Nature Biotechnology is a monthly journal publishing new concepts in biological technology of relevance to bioengineering, medicine, energy, agriculture, food and the environment. It has a magazine covering the commercial, political, ethical, legal and societal aspects of this research. http://feeds.nature.com/nbt/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Biotechnology © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nbt/rss.png http://feeds.nature.com/nbt/rss/current https://www.nature.com/articles/s41587-026-03135-y Nature Biotechnology, Published online: 30 April 2026; doi:10.1038/s41587-026-03135-y

A survey of biological foundation models reveals current trends and provides an outlook for future developments in this rapidly evolving field]]> Yuzhou ChangHao ChengMirage ModiGuangyu WangDong XuQin Ma doi:10.1038/s41587-026-03135-y Nature Biotechnology, Published online: 2026-04-30; | doi:10.1038/s41587-026-03135-y 2026-04-30 Nature Biotechnology 10.1038/s41587-026-03135-y https://www.nature.com/articles/s41587-026-03135-y https://www.nature.com/articles/s41587-026-03125-0 Nature Biotechnology, Published online: 29 April 2026; doi:10.1038/s41587-026-03125-0

A strategy to control translation of mRNA vaccines reveals cell type–specific contributions to immunity that may be harnessed to enhance vaccine efficacy.]]> Haseeb MughalYizong HuDaniel G. Anderson doi:10.1038/s41587-026-03125-0 Nature Biotechnology, Published online: 2026-04-29; | doi:10.1038/s41587-026-03125-0 2026-04-29 Nature Biotechnology 10.1038/s41587-026-03125-0 https://www.nature.com/articles/s41587-026-03125-0 https://www.nature.com/articles/s41587-026-03099-z Nature Biotechnology, Published online: 29 April 2026; doi:10.1038/s41587-026-03099-z

mRNA vaccine efficacy is enhanced by silencing cell-type-specific expression.]]> Adam MarksSophia SiuFilippo BianchiniChunxi WangAshwitha LakshmiMatthew PhelanAndrew ZhuChang MoonJudit Morla-FolchAbraham J. P. TeunissenAngelo AmabileAlessia BaccariniMiriam MeradJoshua D. BrodyYizhou DongBrian D. Brown doi:10.1038/s41587-026-03099-z Nature Biotechnology, Published online: 2026-04-29; | doi:10.1038/s41587-026-03099-z 2026-04-29 Nature Biotechnology 10.1038/s41587-026-03099-z https://www.nature.com/articles/s41587-026-03099-z https://www.nature.com/articles/s41587-026-03145-w Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03145-w

The first-of-its-kind genetic medicine treats a rare and profound otoferlin-related hearing loss, and will be made available by Regeneron for free in the United States.]]> Cormac Sheridan doi:10.1038/s41587-026-03145-w Nature Biotechnology, Published online: 2026-04-28; | doi:10.1038/s41587-026-03145-w 2026-04-28 Nature Biotechnology 10.1038/s41587-026-03145-w https://www.nature.com/articles/s41587-026-03145-w https://www.nature.com/articles/s41587-026-03097-1 Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03097-1

Pooled production of recombinant AAV vectors leads to frequent genetic recombination.]]> Jean-Benoît LalanneChau HuynhJohn K. MichAvery C. HunkerTroy A. McDiarmidHaedong KimBoaz P. LeviJonathan T. TingJay Shendure doi:10.1038/s41587-026-03097-1 Nature Biotechnology, Published online: 2026-04-28; | doi:10.1038/s41587-026-03097-1 2026-04-28 Nature Biotechnology 10.1038/s41587-026-03097-1 https://www.nature.com/articles/s41587-026-03097-1 https://www.nature.com/articles/s41587-026-03109-0 Nature Biotechnology, Published online: 28 April 2026; doi:10.1038/s41587-026-03109-0

AI targets lipid nanoparticles to specific tissues while avoiding off-target delivery to the liver.]]> Muye ZhouYue XuGen LiJingan ChenMargarita SavguiraBreanna SetoFanglin GongTyler ThomsonJuan ChenRick Xing Ze LuSongtao DongDavid ChenChristabel EileenShiqi WuGang ZhengBowen Li doi:10.1038/s41587-026-03109-0 Nature Biotechnology, Published online: 2026-04-28; | doi:10.1038/s41587-026-03109-0 2026-04-28 Nature Biotechnology 10.1038/s41587-026-03109-0 https://www.nature.com/articles/s41587-026-03109-0 https://www.nature.com/articles/s41587-026-03098-0 Nature Biotechnology, Published online: 27 April 2026; doi:10.1038/s41587-026-03098-0

TaxVAMB combines sequence features with taxonomic information for improved metagenome binning.]]> Svetlana KutuzovaPau Piera LíndezLasse Schnell DanielsenKnud Nor NielsenNikoline S. OlsenLeise RiberAlex GobbiLaura Milena Forero-JuncoPeter Erdmann DoughertyJesper Cairo WestergaardPatrick Denis BrowneSvend ChristensenLars Hestbjerg HansenMads NielsenJakob Nybo AndersenSimon Rasmussen doi:10.1038/s41587-026-03098-0 Nature Biotechnology, Published online: 2026-04-27; | doi:10.1038/s41587-026-03098-0 2026-04-27 Nature Biotechnology 10.1038/s41587-026-03098-0 https://www.nature.com/articles/s41587-026-03098-0 https://www.nature.com/articles/s41587-026-03076-6 Nature Biotechnology, Published online: 23 April 2026; doi:10.1038/s41587-026-03076-6

Retron-based systems for genome editing are functional across bacterial species.]]> Alejandro González-DelgadoLaura Bonillo-LopezMilo S. JohnsonNastassia KnödlsederChing-Chung KoYassir LekbachJee-Hwan OhHemaa SelvakumarMichael C. WoldZihan YuVirginia AragónJeffrey A. GralnickMarc GüellGraham F. HatfullBenjamin K. KeitzBritt KoskellaVivek K. MutalikJan-Peter van PijkerenSeth L. Shipman doi:10.1038/s41587-026-03076-6 Nature Biotechnology, Published online: 2026-04-23; | doi:10.1038/s41587-026-03076-6 2026-04-23 Nature Biotechnology 10.1038/s41587-026-03076-6 https://www.nature.com/articles/s41587-026-03076-6