZGF0YS1hZGNvbmZpZwWsAXsiYWRUaXRsZSI6IkFkdmVydGlzZW1lbnQiLCJzbG90Q2xhc3MiOiJhZC1zbG90LWNvbnRhaW5lciIsInRvcEJhbm5lciI6eyJzdGlja3kiOiJ0cnVlIiwic3RpY2t5RHVyYXRpb24iOiI1MDAwIn0sImxhenlMb2FkaW5nRW5hYmxlZCI6ZmFsc2UsIm5waUhhc2giOiIiLCJwYWdlVGFyZ2V0aW5nIjp7fX0eEmRhdGEtdmlkZW9hZGNvbmZpZwWfAnsic2VydmVyVVJMIjoiaHR0cHM6Ly9wdWJhZHMuZy5kb3VibGVjbGljay5uZXQvZ2FtcGFkL2FkcyIsInNpemVzIjoiMzIweDE4MHw2NDB4MzYwIiwib3ZlcmxheVVuaXRQYXRoIjoiLzE1NzI2NzAyNzYxL0Rlc2t0b3AvY28tYWxsZXJneS9WaWRlby9vdmVybGF5IiwicHJlcm9sbFVuaXRQYXRoIjoiLzE1NzI2NzAyNzYxL0Rlc2t0b3AvY28tYWxsZXJneS9WaWRlby9wcmUtcm9sbCIsInBvc3Ryb2xsVW5pdFBhdGgiOiIvMTU3MjY3MDI3NjEvRGVza3RvcC9jby1hbGxlcmd5L1ZpZGVvL3Bvc3Qtcm9sbCJ9HwMFDGpzLWFkLWNvbmZpZx8AZ2QCAg8WAh8AZ2QYEgVVY3RsMDAkY3RsMjkkZ19mZGQyMzc2ZV9lMDU0XzRlNTBfOTcyY18yN2RmZjA4MmJiYTYkY3RsMDMkdG9jU2VjdGlvbnMkbGlzdFZpZXdTZWN0aW9ucw8UKwAOZGRkZGRkZBQrAANkZGQCA2RkZGYC/////w9kBR9jdGwwMCRjdGw1NiRsdkZvckpvdXJuYWxBdXRob3JzDxQrAA5kZGRkZGRkFCsAAmRkAgJkZGRmAv////8PZAXGAWN0bDAwJGN0bDI5JGdfZmRkMjM3NmVfZTA1NF80ZTUwXzk3MmNfMjdkZmYwODJiYmE2JGN0bDAzJHNlY3Rpb25MaXN0Q29udHJvbCRzZWN0aW9uTGlzdFZpZXckY3RybDAkc2VjdGlvbkRpc3BsYXlDb250cm9sJHN1YlNlY3Rpb25MaXN0VmlldyRjdHJsMCRzdWJTZWN0aW9uRGlzcGxheUNvbnRyb2wkaXRlbUxpc3RDb250cm9sJGl0ZW1MaXN0Vmlldw8UKwAOZGRkZGRkZBQrAAFkAgFkZGRmAv////8PZAVTY3RsMDAkY3RsMjkkZ18yNGI4ZGI2Yl81NmM2XzQ1OTZfOWRiMl85MzIwNGUyODBkMWQkX2ZmYzlhZGZmNDNlYjc5MjEkY3RsMDEkSXRlbUxpc3QPFCsADmRkZGRkZGQ8KwAFAAIFZGRkZgL/////D2QFTGN0bDAwJGN0bDUxJEhlYWRlciRVc2VyQWN0aW9uVG9vbHMkcmVjZW50U2VhcmNoZXNDb250cm9sJGx2d1JlY2VudFNlYXJjaExpc3QPPCsADgMIZgxmDQL/////D2QFGmN0bDAwJGN0bDU2JGx2Q29udGVudExpbmtzDxQrAA5kZGRkZGRkPCsABAACBGRkZGYC/////w9kBTxjdGwwMCRjdGw1MSRIZWFkZXIkVXNlckFjdGlvblRvb2xzJGx2QWx0ZXJuYXRpdmVBY2NvdW50TGlua3MPZ2QFxgFjdGwwMCRjdGwyOSRnX2ZkZDIzNzZlX2UwNTRfNGU1MF85NzJjXzI3ZGZmMDgyYmJhNiRjdGwwMyRzZWN0aW9uTGlzdENvbnRyb2wkc2VjdGlvbkxpc3RWaWV3JGN0cmwyJHNlY3Rpb25EaXNwbGF5Q29udHJvbCRzdWJTZWN0aW9uTGlzdFZpZXckY3RybDAkc3ViU2VjdGlvbkRpc3BsYXlDb250cm9sJGl0ZW1MaXN0Q29udHJvbCRpdGVtTGlzdFZpZXcPFCsADmRkZGRkZGQUKwACZGQCAmRkZGYC/////w9kBVtjdGwwMCRjdGwyOSRnX2ZkZDIzNzZlX2UwNTRfNGU1MF85NzJjXzI3ZGZmMDgyYmJhNiRjdGwwMyRzZWN0aW9uTGlzdENvbnRyb2wkc2VjdGlvbkxpc3RWaWV3DxQrAA5kZGRkZGRkFCsAA2RkZAIDZGRkZgL/////D2QFxgFjdGwwMCRjdGwyOSRnX2ZkZDIzNzZlX2UwNTRfNGU1MF85NzJjXzI3ZGZmMDgyYmJhNiRjdGwwMyRzZWN0aW9uTGlzdENvbnRyb2wkc2VjdGlvbkxpc3RWaWV3JGN0cmwxJHNlY3Rpb25EaXNwbGF5Q29udHJvbCRzdWJTZWN0aW9uTGlzdFZpZXckY3RybDAkc3ViU2VjdGlvbkRpc3BsYXlDb250cm9sJGl0ZW1MaXN0Q29udHJvbCRpdGVtTGlzdFZpZXcPFCsADmRkZGRkZGQUKwACZGQCAmRkZGYC/////w9kBRhjdGwwMCRjdGw1NiRsdk90aGVyTGlua3MPZ2QFGWN0bDAwJGN0bDU2JGx2U29jaWFsTGlua3MPFCsADmRkZGRkZGQUKwABZAIBZGRkZgL/////D2QFGGN0bDAwJGN0bDU2JGx2SW5mb1Bob25lcw88KwAOAwhmDGYNAv////8PZAUeX19Db250cm9sc1JlcXVpcmVQb3N0QmFja0tleV9fFgEFUGN0bDAwJGN0bDI5JGdfZmRkMjM3NmVfZTA1NF80ZTUwXzk3MmNfMjdkZmYwODJiYmE2JGN0bDAxJGNoZWNrQm94U2F2ZU15U2VsZWN0aW9uBRdjdGwwMCRjdGw1NiRsdlNpdGVMaW5rcw8UKwAOZGRkZGRkZDwrAAUAAgVkZGRmAv////8PZAWKAWN0bDAwJGN0bDI5JGdfZmRkMjM3NmVfZTA1NF80ZTUwXzk3MmNfMjdkZmYwODJiYmE2JGN0bDAzJHNlY3Rpb25MaXN0Q29udHJvbCRzZWN0aW9uTGlzdFZpZXckY3RybDEkc2VjdGlvbkRpc3BsYXlDb250cm9sJHN1YlNlY3Rpb25MaXN0Vmlldw8UKwAOZGRkZGRkZBQrAAFkAgFkZGRmAv////8PZAWKAWN0bDAwJGN0bDI5JGdfZmRkMjM3NmVfZTA1NF80ZTUwXzk3MmNfMjdkZmYwODJiYmE2JGN0bDAzJHNlY3Rpb25MaXN0Q29udHJvbCRzZWN0aW9uTGlzdFZpZXckY3RybDAkc2VjdGlvbkRpc3BsYXlDb250cm9sJHN1YlNlY3Rpb25MaXN0Vmlldw8UKwAOZGRkZGRkZBQrAAFkAgFkZGRmAv////8PZAWKAWN0bDAwJGN0bDI5JGdfZmRkMjM3NmVfZTA1NF80ZTUwXzk3MmNfMjdkZmYwODJiYmE2JGN0bDAzJHNlY3Rpb25MaXN0Q29udHJvbCRzZWN0aW9uTGlzdFZpZXckY3RybDIkc2VjdGlvbkRpc3BsYXlDb250cm9sJHN1YlNlY3Rpb25MaXN0Vmlldw8UKwAOZGRkZGRkZBQrAAFkAgFkZGRmAv////8PZCGpkZy+anp4OMEvmZJMXPPPp1s6k0fgqrggs4SJdy5c" />


<script type="text/javascript">
//<![CDATA[
var MSOWebPartPageFormName = 'aspnetForm';
var g_presenceEnabled = true;
var g_wsaEnabled = false;

var g_correlationId = 'ebb0b9a1-82d2-f0c3-d9ba-fca9f09de11f';
var g_wsaQoSEnabled = false;
var g_wsaQoSDataPoints = [];
var g_wsaRUMEnabled = false;
var g_wsaLCID = 1033;
var g_wsaListTemplateId = 850;
var g_wsaSiteTemplateId = 'EJOURNALS#7';
var _spPageContextInfo={"webServerRelativeUrl":"/co-allergy","webAbsoluteUrl":"https://journals.lww.com/co-allergy","viewId":"","listId":"{1d013155-e349-4110-b1cd-603e679b9d69}","listPermsMask":{"High":0,"Low":200769},"listUrl":"/co-allergy/Pages","listTitle":"Pages","listBaseTemplate":850,"viewOnlyExperienceEnabled":false,"blockDownloadsExperienceEnabled":false,"idleSessionSignOutEnabled":false,"cdnPrefix":"","siteAbsoluteUrl":"https://journals.lww.com/co-allergy","siteId":"{81de1f85-ea57-47ec-b390-2095d3ed8c8f}","showNGSCDialogForSyncOnTS":false,"supportPoundStorePath":true,"supportPercentStorePath":true,"siteSubscriptionId":null,"CustomMarkupInCalculatedFieldDisabled":true,"AllowCustomMarkupInCalculatedField":false,"isSPO":false,"farmLabel":null,"serverRequestPath":"/co-allergy/pages/default.aspx","layoutsUrl":"_layouts/15","webId":"{f7fcafb5-89d1-4e48-826d-0ebe9ae7adf3}","webTitle":"Current Opinion in Allergy \u0026 Clinical Immunology","webTemplate":"20200","webTemplateConfiguration":"EJOURNALS#7","webDescription":"","tenantAppVersion":"0","isAppWeb":false,"webLogoUrl":"/_layouts/images/titlegraphic.gif","webLanguage":1033,"currentLanguage":1033,"currentUICultureName":"en-US","currentCultureName":"en-US","currentCultureLCID":1033,"env":null,"nid":0,"fid":0,"serverTime":"2025-08-08T08:52:42.4886892Z","siteClientTag":"4$$16.0.10417.20037","crossDomainPhotosEnabled":false,"openInClient":false,"Has2019Era":true,"webUIVersion":15,"webPermMasks":{"High":0,"Low":196608},"pageListId":"{1d013155-e349-4110-b1cd-603e679b9d69}","pageItemId":62,"pagePermsMask":{"High":0,"Low":200769},"pagePersonalizationScope":1,"userEmail":"","userId":0,"userLoginName":null,"userDisplayName":null,"isAnonymousUser":true,"isAnonymousGuestUser":false,"isEmailAuthenticationGuestUser":false,"isExternalGuestUser":false,"systemUserKey":null,"alertsEnabled":true,"siteServerRelativeUrl":"/co-allergy","allowSilverlightPrompt":"True","themeCacheToken":"/co-allergy::5:","themedCssFolderUrl":null,"themedImageFileNames":null,"modernThemingEnabled":true,"isSiteAdmin":false,"ExpFeatures":[480216468,1884350801,1158731092,62197791,538521105,335811073,4194306,34614301,268500996,-1946025984,28445328,-2147475455,134291456,65536,288,950272,1282,808326148,134217873,0,0,-1073217536,545285252,18350656,-467402752,6291457,-2147483644,1074794496,-1728053184,1845537108,622628,4102,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0],"killSwitches":{},"InternalValidAuthorities":["journals.na.lww.com","journals.lww.com","journals.na.lww.com","journals.lww.com","cloud-journals.lww.com","cloud-journals.lww.com"],"CorrelationId":"ebb0b9a1-82d2-f0c3-d9ba-fca9f09de11f","hasManageWebPermissions":false,"isNoScriptEnabled":false,"groupId":null,"groupHasHomepage":true,"groupHasQuickLaunchConversationsLink":false,"departmentId":null,"hubSiteId":null,"hasPendingWebTemplateExtension":false,"isHubSite":false,"isWebWelcomePage":true,"siteClassification":"","hideSyncButtonOnODB":false,"showNGSCDialogForSyncOnODB":false,"sitePagesEnabled":false,"sitePagesFeatureVersion":0,"DesignPackageId":"00000000-0000-0000-0000-000000000000","groupType":null,"groupColor":"#0273eb","siteColor":"#0273eb","headerEmphasis":0,"navigationInfo":null,"guestsEnabled":false,"MenuData":{"SignInUrl":"/co-allergy/_layouts/15/Authenticate.aspx?Source=%2Fco%2Dallergy%2Fpages%2Fdefault%2Easpx"},"RecycleBinItemCount":-1,"PublishingFeatureOn":true,"PreviewFeaturesEnabled":false,"disableAppViews":false,"disableFlows":false,"serverRedirectedUrl":null,"formDigestValue":"0xABA6435B26791825445316B420948613EEF9B8BB3D28616595A14BA3944CDA9F347927D6D2798E05169217FCD46E501F0773BC0B1462BE65F27538D34B689D2A,08 Aug 2025 08:52:42 -0000","maximumFileSize":10240,"formDigestTimeoutSeconds":1800,"canUserCreateMicrosoftForm":false,"canUserCreateVisioDrawing":true,"readOnlyState":null,"isTenantDevSite":false,"preferUserTimeZone":false,"userTimeZoneData":null,"userTime24":false,"userFirstDayOfWeek":null,"webTimeZoneData":null,"webTime24":false,"webFirstDayOfWeek":null,"isSelfServiceSiteCreationEnabled":null,"alternateWebAppHost":"","aadTenantId":"","aadUserId":"","aadInstanceUrl":"","msGraphEndpointUrl":"https://","allowInfectedDownload":true};_spPageContextInfo.updateFormDigestPageLoaded=new Date();_spPageContextInfo.clientServerTimeDelta=new Date(_spPageContextInfo.serverTime)-new Date();if(typeof(define)=='function'){define('SPPageContextInfo',[],function(){return _spPageContextInfo;});}document.onreadystatechange=fnRemoveAllStatus; function fnRemoveAllStatus(){removeAllStatus(true)};//]]>
</script>

<script src="https://lww.com/_layouts/15/1033/Scripts/wk/alerts-subscription.min.js?v=05.25.00.229" type="text/javascript"></script>
<script type="text/javascript">
//<![CDATA[
Flighting.ExpFeatures = [480216468,1884350801,1158731092,62197791,538521105,335811073,4194306,34614301,268500996,-1946025984,28445328,-2147475455,134291456,65536,288,950272,1282,808326148,134217873,0,0,-1073217536,545285252,18350656,-467402752,6291457,-2147483644,1074794496,-1728053184,1845537108,622628,4102,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0]; (function()
{
    if(typeof(window.SP) == "undefined") window.SP = {};
    if(typeof(window.SP.YammerSwitch) == "undefined") window.SP.YammerSwitch = {};

    var ysObj = window.SP.YammerSwitch;
    ysObj.IsEnabled = false;
    ysObj.TargetYammerHostName = "www.yammer.com";
} )(); var _spWebPartComponents = new Object();//]]>
</script>

<script src="https://lww.com/_layouts/15/1033/Scripts/wk/ImageWrapperControl.js?v=05.25.00.229" type="text/javascript"></script>
<script type="text/javascript">
//<![CDATA[
function openEmtcIfAuthenticated(resourceId){logCounterDataEmailToColleagueByAN('', false); window.location.assign('https://journals.lww.com/co-allergy/pages/login.aspx?ReturnUrl=%2fco-allergy%2fpages%2fdefault.aspx');}//]]>
</script>

<script src="https://lww.com/_layouts/15/1033/Scripts/wk/ArticleNavigator.js?v=05.25.00.229" type="text/javascript"></script>
<script type="text/javascript">
//<![CDATA[
function getEmailRegularExpression() { return /^(([a-zA-Z0-9_\-\.]+)@([a-zA-Z0-9_\-\.]+)\.([a-zA-Z]{2,5}){1,25})$/; }function getMultipleEmailsRegularExpression() { return /^(([a-zA-Z0-9_\-\.]+)@([a-zA-Z0-9_\-\.]+)\.([a-zA-Z]{2,5}){1,25})+([;.](([a-zA-Z0-9_\-\.]+)@([a-zA-Z0-9_\-\.]+)\.([a-zA-Z]{2,5}){1,25})+)*$/; }function getMailMessage() { return 'Thought you might appreciate this item(s) I saw in Current Opinion in Allergy and Clinical Immunology.'; }//]]>
</script>

<script src="https://lww.com/_layouts/15/1033/Scripts/wk/ListContainerControlBase.js?v=05.25.00.229" type="text/javascript"></script>
<script type="text/javascript">
//<![CDATA[
function getSelectedItemsField() { return $get("selectedItems"); }function getCheckBoxListContainer() { return $get("checkBoxListContainer"); }function getListActionsContainerTop() { return $get("listActionsContainerTop"); }function getListActionsContainerBottom() { return $get("listActionsContainerBottom"); }function getSelectedItemsCount() {{ return getSelectedItemsField().value.split(';').length - 1; }}function getTocControl() { return $find('tocPopup_1495651488'); }function getSectionNameHidden() { return $get('ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_hfSectionName'); }//]]>
</script>

<script src="https://lww.com/_layouts/15/1033/Scripts/wk/fulltext.js?v=05.25.00.229" type="text/javascript"></script>
<script src="https://lww.com/_layouts/15/1033/Scripts/wk/ArticleDisplayControl.js?v=05.25.00.229" type="text/javascript"></script>
<script src="/_layouts/15/blank.js?rev=OqEYlnomw4m5X%2FMg2wSuyA%3D%3DTAG0" type="text/javascript"></script>
<script src="https://journals.lww.com/co-allergy/_layouts/OAKS.Journals/ArticleInfo.asmx/js" type="text/javascript"></script>
<script type="text/javascript">
//<![CDATA[
window.SPThemeUtils && SPThemeUtils.RegisterCssReferences([]);
(function(){

        if (typeof(_spBodyOnLoadFunctions) === 'undefined' || _spBodyOnLoadFunctions === null) {
            return;
        }
        _spBodyOnLoadFunctions.push(function() {
            SP.SOD.executeFunc('core.js', 'FollowingDocument', function() { FollowingDocument(); });
        });
    })();(function(){

        if (typeof(_spBodyOnLoadFunctions) === 'undefined' || _spBodyOnLoadFunctions === null) {
            return;
        }
        _spBodyOnLoadFunctions.push(function() {
            SP.SOD.executeFunc('core.js', 'FollowingCallout', function() { FollowingCallout(); });
        });
    })();if (typeof(DeferWebFormInitCallback) == 'function') DeferWebFormInitCallback();//]]>
</script>

<input type="hidden" name="__VIEWSTATEGENERATOR" id="__VIEWSTATEGENERATOR" value="2F4363D3" />
<input type="hidden" name="__EVENTVALIDATION" id="__EVENTVALIDATION" value="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" />

            <script type="text/javascript">
                var submitHook = function () { return false; }; theForm._spOldSubmit = theForm.submit; theForm.submit = function () { if (!submitHook()) { this._spOldSubmit(); } };
            </script>
            <span id="DeltaSPWebPartManager">
                
            </span>
            <script type="text/javascript">$.getJSON("https://login.journals.lww.com/AuthCheck.aspx?Callback=?", null, function (data) { if(data.IsAuthenticated.toLowerCase() == "true") {window.location.replace("https://login.journals.lww.com/?wa=wsignin1.0&wtrealm=urn%3ajournals&wctx=https%3a%2f%2fjournals.lww.com%2fco-allergy%2f_layouts%2f15%2fAuthenticate.aspx%3fSource%3d%252fco-allergy%252fpages%252fdefault.aspx"); } }) </script>

        

        

            <span id="DeltaDelegateControls">
                
                
            </span>
            
            <!-- start ( this can all go into PublishingSiteAction:SiteActionMenu )--->
            
            <!-- end ( this can all go into PublishingSiteAction:SiteActionMenu )--->
             
          
            
            

<div class="ejp-corporate-hat">
    <div class="ejp-corporate-hat__content wk-grid-page-container">
        <a href="https://lww.com/pages/default.aspx">
            <div role="img" class="ejp-corporate-hat__logo ejp-corporate-hat__logo--lww" aria-label="Lippincott Logo"></div>
        </a>
    </div>
</div>


            

            <div id="ctl00_MicrobarContainer" class="top-microbar-container">
                
            </div>
            
            <!-- Header Banners delegate control -->
            

           
            
            <a id="HiddenAnchor" href="javascript:;" style="display: none;"></a>
            
            <!-- Header Advertisements delegate control -->
            <div id="ctl00_TopAdvertisementContainer" class="advertisement-content_top top-banner">
                <div class="top-banner__content--centered top-banner--low-opacity">
                    
<div id="ctl00_ctl49_adContainer" class="ej-advertisement ej-advertisement-topcombo">
    <div class="ej-advertisement-content">
        <div>
            <div id="ga_ba458c5d-c153-4ed0-ab61-4765e7e57bdd" class="ad-slot-container ad-slot-container-ga_ba458c5d-c153-4ed0-ab61-4765e7e57bdd" data-sizemap="[[[730, 500], [[728, 90]]], [[0, 0], [[300, 50]]]]" data-adpath="/15726702761/Desktop/co-allergy/Home/Top" data-autoload="yes" data-outofpage="no" data-sticky="yes" data-slottargeting='' data-displayslug="yes" data-sticky-duration="5" data-name="Top"></div>
        </div>
    </div>
</div>

                </div>
            </div>

            <div class="main-wrapper">
                <div id="main-container">

                <!--  Header delegate control -->
                

<header class="header">
    <div class="header__holder">
        

<div class="header__layout-top wk-grid-page-container">
    <script type="text/javascript" src="https://lww.com/_layouts/15/1033/Scripts/wk/UserToolbarDropdown.js?v=05.25.00.229" defer="true">

</script>

<section class="user-action-toolbar">
    <ul class="user-menu user-info" role="tablist">
        
         <li id="ctl00_ctl51_Header_UserActionTools_liLogin" class="user-menu__item user-menu__item--popup-container user-menu__item--login-popup-container dib">
            <button class="user-menu__link user-menu__link--login js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;login&quot;,&quot;eventDetail&quot;:{&quot;source&quot;:&quot;Masthead Dropdown&quot;},&quot;isNull&quot;:false}">
                <i class="fa fa-sign-in"></i> 
                <span>Log in</span>
            </button>
            
        </li>
        <li id="ctl00_ctl51_Header_UserActionTools_liOr" class="dib or-spacing"><span>or</span></li>

        <li id="ctl00_ctl51_Header_UserActionTools_liRegister2" class="user-menu__item dib">
            <a id="ctl00_ctl51_Header_UserActionTools_RegisterUserPopupLnk" class="user-menu__link js-register-link" data-config="{&quot;eventName&quot;:&quot;Register&quot;,&quot;eventDetail&quot;:{&quot;source&quot;:&quot;Masthead Dropdown&quot;},&quot;isNull&quot;:false}" href="https://journals.lww.com/co-allergy/pages/register.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx">Register</a>
        </li>

        <li id="ctl00_ctl51_Header_UserActionTools_liSubscribe" role="presentation" class="user-menu__item dib">
            <a id="ctl00_ctl51_Header_UserActionTools_lnkSubscribe" class="user-menu__link" href="https://shop.lww.com/p/1528-4050" target="_blank"><i class="fa fa-bars"></i>  <span class="hideOnFixed">Subscribe to journal</span><span class="showOnFixed">Subscribe</span></a>
        </li>
        <li id="ctl00_ctl51_Header_UserActionTools_liIssueAlerts" class="user-menu__item dib">
            <i class="fa fa-envelope"></i>
            <a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);;" onclick="javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);" class="user-menu__link"><span id="ctl00_ctl51_Header_UserActionTools_SubscribeToAlertsActionToolLink_defaultText" class="hideOnFixed">Get new issue alerts</span><span id="ctl00_ctl51_Header_UserActionTools_SubscribeToAlertsActionToolLink_stickyText" class="showOnFixed">Get alerts</span></a>

        </li>
        
        
    </ul>
</section>

<span id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_dummyTargetControl"></span>


<div id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pnlunSubscribeToAlerts" style="display: none;">
	
    <div tabindex="-1" role="dialog" class="wk-modal horizontally-centered small wk-modal-with-overlay wk-modal-small ejp-modal">
        <div id="ej-box-modal-style-1">
            <div id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pnlMain">
		               
                <div id="tocUnsubscribeModal" >
                    <section class="wk-modal-content">
                        <header class="wk-modal-header ejp-modal-header">
                            <div class="wk-modal-title ejp-modal-title"></div>
                            <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button>
                        </header>
                        <div class="wk-modal-body">
                            <div class="wk-field-item">
                                <p>
                                    <span id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage"></span>
                                </p>                             
                                <div class="wk-button-bar">
                                    <div class="wk-button-group-left">
                                        <p id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons" Style="display: none;">
                                            <input type="submit" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$btnContinue" value="Yes" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$btnContinue&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, false))" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_btnContinue" class="primary-button" />
                                            <input type="button" value="No" id="btnCancel" aria-label="close dialog" class="js-close secondary-button" />
                                        </p>
                                    </div>
                                </div>
                            </div>
                        </div>
                    </section>
                </div>
            
	</div>
        </div>
    </div>

</div>


<div id="ej-clear-float">
</div>
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnSubscribeAlertType" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnsubscribeJournalId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenUnsubscribeMessage" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenTopicalCollectionId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenTopicalCollectionId" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenOvidId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenOvidId" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$ucUnsubscribeToAlertsUserControl$hiddenJournalId" id="ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId" />
<script type="text/javascript">

    function alerts_ShowUnSubscribeeTOCPopup(title, alertType, journalId) {
        var unSubscribeeTocPopup = $find('unSubscribeToAlerts');
        var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage');
        lblUnsubscribeMessage.innerHTML = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = alertType;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title;

        $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show();

        if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') {
            document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId;
        }

        if (unSubscribeeTocPopup != null) {
            unSubscribeeTocPopup.show();
        }
    }

    function alerts_ShowUnSubscribeeTOCPopup_Root(title, journalId, alertType) {
        var unSubscribeeTocPopup = $find('unSubscribeToAlerts');
        var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage');
        lblUnsubscribeMessage.innerHTML = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = alertType;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId;

        $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show();

        if (unSubscribeeTocPopup != null) {
            unSubscribeeTocPopup.show();
        }
    }

    function alerts_ShowUnSubscribeeTOCPopup_Citation(title, journalId, ovidId) {
        var unSubscribeeTocPopup = $find('unSubscribeToAlerts');
        var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage');
        lblUnsubscribeMessage.innerHTML = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Citation';
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenOvidId').value = ovidId;

        $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show();

        if (unSubscribeeTocPopup != null) {
            unSubscribeeTocPopup.show();
        }

    }

    function alerts_ShowUnSubscribeeTOCPopup_Topical(title, journalId, topicalCollectionId) {
        var unSubscribeeTocPopup = $find('unSubscribeToAlerts');
        var lblUnsubscribeMessage = document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_lblUnsubscribeMessage');
        lblUnsubscribeMessage.innerHTML = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeMessage').value = title;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnSubscribeAlertType').value = 'Topical';
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenUnsubscribeJournalId').value = journalId;
        document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenTopicalCollectionId').value = topicalCollectionId;

        $('#' + 'ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pUnsubscribeButtons').show();

        if (document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == null || document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value == '') {
            document.getElementById('ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_hiddenJournalId').value = journalId;
        }
        if (unSubscribeeTocPopup != null) {
            unSubscribeeTocPopup.show();
        }

    }

    function alerts_ShowUnSubscribeeTOCSuccessPopup() {
        var unSubscribeeTocPopup = $find('unSubscribeToAlerts');
        if (unSubscribeeTocPopup != null) {
            unSubscribeeTocPopup.show();
        }
    }

    $('.js-close').on('click', function() {
        var unSubscribeeTocPopup = $find('unSubscribeToAlerts');
        if (unSubscribeeTocPopup != null) {
            unSubscribeeTocPopup.hide();
        }
        return false;
    });
</script>


<span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl"></span>

<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscribeToEtocPopupState" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState" value="showemail" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenConfirmSubscriptionPageUrl" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenJournalId" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId" />
<input type="hidden" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$hiddenSubscriptionType" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType" />
<div id="divPopupOverLay" class="Popup-Overlay" style="display: none; position: fixed; left: 0; top: 0; z-index: 3800; width: 1920px; height: 4517px;"></div>
<div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc" class="etoc-popup ej-box-modal-drop-shadow" style="display: none;">
	
    <div tabindex="-1" role="dialog" class="wk-modal horizontally-centered small wk-modal-with-overlay wk-modal-small ejp-modal">
        <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain">
		
            <section class="wk-modal-content">
                <header class="wk-modal-header ejp-modal-header">
                    <div class="wk-modal-title ejp-modal-title">
                        <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblTitle"></span>
                    </div>
                    <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close ">
                        <i class="fa fa-times"></i>
                    </button>
                </header>
                <div class="wk-modal-body">
                    <div class="wk-field-item">
                        <div class="wk-field-body">
                            <strong>
                                <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage"></span></strong>
                        </div>
                        <div class="wk-field-body">
                            
                            <label for="Email input">Enter your Email address:</label>
                             <div class="wk-field-body">
                            <input name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$txtEmailAddress" type="text" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress" class="ej-box-modal-style-1-input" />
                        </div>
                        </div>
                        <div class="wk-button-bar">
                            <div class="wk-button-group-left">
                                <input type="submit" name="ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue" value="Continue" onclick="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl51$Header$UserActionTools$SubscribeToEtocPopupControl$btnContinue&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, false))" id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_btnContinue" class="primary-button" />
                                <input type="button" value="Cancel" id="btnCancel" class="js-close secondary-button" />
                            </div>
                        </div>
                    </div>
                    <div class="wk-field-item">                       
                       <div class="wk-field-body">
                           <a id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hypPrivacy" href="https://journals.lww.com/co-allergy/_layouts/oaks.journals/privacy.aspx" target="_blank">Privacy Policy</a>
                           
                        </div>
                    </div>
                </div>
            </section>

        
	</div>
        <div id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser" style="display: none;">
		
                       <section class="wk-modal-content">
                <header class="wk-modal-header ejp-modal-header">
                    <div class="wk-modal-title ejp-modal-title"></div>
                    <button aria-label="close dialog" class="js-close primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button>
                </header>
                <div class="wk-modal-body">
                    <div class="wk-field-item">
                        <p>
                            <strong>
                                <span id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle"></span>
                            </strong>
                        </p>
                    </div>
                    <p id="ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pAuthenticatedUserMessage">
                    </p>
                </div>
            </section>
        
	</div>
    </div>

</div>
<div id="ej-clear-float">
</div>

<script type="text/javascript">

    function alerts_SaveSubscriptionTypeInHiddenField(url, subscriptionType, journalId, yearId, issueId, articleId) {
        if (journalId && yearId && issueId && articleId) {
            logCounterDataAlertWhenCitedSynchronously(journalId, yearId, issueId, articleId);
        }
        
        $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType').val(subscriptionType);
        $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').val(journalId);
        if (url)
            window.location = url;
        else 
            __doPostBack('hypSubscribeToAlerts');
        return false;
    }

    function alerts_ShowSubscribeeTOCPopup(journalTitle, journalId, subscriptionType, displaySubscriptionType) {
        $('#' + 'ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscriptionType').val(subscriptionType);
        var subscribeToEtocPopup = $find('subscribeToEtoc');
        subscribeToEtocPopup.show();
        document.getElementsByTagName( 'html' )[0].classList.add('no-scroll');
        var modelPopupState = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenSubscribeToEtocPopupState');
        var emailTextBox = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress');
        var thanksPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlAuthenticatedUser');
        var mainPanel = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlMain');
        var thankYouMessageUnAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblThankYouMessage');
        var thankYouMessageAuthenticated = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_lblAuthenticatedUserTitle');

        if (!displaySubscriptionType) {
            displaySubscriptionType = subscriptionType;
        }

        if (modelPopupState.value == 'showthanksmessage') {
            thanksPanel.style.display = "block";
            mainPanel.style.display = "none";
            thankYouMessageAuthenticated.innerHTML = "Thank you for subscribing to the " + displaySubscriptionType + " for " + journalTitle + ".";
        }

        if (modelPopupState.value == 'showemail') {
            thanksPanel.style.display = "none";
            mainPanel.style.display = "block";

            thankYouMessageUnAuthenticated.innerHTML = "Thank you for choosing to subscribe to the " + displaySubscriptionType + " for " + journalTitle + ".";
        }

        if ($('.etoc-popup') != null) {
            document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenJournalId').value = journalId;

            if (modelPopupState.value == 'showemail')
                emailTextBox.focus();
        }
    }

    $('.js-close').on('click', function () {
        document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_txtEmailAddress').value = "";
        document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_cvEmailError').style.display = "none";
        var pageUrl = document.getElementById('ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_hiddenConfirmSubscriptionPageUrl');
        var subscribeeTocPopup = $find('subscribeToEtoc');
        if (subscribeeTocPopup != null) {
            subscribeeTocPopup.hide();
            document.getElementsByTagName( 'html' )[0].classList.remove('no-scroll');
            if (pageUrl.value !== '' && pageUrl.value !== window.location.pathname)
                window.location = pageUrl.value;
        }
        return false;
    });
</script>

<div id="ctl00_ctl51_Header_UserActionTools_eTocTopContainer">
    <div id="eTocTop" style="display: none;">
        <a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);;" onclick="javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);"><span id="ctl00_ctl51_Header_UserActionTools_alertLinkControlTop_defaultText" class="hideOnFixed">Subscribe to eTOC</span></a>

    </div>
</div>

<script>
    $(function () {
        //find recent searches link and move container
        var recentSearchesControl = $("a[id$='RecentSearches']");
        if (recentSearchesControl.length) {
            recentSearchesControl.click(function (e) {
                e.stopPropagation();

                if ($("#ResentSearchContainer").is(":hidden")) {
                    $("#ResentSearchContainer").slideDown("slow");
                    recentSearchesControl.addClass('open');
                } else {
                    $("#ResentSearchContainer").hide();
                    recentSearchesControl.removeClass('open');
                }
            });
        }

        var eTocAccountLink = $("ul.js-user-action-toolbar__dropdown>li>a[id='SubscribeToEToc']");
        if (eTocAccountLink.length) {
            eTocAccountLink.parent().html($("#eTocTop>a"));
        }
    });
</script>

    <a class="logo-secondary white" href="http://wolterskluwer.com/" target="_blank">
        <h3 class="logo-secondary-text">Secondary Logo</h3>
    </a>
    <a href="#" class="sticky-search"><i class="fa fa-search"></i></a>
</div>
<div class="header__layout-bottom wk-grid-page-container">
    <a id="hypJournals" class="logo-main" href="https://journals.lww.com/co-allergy/pages/default.aspx">
        <h3 class="logo-main-text">Journal Logo
        </h3>
    </a>
    

<div class="search-v2">

    <div class="search-wrapper">
        <select name="ctl00$ctl51$Header$SearchTopBoxControl$ddlContentScope" id="ctl00_ctl51_Header_SearchTopBoxControl_ddlContentScope">
	<option value="All">All</option>
	<option selected="selected" value="Articles">Articles</option>
	<option value="Images">Images</option>
	<option value="Videos">Videos</option>
	<option value="Podcasts">Podcasts</option>
	<option value="Blogs">Blogs</option>

</select>
        <div class="input-group" id="globalSearch">
            <input name="ctl00$ctl51$Header$SearchTopBoxControl$txtKeywords" type="text" value="Search" id="ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords" class="form-control searchText" />
            <span class="input-group-btn">
                <button id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier" type="submit" class="btn btn-default"><i class="fa fa-search"></i></button>
            </span>
            <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$IsAutoCompleteEnabled" id="ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled" value="true" />
            <input type="hidden" name="ctl00$ctl51$Header$SearchTopBoxControl$AutocompleteApiUrl" id="ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl" value="https://platformservices.wolterskluwerhealth.com/autocomplete/COACI/shingle/" />
        </div>
    </div>

    <div class="advance-search" style="">
        <a id="ctl00_ctl51_Header_SearchTopBoxControl_lnkAdvanceSearch" href="https://journals.lww.com/co-allergy/pages/advancedsearch.aspx">Advanced Search</a>
        <input type="submit" name="ctl00$ctl51$Header$SearchTopBoxControl$btnGlobalSearch" value="" id="ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch" disabled="disabled" class="aspNetDisabled btnGlobalSearch" style="display: none;" />
        <input name="ctl00$ctl51$Header$SearchTopBoxControl$hfldKeywords" type="hidden" id="ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords" class="hfldKeywords" value="disableButton" />
    </div>

</div>
<script>
   
    $(function() {
        try {
            var objSearchBox = {
                btnGlobalSearchMagnifierId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearchMagnifier',
                searchButtonId: 'ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch',
                txtKeywordsId: 'ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords',
                hfldKeywordsHiddenId: 'ctl00_ctl51_Header_SearchTopBoxControl_hfldKeywords',
                defaultSearchText: 'Search'
            };

            new Searchbox(objSearchBox).Init();
        } catch (e) {
            console.error(e);
        }
    });

    //autocomplete functionality for basic search
    //this functionality will call the SBA url and start suggesting after typing 3rd character
    var textKeywords = null;
    var hiddenAutocompleteApiUrl = null;
    var buttonGlobalSearch = null;

    $(function () {
        try {
            var objAutocomplete = {
                hiddenIsAutoCompleteEnabled: $('#ctl00_ctl51_Header_SearchTopBoxControl_IsAutoCompleteEnabled'),
                textKeywords: $('#ctl00_ctl51_Header_SearchTopBoxControl_txtKeywords'),
                hiddenAutocompleteApiUrl: $('#ctl00_ctl51_Header_SearchTopBoxControl_AutocompleteApiUrl'),
                buttonGlobalSearch: $('#ctl00_ctl51_Header_SearchTopBoxControl_btnGlobalSearch'),
                enableNewAutoComplete: true,
                newAutoCompleteUrl: 'https://dxg-search-na-prd.wkgposvc.cloud/Query.svc/Query_Expand',
                newAutoCompleteMaxSuggestions: '10',
                newAutoCompleteDictionaryIds: 'ovid_sted28_mesh22'
            };

            autoComplete(objAutocomplete);
        } catch (e) {
            console.error(e);
        }
    });

    $(function () {
        let searchSelect = $('select[id$="ddlContentScope"]');;

        if (searchSelect.length){
            searchSelect.selectize();
        }
    });
</script>

</div>

        <div id="main-nav-container-v2">
            <nav id="main-nav" class="navbar navbar-default yamm wk-grid-page-container">

                <div class="navbar-header">
                    <button id="fatJuicy" type="button" class="navbar-hamburger-button navbar-toggle collapsed pull-left" data-bs-toggle="collapse" data-bs-target="#zz1_TopNavigationMenu" aria-expanded="false" aria-controls="navbar">
                        <span class="visually-hidden">Toggle navigation</span>
                        <span class="icon-bar"></span>
                        <span class="icon-bar"></span>
                        <span class="icon-bar"></span>
                        <span class="navbar-hamburger-button__text"></span>
                    </button>
                </div>

                <div id="navActionButtons" class="btn-group navbar-hover-color" role="group" aria-label="...">
                    <a id="ctl00_ctl51_lnkSubscribe" class="btn btn-default navbar-button" href="https://shop.lww.com/p/1528-4050" target="_blank">Subscribe</a>
                            
                    <a id="ctl00_ctl51_lnkRegister" class="btn btn-default navbar-button" href="https://journals.lww.com/co-allergy/pages/register.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx">Register</a>
                    

                    
                    <button class="user-menu__link user-menu__link--login js-ejp-login-btn btn btn-default navbar-button" type="button" data-config="{&quot;eventName&quot;:&quot;login&quot;,&quot;eventDetail&quot;:{},&quot;isNull&quot;:false}">
                        <span>Login</span>
                    </button>
                    
                </div>
                <div id="ctl00_ctl51_TopNavigationMenuConfiguration" style="display:none" class="js-top-navigation-menu-configuration" data-config="{&quot;browsingHistory&quot;:{&quot;isEnabled&quot;:true,&quot;serviceUrl&quot;:&quot;https://ee.lww.com/engagementengine-api/api&quot;,&quot;pdfDownloadUrl&quot;:&quot;/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=HistoryTab&quot;}}"></div>
                <div id="zz1_TopNavigationMenu" class="navbar-collapse collapse js-top-navigation-menu noindex ms-core-listMenu-horizontalBox">
	<ul id="zz2_RootAspMenu" class="root ms-core-listMenu-root static">
		<li class="static dynamic-children"><span class="static dynamic-children menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode"><span aria-haspopup="true" class="additional-background ms-navedit-flyoutArrow dynamic-children"><span class="menu-item-text">Articles &amp; Issues</span></span></span><ul aria-hidden="true" class="dynamic">
			<li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/Pages/currenttoc.aspx" accesskey="1"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Current Issue</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/Pages/issuelist.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Previous Issues</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/toc/publishahead"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Published Ahead-of-Print</span></span></a></li>
		</ul></li><li class="static dynamic-children"><span class="static dynamic-children menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode"><span aria-haspopup="true" class="additional-background ms-navedit-flyoutArrow dynamic-children"><span class="menu-item-text">For Authors</span></span></span><ul aria-hidden="true" class="dynamic">
			<li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="https://preflight.paperpal.com/partner/lww/currentopinion/submit"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Submit a Manuscript</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/Pages/informationforauthors.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Information for Authors</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/_layouts/1033/oaks.journals/editservices.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Language Editing Services</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="https://cdn-tp2.mozu.com/16833-m1/cms/files/Author-Document.pdf?_mzts=636519775710000000"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Author Permissions</span></span></a></li>
		</ul></li><li class="static dynamic-children"><span class="static dynamic-children menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode"><span aria-haspopup="true" class="additional-background ms-navedit-flyoutArrow dynamic-children"><span class="menu-item-text">Journal Info</span></span></span><ul aria-hidden="true" class="dynamic">
			<li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/Pages/aboutthejournal.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">About the Journal</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/Pages/editorialboard.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Editorial Board</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="https://www.wolterskluwer.com/en/solutions/lippincott-audience-solutions/media-kits/current-opinion-in-allergy-and-clinical-immunology"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Advertising</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="http://www.wkopenhealth.com/"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Open Access</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/_layouts/1033/oaks.journals/subscriptionservices.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Subscription Services</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/_layouts/1033/oaks.journals/reprintsmedicine.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Reprints</span></span></a></li><li class="dynamic"><a class="dynamic menu-item ms-core-listMenu-item ms-displayInline ms-navedit-linkNode" href="/co-allergy/_layouts/1033/oaks.journals/rightsandpermissions.aspx"><span class="additional-background ms-navedit-flyoutArrow"><span class="menu-item-text">Rights and Permissions</span></span></a></li>
		</ul></li>
	</ul>
</div>

                
                

<div class="search-v2">

    <div class="search-wrapper">
        <select name="ctl00$ctl51$SearchBox$ddlContentScope" id="ctl00_ctl51_SearchBox_ddlContentScope">
	<option value="All">All</option>
	<option selected="selected" value="Articles">Articles</option>
	<option value="Images">Images</option>
	<option value="Videos">Videos</option>
	<option value="Podcasts">Podcasts</option>
	<option value="Blogs">Blogs</option>

</select>
        <div class="input-group" id="globalSearch">
            <input name="ctl00$ctl51$SearchBox$txtKeywords" type="text" value="Search" id="ctl00_ctl51_SearchBox_txtKeywords" class="form-control searchText" />
            <span class="input-group-btn">
                <button id="ctl00_ctl51_SearchBox_btnGlobalSearchMagnifier" type="submit" class="btn btn-default"><i class="fa fa-search"></i></button>
            </span>
            <input type="hidden" name="ctl00$ctl51$SearchBox$IsAutoCompleteEnabled" id="ctl00_ctl51_SearchBox_IsAutoCompleteEnabled" value="true" />
            <input type="hidden" name="ctl00$ctl51$SearchBox$AutocompleteApiUrl" id="ctl00_ctl51_SearchBox_AutocompleteApiUrl" value="https://platformservices.wolterskluwerhealth.com/autocomplete/COACI/shingle/" />
        </div>
    </div>

    <div class="advance-search" style="">
        <a id="ctl00_ctl51_SearchBox_lnkAdvanceSearch" href="https://journals.lww.com/co-allergy/pages/advancedsearch.aspx">Advanced Search</a>
        <input type="submit" name="ctl00$ctl51$SearchBox$btnGlobalSearch" value="" id="ctl00_ctl51_SearchBox_btnGlobalSearch" disabled="disabled" class="aspNetDisabled btnGlobalSearch" style="display: none;" />
        <input name="ctl00$ctl51$SearchBox$hfldKeywords" type="hidden" id="ctl00_ctl51_SearchBox_hfldKeywords" class="hfldKeywords" value="disableButton" />
    </div>

</div>
<script>
   
    $(function() {
        try {
            var objSearchBox = {
                btnGlobalSearchMagnifierId: 'ctl00_ctl51_SearchBox_btnGlobalSearchMagnifier',
                searchButtonId: 'ctl00_ctl51_SearchBox_btnGlobalSearch',
                txtKeywordsId: 'ctl00_ctl51_SearchBox_txtKeywords',
                hfldKeywordsHiddenId: 'ctl00_ctl51_SearchBox_hfldKeywords',
                defaultSearchText: 'Search'
            };

            new Searchbox(objSearchBox).Init();
        } catch (e) {
            console.error(e);
        }
    });

    //autocomplete functionality for basic search
    //this functionality will call the SBA url and start suggesting after typing 3rd character
    var textKeywords = null;
    var hiddenAutocompleteApiUrl = null;
    var buttonGlobalSearch = null;

    $(function () {
        try {
            var objAutocomplete = {
                hiddenIsAutoCompleteEnabled: $('#ctl00_ctl51_SearchBox_IsAutoCompleteEnabled'),
                textKeywords: $('#ctl00_ctl51_SearchBox_txtKeywords'),
                hiddenAutocompleteApiUrl: $('#ctl00_ctl51_SearchBox_AutocompleteApiUrl'),
                buttonGlobalSearch: $('#ctl00_ctl51_SearchBox_btnGlobalSearch'),
                enableNewAutoComplete: true,
                newAutoCompleteUrl: 'https://dxg-search-na-prd.wkgposvc.cloud/Query.svc/Query_Expand',
                newAutoCompleteMaxSuggestions: '10',
                newAutoCompleteDictionaryIds: 'ovid_sted28_mesh22'
            };

            autoComplete(objAutocomplete);
        } catch (e) {
            console.error(e);
        }
    });

    $(function () {
        let searchSelect = $('select[id$="ddlContentScope"]');;

        if (searchSelect.length){
            searchSelect.selectize();
        }
    });
</script>

            </nav>
        </div>
   </div>
</header>

                                
                <!-- topbanner start -->
                

<!-- topbanner start -->

<!-- topbanner end -->

                <!-- topbanner end -->

                <div id="main-container-content" class="wk-grid-page-container">

                    <div id="DeltaWebPartAdderUpdatePanelContainer" class="ms-core-webpartadder">
	
                        <div id="WebPartAdderUpdatePanelContainer">
                            <div id="ctl00_WebPartAdderUpdatePanel">
		
                                    <span id="ctl00_WebPartAdder"></span>
                                
	</div>
                        </div>
                    
</div>

                    <div id="notificationArea" class="ms-notif-box"></div>

                    <div id="DeltaPageStatusBar">
	
                        <div id="pageStatusBar"></div>
                    
</div>

                    <div id="DeltaPlaceHolderMain" class="delta-place-holder-main">
	
                        <a id="mainContent" name="mainContent" tabindex="-1"></a>
                        
                        
    

    


<DIV class="main-content"><div id="ctl00_PlaceHolderMain_ctl00_ctl01_row" class="dpl-row twocolumns flex flex-column" data-dpl-row-id="050ca00bc3f79d8466d96cb6e1c6" data-dpl-default-tag-name="div">

        <div id="ctl00_PlaceHolderMain_ctl00_ctl01_phColumns_ctl00_column" class="dpl-col main-content content" data-dpl-default-css-class="span-6-sm span-6-md" data-dpl-default-zone-id="LeftColumnOne" data-dpl-column-id="204762069032b02a7af9aa8e3e2a" data-dpl-default-tag-name="div">
            <div class="ms-webpart-zone ms-fullWidth">
		<div id="MSOZoneCell_WebPartctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="24334212-4918-4967-83d8-974af134a195" HasPers="false" id="WebPartctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195">

					<!-- ===== ASP._controltemplates_oaks_journals_journalinfousercontrol_ascx generated at 8/8/2025 3:52:44 AM ===== -->

					

<section id="wpCurrentIssue" class="content-box cb-collapsible wp-current-issue">
    <header class="ejp-heading-2">
        <h2 aria-expanded="false">
            Current Issue
        </h2>
    </header>
    <div class="content-box-body">
            <div class="thumb-image-container coverImage">
                <a id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_CoverImageHyperLink" class="cover-image" href="/co-allergy/pages/currenttoc.aspx"><img src="https://images.journals.lww.com/co-allergy/XLargeThumb.00130832-202508000-00000.CV.jpeg" class="preview-image" onmouseover="ImageWrapperControl_ShowRollOverCoverImage(&#39;https://images.journals.lww.com/co-allergy/LargeRollover.00130832-202508000-00000.CV.jpeg&#39;,&#39;400&#39;);" onmouseout="ImageWrapperControl_ImageMouseOut();" border="0" /></a>
            </div>

            <div>
                <h3 id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_CurrentIssueContainer">
                    <a title href="/co-allergy/pages/currenttoc.aspx"> August 2025 - Volume 25 - Issue 4</a>
                </h3>
                <ul>
                    <li id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_liEditorInChief">
                        <label id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_lblEditorInChief">Editor-in-Chief:</label>
                        <span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_editorInChiefLabel">G. Walter Canonica &<br/>Susan M Tarlo</span>
                    </li>
                    
                    
                    <li id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_liIssn">
                        <label>ISSN:</label>
                        <span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_issnLabel">1528-4050</span>
                    </li>
                    <li id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_liOnlineIssn">
                        <label>Online ISSN:</label>
                        <span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_onlineIssnLabel">1473-6322</span>
                    </li>
                    <li id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_liFrequency">
                        <label>Frequency:</label>
                        <span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_frequencyLabel">6 issues / year</span>
                    </li>
                    <li id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_liRanking">
                        <label>Ranking:</label>
                        <span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_rankingLabel">18 of 39 Allergy<br>118 of 183 Immunology</span>
                    </li>
                    <li id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_liImpactFactor">
                        <label>Impact Factor:</label>
                        <span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_impactFactorLabel">2.6</span>
                    </li>
                    
                    
                </ul>

                <div class="content-box-body__links">
                    <div class="subscribe-to-etoc">
                        <span title="alarm-on" class="wk-icon-alarm-on"></span>
                        <a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);;" onclick="javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);"><span id="ctl00_ctl29_g_24334212_4918_4967_83d8_974af134a195_ctl00_alertLinkControl_defaultText" class="hideOnFixed">eTOC Alert</span></a>

                    </div>
                    


                    

    <script type="text/javascript">
        function popupwindow(url, title, w, h) {
            var left = (screen.width / 2) - (w / 2);
            var top = (screen.height / 2) - (h / 2);
            return window.open(url, title, 'toolbar=no, location=no, directories=no, status=no, menubar=no, scrollbars=yes, resizable=yes, width=' + w + ', height=' + h + ', top=' + top + ', left=' + left);
        }
    </script>

    

                </div>
            </div> 
    </div>
</section>

				</div><div class="ms-clear"></div></div>
			</div><div class="ms-PartSpacingVertical"></div>
		</div><div id="MSOZoneCell_WebPartctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="fdd2376e-e054-4e50-972c-27dff082bba6" HasPers="false" id="WebPartctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6">
					<script type="text/javascript" src="https://lww.com/_layouts/15/1033/Scripts/wk/EmailToColleague.js?v=05.25.00.229" defer="true">

					</script>

<a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_hypEmailToColleague" href="javascript:" style="display:none;"></a>


<div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_pnlEmailToColleague" class="wk-modal-table" style="display: none">
						
    <div class="wk-modal-cell">
        <div id="ej-box-modal-drop-shadow" class="wk-modal horizontally-centered small wk-modal-with-overlay wk-modal-small ejp-modal email-to-colleague" tabindex="-1" role="dialog" style="position: static;">
            <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_pnlMain" class="js-main-panel">
							
                <section class="wk-modal-content">
                    <header class="wk-modal-header ejp-modal-header">
                        <div class="wk-modal-title ejp-modal-title">
                            <strong>
                                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_lblEmailToColleague">Email to Colleague</span></strong>
                        </div>
                        <button aria-label="close dialog" class="primary-button wk-button-icon wk-modal-close ejp-modal-close js-close ">
                            <i class="fa fa-times"></i>
                        </button>
                    </header>
                    <div class="wk-modal-body">
                        <div class="wk-field-item">
                            <div class="wk-field-header">
                                <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_divErrorMessage" class="js-error-message-div ej-error-message-panel" style="display: none; color: red; font-style: italic">
                                    <p class="ej-error-message-icon">
                                        <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_lblErrorMessage" class="js-error-message-label">Colleague's E-mail is Invalid</span>
                                    </p>
                                </div>
                            </div>
                        </div>
                        <div class="wk-field-item">
                            <div class="wk-field-header">
                                Your Name:
                            </div>
                            <div class="wk-field-body">
                                <input name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$txtYourName" type="text" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_txtYourName" class="js-name" />
                            </div>

                        </div>

                        <div class="wk-field-item">
                            <div class="wk-field-header">
                                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_lblColleaguesEmail" class="js-collegaues-email-lbl">Colleague's Email:</span>

                            </div>
                            <div class="wk-field-body no-bottom-margin">
                                <input name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$txtColleaguesEmail" type="text" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_txtColleaguesEmail" class="js-collegaues-email" />
                            </div>
                            <div class="wk-field-header"><span class="ej-form-comments">Separate multiple e-mails with a (;).</span></div>
                        </div>
                        <div class="wk-field-item">
                            <div class="wk-field-header">
                                Message:
                            </div>
                            <div class="wk-field-body">
                                <textarea name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$txtMessage" rows="2" cols="20" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_txtMessage" class="js-message">
Thought you might appreciate this item(s) I saw in Current Opinion in Allergy and Clinical Immunology.</textarea>
                            </div>

                        </div>
                        <div class="wk-button-bar">
                            <div class="wk-button-group-left">
                                <input type="submit" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$btnSend" value="Send" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_btnSend" class="js-send-button primary-button grecaptcha-email-colleague-719a546064eb4138aeb46bbf854a88a0" />
                                <input type="button" value="Cancel" id="btnCancel" class="secondary-button js-close" />
                            </div>
                        </div>
                        <div class="wk-field-item wk-email-colleague-captcha-bar">
                            <div class="wk-field-body">
                                

<div id="div-recaptcha-719a546064eb4138aeb46bbf854a88a0" class="div-recaptcha-container" data-uniqueclassidentifier="grecaptcha-email-colleague-719a546064eb4138aeb46bbf854a88a0"
        data-sitekey="6LeeoSAUAAAAACFv8yNuINPv8IWyXHJ6uN447qEK"
        data-callback="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_captchaCallBack"
        data-badge="inline"
        data-size="invisible"
        data-type="image" >
</div>


                            </div>
                        </div>
                    </div>
                </section>
            
						</div>
            <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_pnlSuccessMessage" class="js-success-message-panel" style="display: none;">
							
                <section class="wk-modal-content">
                    <header class="wk-modal-header ejp-modal-header">
                        <div class="wk-modal-title ejp-modal-title"></div>
                        <button aria-label="close dialog" class="primary-button wk-button-icon wk-modal-close ejp-modal-close js-close "><i class="fa fa-times"></i></button>
                    </header>
                    <div class="wk-modal-body">
                        <div class="wk-field-item">
                            <br />
                            <p>
                                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_lblMessageSent">Your message has been successfully sent to your colleague.</span>
                            </p>
                            <br />
                        </div>
                        <div class="wk-button-bar">
                            <div class="wk-button-group-left">
                                <input type="button" value="Close Window" id="btnClose" class="primary-button js-close" />
                            </div>
                        </div>
                    </div>
                </section>
            
						</div>
            <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_pnlErrorMessage" class="js-error-message-panel" style="display: none;">
							
                <section class="wk-modal-content">
                    <header class="wk-modal-header ejp-modal-header">
                        <div class="wk-modal-title ejp-modal-title"></div>
                        <button aria-label="close dialog" class="primary-button wk-button-icon wk-modal-close ejp-modal-close js-close "><i class="fa fa-times"></i></button>
                    </header>
                    <div class="wk-modal-body">
                        <br />
                        <div class="wk-field-item">
                            <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_lblInvalidEmail"><font color="Red">Some error has occurred while processing your request. Please try after some time.</font></span>
                        </div>
                        <br />
                        <div class="wk-button-bar">
                            <div class="wk-button-group-left">
                                <input type="button" value="Close Window" id="btnEClose" class="primary-button js-close" />
                            </div>
                        </div>
                    </div>
                </section>
            
						</div>
        </div>
        <input type="hidden" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$hiddenEmailToColleague" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_hiddenEmailToColleague" />
        <input type="hidden" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$hiddenIsUser" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_hiddenIsUser" />
    </div>

					</div>

<script type="text/javascript">
    window.emailToColleaguePopups = window.emailToColleaguePopups || [];

    var ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_captchaCallBack = function () {
        ejpAnalytics.track('emailColleaguereCAPTCHA');
        ejpAnalytics.track('emailColleagueComplete');
        __doPostBack('ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl00$btnSend','')
    };
    var initEmailToColleaguectl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00 = function () {
        window.emailToColleaguePopups['ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00'] = new
            EmailToColleagueComponent('ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_pnlEmailToColleague',
                'div-recaptcha-719a546064eb4138aeb46bbf854a88a0',
                'grecaptcha-email-colleague-719a546064eb4138aeb46bbf854a88a0',
                'emailToColleaguePopupExtender_1969857039',
                'ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_hiddenEmailToColleague',
                'ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_hiddenIsUser',
                ''
            );
    }
    Sys.WebForms.PageRequestManager.getInstance().add_pageLoaded(initEmailToColleaguectl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00);
</script>
<script type="text/javascript" src="https://lww.com/_layouts/15/1033/Scripts/wk/ExportToCitationManager.js?v=05.25.00.229" defer="true">

					</script>

<a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_hypExportToCitationManager" href="javascript:" style="display:none;"></a>

<div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_pnlExportTo" style="display: none">
						
    <div id="ej-box-modal-drop-shadow">
        <div id="ej-box-modal-style-1"  tabindex="-1" role="dialog" class="wk-modal wk-modal-with-overlay wk-modal-small ejp-modal horizontally-centered" data-behaviorid="OpenExportToPopupExtender__1218782419">
            <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_pnlMainExport">
							
                <section class="wk-modal-content">
                    <header class="wk-modal-header ejp-modal-header">
                        <div class="wk-modal-title ejp-modal-title"><strong>Export to</strong></div>
                        <button onclick="return closeExportToModalPopUp();" aria-label="close dialog" class="primary-button wk-button-icon wk-modal-close ejp-modal-close "><i class="fa fa-times"></i></button>
                    </header>
                    <div class="wk-modal-body">
                        <div class="wk-field-item">
                            <fieldset>
                                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes"><input id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes_0" type="radio" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$radioBtnExportTypes" value="EndNote" checked="checked" /><label for="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes_0">End Note</label><br /><input id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes_1" type="radio" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$radioBtnExportTypes" value="Procite" /><label for="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes_1">Procite</label><br /><input id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes_2" type="radio" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$radioBtnExportTypes" value="ReferenceManager" /><label for="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes_2">Reference Manager</label></span>
                            </fieldset>
                            <p>
                                <label for="default">
                                    <input id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_checkBoxSaveMySelection" type="checkbox" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$checkBoxSaveMySelection" /><label for="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_checkBoxSaveMySelection">Save my selection</label>
                                </label>
                            </p>
                            <div class="wk-button-bar">
                                <div class="wk-button-group-left">
                                    <input type="submit" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$btnOpenExportDialog" value="Export" onclick="return validateExportType();WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$btnOpenExportDialog&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, false))" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_btnOpenExportDialog" class="primary-button" />
                                    <input type="submit" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$btnCancelOpenExportDialog" value="Cancel" onclick="return closeExportToModalPopUp();WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$btnCancelOpenExportDialog&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, false))" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_btnCancelOpenExportDialog" class="secondary-button" />
                                    <p id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_pUnsubscribeButtons">
                                    </p>
                                </div>
                            </div>
                        </div>
                    </div>
                </section>
            
						</div>
        </div>
    </div>
    <div id="ej-clear-float"></div>
    <input type="hidden" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl01$hiddenExportType" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_hiddenExportType" />

					</div>

<script type="text/javascript">
    var hiddenExportType = $get('ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_hiddenExportType');
    function getExportPopup() { return $find('OpenExportToPopupExtender__1218782419'); }
    var pnlMainExport = $get('ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_pnlMainExport');

    document.addEventListener('DOMContentLoaded', function () {
        function dispatchCustomEvent(eventName) {
            try {
                document.dispatchEvent(new CustomEvent(eventName));
            } catch (error) {
                console.error('Error dispatching custom event:', error);
            }
        }

        try {
            var exportButton = document.getElementById('ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_btnOpenExportDialog');
            var radioButtons = document.querySelectorAll('#ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_radioBtnExportTypes input[type=radio]');

            exportButton.addEventListener('click', function (event) {
                var selectedRadioButton = Array.from(radioButtons).find(rb => rb.checked);
                if (selectedRadioButton) {
                    var selectedValue = selectedRadioButton.value;
                    var eventName = '';

                    switch (selectedValue) {
                        case "Procite":
                        case "ReferenceManager":
                            eventName = 'omni:articletools:cite:ris';
                            break;
                        case 'EndNote':
                            eventName = 'omni:articletools:cite:endnote';
                            break;
                        default:
                            eventName = '';
                    }

                    if (eventName) {
                        dispatchCustomEvent(eventName);
                    } else {
                        console.warn('No event name matched for the selected radio button value:', selectedValue);
                    }
                } else {
                    console.warn('No radio button selected');
                }
            });
        } catch (error) {
            console.error('Error initializing event listeners:', error);
        }
    });
</script>

					<!-- ===== ASP._controltemplates_oaks_journals_articlenavigatorusercontrol_ascx generated at 8/8/2025 3:52:44 AM ===== -->

					
<!--link tag emitted to support printing-->
<link rel="stylesheet" type="text/css" href="https://lww.com/_layouts/1033/styles/oaks.journals/print-toc-current.css?v=05.25.00.229" media="print" />

<section class="content-box">
   <header id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_titleContainer" class="ejp-heading-2">
        <h2>
            Current Issue Highlights
        </h2>
    </header>
    
        
        <div class="article-list">
            
            
            

<section id="wp-articles-navigator" class="content-box">
    <header>     
        <h3 aria-expanded="false"> 

            <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_btnToggle">
                <a onclick="javascript: showHide('SubSectionContainer_686400982', 'SimpleImage1_1610379600');">
                 <img id="SimpleImage1_1610379600" src="/_layouts/1033/IMAGES/OAKS.Journals/icon-minus.gif" alt="Collapse Box" border="0" />
                </a>
            </a>                
            EDITORIAL INTRODUCTIONS
        </h3>
        <hr />
    </header>
    <div id="SubSectionContainer_686400982">
						

        <div class="wp-feature-articles">
        
                


                
    

<span id="-1917741488"></span>





<div id="itemListContainer_1338802680" style="overflow: hidden;">
							
    
        
        
        


<article>
    <div>
        <div class="ej-article-input-fluid article">
            <label class="chkSelect">
                
            </label>
        </div>
        <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleThumb" class="article-thumb">
            <a title href="https://journals.lww.com/co-allergy/fulltext/2025/08000/editorial_introductions.1.aspx">
                <img srcset="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00001.figure1.jpeg 1x,https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize@2.00130832-202508000-00001.figure1.jpeg 2x" src="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00001.figure1.jpeg" class border="0" />
            </a>
            
        </div>
        <div>
            
            <header>
                <h4><a title="Editorial introductions" href="https://journals.lww.com/co-allergy/fulltext/2025/08000/editorial_introductions.1.aspx">Editorial introductions</a></h4>
            </header>
            <div class="js-few-authors">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAuthors" class="authors"></span>
            </div>
            <div class="js-all-authors" style="display:none">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAllAuthors" class="authors"> <span><a class='wp-feature-articles__authors-expand' onclick='showFewAuthors(this);'>Less</a></span></span>
            </div>
            
                <p class="featuredArticleCitation" id="paraArticleCitation">
                    <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_lblLegacyJournalTitle" class="journalTitleInSearch">Current Opinion in Allergy and Clinical Immunology.</span>
                    25(4):v-vi, August 2025.
                </p>
            
            
            <p class="ej-featured-article-doi">
                
                
            </p>

            
            
            
            
			<ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAbstract" class="article-precis">
                
                

                 

			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liAddToMyCollections">
                    <button class="user-menu__link user-menu__link--add-to-favorites js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;AddToFavorites&quot;,&quot;eventDetail&quot;:{&quot;items&quot;:[&quot;Article|co-allergy:2025:08000:00001|10.1097/aci.0000000000001080|&quot;],&quot;an&quot;:&quot;00130832-202508000-00001&quot;},&quot;eventOptions&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false},&quot;loginDetail&quot;:{&quot;isLoginOptional&quot;:false,&quot;promptLogin&quot;:true,&quot;loginPromptText&quot;:&quot;To save this item, login or register&quot;},&quot;isNull&quot;:false}">
                        <i class="wk-icon-star display-control-tools-icon" aria-hidden="true"></i><span>Favorite</span>
                    </button>
			    </li>
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liPDFEntitled">
			        <button class="user-menu__link user-menu__link--download js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;PDFDownloadInit&quot;,&quot;eventDetail&quot;:{&quot;url&quot;:&quot;https://journals.lww.com/co-allergy/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleDisplayControl&amp;an=00130832-202508000-00001&quot;,&quot;gating&quot;:false},&quot;eventOptions&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false},&quot;loginDetail&quot;:{&quot;isLoginOptional&quot;:true,&quot;promptLogin&quot;:false},&quot;isNull&quot;:false}">
                        <i class="wk-icon-file-pdf display-control-tools-icon" aria-hidden="true"></i><span>PDF</span>
                    </button>
			    </li>
			    
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liPermissionsLink">
			        <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_hypPermissionsLink" onclick="showRightsLinkPopUp(&#39;https://s100.copyright.com/AppDispatchServlet&#39;, &#39;WoltersKluwer&#39;, &#39;ACI&#39;, &#39;Editorial introductions&#39;, &#39;06262025&#39;, &#39;&#39;, &#39;25&#39;, &#39;4&#39;, &#39;Copyright \u00A9 2025 Wolters Kluwer Health, Inc. All rights reserved.&#39;, &#39;00130832-202508000-00001&#39;, &#39;&#39;, true, &#39;&#39;)" href="javascript:">
                        <i class="article-precis__icon-copyright display-control-tools-icon" aria-hidden="true"></i>Permissions
                    </a>
			    </li>
			</ul>
			
            

            

            

            <ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleindicator" class="article-actions">
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liFree">
                    <div onmouseover="javascript:Tooltip_Free()" onmouseout="javascript:Tooltip_MouseOut()">
								
                        <a title href="https://journals.lww.com/co-allergy/fulltext/2025/08000/editorial_introductions.1.aspx"><span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl0_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_spanFree" class="ejp-indicator ejp-indicator--free">Free</span></a> <!--Free-->
                    
							</div>
                </li>
                    
                           
                
                
                
                
                
                 
                
                
                
                
                
                

                
               


                
                
                
                
                
                 
                 
                
    </ul>
            
    

            
            
            
</div>
</div>

   
</article>


    
    


						</div>




            
            
        </div>

    
					</div>
    
</section>

            
        
            
            

<section id="wp-articles-navigator" class="content-box">
    <header>     
        <h3 aria-expanded="false"> 

            <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_btnToggle">
                <a onclick="javascript: showHide('SubSectionContainer__1576696201', 'SimpleImage1_1418211377');">
                 <img id="SimpleImage1_1418211377" src="/_layouts/1033/IMAGES/OAKS.Journals/icon-minus.gif" alt="Collapse Box" border="0" />
                </a>
            </a>                
            DRUG ALLERGY
        </h3>
        <hr />
    </header>
    <div id="SubSectionContainer__1576696201">
						

        <div class="wp-feature-articles">
        
                


                
    

<span id="1371044140"></span>



<div class="ej-toc-subheader">
							
    <h4>Edited by Luciana Tanno and Dean Naisbitt</h4>
    <hr />

						</div>

<div id="itemListContainer_1740354329" style="overflow: hidden;">
							
    
        
        
        


<article>
    <div>
        <div class="ej-article-input-fluid article">
            <label class="chkSelect">
                
            </label>
        </div>
        <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleThumb" class="article-thumb">
            <a title href="https://journals.lww.com/co-allergy/abstract/2025/08000/the_role_of_regulatory_t_cells_in_preventing_the.2.aspx">
                <img srcset="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00002.FB1.jpeg 1x,https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize@2.00130832-202508000-00002.FB1.jpeg 2x" src="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00002.FB1.jpeg" class border="0" />
            </a>
            
        </div>
        <div>
            
            <header>
                <h4><a title="The role of regulatory T cells in preventing the development of drug hypersensitivity reactions" href="https://journals.lww.com/co-allergy/abstract/2025/08000/the_role_of_regulatory_t_cells_in_preventing_the.2.aspx">The role of regulatory T cells in preventing the development of drug hypersensitivity reactions</a></h4>
            </header>
            <div class="js-few-authors">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAuthors" class="authors">MacDonald, Lonnie; Mitchell, Megan; Thomson, Paul</span>
            </div>
            <div class="js-all-authors" style="display:none">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAllAuthors" class="authors">MacDonald, Lonnie; Mitchell, Megan; Thomson, Paul <span><a class='wp-feature-articles__authors-expand' onclick='showFewAuthors(this);'>Less</a></span></span>
            </div>
            
                <p class="featuredArticleCitation" id="paraArticleCitation">
                    <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_lblLegacyJournalTitle" class="journalTitleInSearch">Current Opinion in Allergy and Clinical Immunology.</span>
                    25(4):221-229, August 2025.
                </p>
            
            
            <p class="ej-featured-article-doi">
                
                
            </p>

            
            
            
            
			<ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAbstract" class="article-precis">
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liAbstract">
                    <div id="absShow_1759116229">
								
                        <a an="00130832-202508000-00002" rel="opener" title href="javascript:void(0);" onclick="javascript:adcShowAbs(&#39;pnlAbstractText_782200185&#39;, &#39;pAbstractText__1903792325&#39;, &#39;Article|co-allergy:2025:08000:00002|10.1097/aci.0000000000001083|&#39;, &#39;absShow_1759116229&#39;, &#39;absHide__1782984348&#39;, &#39;&#39;, &#39;00130832-202508000-00002&#39;);"><i class="wk-icon-plus-circle display-control-tools-icon" aria-hidden="true"></i>Abstract</a>
                    
							</div>
                    <div id="absHide__1782984348" style="display: none">
								
                        <a href="javascript:void(0);" onclick="javascript:adcHideAbs('pnlAbstractText_782200185', 'absShow_1759116229', 'absHide__1782984348');">
                            <i class="wk-icon-minus-circle display-control-tools-icon"></i>Abstract
                        </a>
                    
							</div>
                </li>
                

                 

			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liAddToMyCollections">
                    <button class="user-menu__link user-menu__link--add-to-favorites js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;AddToFavorites&quot;,&quot;eventDetail&quot;:{&quot;items&quot;:[&quot;Article|co-allergy:2025:08000:00002|10.1097/aci.0000000000001083|&quot;],&quot;an&quot;:&quot;00130832-202508000-00002&quot;},&quot;eventOptions&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false},&quot;loginDetail&quot;:{&quot;isLoginOptional&quot;:false,&quot;promptLogin&quot;:true,&quot;loginPromptText&quot;:&quot;To save this item, login or register&quot;},&quot;isNull&quot;:false}">
                        <i class="wk-icon-star display-control-tools-icon" aria-hidden="true"></i><span>Favorite</span>
                    </button>
			    </li>
			    
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liPDF">
			        <div>
								
			            <i class="wk-icon-file-pdf display-control-tools-icon" aria-hidden="true"></i>
			            <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_lblPDF">PDF</span>
			        
							</div>
			    </li>
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liPermissionsLink">
			        <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_hypPermissionsLink" onclick="showRightsLinkPopUp(&#39;https://s100.copyright.com/AppDispatchServlet&#39;, &#39;WoltersKluwer&#39;, &#39;ACI&#39;, &#39;The role of regulatory T cells in preventing the development of drug hypersensitivity reactions&#39;, &#39;06112025&#39;, &#39;Lonnie MacDonald, Megan Mitchell, and Paul Thomson&#39;, &#39;25&#39;, &#39;4&#39;, &#39;Copyright \u00A9 2025 Wolters Kluwer Health, Inc. All rights reserved.&#39;, &#39;00130832-202508000-00002&#39;, &#39;&#39;, false, &#39;&#39;)" href="javascript:">
                        <i class="article-precis__icon-copyright display-control-tools-icon" aria-hidden="true"></i>Permissions
                    </a>
			    </li>
			</ul>
			
            <div id="pnlAbstractText_782200185" class="panel panel-default" style="display: none;">
								
                <div id="pAbstractText__1903792325">
									
                    
                
								</div>

                <p>
                    <div>
									
                        <a title href="https://journals.lww.com/co-allergy/secure/pages/purchase.aspx?an=00130832-202508000-00002"></a>
                    
								</div>
                </p>

                
            
							</div>

            

            

            <ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleindicator" class="article-actions">
                
                    
                           
                
                
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liBuy">
                    <div id="ej-article-indicators-buy" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
								
                       <a title href="https://journals.lww.com/co-allergy/abstract/2025/08000/the_role_of_regulatory_t_cells_in_preventing_the.2.aspx#ContentAccessOptions"><span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_spanBuy" class="ejp-indicator ejp-indicator--buy">Buy</span></a><!--Buy-->
                    
							</div>
                </li>
                
                
                 
                
                
                
                
                
                

                
               


                
                
                
                
                
                 
                 
                
    </ul>
            
    

            
            
            
</div>
</div>

   
</article>


    
        
        


<article>
    <div>
        <div class="ej-article-input-fluid article">
            <label class="chkSelect">
                
            </label>
        </div>
        <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleThumb" class="article-thumb">
            <a title href="https://journals.lww.com/co-allergy/abstract/2025/08000/immune_phenotyping_impacts_on_management_of_severe.3.aspx">
                <img srcset="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00003.FB1.jpeg 1x,https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize@2.00130832-202508000-00003.FB1.jpeg 2x" src="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00003.FB1.jpeg" class border="0" />
            </a>
            
        </div>
        <div>
            
            <header>
                <h4><a title="Immune phenotyping impacts on management of severe cutaneous adverse reaction" href="https://journals.lww.com/co-allergy/abstract/2025/08000/immune_phenotyping_impacts_on_management_of_severe.3.aspx">Immune phenotyping impacts on management of severe cutaneous adverse reaction</a></h4>
            </header>
            <div class="js-few-authors">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleAuthors" class="authors">Hayashi, Ryota; Abe, Riichiro</span>
            </div>
            <div class="js-all-authors" style="display:none">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleAllAuthors" class="authors">Hayashi, Ryota; Abe, Riichiro <span><a class='wp-feature-articles__authors-expand' onclick='showFewAuthors(this);'>Less</a></span></span>
            </div>
            
                <p class="featuredArticleCitation" id="paraArticleCitation">
                    <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_lblLegacyJournalTitle" class="journalTitleInSearch">Current Opinion in Allergy and Clinical Immunology.</span>
                    25(4):230-236, August 2025.
                </p>
            
            
            <p class="ej-featured-article-doi">
                
                
            </p>

            
            
            
            
			<ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleAbstract" class="article-precis">
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liAbstract">
                    <div id="absShow__2070123808">
								
                        <a an="00130832-202508000-00003" rel="opener" title href="javascript:void(0);" onclick="javascript:adcShowAbs(&#39;pnlAbstractText__1678408546&#39;, &#39;pAbstractText__671001344&#39;, &#39;Article|co-allergy:2025:08000:00003|10.1097/aci.0000000000001082|&#39;, &#39;absShow__2070123808&#39;, &#39;absHide_127867327&#39;, &#39;&#39;, &#39;00130832-202508000-00003&#39;);"><i class="wk-icon-plus-circle display-control-tools-icon" aria-hidden="true"></i>Abstract</a>
                    
							</div>
                    <div id="absHide_127867327" style="display: none">
								
                        <a href="javascript:void(0);" onclick="javascript:adcHideAbs('pnlAbstractText__1678408546', 'absShow__2070123808', 'absHide_127867327');">
                            <i class="wk-icon-minus-circle display-control-tools-icon"></i>Abstract
                        </a>
                    
							</div>
                </li>
                

                 

			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liAddToMyCollections">
                    <button class="user-menu__link user-menu__link--add-to-favorites js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;AddToFavorites&quot;,&quot;eventDetail&quot;:{&quot;items&quot;:[&quot;Article|co-allergy:2025:08000:00003|10.1097/aci.0000000000001082|&quot;],&quot;an&quot;:&quot;00130832-202508000-00003&quot;},&quot;eventOptions&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false},&quot;loginDetail&quot;:{&quot;isLoginOptional&quot;:false,&quot;promptLogin&quot;:true,&quot;loginPromptText&quot;:&quot;To save this item, login or register&quot;},&quot;isNull&quot;:false}">
                        <i class="wk-icon-star display-control-tools-icon" aria-hidden="true"></i><span>Favorite</span>
                    </button>
			    </li>
			    
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liPDF">
			        <div>
								
			            <i class="wk-icon-file-pdf display-control-tools-icon" aria-hidden="true"></i>
			            <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_lblPDF">PDF</span>
			        
							</div>
			    </li>
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liPermissionsLink">
			        <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_hypPermissionsLink" onclick="showRightsLinkPopUp(&#39;https://s100.copyright.com/AppDispatchServlet&#39;, &#39;WoltersKluwer&#39;, &#39;ACI&#39;, &#39;Immune phenotyping impacts on management of severe cutaneous adverse reaction&#39;, &#39;06122025&#39;, &#39;Ryota Hayashi and Riichiro Abe&#39;, &#39;25&#39;, &#39;4&#39;, &#39;Copyright \u00A9 2025 Wolters Kluwer Health, Inc. All rights reserved.&#39;, &#39;00130832-202508000-00003&#39;, &#39;&#39;, false, &#39;&#39;)" href="javascript:">
                        <i class="article-precis__icon-copyright display-control-tools-icon" aria-hidden="true"></i>Permissions
                    </a>
			    </li>
			</ul>
			
            <div id="pnlAbstractText__1678408546" class="panel panel-default" style="display: none;">
								
                <div id="pAbstractText__671001344">
									
                    
                
								</div>

                <p>
                    <div>
									
                        <a title href="https://journals.lww.com/co-allergy/secure/pages/purchase.aspx?an=00130832-202508000-00003"></a>
                    
								</div>
                </p>

                
            
							</div>

            

            

            <ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleindicator" class="article-actions">
                
                    
                           
                
                
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liBuy">
                    <div id="ej-article-indicators-buy" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
								
                       <a title href="https://journals.lww.com/co-allergy/abstract/2025/08000/immune_phenotyping_impacts_on_management_of_severe.3.aspx#ContentAccessOptions"><span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl1_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_spanBuy" class="ejp-indicator ejp-indicator--buy">Buy</span></a><!--Buy-->
                    
							</div>
                </li>
                
                
                 
                
                
                
                
                
                

                
               


                
                
                
                
                
                 
                 
                
    </ul>
            
    

            
            
            
</div>
</div>

   
</article>


    
    


						</div>




            
            
        </div>

    
					</div>
    
</section>

            
        
            
            

<section id="wp-articles-navigator" class="content-box">
    <header>     
        <h3 aria-expanded="false"> 

            <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_btnToggle">
                <a onclick="javascript: showHide('SubSectionContainer_42526356', 'SimpleImage1_356307086');">
                 <img id="SimpleImage1_356307086" src="/_layouts/1033/IMAGES/OAKS.Journals/icon-minus.gif" alt="Collapse Box" border="0" />
                </a>
            </a>                
            PHARMACOTHERAPY AND EVIDENCE-BASED MEDICINE
        </h3>
        <hr />
    </header>
    <div id="SubSectionContainer_42526356">
						

        <div class="wp-feature-articles">
        
                


                
    

<span id="1182555242"></span>



<div class="ej-toc-subheader">
							
    <h4>Edited by Giovanni Paoletti and Danilo Di Bona</h4>
    <hr />

						</div>

<div id="itemListContainer_847724090" style="overflow: hidden;">
							
    
        
        
        


<article>
    <div>
        <div class="ej-article-input-fluid article">
            <label class="chkSelect">
                
            </label>
        </div>
        
        <div>
            
            <header>
                <h4><a title="Editorial: pharmacotherapy and evidence-based medicine in allergy and clinical immunology—2025 updates and perspectives" href="https://journals.lww.com/co-allergy/citation/2025/08000/editorial__pharmacotherapy_and_evidence_based.5.aspx">Editorial: pharmacotherapy and evidence-based medicine in allergy and clinical immunology—2025 updates and perspectives</a></h4>
            </header>
            <div class="js-few-authors">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAuthors" class="authors">Paoletti, Giovanni; Cavaglià, Edoardo; Di Biase, Andrea; <span><a class='wp-feature-articles__authors-expand' onclick='showAllAuthors(this);'>More</a></span></span>
            </div>
            <div class="js-all-authors" style="display:none">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAllAuthors" class="authors">Paoletti, Giovanni; Cavaglià, Edoardo; Di Biase, Andrea; Di Bona, Danilo <span><a class='wp-feature-articles__authors-expand' onclick='showFewAuthors(this);'>Less</a></span></span>
            </div>
            
                <p class="featuredArticleCitation" id="paraArticleCitation">
                    <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_lblLegacyJournalTitle" class="journalTitleInSearch">Current Opinion in Allergy and Clinical Immunology.</span>
                    25(4):245-246, August 2025.
                </p>
            
            
            <p class="ej-featured-article-doi">
                
                
            </p>

            
            
            
            
			<ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleAbstract" class="article-precis">
                
                

                 

			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liAddToMyCollections">
                    <button class="user-menu__link user-menu__link--add-to-favorites js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;AddToFavorites&quot;,&quot;eventDetail&quot;:{&quot;items&quot;:[&quot;Article|co-allergy:2025:08000:00005|10.1097/aci.0000000000001087|&quot;],&quot;an&quot;:&quot;00130832-202508000-00005&quot;},&quot;eventOptions&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false},&quot;loginDetail&quot;:{&quot;isLoginOptional&quot;:false,&quot;promptLogin&quot;:true,&quot;loginPromptText&quot;:&quot;To save this item, login or register&quot;},&quot;isNull&quot;:false}">
                        <i class="wk-icon-star display-control-tools-icon" aria-hidden="true"></i><span>Favorite</span>
                    </button>
			    </li>
			    
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liPDF">
			        <div>
								
			            <i class="wk-icon-file-pdf display-control-tools-icon" aria-hidden="true"></i>
			            <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_lblPDF">PDF</span>
			        
							</div>
			    </li>
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liPermissionsLink">
			        <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_hypPermissionsLink" onclick="showRightsLinkPopUp(&#39;https://s100.copyright.com/AppDispatchServlet&#39;, &#39;WoltersKluwer&#39;, &#39;ACI&#39;, &#39;Editorial: pharmacotherapy and evidence-based medicine in allergy and clinical immunology—2025 updates and perspectives&#39;, &#39;06262025&#39;, &#39;Giovanni Paoletti, Edoardo Cavagli\u00E0, Andrea Di Biase, et al&#39;, &#39;25&#39;, &#39;4&#39;, &#39;Copyright \u00A9 2025 Wolters Kluwer Health, Inc. All rights reserved.&#39;, &#39;00130832-202508000-00005&#39;, &#39;&#39;, false, &#39;&#39;)" href="javascript:">
                        <i class="article-precis__icon-copyright display-control-tools-icon" aria-hidden="true"></i>Permissions
                    </a>
			    </li>
			</ul>
			
            

            

            

            <ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_articleindicator" class="article-actions">
                
                    
                           
                
                
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_liBuy">
                    <div id="ej-article-indicators-buy" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
								
                       <a title href="https://journals.lww.com/co-allergy/citation/2025/08000/editorial__pharmacotherapy_and_evidence_based.5.aspx#ContentAccessOptions"><span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl0_itemDisplayControl_ctl00_spanBuy" class="ejp-indicator ejp-indicator--buy">Buy</span></a><!--Buy-->
                    
							</div>
                </li>
                
                
                 
                
                
                
                
                
                

                
               


                
                
                
                
                
                 
                 
                
    </ul>
            
    

            
            
            
</div>
</div>

   
</article>


    
        
        


<article>
    <div>
        <div class="ej-article-input-fluid article">
            <label class="chkSelect">
                
            </label>
        </div>
        <div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleThumb" class="article-thumb">
            <a title href="https://journals.lww.com/co-allergy/abstract/2025/08000/algorithms_for_the_classification_of_patients_with.6.aspx">
                <img srcset="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00006.FB1.jpeg 1x,https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize@2.00130832-202508000-00006.FB1.jpeg 2x" src="https://images.journals.lww.com/co-allergy/DisplayControlArticleImageSize.00130832-202508000-00006.FB1.jpeg" class border="0" />
            </a>
            
        </div>
        <div>
            
            <header>
                <h4><a title="Algorithms for the classification of patients with a β-lactam allergy label: a systematic review" href="https://journals.lww.com/co-allergy/abstract/2025/08000/algorithms_for_the_classification_of_patients_with.6.aspx">Algorithms for the classification of patients with a β-lactam allergy label: a systematic review</a></h4>
            </header>
            <div class="js-few-authors">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleAuthors" class="authors">Sousa, Joana; Balseiro, Joana; Barreto, Mariana; <span><a class='wp-feature-articles__authors-expand' onclick='showAllAuthors(this);'>More</a></span></span>
            </div>
            <div class="js-all-authors" style="display:none">
                <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleAllAuthors" class="authors">Sousa, Joana; Balseiro, Joana; Barreto, Mariana; Mendes, Francisca; Pereira, Ana Margarida; Ribeiro-Vaz, Inês; Cruz-Correia, Ricardo; Sousa-Pinto, Bernardo <span><a class='wp-feature-articles__authors-expand' onclick='showFewAuthors(this);'>Less</a></span></span>
            </div>
            
                <p class="featuredArticleCitation" id="paraArticleCitation">
                    <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_lblLegacyJournalTitle" class="journalTitleInSearch">Current Opinion in Allergy and Clinical Immunology.</span>
                    25(4):247-257, August 2025.
                </p>
            
            
            <p class="ej-featured-article-doi">
                
                
            </p>

            
            
            
            
			<ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleAbstract" class="article-precis">
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liAbstract">
                    <div id="absShow__237701409">
								
                        <a an="00130832-202508000-00006" rel="opener" title href="javascript:void(0);" onclick="javascript:adcShowAbs(&#39;pnlAbstractText_5067103&#39;, &#39;pAbstractText__979656799&#39;, &#39;Article|co-allergy:2025:08000:00006|10.1097/aci.0000000000001086|&#39;, &#39;absShow__237701409&#39;, &#39;absHide_1960289664&#39;, &#39;&#39;, &#39;00130832-202508000-00006&#39;);"><i class="wk-icon-plus-circle display-control-tools-icon" aria-hidden="true"></i>Abstract</a>
                    
							</div>
                    <div id="absHide_1960289664" style="display: none">
								
                        <a href="javascript:void(0);" onclick="javascript:adcHideAbs('pnlAbstractText_5067103', 'absShow__237701409', 'absHide_1960289664');">
                            <i class="wk-icon-minus-circle display-control-tools-icon"></i>Abstract
                        </a>
                    
							</div>
                </li>
                

                 

			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liAddToMyCollections">
                    <button class="user-menu__link user-menu__link--add-to-favorites js-ejp-login-btn" type="button" data-config="{&quot;eventName&quot;:&quot;AddToFavorites&quot;,&quot;eventDetail&quot;:{&quot;items&quot;:[&quot;Article|co-allergy:2025:08000:00006|10.1097/aci.0000000000001086|&quot;],&quot;an&quot;:&quot;00130832-202508000-00006&quot;},&quot;eventOptions&quot;:{&quot;bubbles&quot;:true,&quot;cancelable&quot;:true,&quot;composed&quot;:false},&quot;loginDetail&quot;:{&quot;isLoginOptional&quot;:false,&quot;promptLogin&quot;:true,&quot;loginPromptText&quot;:&quot;To save this item, login or register&quot;},&quot;isNull&quot;:false}">
                        <i class="wk-icon-star display-control-tools-icon" aria-hidden="true"></i><span>Favorite</span>
                    </button>
			    </li>
			    
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liPDF">
			        <div>
								
			            <i class="wk-icon-file-pdf display-control-tools-icon" aria-hidden="true"></i>
			            <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_lblPDF">PDF</span>
			        
							</div>
			    </li>
			    <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liPermissionsLink">
			        <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_hypPermissionsLink" onclick="showRightsLinkPopUp(&#39;https://s100.copyright.com/AppDispatchServlet&#39;, &#39;WoltersKluwer&#39;, &#39;ACI&#39;, &#39;Algorithms for the classification of patients with a β-lactam allergy label: a systematic review&#39;, &#39;06202025&#39;, &#39;Joana Sousa, Joana Balseiro, Mariana Barreto, et al&#39;, &#39;25&#39;, &#39;4&#39;, &#39;Copyright \u00A9 2025 Wolters Kluwer Health, Inc. All rights reserved.&#39;, &#39;00130832-202508000-00006&#39;, &#39;&#39;, false, &#39;&#39;)" href="javascript:">
                        <i class="article-precis__icon-copyright display-control-tools-icon" aria-hidden="true"></i>Permissions
                    </a>
			    </li>
			</ul>
			
            <div id="pnlAbstractText_5067103" class="panel panel-default" style="display: none;">
								
                <div id="pAbstractText__979656799">
									
                    
                
								</div>

                <p>
                    <div>
									
                        <a title href="https://journals.lww.com/co-allergy/secure/pages/purchase.aspx?an=00130832-202508000-00006"></a>
                    
								</div>
                </p>

                
            
							</div>

            

            

            <ul id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_articleindicator" class="article-actions">
                
                    
                           
                
                
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liBuy">
                    <div id="ej-article-indicators-buy" onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
								
                       <a title href="https://journals.lww.com/co-allergy/abstract/2025/08000/algorithms_for_the_classification_of_patients_with.6.aspx#ContentAccessOptions"><span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_spanBuy" class="ejp-indicator ejp-indicator--buy">Buy</span></a><!--Buy-->
                    
							</div>
                </li>
                
                <li id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_liSAMWithoutHyperlink">
                    <div id="ejp-indicator ejp-indicator--sam" onmouseover="javascript:Tooltip_SDC()" onmouseout="javascript:Tooltip_MouseOut()">
								
                        <span id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_sectionListControl_sectionListView_ctrl2_sectionDisplayControl_subSectionListView_ctrl0_subSectionDisplayControl_itemListControl_itemListView_ctrl1_itemDisplayControl_ctl00_spanSDCWithoutHyperlink" class="ejp-indicator ejp-indicator--sam">SDC</span>
                    
							</div>
                </li>
                 
                
                
                
                
                
                

                
               


                
                
                
                
                
                 
                 
                
    </ul>
            
    

            
            
            
</div>
</div>

   
</article>


    
    


						</div>




            
            
        </div>

    
					</div>
    
</section>

            
        
        </div>
    

        

<a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_tocSections_hypGetSections" href="../../_controltemplates/OAKS.Journals/#"></a>
<div id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_tocSections_pnlSectionsTable" class="etoc-popup ej-box-modal-drop-shadow" style="display: none">
						
    <div id="ej-box-modal-drop-shadow" class="wk-modal wk-modal-with-overlay wk-modal-small ejp-modal" tabindex="-1" role="dialog">
        <div id="ej-box-modal-style-2">
            <section class="wk-modal-content" id="tocSectionsPopup">
                <header class="wk-modal-header ejp-modal-header">
                    <div class="wk-modal-title ejp-modal-title">
                        <strong>
                            Table of Contents Sections</strong>
                    </div>
                    <a id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_tocSections_addOk" class="primary-button wk-button-icon wk-modal-close ejp-modal-close" href="javascript:WebForm_DoPostBackWithOptions(new WebForm_PostBackOptions(&quot;ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl03$tocSections$addOk&quot;, &quot;&quot;, true, &quot;&quot;, &quot;&quot;, false, true))"><i class="fa fa-times"></i></a>
                </header>
                <div class="wk-modal-body">
                    <div id="ej-box-modal-outline-scroll">
                        
                                <ul>
                                    
                                <li>
                                    <a href="javascript:" onclick="anavSetSectionName('-1917741488');">
                                        EDITORIAL INTRODUCTIONS
                                    </a>
                                </li>
                            
                                <li>
                                    <a href="javascript:" onclick="anavSetSectionName('1371044140');">
                                        DRUG ALLERGY: Edited by Luciana Tanno and Dean Naisbitt
                                    </a>
                                </li>
                            
                                <li>
                                    <a href="javascript:" onclick="anavSetSectionName('1182555242');">
                                        PHARMACOTHERAPY AND EVIDENCE-BASED MEDICINE: Edited by Giovanni Paoletti and Danilo Di Bona
                                    </a>
                                </li>
                            
                                </ul>
                            
                    </div>                    
                </div>
            </section>
        </div>
    </div>

					</div>


        <input type="hidden" name="ctl00$ctl29$g_fdd2376e_e054_4e50_972c_27dff082bba6$ctl03$hfSectionName" id="ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_hfSectionName" />



   

<script type="text/javascript">
    function selectize() {
        $('.js-items-on-page-selectize.list-items--desktop').selectize();
    }

    $(document).ready(function () {
        selectize();
    });

    Sys.WebForms.PageRequestManager.getInstance().add_endRequest(function () {
        selectize();
    });
</script>
<input type="hidden" id="selectedItems" name="selectedItems" value="" />
				</div><div class="ms-clear"></div></div>
			</div>
		</div>
	</div>
        </div>
    
        <div id="ctl00_PlaceHolderMain_ctl00_ctl01_phColumns_ctl01_column" class="dpl-col main-content aside" data-dpl-default-css-class="span-6-sm span-6-md" data-dpl-default-zone-id="RightColumnOne" data-dpl-column-id="2877986187e6581cf0731acf8482" data-dpl-default-tag-name="div">
            <div class="ms-webpart-zone ms-fullWidth">
		<div id="MSOZoneCell_WebPartWPQ1" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="4fbe68c1-9c53-4438-87b6-c672c4b240ed" HasPers="false" id="WebPartWPQ1" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_4fbe68c1_9c53_4438_87b6_c672c4b240ed">
					
<div id="ctl00_ctl29_g_4fbe68c1_9c53_4438_87b6_c672c4b240ed_ctl00_adContainer" class="ej-advertisement ej-advertisement-middle">
    <div class="ej-advertisement-content">
        <div>
            <div id="ga_d33c3531-f0e4-45e1-b299-c63bd0b38b11" class="ad-slot-container ad-slot-container-ga_d33c3531-f0e4-45e1-b299-c63bd0b38b11" data-sizemap="[[[0, 0], [[300, 250]]]]" data-adpath="/15726702761/Desktop/co-allergy/Home/Right" data-autoload="no" data-outofpage="no" data-sticky="no" data-slottargeting='' data-displayslug="yes" data-sticky-duration="0" data-name="Right"></div>
        </div>
    </div>
</div>

				</div><div class="ms-clear"></div></div>
			</div><div class="ms-PartSpacingVertical"></div>
		</div><div id="MSOZoneCell_WebPartctl00_ctl29_g_48c818d8_afe2_47cf_91ea_9f959758b907" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="48c818d8-afe2-47cf-91ea-9f959758b907" HasPers="false" id="WebPartctl00_ctl29_g_48c818d8_afe2_47cf_91ea_9f959758b907" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_48c818d8_afe2_47cf_91ea_9f959758b907">
					

<section id="wpHealthJobPlus" class="content-box cb-collapsible">
    <header class="ejp-heading-2">
        <h2 aria-expanded="false">
            Featured Jobs
        </h2>
    </header>

   <div class="lww-jobs-widget">
         <iframe id="ctl00_ctl29_g_48c818d8_afe2_47cf_91ea_9f959758b907_ctl00_mdgxWidgetiFrame" style="width: 100%; border: 0; height: 400px; background: 0" frameBorder="0" src="https://physicianjobs.lww.com/widget/bootstrap/job/#i=14"></iframe>
    </div>
</section>


				</div><div class="ms-clear"></div></div>
			</div><div class="ms-PartSpacingVertical"></div>
		</div><div id="MSOZoneCell_WebPartWPQ2" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="f4281d33-4981-4c04-bd17-85b426d6cf95" HasPers="false" id="WebPartWPQ2" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_f4281d33_4981_4c04_bd17_85b426d6cf95">
					
<div id="ctl00_ctl29_g_f4281d33_4981_4c04_bd17_85b426d6cf95_ctl00_adContainer" class="ej-advertisement ej-advertisement-bannercombo">
    <div class="ej-advertisement-content">
        <div>
            <div id="ga_53b073ea-0e34-4930-ab94-0781e6423dfc" class="ad-slot-container ad-slot-container-ga_53b073ea-0e34-4930-ab94-0781e6423dfc" data-sizemap="[[[1050, 200], [[300, 600], [300, 250], [160, 600]]], [[730, 600], [[300, 600], [300, 250]]], [ [ 0, 0 ], [ [300, 250] ] ] ]" data-adpath="/15726702761/Desktop/co-allergy/Home/Right1" data-autoload="no" data-outofpage="no" data-sticky="no" data-slottargeting='' data-displayslug="yes" data-sticky-duration="0" data-name="Right1"></div>
        </div>
    </div>
</div>

				</div><div class="ms-clear"></div></div>
			</div><div class="ms-PartSpacingVertical"></div>
		</div><div id="MSOZoneCell_WebPartctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="24b8db6b-56c6-4596-9db2-93204e280d1d" HasPers="false" id="WebPartctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d">
					
<!-- ===== ASP._controltemplates_oaks_journals_latestarticleswidgetcontrol_ascx generated at 8/8/2025 3:52:44 AM ===== -->



<section id="latest-articles-widget-section" class="content-box">
    <header class="ejp-heading-2">
        <h2 aria-expanded="false">
            <span id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_Title">Latest Articles</span>
        </h2>
    </header>
    <div id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_UpdateLatestArticlesPanel">
	
            
        <div class="latest-articles-widget">
            <ul id="latest-articles-widget-list">
                
        <li class>
            <div class="latest-articles-widget-article-container">
                <div class="latest-articles-widget-article-content">
                    
                    <div class="latest-articles-widget-information">
		
                        <div class="latest-articles-widget-title">
                            <a title href="https://journals.lww.com/co-allergy/abstract/9900/from_innovation_to_implementation__strengthening.214.aspx" onmouseover="javascript:event.cancelBubble = true;Tooltip_Article(&#39;From innovation to implementation: strengthening anterior ocular inflammatory surface diseases diagnostics through global health policy&#39;, &#39;Alnsour Sabaa; Bielory, Leonard&#39;, &#39;Current Opinion in Allergy and Clinical Immunology&#39;, &#39;&#39;, &#39;&#39;, &#39;&#39; , &#39;10.1097/ACI.0000000000001106&#39;);" onmouseout="javascript:Tooltip_MouseOut()">From innovation to implementation: strengthening anterior ocular inflammatory surface diseases diagnostics through global health policy</a>
                        </div>
                        <div>
                            <ul id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_ctl01_ItemList_ctrl0_articleindicator" class="article-actions">
                                <li>
                                    <div onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
			<div>
				<p><i class="ejp-indicator ejp-indicator--buy latest-article-item-indicator"></i></p>
			</div>
		</div>
                                </li>
                                
                            </ul>
                        </div>
                    
	</div>
                </div>

                <div class="latest-articles-widget-separator">
                </div>
            </div>
        </li>
    
        <li class>
            <div class="latest-articles-widget-article-container">
                <div class="latest-articles-widget-article-content">
                    
                    <div class="latest-articles-widget-information">
		
                        <div class="latest-articles-widget-title">
                            <a title href="https://journals.lww.com/co-allergy/fulltext/9900/emerging_concepts_in_atopic_dermatitis_and_atopic.215.aspx" onmouseover="javascript:event.cancelBubble = true;Tooltip_Article(&#39;Emerging concepts in atopic dermatitis and atopic keratoconjunctivitis&#39;, &#39;Jafari Keya; Calder, Virginia L.&#39;, &#39;Current Opinion in Allergy and Clinical Immunology&#39;, &#39;&#39;, &#39;&#39;, &#39;&#39; , &#39;10.1097/ACI.0000000000001102&#39;);" onmouseout="javascript:Tooltip_MouseOut()">Emerging concepts in atopic dermatitis and atopic keratoconjunctivitis</a>
                        </div>
                        <div>
                            <ul id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_ctl01_ItemList_ctrl1_articleindicator" class="article-actions">
                                <li>
                                    <div onmouseover="javascript:Tooltip_Open()" onmouseout="javascript:Tooltip_MouseOut()">
			<div>
				<p><i class="ejp-indicator ejp-indicator--open latest-article-item-indicator"></i></p>
			</div>
		</div>
                                </li>
                                
                            </ul>
                        </div>
                    
	</div>
                </div>

                <div class="latest-articles-widget-separator">
                </div>
            </div>
        </li>
    
        <li class>
            <div class="latest-articles-widget-article-container">
                <div class="latest-articles-widget-article-content">
                    
                    <div class="latest-articles-widget-information">
		
                        <div class="latest-articles-widget-title">
                            <a title href="https://journals.lww.com/co-allergy/abstract/9900/chronic_urticaria_and_autoinflammatory_syndromes.207.aspx" onmouseover="javascript:event.cancelBubble = true;Tooltip_Article(&#39;Chronic urticaria and autoinflammatory syndromes&#39;, &#39;Yacoub Mona-Rita; Ferlito, Arianna; Nettis, Eustachio&#39;, &#39;Current Opinion in Allergy and Clinical Immunology&#39;, &#39;&#39;, &#39;&#39;, &#39;&#39; , &#39;10.1097/ACI.0000000000001093&#39;);" onmouseout="javascript:Tooltip_MouseOut()">Chronic urticaria and autoinflammatory syndromes</a>
                        </div>
                        <div>
                            <ul id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_ctl01_ItemList_ctrl2_articleindicator" class="article-actions">
                                <li>
                                    <div onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
			<div>
				<p><i class="ejp-indicator ejp-indicator--buy latest-article-item-indicator"></i></p>
			</div>
		</div>
                                </li>
                                
                            </ul>
                        </div>
                    
	</div>
                </div>

                <div class="latest-articles-widget-separator">
                </div>
            </div>
        </li>
    
        <li class>
            <div class="latest-articles-widget-article-container">
                <div class="latest-articles-widget-article-content">
                    
                    <div class="latest-articles-widget-information">
		
                        <div class="latest-articles-widget-title">
                            <a title href="https://journals.lww.com/co-allergy/abstract/9900/biologic_and_small_molecule_therapies_in_chronic.208.aspx" onmouseover="javascript:event.cancelBubble = true;Tooltip_Article(&#39;Biologic and small molecule therapies in chronic spontaneous urticaria: an update&#39;, &#39;Wedi Bettina&#39;, &#39;Current Opinion in Allergy and Clinical Immunology&#39;, &#39;&#39;, &#39;&#39;, &#39;&#39; , &#39;10.1097/ACI.0000000000001095&#39;);" onmouseout="javascript:Tooltip_MouseOut()">Biologic and small molecule therapies in chronic spontaneous urticaria: an update</a>
                        </div>
                        <div>
                            <ul id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_ctl01_ItemList_ctrl3_articleindicator" class="article-actions">
                                <li>
                                    <div onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
			<div>
				<p><i class="ejp-indicator ejp-indicator--buy latest-article-item-indicator"></i></p>
			</div>
		</div>
                                </li>
                                
                            </ul>
                        </div>
                    
	</div>
                </div>

                <div class="latest-articles-widget-separator">
                </div>
            </div>
        </li>
    
        <li class>
            <div class="latest-articles-widget-article-container">
                <div class="latest-articles-widget-article-content">
                    
                    <div class="latest-articles-widget-information">
		
                        <div class="latest-articles-widget-title">
                            <a title href="https://journals.lww.com/co-allergy/abstract/9900/where_eye_meets_body_part_2__uniting_allergy.209.aspx" onmouseover="javascript:event.cancelBubble = true;Tooltip_Article(&#39;Where eye meets body part 2: uniting allergy pathways in ocular and atopic disease – T cells take the lead&#39;, &#39;Borges Sebastian; Pereira, Victoria A.; Chang, Christopher; Galor, Anat&#39;, &#39;Current Opinion in Allergy and Clinical Immunology&#39;, &#39;&#39;, &#39;&#39;, &#39;&#39; , &#39;10.1097/ACI.0000000000001097&#39;);" onmouseout="javascript:Tooltip_MouseOut()">Where eye meets body part 2: uniting allergy pathways in ocular and atopic disease – T cells take the lead</a>
                        </div>
                        <div>
                            <ul id="ctl00_ctl29_g_24b8db6b_56c6_4596_9db2_93204e280d1d__ffc9adff43eb7921_ctl01_ItemList_ctrl4_articleindicator" class="article-actions">
                                <li>
                                    <div onmouseover="javascript:Tooltip_Buy()" onmouseout="javascript:Tooltip_MouseOut()">
			<div>
				<p><i class="ejp-indicator ejp-indicator--buy latest-article-item-indicator"></i></p>
			</div>
		</div>
                                </li>
                                
                            </ul>
                        </div>
                    
	</div>
                </div>

                <div class="latest-articles-widget-separator">
                </div>
            </div>
        </li>
    
            </ul>

        </div>
    


            <p class="latest-articles-widget-button-container">
                <a title href="https://journals.lww.com/co-allergy/toc/publishahead" class="latest-articles-widget-button">View More Recent Articles</a>
            </p>
        
</div>
</section>
  

				</div><div class="ms-clear"></div></div>
			</div>
		</div>
	</div>
        </div>
    
</div>
<div id="ctl00_PlaceHolderMain_ctl00_ctl02_row" class="dpl-row" data-dpl-row-id="5a3fe7f7c81d012477c93d8ad217" data-dpl-default-tag-name="div">

        <div id="ctl00_PlaceHolderMain_ctl00_ctl02_phColumns_ctl00_column" class="dpl-col span-12-sm span-12-md" data-dpl-default-css-class="span-12-sm span-12-md" data-dpl-default-zone-id="CentralColumnTwo" data-dpl-column-id="4ef16a7ca46db412ad19404b7466" data-dpl-default-tag-name="div">
            <menu class="ms-hide">
		<ie:menuitem id="MSOMenu_Help" iconsrc="/_layouts/15/images/HelpIcon.gif" onmenuclick="MSOWebPartPage_SetNewWindowLocation(MenuWebPart.getAttribute('helpLink'), MenuWebPart.getAttribute('helpMode'))" text="Help" type="option" style="display:none">

		</ie:menuitem>
	</menu>
        </div>
    
</div>
<div id="ctl00_PlaceHolderMain_ctl00_ctl03_row" class="dpl-row" data-dpl-row-id="a9f01736250a15c3f0baecc751c5" data-dpl-default-tag-name="div">

        <div id="ctl00_PlaceHolderMain_ctl00_ctl03_phColumns_ctl00_column" class="dpl-col span-12-sm span-12-md" data-dpl-default-css-class="span-12-sm span-12-md" data-dpl-default-zone-id="CentralColumnThree" data-dpl-column-id="9f9b35e9c3e4a57f99553c53f162" data-dpl-default-tag-name="div">
            <div class="ms-webpart-zone ms-fullWidth">
		<div id="MSOZoneCell_WebPartWPQ3" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="a8c02183-c7f3-476d-b4bf-00e4980dc103" HasPers="false" id="WebPartWPQ3" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_a8c02183_c7f3_476d_b4bf_00e4980dc103">
					<a href="https://journals.lww.com/co-allergy/fulltext/2025/08000/new_treatments_for_systemic_mastocytosis_in_2025.9.aspx"></a><a href="https://journals.lww.com/co-allergy/fulltext/2013/06000/post_hoc_data_analysis__benefits_and_limitations.2.aspx"></a><a href="https://journals.lww.com/co-allergy/fulltext/2022/06000/cow_s_milk_allergy.6.aspx"></a><a href="https://journals.lww.com/co-allergy/fulltext/2023/10000/diagnostic_criteria_of_chronic_conjunctivitis_.9.aspx"></a>
				</div><div class="ms-clear"></div></div>
			</div>
		</div>
	</div>
        </div>
    
</div>
<div id="ctl00_PlaceHolderMain_ctl00_ctl04_row" class="dpl-row" data-dpl-row-id="902690b6df03a69ca61c43b6fe8b" data-dpl-default-tag-name="div">

        <div id="ctl00_PlaceHolderMain_ctl00_ctl04_phColumns_ctl00_column" class="dpl-col span-12-sm span-12-md" data-dpl-default-css-class="span-12-sm span-12-md" data-dpl-default-zone-id="CentralColumnFour" data-dpl-column-id="524c65ec563d081fd2e7d97c332b" data-dpl-default-tag-name="div">
            <div class="ms-webpart-zone ms-fullWidth">
		<div id="MSOZoneCell_WebPartWPQ4" class="s4-wpcell-plain ms-webpartzone-cell ms-webpart-cell-vertical-inline-table ms-webpart-cell-vertical ms-fullWidth ">
			<div class="ms-webpart-chrome ms-webpart-chrome-vertical ms-webpart-chrome-fullWidth ">
				<div WebPartID="0ed7e662-7b9d-42a6-a1df-91789070e2ef" HasPers="false" id="WebPartWPQ4" width="100%" class="ms-WPBody noindex " allowDelete="false" style="" ><div id="ctl00_ctl29_g_0ed7e662_7b9d_42a6_a1df_91789070e2ef">
					<a href="https://journals.lww.com/co-allergy/fulltext/2012/10000/the_farm_effect,_or__when,_what_and_how_a_farming.5.aspx"></a><a href="https://journals.lww.com/co-allergy/fulltext/2023/04000/fungal_bioaerosols_as_an_occupational_hazard.6.aspx"></a><a href="https://journals.lww.com/co-allergy/fulltext/2015/10000/the_genetics_of_the_skin_barrier_in_eczema_and.6.aspx"></a><a href="https://journals.lww.com/co-allergy/fulltext/2016/04000/do_chronic_workplace_irritant_exposures_cause.2.aspx"></a>
				</div><div class="ms-clear"></div></div>
			</div>
		</div>
	</div>
        </div>
    
</div>
</DIV>



















<div style='display:none' id='hidZone'></div>
                    
</div>

                    <div id="DeltaFormDigest">
	
                        
                            <script type="text/javascript">//<![CDATA[
        var formDigestElement = document.getElementsByName('__REQUESTDIGEST')[0];
        if (!((formDigestElement == null) || (formDigestElement.tagName.toLowerCase() != 'input') || (formDigestElement.type.toLowerCase() != 'hidden') ||
            (formDigestElement.value == null) || (formDigestElement.value.length <= 0)))
        {
            formDigestElement.value = '0xE36C1DAC568748460FD9D80D51EF51DFD6DA36FD1ECD0274A639BD13FFCE9DE44E32AA8C3FCB27B62CEE545C399652E80A3066DDA8F15445905D3761763E34DF,08 Aug 2025 08:52:44 -0000';_spPageContextInfo.updateFormDigestPageLoaded = new Date();
        }
        //]]>
        </script>
                        
                    
</div>

                </div>
                
                <!-- Footer Delegate Control -->
                


<footer class="ejp-footer">
    <div class="container wk-grid-page-container">
        <a class="ejp-footer__back-to-top-link"><i class="fa fa-angle-up b ejp-footer__back-to-top-link-icon"></i>Back to Top</a>

        <div class="ejp-footer__main-content">
            <!-- Footer smart control -->
            <div class="ejp-footer__smart-control-section">
                



<section class="ejp-footer__smart-control-section-wrapper js-section-alert">
    <div class="ejp-footer__smart-control-section-image-container">
        <img src="https://images.journals.lww.com/co-allergy/XLargeThumb.00130832-202508000-00000.CV.jpeg" id="ctl00_ctl56_FooterSmartControl_ctl00_imgAlertControl" alt="Current Issue Cover Image" class="" />
    </div>
    <div class="ejp-footer__smart-control-section-text-holder">
        <h4 id="ctl00_ctl56_FooterSmartControl_ctl00_headerAlertControl">Never Miss an Issue</h4>
        <div class="js-section-alert__content">
            <span id="ctl00_ctl56_FooterSmartControl_ctl00_spanBodyAlertControl" class="ejp-footer__smart-control-section-info">Get new journal Tables of Contents sent right to your email inbox</span>
            <input name="ctl00$ctl56$FooterSmartControl$ctl00$userEmailAlertControl" type="text" id="ctl00_ctl56_FooterSmartControl_ctl00_userEmailAlertControl" class="js-section-alert__email" placeholder="Type your email" />
            <span class="js-section-alert--error"></span>
            <button id="ctl00_ctl56_FooterSmartControl_ctl00_buttonAlertControl" type="button" class="js-section-alert__subscribe-button" data-alert-type="Etoc" data-subscribed-msg="You are now subscribed to receive eTOC alerts whenever new issues are published">Get New Issue Alerts</button>
        </div>
    </div>
</section>



<script type="text/javascript">
    (function($) {
            $("#smartWpMostPopularLink").on('click', function() {
                window.location = "https://journals.lww.com/co-allergy/pages/viewallmostpopulararticles.aspx?WT.mc_id=HPxADx20100319xMP";
            });
       
    })(jQuery);
</script>

            </div>
            <div class="ejp-footer__info-holder">
                <div id="ctl00_ctl56_divLeftColumn" class="ejp-footer__info-left-wrapper">
                    <div class="ejp-footer__info-block">
                        <h4 class="ejp-footer__info-block-header">Browse Journal Content</h4>
                        <ul class="ejp-footer__info-block-two-col-list">
                             
                                    <li>
                                        <a href='/co-allergy/pages/viewallmostpopulararticles.aspx' target='' rel="noopener">Most Popular</a>
                                    </li>
                                
                                    <li>
                                        <a href='/co-allergy/_layouts/1033/oaks.journals/informationforauthors.aspx' target='' rel="noopener">For Authors</a>
                                    </li>
                                
                                    <li>
                                        <a href='/co-allergy/pages/aboutthejournal.aspx' target='' rel="noopener">About the Journal</a>
                                    </li>
                                
                                    <li>
                                        <a href='/co-allergy/pages/issuelist.aspx' target='' rel="noopener">Past Issues</a>
                                    </li>
                                
                                    <li>
                                        <a href='/co-allergy/pages/currenttoc.aspx' target='' rel="noopener">Current Issue</a>
                                    </li>
                                
                            <li id="ctl00_ctl56_liRegister"><a id="ctl00_ctl56_lnkRegister" href="https://journals.lww.com/co-allergy/pages/register.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx">Register on the website</a></li>
                            <li id="ctl00_ctl56_liSubscribe" role="presentation"><a id="ctl00_ctl56_lnkSubscribe" href="https://shop.lww.com/p/1528-4050" target="_blank">Subscribe</a></li>
                            <li id="ctl00_ctl56_liHyperSubscribeToEtoc"><a rel="nofollow" title href="javascript:javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);;" onclick="javascript: alerts_ShowSubscribeeTOCPopup(&#39;Current Opinion in Allergy and Clinical Immunology&#39;,&#39;co-allergy&#39;,&#39;eTOC&#39;, &#39;eTOC&#39;);"><span id="ctl00_ctl56_alertLinkControl_defaultText" class="hideOnFixed">Get eTOC Alerts</span></a>
</li>
                        </ul>
                    </div>

                    

                    
                </div>

                <div id="ctl00_ctl56_divRightColumn" class="ejp-footer__info-right-wrapper">
                    <div id="ctl00_ctl56_divForJournalAuthors" class="ejp-footer__info-block">
                        <h4 class="ejp-footer__info-block-header">For Journal Authors</h4>
                        <ul>
                            
                                    <li class=''>
                                        <a href='/co-allergy/_layouts/15/1033/oaks.journals/informationforauthors.aspx' target='' rel="noopener">Submit an article</a>
                                    </li>
                                
                                    <li class=''>
                                        <a href='https://wkauthorservices.editage.com/' target='_blank' rel="noopener">How to publish with us</a>
                                    </li>
                                
                        </ul>
                    </div>

                    <div class="ejp-footer__info-block ejp-footer__info-block--custom-service">
                        <h4 class="ejp-footer__info-block-header">Customer Service</h4>
                        

    <div id="liveagent_button_online_5730V0000019KUh" style="display: none; border: 0px none; cursor: pointer" onclick="liveagent.startChat('5730V0000019KUh')" class="live-chat__button live-chat__button--on">
        <i class="live-chat__button-icon wk-icon-filled-dialogue-white-r"></i>
        <span class="live-chat__button-text">Live Chat</span>
    </div>

    <div id="liveagent_button_offline_5730V0000019KUh" style="display: none; border: 0px none;" class="live-chat__button live-chat__button--off">
        <i class="live-chat__button-icon wk-icon-filled-dialogue-gray-r"></i>
        <span class="live-chat__button-text">Chat Offline</span>
    </div>

    <script type="text/javascript">
        if (!window._laq) { window._laq = []; }
        window._laq.push(function () {
            liveagent.showWhenOnline('5730V0000019KUh', document.getElementById('liveagent_button_online_5730V0000019KUh'));
            liveagent.showWhenOffline('5730V0000019KUh', document.getElementById('liveagent_button_offline_5730V0000019KUh'));
        });
    </script>
    <script type='text/javascript' src='https://c.la1-c1-ia5.salesforceliveagent.com/content/g/js/47.0/deployment.js'></script>
    <script type='text/javascript'>
        liveagent.init('https://d.la1-c1-ia5.salesforceliveagent.com/chat', '5720V00000158LL', '00Dd0000000dixc');
    </script>



                        <ul>
                                
                                        <li class='ejp-footer--show-on-mobile'>
                                            <a href='https://lww.com/secure/pages/activatesubscription.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx' target='' rel="noopener">Activate your journal subscription</a>
                                        </li>
                                    
                                        <li class='ejp-footer--hide-on-mobile'>
                                            <a href='https://lww.com/secure/pages/activatesubscription.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx' target='' rel="noopener">Activate Journal Subscription</a>
                                        </li>
                                    
                                        <li class='ejp-footer--hide-on-mobile'>
                                            <a href='https://wkhlrp.my.site.com/LippincottOnlineHelpCenter/s/' target='' rel="noopener">Browse the help center</a>
                                        </li>
                                    
                                        <li class='ejp-footer--show-on-mobile'>
                                            <a href='https://wkhealth.force.com/lwwonline/s/topic/0TO0V000001YgLZWA0/lww-online?tabset-ddbfe=2' target='' rel="noopener">Help</a>
                                        </li>
                                    
                            <li><span class="ejp-footer--show-on-mobile">Contact us at:</span>
                                <ul>
                                    <li class="ejp-footer__contacts-wrapper ejp-footer__email-settings">
                                        <div class="ejp-footer--show-on-mobile">Support:</div>
                                        <a href="https://www.tfaforms.com/4966570" id="ctl00_ctl56_custSupport" target="_blank">Submit a Service Request</a>
                                    </li>
                                    <li class="ejp-footer__contacts-wrapper ejp-footer__phone-settings">
                                        <div class="ejp-footer--show-on-mobile ejp-footer__phone-settings--version">
                                            <div id="ctl00_ctl56_telMobileUSA">TEL: (USA):</div>
                                            <div id="ctl00_ctl56_telMobileInt">TEL: (Int’l):</div>
                                            
                                        </div>

                                        <div class="ejp-footer__phone-settings--holder">
                                            
                                                    <div>
                                                        800-638-3030
                                                            <span class="ejp-footer--hide-on-mobile">(within USA)</span>
                                                    </div>
                                                    <div>
                                                        301-223-2300
                                                            <span class="ejp-footer--hide-on-mobile">(international)</span>
                                                    </div>
                                                
                                        </div>
                                    </li>
                                </ul>
                            </li>
                        </ul>
                        
<ul><li>
    <button id="ot-sdk-btn" class="ot-sdk-show-settings ot-ejp-btn" onclick="return false;">Cookie Settings</button>
</li>
</ul>

                    </div>
                </div>
            </div>
            <span id="ctl00_ctl56_FooterConfiguration" class="js-config-provider" data-config="{&quot;loginConfiguration&quot;:{&quot;serviceUrl&quot;:&quot;https://services.journals.lww.com/IntegrationServices/AccountService.svc/Login&quot;,&quot;registerUrl&quot;:&quot;https://journals.lww.com/co-allergy/pages/register.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx&quot;,&quot;forgotPasswordUrl&quot;:&quot;https://journals.lww.com/co-allergy/pages/forgotpassword.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx&quot;,&quot;redirectUrl&quot;:&quot;https://journals.lww.com/co-allergy/pages/login.aspx?ContextUrl=%2fco-allergy%2fpages%2fdefault.aspx&quot;,&quot;tokenKey&quot;:&quot;AppSsoToken&quot;,&quot;ssoLoginOptions&quot;:[],&quot;customerService&quot;:{&quot;customerServiceUSPhone&quot;:&quot;(800) 638-3030&quot;,&quot;customerServiceInternationalPhone&quot;:&quot;301-223-2300&quot;,&quot;customerServiceEmail&quot;:&quot;customerservice@lww.com&quot;},&quot;useAlternativeAccountLinks&quot;:false},&quot;commonConfiguration&quot;:{&quot;commonEndpoints&quot;:{&quot;addToFavoritesServiceUrl&quot;:&quot;https://journals.lww.com/co-allergy/_layouts/15/OAKS.Journals/UserCollectionsService.svc/AddToFavorites&quot;,&quot;saveSearchServiceUrl&quot;:&quot;https://journals.lww.com/co-allergy/_layouts/15/OAKS.Journals/UserCollectionsService.svc/SaveSearch&quot;,&quot;counterDataServiceUrl&quot;:&quot;https://journals.lww.com/co-allergy/_layouts/15/OAKS.Journals/DualAccessService.svc/SendCounterDataRequestByAN&quot;},&quot;kaltura&quot;:{&quot;partnerId&quot;:&quot;1315631&quot;,&quot;playerId&quot;:&quot;52253872&quot;,&quot;kalturaWidgetUrl&quot;:&quot;https://cdnapisec.kaltura.com/p/1315631/embedPlaykitJs/uiconf_id/52253872&quot;},&quot;brightCove&quot;:{&quot;brightCoveScriptUrl&quot;:&quot;https://players.brightcove.net/2324982687001/HyP0JSARx_default/index.min.js&quot;,&quot;dataAccount&quot;:&quot;2324982687001&quot;,&quot;dataPlayer&quot;:&quot;HyP0JSARx&quot;},&quot;math&quot;:{&quot;libUrl&quot;:&quot;https://cdn.jsdelivr.net/npm/mathjax@3/es5/tex-mml-chtml.js&quot;},&quot;recoWidget&quot;:{&quot;journals&quot;:[{&quot;Id&quot;:&quot;co-allergy&quot;,&quot;Version&quot;:&quot;04.03&quot;,&quot;ProductCode&quot;:&quot;coaci&quot;}],&quot;pubFilter&quot;:{},&quot;clientId&quot;:&quot;ejp_v3&quot;,&quot;libUrl&quot;:&quot;https://assets.ovid.com/widget/v3/widget.js&quot;},&quot;sciteBadge&quot;:{&quot;libUrl&quot;:&quot;https://cdn.scite.ai/badge/scite-badge-latest.min.js&quot;}}}"></span>
        </div>

        <div id="ctl00_ctl56_footerSocialDiv" class="ejp-footer__social-links ejp-footer--dashed-decore">
            <ul id="ctl00_ctl56_socialList">
                
                        <li class=''>
                            <a href='https://X.com/CO_AllergyCI' target='_blank' title="X" aria-label="X" rel="noopener">
                                <img style='display:none' src=''>
                                <i class='wk-icon-filled-x' aria-hidden="true"></i>
                            </a>
                        </li>
                    
            </ul>
        </div>

        <div class="ejp-footer__bottom-links">
            <ul class="ejp-footer__useful-links">
                <li><a id="ctl00_ctl56_hlkPrivacy" href="https://journals.lww.com/co-allergy/_layouts/oaks.journals/privacy.aspx">Privacy Policy</a></li>
                <li><a id="ctl00_ctl56_hlkLegal" href="https://journals.lww.com/co-allergy/_layouts/oaks.journals/disclaimer.aspx">Legal Disclaimer</a></li>
                <li><a id="ctl00_ctl56_hlkTermsOfUse" href="https://journals.lww.com/co-allergy/_layouts/oaks.journals/terms.aspx">Terms of Use</a></li>
                <li><a id="ctl00_ctl56_hlkNIHPublicAccess" href="https://www.wolterskluwer.com/en/solutions/lippincott-journals/lippincott-open-access">Open Access Policy</a></li>
                
                        <li class=''>
                            <a href='/co-allergy/Secure/Pages/feedback.aspx' target=''>
                                <img style='display:none' src='' />
                                <i class=''></i>
                                Feedback
                            </a>
                        </li>
                    
                        <li class=''>
                            <a href='http://journals.lww.com/co-allergy/_layouts/1033/oaks.journals/sitemap.aspx' target='blank'>
                                <img style='display:none' src='' />
                                <i class=''></i>
                                Sitemap
                            </a>
                        </li>
                    
                        <li class=''>
                            <a href='/co-allergy/_layouts/OAKS.Journals/feeds.aspx' target=''>
                                <img style='display:none' src='' />
                                <i class=''></i>
                                RSS Feeds
                            </a>
                        </li>
                    
                        <li class=''>
                            <a href='https://lww.com/' target=''>
                                <img style='display:none' src='' />
                                <i class=''></i>
                                LWW Journals
                            </a>
                        </li>
                    
                <li><a id="ctl00_ctl56_hlkCAPrivacyChoices" href="https://privacyportal-de.onetrust.com/webform/2217e117-526b-4696-8a98-8c402f8f2b81/5b049ba3-0106-4b77-a7da-5d12238c90a4">Your California Privacy Choices</a>
                    <img src="/_layouts/1033/IMAGES/OAKS.Journals/CAPrivacyPolicy.png" id="ctl00_ctl56_imgCAPrivacyPolicyChoices" class="wk-footer__ca-privacy-logo" alt="California Consumer Privacy Act (CCPA) Opt-Out Icon" />
                </li>
            </ul>
            <ul class="ejp-footer__copyright-block">
                <li><span>Copyright&nbsp;&copy;&nbsp;2025</span></li>
                <li><a href="https://www.wolterskluwer.com/en/health" target="_blank">Wolters Kluwer Health, Inc. and/or its subsidiaries.  All rights reserved. | Content use for text and data mining and artificial intelligence training is not permitted.</a></li>
            </ul>
        </div>
    </div>
</footer>


            </div>
            </div>
            <!--Scripts -->
            <!--<script src="~/js/ejp-scripts.js"></script> -->

            <script>
                $(document).on('click', '.yamm .dropdown-menu', function (e) {
                    e.stopPropagation();
                });				
            </script>

            <!-- Additional custom controls -->
            







            <!-- High Impact Advertisement -->
            
<div id="ctl00_ctl59_adContainer" class="ej-advertisement ejp-advertisement-highimpact js-advertisement-highimpact">
    <div class="ej-advertisement-content">
        <div>
            <div id="ga_d9b7110e-15e7-4a87-bc11-1d62550d0cd4" class="ad-slot-container ad-slot-container-ga_d9b7110e-15e7-4a87-bc11-1d62550d0cd4" data-sizemap="[[[992, 500], [[300, 250]]], [[768, 180], [[728, 90]]], [[0, 0], [[300, 50]]]]" data-adpath="/15726702761/Desktop/co-allergy/HighImpact" data-autoload="yes" data-outofpage="no" data-sticky="yes" data-slottargeting='' data-displayslug="yes" data-sticky-duration="10" data-name="HighImpact"></div>
        </div>
    </div>
</div>


            <!-- Bottom Banner -->
            


            
            

            <!-- QuantcastTracker - don't have key in configuration DB, seems like controls is deprecated -->
            <!---->

            
            
            
            
            
            
            
            
            
            
            
            
            
            
            
            
            
            

        <div id="ga_Top1" class="ad-slot-container" data-sizemap="" data-adpath="/15726702761/Desktop/co-allergy/Home/Interstitial" data-autoload="yes" data-outofpage="yes" data-sticky="no" data-slottargeting='' data-displayslug="yes" data-sticky-duration="0" data-name="Interstitial"></div>

<script type="text/javascript">
//<![CDATA[
var _spFormDigestRefreshInterval = 1440000;window.SPThemeUtils && SPThemeUtils.ApplyCurrentTheme(true); IsSPSocialSwitchEnabled = function() { return true; };var _fV4UI = true;
function _RegisterWebPartPageCUI()
{
    var initInfo = {editable: false,isEditMode: false,allowWebPartAdder: false,listId: "{1d013155-e349-4110-b1cd-603e679b9d69}",itemId: 62,recycleBinEnabled: true,enableMinorVersioning: false,enableModeration: false,forceCheckout: false,rootFolderUrl: "\u002fco-allergy\u002fPages",itemPermissions:{High:0,Low:200769}};
    SP.Ribbon.WebPartComponent.registerWithPageManager(initInfo);
    var wpcomp = SP.Ribbon.WebPartComponent.get_instance();
    var hid;
    hid = document.getElementById("_wpSelected");
    if (hid != null)
    {
        var wpid = hid.value;
        if (wpid.length > 0)
        {
            var zc = document.getElementById(wpid);
            if (zc != null)
                wpcomp.selectWebPart(zc, false);
        }
    }
    hid = document.getElementById("_wzSelected");
    if (hid != null)
    {
        var wzid = hid.value;
        if (wzid.length > 0)
        {
            wpcomp.selectWebPartZone(null, wzid);
        }
    }
};
function __RegisterWebPartPageCUI() {
ExecuteOrDelayUntilScriptLoaded(_RegisterWebPartPageCUI, "sp.ribbon.js");}
_spBodyOnLoadFunctionNames.push("__RegisterWebPartPageCUI");var __wpmExportWarning='This Web Part Page has been personalized. As a result, one or more Web Part properties may contain confidential information. Make sure the properties contain information that is safe for others to read. After exporting this Web Part, view properties in the Web Part description file (.WebPart) by using a text editor such as Microsoft Notepad.';var __wpmCloseProviderWarning='You are about to close this Web Part.  It is currently providing data to other Web Parts, and these connections will be deleted if this Web Part is closed.  To close this Web Part, click OK.  To keep this Web Part, click Cancel.';var __wpmDeleteWarning='You are about to permanently delete this Web Part.  Are you sure you want to do this?  To delete this Web Part, click OK.  To keep this Web Part, click Cancel.';var lblColleaguesEmail = $get('ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_lblColleaguesEmail');$(function() {
                                                    $(document).on('click.article-display-control', function(e) {
                                                        if (e.target.parentElement && e.target.parentElement.classList) {
                                                            var target = e.target.parentElement;
                                                            if (target.classList.contains('showmoremobile')) {
                                                                $target = $(target);
                                                                $target.next('div').next('p').show();
                                                                $target.next('div').show();
                                                                $target.hide();
                                                                e.preventDefault();
                                                            } else if (target.classList.contains('showlessmobile')) {
                                                                $target = $(target);
                                                                $target.next('p').hide();
                                                                $target.prev('div').show();
                                                                $target.hide();
                                                                e.preventDefault();
                                                            }
                                                        }
                                                    });
                                                });//]]>
</script>
<script type='text/javascript'>SP.SOD.set_prefetch(0);</script>
<script type="text/javascript">
//<![CDATA[
var g_clientIdDeltaPlaceHolderMain = "DeltaPlaceHolderMain";
var g_clientIdDeltaPlaceHolderUtilityContent = "DeltaPlaceHolderUtilityContent";
Sys.Application.add_init(function() {
    $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"PopupControlID":"ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_pnlunSubscribeToAlerts","dynamicServicePath":"/co-allergy/pages/default.aspx","id":"unSubscribeToAlerts"}, null, null, $get("ctl00_ctl51_Header_UserActionTools_ucUnsubscribeToAlertsUserControl_dummyTargetControl"));
});
Sys.Application.add_init(function() {
    $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"PopupControlID":"ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_pnlSubscribeToEtoc","dynamicServicePath":"/co-allergy/pages/default.aspx","id":"subscribeToEtoc"}, null, null, $get("ctl00_ctl51_Header_UserActionTools_SubscribeToEtocPopupControl_dummyTargetControl"));
});
g_QuickLaunchControlIds.push("zz1_TopNavigationMenu");_spBodyOnLoadFunctionNames.push('QuickLaunchInitDroppable'); var g_zz1_TopNavigationMenu = null; function init_zz1_TopNavigationMenu() { if (g_zz1_TopNavigationMenu == null) g_zz1_TopNavigationMenu = $create(SP.UI.AspMenu, null, null, null, $get('zz1_TopNavigationMenu')); } if(g_spPreFetchKeys) {{ g_spPreFetchKeys.push('SP.Core.js');}}EnsureScriptFunc('SP.Core.js', 'SP.UI.AspMenu', init_zz1_TopNavigationMenu);
Sys.Application.add_init(function() {
    $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_pnlEmailToColleague","dynamicServicePath":"/co-allergy/pages/default.aspx","id":"emailToColleaguePopupExtender_1969857039"}, null, null, $get("ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl00_hypEmailToColleague"));
});
Sys.Application.add_init(function() {
    $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","PopupControlID":"ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_pnlExportTo","dynamicServicePath":"/co-allergy/pages/default.aspx","id":"OpenExportToPopupExtender__1218782419"}, null, null, $get("ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl01_hypExportToCitationManager"));
});
Sys.Application.add_init(function() {
    $create(AjaxControlToolkit.ModalPopupBehavior, {"BackgroundCssClass":"Popup-Overlay","DropShadow":true,"OkControlID":"ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_tocSections_addOk","PopupControlID":"ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_tocSections_pnlSectionsTable","dynamicServicePath":"/co-allergy/pages/default.aspx","id":"tocPopup_1495651488"}, null, null, $get("ctl00_ctl29_g_fdd2376e_e054_4e50_972c_27dff082bba6_ctl03_tocSections_hypGetSections"));
});
//]]>
</script>
</form>

        <span id="DeltaPlaceHolderUtilityContent">
            
            
        </span>

        <script type="text/javascript">// <![CDATA[ 


            var g_Workspace = "s4-workspace";
        // ]]>
</script>

        <div id="ctl00_ctl64_divAdConfig" data-adconfig="{&quot;adTitle&quot;:&quot;Advertisement&quot;,&quot;slotClass&quot;:&quot;ad-slot-container&quot;,&quot;topBanner&quot;:{&quot;sticky&quot;:&quot;true&quot;,&quot;stickyDuration&quot;:&quot;5000&quot;},&quot;lazyLoadingEnabled&quot;:false,&quot;npiHash&quot;:&quot;&quot;,&quot;pageTargeting&quot;:{}}" data-videoadconfig="{&quot;serverURL&quot;:&quot;https://pubads.g.doubleclick.net/gampad/ads&quot;,&quot;sizes&quot;:&quot;320x180|640x360&quot;,&quot;overlayUnitPath&quot;:&quot;/15726702761/Desktop/co-allergy/Video/overlay&quot;,&quot;prerollUnitPath&quot;:&quot;/15726702761/Desktop/co-allergy/Video/pre-roll&quot;,&quot;postrollUnitPath&quot;:&quot;/15726702761/Desktop/co-allergy/Video/post-roll&quot;}" class="js-ad-config">
</div>

<div id="ctl00_ctl64_divScripts"><script type="text/plain" async="async" src="https://securepubads.g.doubleclick.net/tag/js/gpt.js" class="optanon-category-C0004"></script>
    <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/ads.js?v=05.25.00.229" defer="true">

</script>
</div>

        
        
        
    <!-- Control to add scripts depending on settings from Configuration DB like -->
    
	
    <script type="text/javascript">
        (function($) {
            if (false) {				
                $(".top-microbar-container").addClass('top-microbar-container-moved').insertAfter(".advertisement-content_top");
            }

            $(function () {
                if (false) {
                    $(
                            '<div class="top-banner-verify-email">Be sure to check your email to verify your new user account! Thanks!</div>')
                        .insertAfter(".top-microbar-container");
                } 
            });

        })(jQuery);
		
    </script>
    

    <script type="text/javascript">
       window.twttr = (function(d, s, id) {
         var js, fjs = d.getElementsByTagName(s)[0],
           t = window.twttr || {};
         if (d.getElementById(id)) return t;
         js = d.createElement(s);
         js.id = id;
         js.src = "https://platform.twitter.com/widgets.js";
         fjs.parentNode.insertBefore(js, fjs);
       
         t._e = [];
         t.ready = function(f) {
           t._e.push(f);
         };
       
         return t;
       }(document, "script", "twitter-wjs"));
    </script>   
    <script type="text/javascript" src="https://lww.com/_layouts/15/oaks.journals/core/ee.js?v=05.25.00.229" defer="true">

</script>
<script type="text/javascript">
    function OTScriptExecutedEventHandler(e) {
        if (window.WKTracker && window.TrackingSetup) {
            window.TrackingSetup.api = window.TrackingSetup.api || {};
            window.TrackingSetup.api.baseUrl = 'https://ee.lww.com/engagementengine-api/api';
            window.TrackingSetup.api.log = window.TrackingSetup.api.log || {};
            window.TrackingSetup.api.resolve = window.TrackingSetup.api.resolve || {};

            window.TrackingSetup.gdpr = window.TrackingSetup.gdpr || {};
            window.TrackingSetup.gdpr.cookieUsageConsent = window.cookieUsageConsent || false;

            window.WKTracker.configure(window.TrackingSetup);
            window.WKTracker.track();

            // Remove the event listener
            window.removeEventListener('OTScriptExecuted', OTScriptExecutedEventHandler);
        }
    }
    window.addEventListener('OTScriptExecuted', OTScriptExecutedEventHandler);
</script>



    


    <script>(function(){function c(){var b=a.contentDocument||a.contentWindow.document;if(b){var d=b.createElement('script');d.innerHTML="window.__CF$cv$params={r:'96bdc7747f6bbb84',t:'MTc1NDY0MzE2NC4wMDAwMDA='};var a=document.createElement('script');a.nonce='';a.src='/cdn-cgi/challenge-platform/scripts/jsd/main.js';document.getElementsByTagName('head')[0].appendChild(a);";b.getElementsByTagName('head')[0].appendChild(d)}}if(document.body){var a=document.createElement('iframe');a.height=1;a.width=1;a.style.position='absolute';a.style.top=0;a.style.left=0;a.style.border='none';a.style.visibility='hidden';document.body.appendChild(a);if('loading'!==document.readyState)c();else if(window.addEventListener)document.addEventListener('DOMContentLoaded',c);else{var e=document.onreadystatechange||function(){};document.onreadystatechange=function(b){e(b);'loading'!==document.readyState&&(document.onreadystatechange=e,c())}}}})();</script></body>
</html>
