Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-026-03251-9 Nature Biotechnology, Published online: 29 July 2026; doi:10.1038/s41587-026-03251-9

As biotechnology becomes one of the defining technologies that will shape economic strength, national resilience and geopolitical influence over the coming decades, the industry must commit to rebuilding and preserving public trust in the face of growing pressures on the institutions that underpin scientific leadership.]]> Jeremy M. Levin doi:10.1038/s41587-026-03251-9 Nature Biotechnology, Published online: 2026-07-29; | doi:10.1038/s41587-026-03251-9 2026-07-29 Nature Biotechnology 10.1038/s41587-026-03251-9 https://www.nature.com/articles/s41587-026-03251-9 https://www.nature.com/articles/s41587-026-03207-z Nature Biotechnology, Published online: 29 July 2026; doi:10.1038/s41587-026-03207-z

On-the-fly conditioning of pretrained protein generative models guides protein generation toward specific properties.]]> Junhao XiongIshan GaurMaria LukarskaHunter NisonoffLuke M. OltroggeDavid F. SavageJennifer Listgarten doi:10.1038/s41587-026-03207-z Nature Biotechnology, Published online: 2026-07-29; | doi:10.1038/s41587-026-03207-z 2026-07-29 Nature Biotechnology 10.1038/s41587-026-03207-z https://www.nature.com/articles/s41587-026-03207-z https://www.nature.com/articles/s41587-026-03239-5 Nature Biotechnology, Published online: 29 July 2026; doi:10.1038/s41587-026-03239-5

Phosphorylation potential and kinase specificity are assigned for the entire human proteome.]]> David R. VanderwallEdward L. HuttlinJulian MintserisTomer M. Yaron-BarirJared L. JohnsonKevin D. DongAlex J. BottYuchen HeChristina B. SchroeterGeordon A. FrereMohamed UdumanHarin LeeSean LandrySean A. BeausoleilJoao A. PauloLewis C. CantleySteven P. Gygi doi:10.1038/s41587-026-03239-5 Nature Biotechnology, Published online: 2026-07-29; | doi:10.1038/s41587-026-03239-5 2026-07-29 Nature Biotechnology 10.1038/s41587-026-03239-5 https://www.nature.com/articles/s41587-026-03239-5 https://www.nature.com/articles/s41587-026-03264-4 Nature Biotechnology, Published online: 28 July 2026; doi:10.1038/s41587-026-03264-4

The new laws break away from 20-year-old restrictive GMO directives to give an official nod to plants made with new genomic techniques.]]> Cormac Sheridan doi:10.1038/s41587-026-03264-4 Nature Biotechnology, Published online: 2026-07-28; | doi:10.1038/s41587-026-03264-4 2026-07-28 Nature Biotechnology 10.1038/s41587-026-03264-4 https://www.nature.com/articles/s41587-026-03264-4 https://www.nature.com/articles/s41587-026-03229-7 Nature Biotechnology, Published online: 27 July 2026; doi:10.1038/s41587-026-03229-7

Polyketide synthases are engineered for the production of sustainable plastics.]]> Zilong WangSeokjung CheongHai WangJeremy DemarteauAlexander R. EpsteinBaishakhi BoseWeixi HuMatthias SchmidtLeah KeiserMei ZhaoBeibei GeAlberto A. NavaRamu KakumanuEdward E. K. BaidooYan ChenChristopher J. PetzoldYifan GuoNawa Raj BaralNemi VoraSarah L. NordahlYuzhong LiuRithwik GhantaPablo Cruz-MoralesKevin YinRobert W. HaushalterKristin A. PerssonCorinne D. ScownBrett A. HelmsJay D. Keasling doi:10.1038/s41587-026-03229-7 Nature Biotechnology, Published online: 2026-07-27; | doi:10.1038/s41587-026-03229-7 2026-07-27 Nature Biotechnology 10.1038/s41587-026-03229-7 https://www.nature.com/articles/s41587-026-03229-7 https://www.nature.com/articles/s41587-026-03203-3 Nature Biotechnology, Published online: 22 July 2026; doi:10.1038/s41587-026-03203-3

The cell-by-cell interactions between neoantigen-expressing tumor cells and tumor-specific T cells remained largely unexplored. A single-cell spatial transcriptomics framework enables mapping of neoantigen-expressing tumor cells and tumor-infiltrating T cells, as well as T cell receptor sequencing. This approach reveals distinct immune niches in the tumor microenvironment and their properties that determine tumor-specific responses.]]> doi:10.1038/s41587-026-03203-3 Nature Biotechnology, Published online: 2026-07-22; | doi:10.1038/s41587-026-03203-3 2026-07-22 Nature Biotechnology 10.1038/s41587-026-03203-3 https://www.nature.com/articles/s41587-026-03203-3 https://www.nature.com/articles/s41587-026-03194-1 Nature Biotechnology, Published online: 22 July 2026; doi:10.1038/s41587-026-03194-1

Spatial relationships between tumor neoantigens and cognate T cells are studied.]]> Adi NaglerAmit SudJack Y. GhannamLucas PomeranceCamila Robles-OteizaAlexander B. AfeyanJackson A. WeirAndrew J. C. RussellWesley S. LuMcKayla Van OrdenAndrea SonnenholznerGiovanni J. MarreroQiyu GongVipin KumarKun HuangChloe TuEmma LinBohoon ShimGabriel R. De OliveiraMacLean C. SellarsCharles H. YoonDavid A. ReardonToni K. ChoueiriLars R. OlsenSabina SignorettiPatrick A. OttDavid A. BraunGiacomo OliveiraShuqiang LiKenneth J. LivakNir HacohenFei ChenCatherine J. Wu doi:10.1038/s41587-026-03194-1 Nature Biotechnology, Published online: 2026-07-22; | doi:10.1038/s41587-026-03194-1 2026-07-22 Nature Biotechnology 10.1038/s41587-026-03194-1 https://www.nature.com/articles/s41587-026-03194-1 https://www.nature.com/articles/s41587-026-03230-0 Nature Biotechnology, Published online: 21 July 2026; doi:10.1038/s41587-026-03230-0

A resource of dissolved organic matter illuminates carbon and microbial life in Earth’s ecosystems.]]> Benjamin P. BowenThomas V. HarwoodMarkus de RaadKatherine B. LouieSuzanne M. KosinaKatherine D. McMahonNeslihan TaşNicholas J. BouskillTerry C. HazenShellie R. BenchRachel MackelprangDaniel PetrasMingxun WangFernando T. MaestreStephen J. GiovannoniTrent R. Northen doi:10.1038/s41587-026-03230-0 Nature Biotechnology, Published online: 2026-07-21; | doi:10.1038/s41587-026-03230-0 2026-07-21 Nature Biotechnology 10.1038/s41587-026-03230-0 https://www.nature.com/articles/s41587-026-03230-0