Life Science Alliance | Physiology https://www.life-science-alliance.org/physiology Sun, 10 Jul 2022 18:54:00 GMT Feed43 Proxy/1.0 (www.feed43.com) 360 e29839d6979c39fa472021c2771c1cfb Sun, 10 Jul 2022 18:54:00 GMT Septins tune lipid kinase activity and PI(4,5)P2 turnover during G-protein–coupled PLC signalling in vivo https://www.life-science-alliance.org/content/5/6/e202101293 Septins tune lipid kinase activity and PI(4,5)P<sub>2</sub> turnover during G-protein–coupled PLC signalling in vivo Aastha Kumari, Avishek Ghosh, Sourav Kolay, Padinjat Raghu

In Drosophila photoreceptors, PI(4,5)P2 synthesis during PLC signalling is regulated by PIP5K and septins.

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]]> 7cb76bffb3af1de6278d4e67ac00c26b Sun, 10 Jul 2022 18:53:59 GMT MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea https://www.life-science-alliance.org/content/5/2/e202101068 MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea Kuu Ikäheimo, Anni Herranen, Vilma Iivanainen, Tuuli Lankinen, Antti A Aarnisalo, Ville Sivonen, Kashyap A Patel, Korcan Demir, Mart Saarma, Maria Lindahl, Ulla Pirvola

The authors show in the mouse how the auditory hair cell structural maintenance is perturbed by the inactivation of Manf and the concomitant ER stress, causing early-onset, progressive hearing loss.

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]]> 6fcba8000a094e2fde22a8b6ff14d36b Sun, 10 Jul 2022 18:53:58 GMT SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart https://www.life-science-alliance.org/content/4/12/e202101048 SnRNA sequencing defines signaling by RBC-derived extracellular vesicles in the murine heart Nedyalka Valkov, Avash Das, Nathan R Tucker, Guoping Li, Ane M Salvador, Mark D Chaffin, Getulio Pereira De Oliveira Junior, Ivan Kur, Priyanka Gokulnath, Olivia Ziegler, Ashish Yeri, Shulin Lu, Aushee Khamesra, Chunyang Xiao, Rodosthenis Rodosthenous, Srimeenakshi Srinivasan, Vasilis Toxavidis, John Tigges, Louise C Laurent, Stefan Momma, Robert Kitchen, Patrick Ellinor, Ionita Ghiran, Saumya Das

In a unique model of fluorescent based mapping of EV recipient cells, RBC-EVs were found to signal to cardiac cells and regulate gene expression in a model of ischemic heart failure.

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]]> 9f88e8f58dee7969c14fc274648a6119 Sun, 10 Jul 2022 18:53:57 GMT Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells https://www.life-science-alliance.org/content/4/9/e202000987 Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells Yelena Sargsyan, Uta Bickmeyer, Christine S Gibhardt, Katrin Streckfuss-Bömeke, Ivan Bogeski, Sven Thoms

Using genetically encoded Förster resonance energy transfer calcium sensors for the peroxisome, this study dissects the previously contentious peroxisome involvement in calcium handling in HeLa cells and in cardiomyocytes derived from human induced pluripotent stem cells.

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]]> 014183df2d160d369d3af2e9c2af91f6 Sun, 10 Jul 2022 18:53:56 GMT Small intestinal flora graft alters fecal flora, stool, cytokines and mood status in healthy mice https://www.life-science-alliance.org/content/4/9/e202101039 Small intestinal flora graft alters fecal flora, stool, cytokines and mood status in healthy mice Yinyin Xie, Linyang Song, Junhua Yang, Taoqi Tao, Jing Yu, Jingrong Shi, Xiaobao Jin

Transplantation of microbiota from small intestine, not large intestine, of healthy mice exerts obvious effects on healthy recipients, bringing a new perspective on gut flora transplantation.

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]]> d2c9687549eef09b463a816e2521215c Sun, 10 Jul 2022 18:53:55 GMT Role of opioid signaling in kidney damage during the development of salt-induced hypertension https://www.life-science-alliance.org/content/3/12/e202000853 Role of opioid signaling in kidney damage during the development of salt-induced hypertension Daria Golosova, Oleg Palygin, Ruslan Bohovyk, Christine A Klemens, Vladislav Levchenko, Denisha R Spires, Elena Isaeva, Ashraf El-Meanawy, Alexander Staruschenko

Stimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.

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]]> d13b78b81e0e21c72cbce9c9922cb199 Sun, 10 Jul 2022 18:53:54 GMT Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer https://www.life-science-alliance.org/content/3/8/e202000694 Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer Anna Zagórska, Paqui G Través, Lidia Jiménez-García, Jenna D Strickland, Joanne Oh, Francisco J Tapia, Rafael Mayoral, Patrick Burrola, Bryan L Copple, Greg Lemke

The TAM receptor tyrosine kinases Mer and Axl play critical roles in liver homeostasis and in the response to both acute and chronic liver injury.

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]]> b7f9fd2e651e22c4f9d1db6ccd11a517 Sun, 10 Jul 2022 18:53:53 GMT Mylk3 null C57BL/6N mice develop cardiomyopathy, whereas Nnt null C57BL/6J mice do not https://www.life-science-alliance.org/content/3/4/e201900593 <em>Mylk3</em> null C57BL/6N mice develop cardiomyopathy, whereas <em>Nnt</em> null C57BL/6J mice do not Jack L Williams, Anju Paudyal, Sherine Awad, James Nicholson, Dominika Grzesik, Joaquin Botta, Eirini Meimaridou, Avinaash V Maharaj, Michelle Stewart, Andrew Tinker, Roger D Cox, Lou A Metherell

Genetic differences between C57BL/6 substrains lead to different cardiovascular traits; a null mutation in Mylk3 likely causes cardiomyopathy in C57BL/6N mice, whereas C57BL/6J Nnt-null mice do not develop cardiomyopathy.

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]]> 5347249679fed0bbf8158afd9601cd45 Sun, 10 Jul 2022 18:53:52 GMT The health status alters the pituitary function and reproduction of mice in a Cxcr2-dependent manner https://www.life-science-alliance.org/content/3/3/e201900599 The health status alters the pituitary function and reproduction of mice in a <em>Cxcr2</em>-dependent manner Colin Timaxian, Isabelle Raymond-Letron, Céline Bouclier, Linda Gulliver, Ludovic Le Corre, Karim Chébli, Anne Guillou, Patrice Mollard, Karl Balabanian, Gwendal Lazennec

This study explores the effects of microbiota on reproductive function of Cxcr2 knockout animals. Cxcr2 is involved in the control of pituitary action and the subsequent development of mammary gland, uterus and ovary.

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]]> 853b9fcedade666cbc75924f5d217a02 Sun, 10 Jul 2022 18:53:51 GMT Loss of autophagy impairs physiological steatosis by accumulation of NCoR1 https://www.life-science-alliance.org/content/3/1/e201900513 Loss of autophagy impairs physiological steatosis by accumulation of NCoR1 Shun-saku Takahashi, Yu-Shin Sou, Tetsuya Saito, Akiko Kuma, Takayuki Yabe, Yuki Sugiura, Hyeon-Cheol Lee, Makoto Suematsu, Takehiko Yokomizo, Masato Koike, Shuji Terai, Noboru Mizushima, Satoshi Waguri, Masaaki Komatsu

Autophagy regulates fatty acid and triglyceride synthesis at the transcriptional level by fine-tuning the levels of NCoR1, a negative regulator of nuclear receptors. Defective autophagy impairs physiological steatosis both under fasting conditions and after hepatectomy.

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