Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-026-03377-w Nature Biotechnology, Published online: 03 November 2026; doi:10.1038/s41587-026-03377-w

Each year, Nature Biotechnology highlights companies that received sizeable early-stage funding in the previous year. Wild Bioscience is pursuing crop gene editing for higher yields and climate resilience.]]> Charlie Schmidt doi:10.1038/s41587-026-03377-w Nature Biotechnology, Published online: 2026-11-03; | doi:10.1038/s41587-026-03377-w 2026-11-03 Nature Biotechnology 10.1038/s41587-026-03377-w https://www.nature.com/articles/s41587-026-03377-w https://www.nature.com/articles/s41587-026-03352-5 Nature Biotechnology, Published online: 28 October 2026; doi:10.1038/s41587-026-03352-5

smCRISPRa is a compact platform for high-efficiency multiplexed gene activation in mouse models.]]> Hainan ZhangLin YangYuling LiuDingyi HanYingnan LiJiajia LinBingyan WangJiaxu HuYaru ZhangYi ZhangJinhui LiShuping WeiSimiao LiuTong LiNa ZhongGanggang ZhangXingtao ZhouLinyu ShiJinhai HuangHui YangGuohe TanYingsi ZhouGuoling Li doi:10.1038/s41587-026-03352-5 Nature Biotechnology, Published online: 2026-10-28; | doi:10.1038/s41587-026-03352-5 2026-10-28 Nature Biotechnology 10.1038/s41587-026-03352-5 https://www.nature.com/articles/s41587-026-03352-5 https://www.nature.com/articles/s41587-026-03343-6 Nature Biotechnology, Published online: 28 October 2026; doi:10.1038/s41587-026-03343-6

Dairy cows are protected from H5N1 influenza by an mRNA vaccine.]]> Jefferson J. S. SantosCarine K. SouzaGiovana C. ZanellaDébora B. GoulartBailey ArrudaPaola BoggiattoMitchell V. PalmerCeleste A. SnyderMichaela A. KristulaCharlene DickensTerry L. WebbReilly K. AtkinsonBernadeta DadonaiteGarima DwivediMohamad-Gabriel AlamehChristopher A. HunterLisa A. MurphyJesse D. BloomDrew WeissmanGary C. AlthouseAmy L. BakerScott E. Hensley doi:10.1038/s41587-026-03343-6 Nature Biotechnology, Published online: 2026-10-28; | doi:10.1038/s41587-026-03343-6 2026-10-28 Nature Biotechnology 10.1038/s41587-026-03343-6 https://www.nature.com/articles/s41587-026-03343-6 https://www.nature.com/articles/s41587-026-03369-w Nature Biotechnology, Published online: 26 October 2026; doi:10.1038/s41587-026-03369-w

Giving AI a seat at the peer review table]]> Konstantinos DrosatosAristotelis Tsirigos doi:10.1038/s41587-026-03369-w Nature Biotechnology, Published online: 2026-10-26; | doi:10.1038/s41587-026-03369-w 2026-10-26 Nature Biotechnology 10.1038/s41587-026-03369-w https://www.nature.com/articles/s41587-026-03369-w https://www.nature.com/articles/s41587-026-03350-7 Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03350-7

RNA sequencing can capture high-resolution snapshots of a cell’s transcriptome, but transient changes in individual cells cannot be captured over long periods at a transcriptome-wide scale. Now, a synthetic organelle termed the ‘recordanelle’ can record cellular RNAs in cells for several days and be read with single-cell sensitivity.]]> doi:10.1038/s41587-026-03350-7 Nature Biotechnology, Published online: 2026-10-22; | doi:10.1038/s41587-026-03350-7 2026-10-22 Nature Biotechnology 10.1038/s41587-026-03350-7 https://www.nature.com/articles/s41587-026-03350-7 https://www.nature.com/articles/s41587-026-03358-z Nature Biotechnology, Published online: 22 October 2026; doi:10.1038/s41587-026-03358-z

ALTER is a programmable RNA base editor built entirely from human proteins. By using human AGO2 instead of bacterial CRISPR–Cas proteins, ALTER mitigates a key risk factor for harmful immune responses in therapeutic applications while also proving generally more effective than dCas13-based editors.]]> doi:10.1038/s41587-026-03358-z Nature Biotechnology, Published online: 2026-10-22; | doi:10.1038/s41587-026-03358-z 2026-10-22 Nature Biotechnology 10.1038/s41587-026-03358-z https://www.nature.com/articles/s41587-026-03358-z https://www.nature.com/articles/s41587-026-03348-1 Nature Biotechnology, Published online: 21 October 2026; doi:10.1038/s41587-026-03348-1

DynaVelo integrates single-cell omics data to infer cell state dynamics and regulatory interactions.]]> Alireza KarbalaygharehBenedikt PelzerChristopher R. ChinAri MelnickDarko BarisicChristina S. Leslie doi:10.1038/s41587-026-03348-1 Nature Biotechnology, Published online: 2026-10-21; | doi:10.1038/s41587-026-03348-1 2026-10-21 Nature Biotechnology 10.1038/s41587-026-03348-1 https://www.nature.com/articles/s41587-026-03348-1 https://www.nature.com/articles/s41587-026-03327-6 Nature Biotechnology, Published online: 21 October 2026; doi:10.1038/s41587-026-03327-6

Recordanelles continuously and unbiasedly record the transcriptome throughout time in living mammalian cells.]]> Christopher D. ReinkemeierMarcos Manero-CarranzaRick FarouniFederica FiliceAlexander KlotzKonstantin Schneider-HeieckTim L. AndermannRandall J. Platt doi:10.1038/s41587-026-03327-6 Nature Biotechnology, Published online: 2026-10-21; | doi:10.1038/s41587-026-03327-6 2026-10-21 Nature Biotechnology 10.1038/s41587-026-03327-6 https://www.nature.com/articles/s41587-026-03327-6