Proceedings of the National Academy of Sciences Most-Cited Full-Text Articles https://www.pnas.org/loi/pnas?af=R Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents Proceedings of the National Academy of Sciences en-US Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences https://www.pnas.org/cms/asset/433b8ee2-291a-4032-a821-9a689e8fcaa8/default_cover.png https://www.pnas.org/loi/pnas?af=R In This Issue https://www.pnas.org/doi/abs/10.1073/iti2026123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> In This Issue doi:10.1073/iti2026123 Proceedings of the National Academy of Sciences 2026-05-19T07:00:00Z Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/iti2026123 https://www.pnas.org/doi/abs/10.1073/iti2026123?af=R Profile of Richard Robson, Susumu Kitagawa, and Omar M. Yaghi: 2025 Nobel laureates in Chemistry https://www.pnas.org/doi/abs/10.1073/pnas.2605022123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>The 2025 Nobel Prize in Chemistry honors Richard Robson, Susumu Kitagawa, and Omar M. Yaghi for establishing metal-organic frameworks (MOFs) as a new class of crystalline porous materials and, more broadly, for transforming how chemists design extended ... Profile of Richard Robson, Susumu Kitagawa, and Omar M. Yaghi: 2025 Nobel laureates in Chemistry doi:10.1073/pnas.2605022123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Laura Gagliardi Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2605022123 https://www.pnas.org/doi/abs/10.1073/pnas.2605022123?af=R The Antarctic Treaty System needs a disaster management authority to guard the continent against disasters https://www.pnas.org/doi/abs/10.1073/pnas.2535757123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> The Antarctic Treaty System needs a disaster management authority to guard the continent against disasters doi:10.1073/pnas.2535757123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Michael BodeConstance JohnsonAndrew MackintoshRhianna HamiltonMd Saiful KarimSteven L. ChownaSecuring Antarctica’s Environmental Future, School of Mathematical Sciences, Queensland University of Technology, Brisbane, QLD 4000, Australiabhttps://ror.org/00jtmb277Securing Antarctica’s Environmental Future, Australian National Centre for Ocean Resources and Security, University of Wollongong, Wollongong, NSW 2522, Australiachttps://ror.org/02bfwt286Securing Antarctica’s Environmental Future, School of Earth, Atmosphere and Environment, Monash University, Melbourne, VIC 3800, AustraliadSecuring Antarctica’s Environmental Future, The University of Adelaide, Adelaide, SA 5005, Australiaehttps://ror.org/04sjbnx57School of Law and Justice, University of Southern Queensland, Ipswich, QLD 4305, Australiafhttps://ror.org/02bfwt286Securing Antarctica’s Environmental Future, School of Biological Sciences, Monash University, Melbourne, VIC 3800, Australia Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535757123 https://www.pnas.org/doi/abs/10.1073/pnas.2535757123?af=R Fungal proliferation before and after the Cretaceous–Paleogene mass extinction event in North America https://www.pnas.org/doi/abs/10.1073/pnas.2536899123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceFungal proliferation in geologic samples can signify major ecosystem disruptions. Such spikes are documented globally for the Permian-Triassic extinction but for the Cretaceous–Paleogene extinction have been reported previously only in New ... Fungal proliferation before and after the Cretaceous–Paleogene mass extinction event in North America doi:10.1073/pnas.2536899123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Rosanna P. BakerArturo CasadevallaDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2536899123 https://www.pnas.org/doi/abs/10.1073/pnas.2536899123?af=R Soil temperature fluctuations modulated millet agriculture evolution in Neolithic East Asia https://www.pnas.org/doi/abs/10.1073/pnas.2529151123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceAgriculture was the critical intermediary through which climate change influenced the trajectory of ancient civilizations, yet the mechanisms linking environmental shifts and early farming practices remain poorly delineated. In Neolithic East ... Soil temperature fluctuations modulated millet agriculture evolution in Neolithic East Asia doi:10.1073/pnas.2529151123 Proceedings of the National Academy of Sciences 2026-05-04T07:00:00Z Yongxiu LuJiaoyang RuanRuiliang LiuJade d’Alpoim GuedesJixiao WangYuanxin LiXin WangYongxiang XuLiangcheng TanJiahan ShangShugang KangGuanghui DongaState Key Laboratory of Loess Science, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710061, ChinabKey Laboratory of Western China’s Environmental System (Ministry of Education), Center for Excellence in Archaeological Science and Cultural Heritage, Lanzhou University, Lanzhou 730000, ChinacCenter for Climate Physics, Institute for Basic Science, Busan 46241, Republic of KoreadState Key Laboratory of Lithospheric and Environmental Coevolution, Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, ChinaeThe Department of Asia, British Museum, London WC1E 7JW, United KingdomfDepartment of Anthropology, University of Washington, Seattle, WA 98101 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2529151123 https://www.pnas.org/doi/abs/10.1073/pnas.2529151123?af=R Tracing the origins and recurrence of the South Atlantic Anomaly: A 2000-year absolute paleointensity record from central South America https://www.pnas.org/doi/abs/10.1073/pnas.2536503123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe geomagnetic field, generated by fluid motion in the outer core, protects the planet from harmful cosmic radiation. Over the past two centuries, the field has weakened significantly, coinciding with the growth of the South Atlantic Anomaly (... Tracing the origins and recurrence of the South Atlantic Anomaly: A 2000-year absolute paleointensity record from central South America doi:10.1073/pnas.2536503123 Proceedings of the National Academy of Sciences 2026-05-04T07:00:00Z Miriam Gómez-PaccardF. Javier Pavón-CarrascoAnnick ChauvinAlicia Palencia-OrtasMercedes Rivero-MonteroMarina Puente-BorqueSaioa A. CampuzanoAída AdsuarRaquel Bonilla-AlbaJudit del RíoRegina Velázquez-MartínMaría Luisa OseteMaría Gabriela OrtízMaría Amalia ZaburlínMaría Marta Sampietro-VattuoneDiego Martín BassoJosé Luis Peña-MonnéClarisa OteroAgustina ScaroaInstituto de Geociencias (Consejo Superior de Investigaciones Científicas-Universidad Complutense de Madrid), Spanish National Research Council, Madrid 28040, SpainbDepartamento de Física de la Tierra y Astrofísica, Universidad Complutense de Madrid, Madrid 28040, SpaincUniversity of Rennes, French National Centre for Scientific Research, Géosciences-Rennes-UMR 6118, Rennes 35000, FrancedDepartamento de Ingeniería Eléctrica, Electrónica, Automática y Física Aplicada, Escuela Técnica Superior, Ingeniería y diseño industrial, Universidad Politécnica de Madrid, Madrid 28012, SpaineDepartamento de Didáctica de las Matemáticas y de las Ciencias de la Educación, Universidad de Salamanca, Salamanca 37008, SpainfDepartamento de Didáctica de las Matemáticas y de las Ciencias de la Educación, Universidad Internacional de La Rioja, La Rioja 26008, SpaingIstituto Nazionale di Geofisica e Vulcanologia–Roma, Roma 00143, ItalyhDepartamento de Historia, Universidad de Burgos, Geografía y Comunicación, Burgos 09001, SpainiConsejo Nacional de Investigaciones Científicas y Técnicas, Unidad Ejecutora en Ciencias Sociales Regionales y Humanidades, Universidad Nacional de Jujuy, Facultad de Humanidades y Ciencias Sociales, San Salvador de Jujuy Y4600, ArgentinajInstituto de Datación y Arqueometría, Centro de Desarrollo Tecnológico “Gral Manuel Savio”, Palpalá, ArgentinakCentro Regional de Estudios Arqueológicos, Facultad de Humanidades y Ciencias Sociales, Universidad Nacional de Jujuy, San Salvador de Jujuy Y4600, ArgentinalConsejo Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Tucumán, Laboratorio de Geoarqueología, San Miguel de Tucumán 4000, ArgentinamDepartamento de Geografía y Ordenación del Territorio, Universidad de Zaragoza, Zaragoza 50009, SpainnConsejo Nacional de Investigaciones Científicas y Técnicas, Universidad de Buenos Aires, Facultad de Filosofía y Letras, Buenos Aires C1406, Argentina Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2536503123 https://www.pnas.org/doi/abs/10.1073/pnas.2536503123?af=R Disparate social structures are underpinned by distinct social rules across a primate radiation https://www.pnas.org/doi/abs/10.1073/pnas.2520774123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceWhat forces explain variation in primate societies? While kinship and dominance shape the social lives of many of our close relatives, it is unclear how their effects differ across species. Using a new database comprising decades of field ... Disparate social structures are underpinned by distinct social rules across a primate radiation doi:10.1073/pnas.2520774123 Proceedings of the National Academy of Sciences 2026-05-01T07:00:00Z Jacob A. FederSusan C. AlbertsElizabeth A. ArchieMałgorzata E. ArletAlice BanielJacinta C. BeehnerThore J. BergmanAlecia J. CarterMarie J. E. CharpentierKenneth L. ChiouCatherine CrockfordGuy CowlishawFederica Dal PescoDavid FernándezJulia FischerJames P. HighamElise HuchardAuriane Le FlochJulia LehmannAmy LuGráinne M. McCabeAlexander MielkeLiza R. MoscoviceBenjamin MubembaMegan PetersdorfCaroline RossIndia A. Schneider-CreaseRobert M. SeyfarthNoah Snyder-MacklerLarissa SwedellFranziska TredeJenny TungAnna H. WeyherRoman M. WittigJason M. KamilarJoan B. SilkaInstitute of Human Origins, Arizona State University, Tempe, AZ 85287bSchool of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85287cDepartment of Biology, Duke University, Durham, NC 27708dDepartment of Evolutionary Anthropology, Duke University, Durham, NC 27708eDuke University Population Research Institute, Duke University, Durham, NC 27708fDepartment of Biological Sciences, University of Notre Dame, South Bend, IN 46556gInstitute of Human Biology and Evolution, Faculty of Biology, Adam Mickiewicz University in Poznań, Poznań 61-712, PolandhInstitut Des Sciences de L’Evolution de Montpellier UMR5554, Centre National de la Recherche Scientifique, Institut de Recherche pour le développement, Université de Montpellier, Montpellier 34095, FranceiDepartment of Anthropology, University of Michigan, Ann Arbor, MI 48109jDepartment of Psychology, University of Michigan, Ann Arbor, MI 48109IkDepartment of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109lDepartment of Anthropology, University College London, London WC1H 0BW, United KingdommGobabeb Namib Research Institute, Walvis Bay 13103, NamibianDepartment for the Ecology of Animal Societies, Max Planck Institute of Animal Behavior, Konstanz 78467, GermanyoDepartment of Biology, University of Alabama at Birmingham, Birmingham, AL 35294pThe Ape Social Mind Laboratory, Institut des Sciences Cognitives, UMR5229 Centre National de la Recherche Scientifique/Université de Lyon 1, Bron 69500, FranceqTaï Chimpanzee Project, International Research Laboratory Chimpanzee and Monkey Protection for Intact Cultures, International Research Laboratory 2041 CNRS/Centre Suisse de Recherches Scientifique en Côte d’Ivoire, Abidjan 01, Côte, d’IvoirerInstitute of Zoology, Zoological Society of London, London NW1 4RY, United KingdomsCognitive Ethology Laboratory, German Primate Center, Göttingen 37077, GermanytDepartment for Primate Cognition, Georg-August-University Göttingen, Göttingen 37077, GermanyuDepartment of Anthropology and Archaeology, University of Calgary, Calgary, AB T2N 1N4, CanadavDepartment of Anthropology, New York University, New York, NY 10003wInstitute of Biology, University of Neuchâtel, Neuchâtel CH-2000, SwitzerlandxSchool of Human and Life Sciences, University of Roehampton, London SW15 5PJ, United KingdomyDepartment of Anthropology, Stony Brook University, Stony Brook, NY 11794zInterdepartmental Doctoral Program in Anthropological Sciences, Stony Brook University, Stony Brook, NY 11794aaWilder Institute, Calgary, AB T2E 7V6, CanadabbSchool of Biological and Behavioural Sciences, Queen Mary University of London, London E1 4DQ, United KingdomccPsychophysiology Working Group, Research Institute for Farm Animal Biology, Dummerstorf 18196, GermanyddDepartment of Wildlife Sciences, School of Natural Resources, Copperbelt University, Kitwe 10101, ZambiaeeDepartment of Anthropology, Tulane University, New Orleans, LA 70118ffCenter for Evolution and Medicine, Arizona State University, Tempe, AZ 85287ggDepartment of Psychology, University of Pennsylvania, Philadelphia, PA 19104hhSchool of Life Sciences, Arizona State University, Tempe, AZ 85287iiDepartment of Anthropology, Queens College and Graduate Center, City University of New York, New York, NY 11367jjNew York Consortium in Evolutionary Primatology, New York, NY 10016kkDepartment of Archaeology, University of Cape Town, Rondebosch, Western Cape 7700, South AfricallDepartment of Primate Behavior and Evolution, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, GermanymmDepartment of Anthropology, University of Massachusetts Amherst, Amherst, MA 01003nnGraduate Program in Organismic and Evolutionary Biology, University of Massachusetts Amherst, Amherst, MA 01003 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2520774123 https://www.pnas.org/doi/abs/10.1073/pnas.2520774123?af=R Metabolic engineering of Escherichia coli for the biosynthesis of nylon 6 and nylon 6,6 monomers https://www.pnas.org/doi/abs/10.1073/pnas.2535786123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe global transition toward sustainable materials requires renewable production routes for key nylon monomers—hexamethylenediamine (HMD), adipic acid, and ε-caprolactam (ε-CL). Here, we establish a modular microbial platform that enables de ... Metabolic engineering of Escherichia coli for the biosynthesis of nylon 6 and nylon 6,6 monomers doi:10.1073/pnas.2535786123 Proceedings of the National Academy of Sciences 2026-05-04T07:00:00Z Da-Hee AhnTong Un ChaeSang Yup Leeahttps://ror.org/05apxxy63Metabolic and Biomolecular Engineering National Research Laboratory and Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BrainKorea21 four), Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Koreabhttps://ror.org/05apxxy63BioInformatics Research Center and BioProcess Engineering Research Center, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Koreachttps://ror.org/05apxxy63Graduate School of Engineering Biology, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535786123 https://www.pnas.org/doi/abs/10.1073/pnas.2535786123?af=R Early evidence for a stable and flexible foraging niche in the evolution of Homo https://www.pnas.org/doi/abs/10.1073/pnas.2537631123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe Koobi Fora Formation preserves a rich Plio-Pleistocene record of hominins, fauna, and environments, providing a cornerstone for understanding human evolution. Nearly all zooarchaeological evidence comes from the Okote Member (~1.5 Ma), ... Early evidence for a stable and flexible foraging niche in the evolution of Homo doi:10.1073/pnas.2537631123 Proceedings of the National Academy of Sciences 2026-05-04T07:00:00Z Frances ForrestEimy Gonzalez-AlvarezDan Palcu RolierSharon KuoMatthew SkinnerJonathan ReevesErin DiMaggioSarah HlubikSahleselasie MelakuMathilde RibordyAlemu Gebresilassie WoldeEmmanuel NdiemaDavid R. BraunaDepartment of Sociology and Anthropology, Fairfield University, Fairfield, CT 06824bDepartment of Anthropology, City University of New York Graduate Center and the New York Consortium in Evolutionary Primatology, New York, NY 10016cNational Institute of Marine Geology and Geo-Ecology, Bucharest 024053, RomaniadInstitute of Astronomy, Geophysics and Atmospheric Sciences, University of São Paulo, São Paulo, SP 05508-090, BrazileDepartment of Biomedical Sciences, University of Minnesota, Duluth, MN 55812fTechnological Primates Research Group, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, GermanygDepartment of Human Origins, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, GermanyhInterdisciplinary Center for Archaeology and the Evolution of Human Behavior, Universidade do Algarve, Faro 8005-139, PortugaliDepartment of Earth Sciences and Archaeology, National Museums of Kenya, Nairobi 00100, KenyajDepartment of Geosciences, The Pennsylvania State University, University Park, PA 16802kSociology and Anthropology Department, St. Mary’s College of Maryland, St. Mary’s City, MD 20686lPaleontology and Paleoanthropology Department, Ethiopian Heritage Authority, Addis Ababa 1000, EthiopiamDepartment of Anthropology, Harvard University, Cambridge, MA 02138nDepartment of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138oDepartment of Archaeology and Heritage Management, Wolaita Sodo University, Wolaita Sodo 4620, EthiopiapDynamiques bio-culturelles en Afrique, De la Préhistoire à l’Actuel: Culture, Environnement et Anthropologie Laboratory (UMR 5199), Université de Bordeaux, Pessac 33615, FranceqCenter for the Advanced Study of Human Paleobiology, Department of Anthropology, George Washington University, Washington, DC 20052 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537631123 https://www.pnas.org/doi/abs/10.1073/pnas.2537631123?af=R Choice of cardioplegia influences metabolomics of human cardiac tissue https://www.pnas.org/doi/abs/10.1073/pnas.2602039123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceAbnormal cardiac metabolism contributes to the pathophysiology of heart failure, and metabolomics analysis has provided novel insights. Procuring human cardiac samples is challenging. To capture metabolic status at the time of harvest, samples ... Choice of cardioplegia influences metabolomics of human cardiac tissue doi:10.1073/pnas.2602039123 Proceedings of the National Academy of Sciences 2026-05-07T07:00:00Z Sho TanosakiYuan ZhangKenneth BediKenneth MarguliesJames E. CoxZoltan AranyE. Dale AbelaCardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104bDivision of Cardiovascular Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104cDepartment of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104dDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of California, Los Angeles, CA 90095eDepartment of Biochemistry, University of Utah, Salt Lake City, UT 84112fMetabolomics Core Research Facility, University of Utah, Salt Lake City, UT 84112 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2602039123 https://www.pnas.org/doi/abs/10.1073/pnas.2602039123?af=R A multinational megastudy of the effects of gratitude practices on subjective well-being https://www.pnas.org/doi/abs/10.1073/pnas.2537789123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceIn a large-scale collaboration, we tested the effects of six brief gratitude interventions among 10,696 participants from 34 culturally diverse countries. Compared to control tasks, gratitude interventions produced several theorized benefits: ... A multinational megastudy of the effects of gratitude practices on subjective well-being doi:10.1073/pnas.2537789123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Nicholas A. ColesAnnabel V. DangShigehiro OishiAbigail AdadeAderonke A. AkintolaBeatriz B. de SouzaBiljana GjoneskaChristine R. HarrisDev KesarwaniDinara PisarevaEugene Y. J. TeeGoo LyannGul GunaydinGyuri LeeHongbo YuHyewon ChoiJohnBosco Chika ChukwuorjiKaroline KlitgaardMaciej BehnkeMagnus BergquistMarit Gunda Gundersen EngesetNattasuda TaephantNikita DurnevOgnen SpasovskiPaulo Sergio BoggioRam Manohar SinghRobin IrmelSergio BarbosaShangcheng ZhaoSinem Acar-BurkayStefan PfattheicherTatsunori IshiiVictor Goh Weng YewVivian DzokotoZeynep SoyalanMichael E. McCulloughahttps://ror.org/02y3ad647Department of Psychology, University of Florida, Gainesville, FL 32611bhttps://ror.org/024mw5h28Department of Psychology, University of Chicago, Chicago, IL 60637chttps://ror.org/02nkdxk79Department of Psychology, Virginia Commonwealth University, Richmond, VA 23284dhttps://ror.org/01v0we819Department of Psychology, Redeemer’s University, Ede 232101, NigeriaeNational Institute of Science and Technology on Social and Affective Neuroscience, São Paulo 05508-000, Brazilfhttps://ror.org/003jsdw96Macedonian Academy of Sciences and Arts, Skopje 1000, North Macedoniaghttps://ror.org/0168r3w48Department of Psychology, University of California San Diego, La Jolla, CA 92093hhttps://ror.org/00582g326Department of Humanities and Social Sciences, Indian Institute of Technology Roorkee, Roorkee 247667, Indiaihttps://ror.org/052bx8q98Department of Political Science and Internal Relations, Nazarbayev University, Astana 010000, Kazakhstanjhttps://ror.org/026wwrx19Department of Psychology, Higher Education Learning Philosophy University, Kuala Lumpur 50490, Malaysiakhttps://ror.org/049asqa32Psychology Program, Sabancı University, Istanbul 34956, Türkiyelhttps://ror.org/01zqcg218Department of Sociology, Kyung Hee University, Seoul 02447, Koreamhttps://ror.org/02t274463Department of Psychological and Brain Sciences, University of California Santa Barbara, Santa Barbara, CA 93106nhttps://ror.org/01sn1yx84Department of Psychology, University of Nigeria, Nsukka 410001, Nigeriaohttps://ror.org/01aj84f44Department of Psychology, Aarhus University, Aarhus C 8000, DenmarkpFaculty of Physics and Astronomy, Adam Mickiewicz University, Poznań 61-614, Polandqhttps://ror.org/01tm6cn81Department of Psychology, University of Gothenburg, Gothenburg 405 30, Swedenrhttps://ror.org/05ecg5h20Department of Business, Marketing and Law, University of South-Eastern Norway, Notodden 3679, Norwayshttps://ror.org/028wp3y58Department of Psychology, Chulalongkorn University, Bangkok 10330, Thailandthttps://ror.org/00hj8s172Mailman School of Public Health, Columbia University, New York, NY 10027uhttps://ror.org/02wk2vx54Department of Psychology, Ss. Cyril and Methodius University of Skopje, Skopje 1000, North Macedoniavhttps://ror.org/006nc8n95Center for Health and Biological Sciences, Mackenzie Presbyterian University, São Paulo 01302-907, Brazilwhttps://ror.org/0108mwc04School of Medicine and Health Sciences, Universidad del Rosario, Bogotá 111221, Colombiaxhttps://ror.org/04gpcyk21Department of Psychology, Japan Women’s University, Tokyo 112-8681, Japan Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537789123 https://www.pnas.org/doi/abs/10.1073/pnas.2537789123?af=R Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes https://www.pnas.org/doi/abs/10.1073/pnas.2527503123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMaintenance of retinal proteostasis is essential for normal function, and its failure underlies common age-related degenerative retinal diseases. In this study, we show that chaperone-mediated autophagy (CMA), a selective form of autophagy ... Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes doi:10.1073/pnas.2527503123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Raquel Gómez-SintesInmaculada TassetIgnacio Ramírez-PardoAdrián Martín-SeguraSandra Alonso-GilAntonio DíazKristen LindenauConcepción LilloPedro de la VillaSimone SidoliEvripidis GavathiotisAna María CuervoPatricia BoyaaDepartment of Cellular and Molecular Biology, Centro de Investigaciones Biológicas Margarita Salas, Consejo superior de Investigaciones Científicas (CSIC), Madrid 28040, SpainbDepartment of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY 10461cDepartment of Biochemistry and Molecular Biology, University of Córdoba, Córdoba 14078, SpaindDepartment of Medicine and Life Sciences, Universitat Pompeu Fabra, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas (CIBERNED), Barcelona 08003, SpaineDepartamento Biología Celular y Patología, Instituto de Neurociencias de Castilla y León (INCYL), Instituto de Investigación Biomédica de Salamanca (IBSAL), Universidad de Salamanca, Salamanca 37007, SpainfDepartamento Fisiología, Universidad de Alcalá de Henares, Madrid 28801, SpaingDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461hDepartment of Medicine, Institute for Geroscience, Albert Einstein College of Medicine, Bronx, NY 10461iDepartment of Neuroscience and Movement Science, Faculty of Science and Medicine, University of Fribourg, Fribourg 1700, Switzerland Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2527503123 https://www.pnas.org/doi/abs/10.1073/pnas.2527503123?af=R Emergent anisotropic three-phase order in critically doped superconducting diamond films https://www.pnas.org/doi/abs/10.1073/pnas.2607730123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceIn heavily boron doped diamond (HBDD), doping induced disorder can lead to inhomogeneity in the superconducting order parameter even in structurally homogeneous samples. We probe this intrinsically granular superconducting state in single ... Emergent anisotropic three-phase order in critically doped superconducting diamond films doi:10.1073/pnas.2607730123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Jyotirmay DwivediSaurav IslamJake MorrisKalana D. HalanayakeGabriel A. Vázquez-LizardiDavid SnyderAnthony RichardellaLuke LyleDanielle Reifsnyder HickeyNazar DeleganF. Joseph HeremansDavid D. AwschalomNitin Samarthahttps://ror.org/04p491231Department of Physics, The Pennsylvania State University, University Park, PA 16802bhttps://ror.org/04p491231Department of Chemistry, The Pennsylvania State University, University Park, PA 16802cElectronic Materials and Devices Department, Applied Research Lab, The Pennsylvania State University, University Park, PA 16802dhttps://ror.org/04p491231Department of Materials Science and Engineering, The Pennsylvania State University, University Park, PA 16802eMaterials Research Institute, The Pennsylvania State University, University Park, PA 16802fhttps://ror.org/05gvnxz63Q-NEXT, Argonne National Laboratory, Lemont, IL 60439ghttps://ror.org/024mw5h28Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637hhttps://ror.org/05gvnxz63Materials Science Division, Argonne National Laboratory, Lemont, IL 60439ihttps://ror.org/024mw5h28Department of Physics, University of Chicago, Chicago, IL 60637 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2607730123 https://www.pnas.org/doi/abs/10.1073/pnas.2607730123?af=R Refining the mechanism of heme acquisition from free hemoglobin by Staphylococcus aureus IsdH https://www.pnas.org/doi/abs/10.1073/pnas.2601134123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceBacterial pathogens must acquire essential nutrients from the human host to survive and cause infection. One of the most important is iron, which in our bloodstream is sequestered inside hemoglobin.Staphylococcus aureusovercomes this barrier ... Refining the mechanism of heme acquisition from free hemoglobin by Staphylococcus aureus IsdH doi:10.1073/pnas.2601134123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Valeria Buoli ComaniOmar De BeiGiulia ParisMarialaura MarchettiFrancesca PancraziBarbara CampaniniLuca RondaBen F. LuisiSerena FaggianoAnna Rita BizzarriStefano Bettatiahttps://ror.org/02k7wn190Department of Food and Drug, University of Parma, Parma 43124, Italybhttps://ror.org/02k7wn190Interdepartmental Center Biopharmanet-TEC, University of Parma, Parma 43124, Italychttps://ror.org/02k7wn190Department of Medicine and Surgery, University of Parma, Parma 43125, Italydhttps://ror.org/013meh722Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, United KingdomeBiophysics and Nanoscience Centre, Department of Ecological and Biological Sciences, Università della Tuscia, Viterbo 01100, Italyfhttps://ror.org/04zaypm56Institute of Biophysics, National Research Council, Pisa 56124, Italy Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2601134123 https://www.pnas.org/doi/abs/10.1073/pnas.2601134123?af=R Politics embodied: How politics shapes and is shaped by the bodily experience of emotions https://www.pnas.org/doi/abs/10.1073/pnas.2534895123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceEmotions are central to politics, and the body is central to emotional experience, yet we know little about how political emotions are actually felt and represented in the body. This study shows that political emotions, such as political anger,... Politics embodied: How politics shapes and is shaped by the bodily experience of emotions doi:10.1073/pnas.2534895123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Andrea VikAlejandro Galvez-PolSohee ParkManos TsakirisaDepartment of Psychology, Royal Holloway, University of London, Surrey TW20 0EX, United KingdombCentre for the Politics of Feelings. School of Advanced Study, University of London, London WC1 7HU, United KingdomcDepartment of Psychology, University of the Balearic Islands, Mallorca 07122, SpaindActive Cognition, Embodiment, and Environment Lab, Cognition and Society Research Unit, University of the Balearic Islands, Mallorca 07122, SpaineDepartment of Psychology, Vanderbilt University, Nashville TN 37240 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2534895123 https://www.pnas.org/doi/abs/10.1073/pnas.2534895123?af=R Exploring entropy landscapes using hard particle Monte Carlo metadynamics https://www.pnas.org/doi/abs/10.1073/pnas.2537764123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceUnderstanding how colloidal particles self-assemble into ordered structures is central to material design, yet many colloidal systems composed of hard particles remain partially understood because their assembly pathways are inaccessible to ... Exploring entropy landscapes using hard particle Monte Carlo metadynamics doi:10.1073/pnas.2537764123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Charlotte Shiqi ZhaoSun-Ting TsaiSharon C. Glotzerahttps://ror.org/00jmfr291Department of Chemical Engineering, University of Michigan, Ann Arbor, MI 48109bhttps://ror.org/00jmfr291Biointerfaces Institute, University of Michigan, Ann Arbor, MI 48109 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537764123 https://www.pnas.org/doi/abs/10.1073/pnas.2537764123?af=R Temperature-dependent feedbacks drive the pattern of Antarctic temperature change https://www.pnas.org/doi/abs/10.1073/pnas.2513383123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceChanges in Earth’s climate are caused by changes in incoming and outgoing energy. However, understanding the patterns of temperature response that result from changes in energy balance is not straightforward. Here we investigate the patterns ... Temperature-dependent feedbacks drive the pattern of Antarctic temperature change doi:10.1073/pnas.2513383123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Bradley R. MarkleEric J. SteigaDepartment of Geological Sciences, University of Colorado, Boulder, CO 80309bInstitute of Arctic and Alpine Research, University of Colorado, Boulder, CO 80309cDepartment of Earth and Space Sciences, University of Washington, Seattle, WA 98195dDepartment of Atmospheric Sciences, University of Washington, Seattle, WA 98195 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2513383123 https://www.pnas.org/doi/abs/10.1073/pnas.2513383123?af=R Observing the mechanism of delayed collapse in colloidal gels: Yielding while becoming stronger https://www.pnas.org/doi/abs/10.1073/pnas.2528499123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceColloidal gels are everyday materials from cosmetics to foods and even cement, but they challenge our understanding because they are not in thermodynamic equilibrium and so their properties change over time. A particularly surprising ... Observing the mechanism of delayed collapse in colloidal gels: Yielding while becoming stronger doi:10.1073/pnas.2528499123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Rui ChengMalcolm A. FaersFrancesco TurciAbraham Mauleon-AmievaTanniemola B. LiverpoolRobert L. JackC. Patrick RoyallaGulliver UMR CNRS 7083, École Supérieure de Physique et de Chimie Paris, Université PSL, Paris 75005, FrancebBristol Centre for Functional Nanomaterials, Bristol BS8 1TL, United KingdomcFormulation Technology, Bayer AG, Monheim am Rhein 40789, GermanydHH Wills Physics Laboratory, Bristol BS8 1TL, United KingdomeSchool of Mathematics, University of Bristol, Bristol BS8 1UG, United KingdomfYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United KingdomgDepartment of Applied Mathematics and Theoretical Physics, Centre for Mathematical Sciences, University of Cambridge, Cambridge CB3 0WA, United KingdomhDepartment of Physics, University of Warwick, Coventry CV4 7AL, United Kingdom Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2528499123 https://www.pnas.org/doi/abs/10.1073/pnas.2528499123?af=R Global and regional climate modes modulate armed conflict risk https://www.pnas.org/doi/abs/10.1073/pnas.2532935123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceClimate variability can alter the risk of armed conflict. Leveraging empirical modeling on a dataset of armed conflicts and the natural experiments provided by the El Niño-Southern Oscillation (ENSO) and the Indian Ocean Dipole (IOD), we offer ... Global and regional climate modes modulate armed conflict risk doi:10.1073/pnas.2532935123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Tyler E. BagwellSylvia G. DeeXinyue LuoAnna StravatoDivya SaikumarFrederi ViensBomi K. LeeDiana Z. O’BrienJustin S. Mankinahttps://ror.org/008zs3103Department of Statistics, Rice University, Houston, TX 77005bhttps://ror.org/008zs3103Department of Earth, Environmental, and Planetary Sciences, Rice University, Houston, TX 77005cZhejiang Climate Center, Hangzhou, Zhejiang 310051, Chinadhttps://ror.org/008zs3103Department of English, Rice University, Houston, TX 77005ehttps://ror.org/008zs3103Department of BioSciences, Rice University, Houston, TX 77005fhttps://ror.org/00fc1qt65Department of Political Science, Bucknell University, Lewisburg, PA 17837ghttps://ror.org/01yc7t268Department of Political Science, Washington University in St. Louis, St. Louis, MO 63130hhttps://ror.org/049s0rh22Department of Geography, Dartmouth College, Hanover, NH 03755 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2532935123 https://www.pnas.org/doi/abs/10.1073/pnas.2532935123?af=R Oak masting breaks down in a highly fragmented, pollen-limited landscape https://www.pnas.org/doi/abs/10.1073/pnas.2533900123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMast seeding, boom and bust seed production, has rippling effects throughout forest food webs These variable seed crops rely on interannual differences in flower production and pollination. We hypothesized that fragmentation, an important ... Oak masting breaks down in a highly fragmented, pollen-limited landscape doi:10.1073/pnas.2533900123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Ian S. PearseJill H. BatyMario B. PesendorferRobert OlsonWalter D. KoenigaU.S. Geological Survey, Fort Collins Science Center, Fort Collins, CO 80526bCity of Fort Collins, Dept Planning and Development, Fort Collins, CO 80524chttps://ror.org/057ff4y42Universität für Bodenkultur Wien, Dept Forest Ecology, Vienna 1180, AustriadSmithsonian’s National Zoo and Conservation Biology Institute, Washington, D.C. 20008eNet Contents Consulting, Los Altos, CA 94022fhttps://ror.org/01an7q238Hastings Natural History Reservation, University of California Berkeley, Carmel Valley, CA 93924 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2533900123 https://www.pnas.org/doi/abs/10.1073/pnas.2533900123?af=R Synovial fibroblasts modulate endothelial activation in an acute injury-on-a-chip model https://www.pnas.org/doi/abs/10.1073/pnas.2524677123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceDue to the clinical treatment timeframe, much is unknown about the initial cellular response within the human knee joint after an injury. This knowledge could guide early interventions to prevent injury-induced joint disease. Tissue-on-a-chip ... Synovial fibroblasts modulate endothelial activation in an acute injury-on-a-chip model doi:10.1073/pnas.2524677123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Hannah M. ZlotnickDeclan N. GoddardChristopher J. CaloAbhishek P. DhandMatthew D. DavidsonAina Solsona-PujolJonathan T. MakhoulHannah K. WeppnerMelissa WongCarla R. ScanzelloLaurel E. HindJason A. Burdickahttps://ror.org/02ttsq026BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80303bhttps://ror.org/02ttsq026Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303chttps://ror.org/00b30xv10Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104dhttps://ror.org/02ttsq026Department of Biomedical Engineering, University of Colorado Boulder, Boulder, CO 80303ehttps://ror.org/03j05zz84Cartilage Regeneration using Advanced Technologies to Enable Motion Center, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA 19104fDivision of Rheumatology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2524677123 https://www.pnas.org/doi/abs/10.1073/pnas.2524677123?af=R Anoxic photo-oxidation of Mn(II)-bearing carbonates on Mars and early Earth https://www.pnas.org/doi/abs/10.1073/pnas.2607260123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceManganese oxides are important redox catalysts in planetary (bio)geochemical cycles and have long been interpreted as proxies for the rise of atmospheric oxygen on early Earth. While pure MnCO3is photoactive under ultraviolet (UV) irradiation,... Anoxic photo-oxidation of Mn(II)-bearing carbonates on Mars and early Earth doi:10.1073/pnas.2607260123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Jiye GuoYuke ZhuNicholas J. ToscaLu PanDavid C. CatlingYi LiuWenhua ZhangAmrit S. ChaddhaPengcheng JuJie LiZongbin ZhangAnya HuoYunguo LiFang HuangPaul G. FalkowskiJihua HaoaState Key Laboratory of Lithospheric and Environmental Coevolution, School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, Anhui ChinabNational Key Laboratory of Deep Space Exploration, School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, Anhui ChinacDepartment of Earth Sciences, University of Cambridge, Cambridge CB2 3EQ, United KingdomdState Key Laboratory of Precision Geodesy, School of Earth and Space Sciences, University of Science and Technology of China, Hefei 230026, ChinaeDepartment of Earth and Space Sciences and Cross-Campus Astrobiology Program, University of Washington, Seattle, WA 98195fNational Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230029, Anhui ChinagDepartment of Earth and Planetary Sciences, Rutgers University, Piscataway, NJ 08854hDepartment of Marine and Coastal Sciences, Rutgers University, New Brunswick, NJ 08901 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2607260123 https://www.pnas.org/doi/abs/10.1073/pnas.2607260123?af=R Swartkrans Paranthropus and Sterkfontein Australopithecus from southern Africa had different locomotor repertoires https://www.pnas.org/doi/abs/10.1073/pnas.2532193123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceSouthern AfricanParanthropus robustusand SterkfonteinAustralopithecusare traditionally distinguished by their dentition and cranial architecture, while postcranial anatomy has often been assumed to be similar, reflecting a combination of ... Swartkrans Paranthropus and Sterkfontein Australopithecus from southern Africa had different locomotor repertoires doi:10.1073/pnas.2532193123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Marine CazenaveAnnalisa PietrobelliAndrea LukováSebastian BachmannMatthew V. CaruanaRonald J. ClarkeChristopher J. DunmoreAshley S. HammondJason L. HeatonA. J. HeileJakobus HoffmanKathleen KumanDieter H. PahrChristopher M. SmithDominic StratfordAlexander SynekZewdi J. TsegaiTracy L. KivellTravis Rayne PickeringMatthew M. Skinnerahttps://ror.org/02a33b393Department of Human Origins, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germanybhttps://ror.org/03thb3e06Division of Anthropology, American Museum of Natural History, New York, NY 10024-5102chttps://ror.org/00g0p6g84Department of Anatomy, Faculty of Health Sciences, University of Pretoria, Pretoria 0084, South Africadhttps://ror.org/040t43x18Department of Anthropology, University of West Bohemia in Pilsen, Pilsen 301 00, Czech Republicehttps://ror.org/04d836q62Institute of Lightweight Design and Structural Biomechanics, Technischen Universität Wien, Vienna 1060, Austriafhttps://ror.org/03rp50x72Evolutionary Studies Institute, University of the Witwatersrand, Johannesburg 2017, South Africaghttps://ror.org/04z6c2n17Palaeo-Research Institute, University of Johannesburg, Johannesburg 2006, South Africahhttps://ror.org/00xkeyj56School of Biosciences, University of Kent, Canterbury CT2 7NZ, United KingdomiInstitut Català de Paleontologia Miquel Crusafont, Universitat Autònoma de Barcelona, Barcelona 08193, Spainjhttps://ror.org/0371hy230Institució Catalana de Recerca i Estudis Avançats, Barcelona 08010, Spainkhttps://ror.org/008s83205Department of Biology, University of Alabama at Birmingham, Birmingham, AL 35205lhttps://ror.org/01y2jtd41Department of Anthropology, University of Wisconsin, Madison, WI 53706mhttps://ror.org/04a711r87South African Nuclear Energy Corporation, Pelindaba 0240, South Africanhttps://ror.org/03rp50x72School of Geography, Archaeology and Environmental Studies, University of the Witwatersrand, Johannesburg 2000, South Africaohttps://ror.org/04z49n283Department of Biology, Fairfield University, Fairfield, CT 06824phttps://ror.org/03p65m515New York Consortium in Evolutionary Primatology, New York, NY 10024qhttps://ror.org/05qghxh33Department of Anthropology, Stony Brook University, Stony Brook, NY 11794rhttps://ror.org/024mw5h28Department of Organismal Biology and Anatomy, University of Chicago, Chicago, IL 60637shttps://ror.org/02a33b393Department of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig 04103, Germany Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2532193123 https://www.pnas.org/doi/abs/10.1073/pnas.2532193123?af=R MHC-I diversity enables rapid adaptation during a viral pandemic in wild rabbit populations https://www.pnas.org/doi/abs/10.1073/pnas.2532064123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe Major Histocompatibility Complex (MHC) encodes a family of highly polymorphic immune recognition molecules whose role in disease resistance is well established. However, direct evidence that pathogens drive MHC evolution in natural ... MHC-I diversity enables rapid adaptation during a viral pandemic in wild rabbit populations doi:10.1073/pnas.2532064123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Yexin ZhangJonathan P. DayMarina LirintziJiayi JiClive A. TregaskesMiguel CarneiroJoel M. AlvesTanja StriveJim KaufmanFrancis M. JigginsaDepartment of Genetics, University of Cambridge, Cambridge CB2 3EH, United KingdombDepartment of Genetics, Evolution and Environment, University College London, London WC1E 6BT, United KingdomcCentro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, Vairão 4485-661, PortugaldBIOPOLIS Program in Genomics, Biodiversity and Land Planning, Centro de Investigação em Biodiversidade e Recursos Genéticos, InBIO Laboratório Associado, Universidade do Porto, Vairão 4485-661, PortugalePalaeogenomics and Bio-Archaeology Research Network, School of Archaeology, University of Oxford, Oxford OX1 3QY, United KingdomfCommonwealth Scientific and Industrial Research Organisation, Health and Biosecurity Business Unit, Acton, Australian Capital Territory 2601, AustraliagInstitute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, United KingdomhDepartment of Immunobiology, Yale University, New Haven, CT 06510 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2532064123 https://www.pnas.org/doi/abs/10.1073/pnas.2532064123?af=R Identification of immunostimulatory antigens in Group A Streptococcus–derived vesicles https://www.pnas.org/doi/abs/10.1073/pnas.2537351123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceGroup A streptococci (GAS) are responsible for a wide array of infections, ranging from mild throat and skin infections to less common but more severe invasive infections and autoimmune complications. Despite being a significant burden for the ... Identification of immunostimulatory antigens in Group A Streptococcus–derived vesicles doi:10.1073/pnas.2537351123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Meztlli O. GaytánRebecca S. DookieSayoni ChakrabortyAnandi Narayana MoorthyStefan KreidaAnna Norrby-TeglundJohn BossMax HeurgrenStaffan NormarkBirgitta Henriques-NormarkaDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm SE-171 65, SwedenbCenter for Infectious Medicine, Department of Medicine, Alfred Nobels Allé Futura, Karolinska Institutet, Karolinska University Hospital, Huddinge SE-141 52, SwedencClinical Microbiology, Karolinska University Hospital, Stockholm SE-171 76, Sweden Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537351123 https://www.pnas.org/doi/abs/10.1073/pnas.2537351123?af=R Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids https://www.pnas.org/doi/abs/10.1073/pnas.2528332123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceWe show that a peptide corresponding to the Kinesin Tail Domain selectively removes kinesin-1 motors from Lipid Droplets (LDs), thus blocking the delivery of lipids for very low density lipoproteins (VLDL) assembly inside hepatocytes in the ... Selective targeting of kinesin on lipid droplets in the liver reduces plasma lipids doi:10.1073/pnas.2528332123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Subham Kumar TripathyArchisman MahapatraOjal SaharanHindol ChatterjeeNeelanjana SenguptaSiddhesh KamatSreelaja NairRoop Mallikahttps://ror.org/02qyf5152Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400076, Indiabhttps://ror.org/028qa3n13Department of Biology, Indian Institute of Science Education and Research, Pune 411008, Indiachttps://ror.org/00djv2c17Department of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, India Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2528332123 https://www.pnas.org/doi/abs/10.1073/pnas.2528332123?af=R Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization https://www.pnas.org/doi/abs/10.1073/pnas.2533968123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificancePachytene piRNAs are essential for male fertility, yet how their biogenesis is spatially organized within germ cells remains unclear. This study identifies mitochondrial scaffold proteins that govern the recruitment and compartmentalization of ... Spatiotemporal control of PIWI compartmentalization by mitochondrial scaffolds defines pachytene piRNA pathway organization doi:10.1073/pnas.2533968123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Xiaoyuan YanChao WeiJeffrey M. MannGuanyi ShangQianyi WangHuirong XieElena Y. DemirevaLiangliang SunDeqiang DingChen ChenaDepartment of Animal Science, Michigan State University, East Lansing, MI 48824bShanghai Key Laboratory of Maternal and Fetal Medicine, Clinical and Translational Research Center, Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, ChinacDepartment of Chemistry, Michigan State University, East Lansing, MI 48824dTransgenic and Genome Editing Facility, Michigan State University, East Lansing, MI 48824eReproductive and Developmental Sciences Program, Michigan State University, East Lansing, MI 48824fDepartment of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI 49503 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2533968123 https://www.pnas.org/doi/abs/10.1073/pnas.2533968123?af=R Ancestral splice variation is a key substrate for rapid diversification in African cichlids https://www.pnas.org/doi/abs/10.1073/pnas.2516477123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceAdaptive radiation—when species rapidly diversify to fill new ecological niches—is a key driver of biodiversity, but its underlying molecular mechanisms remain unclear. Using comparative transcriptome sequencing across multiple African cichlid ... Ancestral splice variation is a key substrate for rapid diversification in African cichlids doi:10.1073/pnas.2516477123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Pooja SinghEhsan Pashay AhiAnna DuenserMarija DurdevicWolfgang GesslSylvia SchaefferJulian GallaunOle SeehausenChristian SturmbaueraDepartment of Biology, University of Graz, Graz 8010, AustriabDivision of Aquatic Ecology and Evolution, Institute of Ecology and Evolution, University of Bern, Bern 3012, SwitzerlandcDepartment of Fish Ecology and Evolution, Swiss Federal Institute of Aquatic Science and Technology (EAWAG), Kastanienbaum 6048, SwitzerlanddOrganismal and Evolutionary Biology Research Programme, University of Helsinki, Helsinki 00014, FinlandeFederal Agency for Water Management, Institute for Water Ecology, Fisheries and Lake Research, Mondsee 5310, AustriafDiagnostic and Research Centre for Molecular BioMedicine, Institute of Pathology, Medical University of Graz, Graz 8010, AustriagCore Facility Computational Bioanalytic, Centre for Medical Research, Medical University of Graz, Graz 8010, Austria Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2516477123 https://www.pnas.org/doi/abs/10.1073/pnas.2516477123?af=R Binocular vision emerges from the coordinated development of orbit convergence, eye orientation, and high-acuity retinal specializations https://www.pnas.org/doi/abs/10.1073/pnas.2537038123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceBinocular vision depends on the alignment of eye and orbit orientation, retinal specializations, and central visual circuitry. By integrating anatomical and behavioral analyses across postnatal development, this study demonstrates that ... Binocular vision emerges from the coordinated development of orbit convergence, eye orientation, and high-acuity retinal specializations doi:10.1073/pnas.2537038123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Alfonso DeichlerMacarena Ruiz-FloresNatalia I. MárquezCristian MoralesLuciana López-JuryTomas Vega-ZunigaJorge MpodozisMacarena FaunesGonzalo J. Marínahttps://ror.org/047gc3g35Departamento de Biología, Facultad de Ciencias, Universidad de Chile, Santiago 7800003, ChilebMillennium Nucleus Early Evolutionary Transitions of Mammals, Santiago 7800003, Chilechttps://ror.org/04teye511Escuela de Medicina Veterinaria, Facultad de Agronomía y Sistemas Naturales, Facultad de Ciencias Biológicas y Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago 7820436, Chiledhttps://ror.org/0225snd59Facultad de Medicina y Salud, Universidad Finis Terrae, Santiago 7501015, Chile Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537038123 https://www.pnas.org/doi/abs/10.1073/pnas.2537038123?af=R Alleviating administrative burdens in rental assistance promotes access and program efficiency https://www.pnas.org/doi/abs/10.1073/pnas.2512756123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMillions of people struggle to access government benefits that they are eligible to receive. Existing research has shown administrative burdens like documentation requirements can be a major barrier to accessing benefits. We study the impact ... Alleviating administrative burdens in rental assistance promotes access and program efficiency doi:10.1073/pnas.2512756123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Tyler SimkoRebecca A. JohnsonaDepartment of Political Science, University of Michigan, Ann Arbor, MI 48109bMcCourt School of Public Policy, Washington, DC 20001 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2512756123 https://www.pnas.org/doi/abs/10.1073/pnas.2512756123?af=R SFTSV NSs protein is a tick antiviral RNAi response suppressor https://www.pnas.org/doi/abs/10.1073/pnas.2524728123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis study reveals a critical requirement for severe fever with thrombocytopenia syndrome virus (SFTSV) infection that differs between hosts. While the viral NSs protein is dispensable in interferon deficient mammalian cells, it is essential ... SFTSV NSs protein is a tick antiviral RNAi response suppressor doi:10.1073/pnas.2524728123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Mazigh FaresMelanie McFarlaneRhys H. ParryRozeena ArifAndrew T. ClarkeWael KamelKelsey DaviesRiona Datta-SavageUlrich Schwarz-LinekLesley Bell-SakyiMarine J. PetitEsther SchnettlerAlfredo CastelloAlain KohlBenjamin Brennanahttps://ror.org/00vtgdb53Medical Research Council–University of Glasgow Centre for Virus Research, Glasgow, Scotland G61 1QH, United Kingdombhttps://ror.org/00rqy9422School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia 4072, Australiachttps://ror.org/02wn5qz54Biomedical Sciences Research Complex, University of St Andrews, St Andrews, Scotland KY16 9ST, United Kingdomdhttps://ror.org/04xs57h96Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool L3 5RF, United Kingdomehttps://ror.org/00ks66431Microbes, Infection and Immunity, School of Biosciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7YH, United Kingdomfhttps://ror.org/01evwfd48Bernhard-Nocht-Institute for Tropical Medicine, Hamburg 20359, Germanyghttps://ror.org/028s4q594German Centre for Infection Research, Hamburg 20359, Germanyhhttps://ror.org/00g30e956Faculty of Mathematics, Informatics and Natural Sciences, University Hamburg, Hamburg 20148, Germanyihttps://ror.org/03svjbs84Departments of Tropical Disease Biology and Vector Biology, Liverpool School of Tropical Medicine, Centre for Neglected Tropical Diseases, Liverpool L3 5QA, United Kingdom Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2524728123 https://www.pnas.org/doi/abs/10.1073/pnas.2524728123?af=R Evolution of noisy learning in games https://www.pnas.org/doi/abs/10.1073/pnas.2529959123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceIn strategic interactions, people can improve their performance by reasoning about their available strategies. This reasoning process can be captured with models of learning and evolutionary game theory. These models often contain a parameter ... Evolution of noisy learning in games doi:10.1073/pnas.2529959123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Marta C. CoutoFernando P. SantosChristian Hilbeahttps://ror.org/04dkp9463Socially Intelligent Artificial Systems Group, Informatics Institute, University of Amsterdam, Amsterdam 1098XH, The Netherlandsbhttps://ror.org/0534re684Max Planck Research Group on the Dynamics of Social Behavior, Max Planck Institute for Evolutionary Biology, Plön 24306, Germanychttps://ror.org/03jzk4720Interdisciplinary Transformation University, Linz 4040, Austria Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2529959123 https://www.pnas.org/doi/abs/10.1073/pnas.2529959123?af=R Modular genetic architecture underlies human hand and foot evolution https://www.pnas.org/doi/abs/10.1073/pnas.2603297123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceCorresponding bones of the hands and feet are known to covary in size and shape in humans and other primates, suggesting that the human hand and foot may have coevolved. While this pattern has been well characterized at the anatomical level, ... Modular genetic architecture underlies human hand and foot evolution doi:10.1073/pnas.2603297123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Alexander S. OkamotoGayani SenevirathnePushpanathan MuthuirulanCampbell RolianIan A. GlassTerence D. Capelliniahttps://ror.org/03vek6s52Department of Human Evolutionary Biology, Harvard University, Cambridge, MA 02138bhttps://ror.org/01pxwe438Department of Anatomy and Cell Biology, McGill University, Montreal, QC H3A 0C7, Canadachttps://ror.org/00cvxb145Department of Pediatrics and the Division of Genetic Medicine, University of Washington, Seattle, WA 98101dhttps://ror.org/00cz0md82Center for Developmental Biology and Regenerative Medicine, Seattle Children’s Research Institute, Seattle, WA 98101eBroad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142Ian A. GlassKimberly A. AldingerDan DohertyIan G. PhelpsJennifer C. DempseyMei DengEric Y. SoYasmeen OtaibiIris M. Rappin Benge Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2603297123 https://www.pnas.org/doi/abs/10.1073/pnas.2603297123?af=R Dpp and immune response pathway factors mediate paracrine induction of senescent cells in Drosophila https://www.pnas.org/doi/abs/10.1073/pnas.2602167123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceSenescent cells are a special cell type that builds up in animal tissues. They usually appear upon exposure to stresses that occur during lifetime. They stop dividing and acquire unique properties that make them very different from surrounding ... Dpp and immune response pathway factors mediate paracrine induction of senescent cells in Drosophila doi:10.1073/pnas.2602167123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Juan Manuel Garcia-AriasMireya Ruiz-LosadaNatalia AzpiazuGinés MorataaCentro de Biología Molecular, Consejo Superior de Investigaciones Científicas- Universidad Autónoma de Madrid, Madrid 28049, Spain Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2602167123 https://www.pnas.org/doi/abs/10.1073/pnas.2602167123?af=R Superconductivity suppression and bilayer decoupling in Pr-substituted YBa2Cu3O7−δ https://www.pnas.org/doi/abs/10.1073/pnas.2536919123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceFor decades, it has been a puzzle why praseodymium—unlike other rare earth substitutions—so effectively suppresses superconductivity in YBa2Cu3O7−δ. Prevailing theories attributed this to a 4f–2phybridization effect depleting holes on the CuO2... Superconductivity suppression and bilayer decoupling in Pr-substituted YBa2Cu3O7−δ doi:10.1073/pnas.2536919123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Jinming YangZheting JinSiqi WangCamilla M. MoirMingyu XuBrandon GunnRourav BasakJoshua R. EvansXian DuZhibo KangKeke FengMakoto HashimotoDonghui LuJessica L. McChesneyMartin SundermannHlynur GretarssonShize YangWeiwei XieAlex FranoSohrab Ismail-BeigiM. Brian MapleYu HeaDepartment of Physics, Yale University, New Haven, CT 06511bDepartment of Applied Physics, Yale University, New Haven, CT 06511cDepartment of Physics, University of California, San Diego, CA 92093dDepartment of Chemistry, Michigan State University, East Lansing, MI 48824eStanford Synchrotron Radiation Lightsource, Stanford Linear Accelerator Center National Accelerator Laboratory, Menlo Park, CA 94025fAdvanced Photon Source, Argonne National Laboratory, Lemont, IL 60439gPETRA III, Deutsches Elektronen-Synchrotron, Hamburg 22607, GermanyhMax Planck Institute for Chemical Physics of Solids, Dresden 01187, GermanyiAberration Corrected Electron Microscopy Core, Yale University, West Haven, CT 06516 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2536919123 https://www.pnas.org/doi/abs/10.1073/pnas.2536919123?af=R Predicting rates of manganese oxide reduction from thermodynamic driving forces and structural properties https://www.pnas.org/doi/abs/10.1073/pnas.2525899123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceManganese oxides are powerful natural oxidants that regulate the cycling of carbon and nutrients in soils and sediments. However, their redox reactivity is difficult to predict because of their diverse oxidation states and mineral structures. ... Predicting rates of manganese oxide reduction from thermodynamic driving forces and structural properties doi:10.1073/pnas.2525899123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Xinru LiuVineeth PothanamkandathilLorenz SchwabShun MaoMeret AeppliaSoil Biogeochemistry Laboratory, Environmental Engineering Institute, Swiss Federal Institute of Technology Lausanne (EPFL), Sion 1950, SwitzerlandbCollege of Environmental Science and Engineering, State Key Laboratory of Water Pollution Control and Green Resource Recycling, Tongji University, Shanghai 200092, China Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2525899123 https://www.pnas.org/doi/abs/10.1073/pnas.2525899123?af=R A hemispheric decoding principle for vestibular heading perception in the posterior sylvian area https://www.pnas.org/doi/abs/10.1073/pnas.2533498123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe vestibular system plays a crucial role in important fundamental as well as high cognitive functions. Supporting this, vestibular signals have been found widely distributed in the brain including the cerebral neocortex, yet they are mostly ... A hemispheric decoding principle for vestibular heading perception in the posterior sylvian area doi:10.1073/pnas.2533498123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Yue XuYong GuaChinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Key laboratory of Brain Cognition and Brain-inspired Intelligence Technology, Institute of Neuroscience, International Center for Primate Brain Research, Chinese Academy of Sciences, Shanghai 200031, ChinabUniversity of Chinese Academy of Sciences, Beijing 100049, China Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2533498123 https://www.pnas.org/doi/abs/10.1073/pnas.2533498123?af=R PAM1 regulates meiosis by coupling RNA processing to the chromosome axis https://www.pnas.org/doi/abs/10.1073/pnas.2535316123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMeiosis is an evolutionarily conserved process, in which chromosomes interact with each other and exchange parts. This behavior is distinct during organism’s development and requires activity of many specialized genes that must be turned on ... PAM1 regulates meiosis by coupling RNA processing to the chromosome axis doi:10.1073/pnas.2535316123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Qian DuMinghui WangChoon-Lin TiangMoira J. SheehanPaul AltendorfJu-Kyung YuOtto HudeczElisabeth RoitingerChung-Ju Rachel WangRobert BukowskiRobert B. MeeleyClint KoInna N. GolubovskayaWojciech P. PawlowskiaSection of Plant Biology, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853bBioinformatics Facility, Cornell University, Ithaca, NY 14853cSyngenta Biotechnology, Inc., Stanton, MN 55018dInstitute of Molecular Biotechnology, Vienna 1030, AustriaeInstitute of Plant and Microbial Biology, Academia Sinica, Taipei 11529, TaiwanfPioneer Hi-Bred International, Inc.—A DuPont Company, Johnston, IA 50131gDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535316123 https://www.pnas.org/doi/abs/10.1073/pnas.2535316123?af=R Human pannexin mutations and their implications in erosive osteoarthritis https://www.pnas.org/doi/abs/10.1073/pnas.2535302123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceIn this collaborative paper, we discovered the first germline mutation in the Pannexin 3 (PANX3) gene that is associated with disease. This PANX3 mutation results in a loss of channel function that is associated with erosive hand ... Human pannexin mutations and their implications in erosive osteoarthritis doi:10.1073/pnas.2535302123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Justin TangJason LuDanielle JohnstonKazuyuki HoshijimaBrent WakefieldDonglin BaiPeter B. StathopulosRoger J. ThompsonAlexander W. LohmanMichael J. JurynecFrank BeierSilvia PenuelaaDepartment of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, CanadabWestern Bone and Joint Institute, The Dr. Sandy Kirkley Centre for Musculoskeletal Research, University Hospital, London, ON N6G 2V4, CanadacDepartment of Orthopedics School of Medicine, University of Utah, Salt Lake City, UT 84113dDepartment of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON N6A 5C1, CanadaeDepartment of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535302123 https://www.pnas.org/doi/abs/10.1073/pnas.2535302123?af=R Rapid sensing and relaying of cellular hyperosmotic stress signals via RAF–SnRK2 core condensates https://www.pnas.org/doi/abs/10.1073/pnas.2603627123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificancePlants face hyperosmotic stress from drought, salinity, and cold, yet how they sense and rapidly respond to such stress has remained unclear. We show that B4-subgroup RAF kinases directly detect cellular hyperosmolarity through liquid–liquid ... Rapid sensing and relaying of cellular hyperosmotic stress signals via RAF–SnRK2 core condensates doi:10.1073/pnas.2603627123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Guting LiuZhen LinGuanquan LinXinyong WangXiaolei LiuZhaobo LangJian-Kang ZhuPengcheng WangaInstitute of Advanced Biotechnology, Institute of Homeostatic Medicine, and School of Medicine, Southern University of Science and Technology, Shenzhen 518055, ChinabChinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai 200032, ChinacSchool of Medicine, Macau University of Science and Technology, Macau SAR 999078, China Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2603627123 https://www.pnas.org/doi/abs/10.1073/pnas.2603627123?af=R Inside-out-engineered CuOx/Ru sites for efficient electrochemical nitrate reduction to ammonia https://www.pnas.org/doi/abs/10.1073/pnas.2537982123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceElectrochemical nitrate reduction offers a sustainable route for ammonia synthesis, but its progress is limited by competing side reactions and unclear active site dynamics. In this study, we propose an innovative inside-out catalyst ... Inside-out-engineered CuOx/Ru sites for efficient electrochemical nitrate reduction to ammonia doi:10.1073/pnas.2537982123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Dechao ChenYong LiZengxi WeiYi XiaoChangsheng CaoDongdong XiaoChi-Feng LeeChieh-Kai HsuHsiao-Tsu WangLili HanaState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, ChinabFujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou 350108, Fujian, Chinachttps://ror.org/020azk594College of Chemistry, Fujian Normal University, Fuzhou 350117, Chinadhttps://ror.org/02c9qn167Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology and School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, Chinaehttps://ror.org/011xvna82Key Laboratory of Advanced Carbon-Based Functional Materials (Fujian Province University), Fuzhou University, Fuzhou 350016, Fujian, Chinafhttps://ror.org/034t30j35Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, Chinaghttps://ror.org/04tft4718Department of Physics, Tamkang University, New Taipei City 251301, Taiwan Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537982123 https://www.pnas.org/doi/abs/10.1073/pnas.2537982123?af=R Soft, skin-interfaced electronics enable cannula-free wireless monitoring of sleep respiration https://www.pnas.org/doi/abs/10.1073/pnas.2605960123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis study addresses limitations of conventional respiratory monitoring by introducing a cannula-free, skin-like nasal patch for at-home sleep monitoring. Rather than measuring airflow directly, the device senses airflow-induced soft-tissue ... Soft, skin-interfaced electronics enable cannula-free wireless monitoring of sleep respiration doi:10.1073/pnas.2605960123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Byeongjun LeeHoon YiJungmin KimJimin LeeSeong J. ChoWoon-Hong Yeoahttps://ror.org/01zkghx44Wearable Intelligent Systems and Healthcare Center at the Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA 30332bhttps://ror.org/0227as991Department of Mechanical Engineering, Chungnam National University, Daejeon 34134, Republic of Koreachttps://ror.org/01zkghx44George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332dhttps://ror.org/04qfph657Biomedical Manufacturing Technology Center, Korea Institute of Industrial Technology, Yeongcheon 38822, Republic of KoreaeWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA 30332fhttps://ror.org/01zkghx44Parker H. Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332gKorea Institute for Advancement of Technology–Georgia Tech Semiconductor Electronics Center at the Institute for Matter and Systems, Georgia Institute of Technology, Atlanta, GA 30332 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2605960123 https://www.pnas.org/doi/abs/10.1073/pnas.2605960123?af=R Data-driven particle dynamics: Structure-preserving coarse-graining for emergent behavior in nonequilibrium systems https://www.pnas.org/doi/abs/10.1073/pnas.2519631123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMultiscale systems far from equilibrium are challenging to model due to coupling between unresolved physics and emergent stochastic behavior. Our hybrid machine learning framework generates models embedding thermodynamic principles and ... Data-driven particle dynamics: Structure-preserving coarse-graining for emergent behavior in nonequilibrium systems doi:10.1073/pnas.2519631123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Quercus HernándezMax WinThomas C. O’ConnorPaulo E. ArratiaNathaniel TraskaDepartment of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104bDepartment of Materials Science and Engineering, Carnegie Mellon University, Pittsburgh, PA 15213 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2519631123 https://www.pnas.org/doi/abs/10.1073/pnas.2519631123?af=R Wolbachia-mediated viral transmission enhancement in insect vectors https://www.pnas.org/doi/abs/10.1073/pnas.2607638123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceInsect symbionts likeWolbachiaare known for limiting virus transmission. Here, we report a contrasting, facilitative role:Wolbachiaacts as a crucial carrier for the southern rice black-streaked dwarf virus (SRBSDV) in its insect vector, ... Wolbachia-mediated viral transmission enhancement in insect vectors doi:10.1073/pnas.2607638123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Ying WangShunkang ZhouShuwei LiLizhi WangShupei AiJilei HuangXin YiKan ZhuoGuohui ZhouXin YangTong ZhangaGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, South China Agricultural University, Guangzhou 510642, ChinabGuangdong Province Key Laboratory of Microbial Signals and Disease Control, College of Plant Protection, South China Agricultural University, Guangzhou 510642, ChinacInstrumental Analysis and Research Center, South China Agricultural University, Guangzhou 510642, China Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2607638123 https://www.pnas.org/doi/abs/10.1073/pnas.2607638123?af=R Speed and quality of complex strategic decisions https://www.pnas.org/doi/abs/10.1073/pnas.2531472123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe association between the speed and quality of complex strategic decisions is a priori unclear. Taking more time to make a decision may result in a better thought-out decision of higher quality, but it may also reflect a greater perceived ... Speed and quality of complex strategic decisions doi:10.1073/pnas.2531472123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Uwe SundeDainis ZegnersAnthony Strittmatterahttps://ror.org/05591te55Economics Department, Ludwig-Maximilians-Universität München, München 80539, Germanybhttps://ror.org/057w15z03Department for Technology and Operations Management, Rotterdam School of Management, Erasmus University, Rotterdam 3062 PA, Netherlandschttps://ror.org/03exthx58Faculty of Business and Economics, UniDistance Suisse, Brig-Glis 3900, Switzerland Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2531472123 https://www.pnas.org/doi/abs/10.1073/pnas.2531472123?af=R Phospholipase D regulates on-membrane diffusivity of a myristoylated protein and defines the PIP3 patch territory https://www.pnas.org/doi/abs/10.1073/pnas.2608790123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceIn living cells, biochemical reactions are often confined to subregions in the membrane, facilitating local occurrences of specific signals that regulate membrane protrusion, internalization, fusion, and fission. This is puzzling from a ... Phospholipase D regulates on-membrane diffusivity of a myristoylated protein and defines the PIP3 patch territory doi:10.1073/pnas.2608790123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Gen HondaChihuku TanakaHidenori HashimuraTomoko AdachiMina FujishiroNao ShimadaSatoshi SawaiMiho YanagisawaaDepartment of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku 153-8902, Tokyo, JapanbKomaba Institute for Science, Graduate School of Arts and Sciences, The University of Tokyo, Meguro-ku 153-8902, Tokyo, JapancDepartment of Physics, Faculty of Science, The University of Tokyo, Bunkyo-ku 113-0033, Tokyo, JapandResearch Center for Complex Systems Biology, Universal Biology Institute, The University of Tokyo, Meguro-ku 153-8902, Tokyo, JapaneDepartment of Biology, Graduate School of Science, The University of Tokyo, Bunkyo-ku 113-0033, Tokyo, JapanfDepartment of Physics, Graduate School of Science, The University of Tokyo, Bunkyo-ku 113-0033, Tokyo, Japan Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2608790123 https://www.pnas.org/doi/abs/10.1073/pnas.2608790123?af=R Directly adopting inverse biosensors to image live cell enzyme activities in nanodomains https://www.pnas.org/doi/abs/10.1073/pnas.2531118123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceVisualizing enzyme activity at superresolution is a powerful way to understand how biochemistry is conducted locally across space and time in living cells. But half of all biosensors fail in this application because they give quantitatively ... Directly adopting inverse biosensors to image live cell enzyme activities in nanodomains doi:10.1073/pnas.2531118123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Kriti SrivastavaKevin P. SchnurKay PetruzziGary C. H. MoaDepartment of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, Chicago, IL 60612bRichard and Loan Hill Department of Biomedical Engineering, University of Illinois College of Medicine, Chicago, IL 60612 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2531118123 https://www.pnas.org/doi/abs/10.1073/pnas.2531118123?af=R NAT10/ac4C drives intrahepatic cholangiocarcinoma by suppressing transposable elements via chromatin remodeling https://www.pnas.org/doi/abs/10.1073/pnas.2532263123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis work uncovers how a specific chemical modification on RNA, driven by the enzyme N-acetyltransferase 10, promotes a deadly liver cancer. We found that this modification stabilizes a key message that controls chromatin, leading to the ... NAT10/ac4C drives intrahepatic cholangiocarcinoma by suppressing transposable elements via chromatin remodeling doi:10.1073/pnas.2532263123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Yunkun LuKainan LinQianqian WangXiang HuangLianyu LinJie DouYajuan JiaoYali WangPeng XiaoHongjun ChenSilin LiYangtao XueShunmin HeJunjie Xuahttps://ror.org/00ka6rp58Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinabNational Engineering Research Center of Innovation and Application of Minimally Invasive Instruments, Hangzhou 310016, ChinacProvincial Key Laboratory of Minimally Invasive Procedure and Precision Medicine, Hangzhou 310016, ChinadZhejiang University Cancer Center, Hangzhou 310058, Chinaehttps://ror.org/04kx2sy84College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350002, Chinafhttps://ror.org/00ka6rp58Department of Gastroenterology, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, ChinagInstitute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, ChinahKey Laboratory of RNA Biology, Center for Big Data Research in Health, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, Chinaihttps://ror.org/05qbk4x57University of Chinese Academy of Sciences, Beijing 100049, China Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2532263123 https://www.pnas.org/doi/abs/10.1073/pnas.2532263123?af=R Educational policies can strengthen climate coalitions https://www.pnas.org/doi/abs/10.1073/pnas.2533821123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceEducation is widely used as a tool to build public support for climate action, yet little evidence exists about its effectiveness. We show in a large-scale field experiment that a brief, interactive climate workshop increases support for ... Educational policies can strengthen climate coalitions doi:10.1073/pnas.2533821123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Max BradleyRens ChazottesSusanna GarsideNina Lopez-Urozahttps://ror.org/0031wrj91Department of Political and Social Sciences, European University Institute, Fiesole 50014, FI, Italybhttps://ror.org/02s376052Swiss Federal Institute of Technology Lausanne, Lausanne 1015, Switzerlandchttps://ror.org/052gg0110Department of Politics and International Relations, University of Oxford, Oxford OX1 3UQ, United Kingdomdhttps://ror.org/01dwpbz64Max Planck Institute for the Study of Societies, Cologne 50676, Germany Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2533821123 https://www.pnas.org/doi/abs/10.1073/pnas.2533821123?af=R Cross-individual translation of spontaneous zebrafish brain activity through a shared latent representation https://www.pnas.org/doi/abs/10.1073/pnas.2529064123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceSpontaneous brain activity, without external stimuli, shapes development, constrains coding, and reflects neural organization. Whether this activity reveals similar organization across individuals has been unclear. Using single-cell, whole-... Cross-individual translation of spontaneous zebrafish brain activity through a shared latent representation doi:10.1073/pnas.2529064123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Mattéo Dommanget-KottJorge Fernandez-de-Cossio-DiazGuillaume Faye-BédrinGeorges DebrégeasVolker BormuthaInstitut de Biologie Paris-Seine, Laboratoire Jean Perrin, Sorbonne Université, CNRS, Paris 75005, FrancebUniversité Paris Cité, Paris 75006, FrancecInstitut de Physique Théorique, Université Paris-Saclay, CNRS, Commissariat à l’énergie atomique et aux énergies alternatives, Gif-sur-Yvette 91191, FrancedLaboratoire de Physique de l’École Normale Supérieure, CNRS, Paris Sciences et Lettres, Sorbonne Université, Université de Paris, Paris 75005, France Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2529064123 https://www.pnas.org/doi/abs/10.1073/pnas.2529064123?af=R Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the extracellular HMGB1 protein https://www.pnas.org/doi/abs/10.1073/pnas.2538042123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceReactive oxygen species (ROS) can profoundly alter protein function through oxidative posttranslational modifications. A notable example is the extracellular HMGB1 protein, whose proinflammatory activity is terminated by ROS-mediated cysteine ... Cysteine thiol-to-sulfonate oxidation induces unfolding for the functional switching of the extracellular HMGB1 protein doi:10.1073/pnas.2538042123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Jonathan M. Paz-VillatoroBinhan YuOrion SongeXi WangJunji IwaharaaDepartment of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, TX 77555-1068 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2538042123 https://www.pnas.org/doi/abs/10.1073/pnas.2538042123?af=R Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids https://www.pnas.org/doi/abs/10.1073/pnas.2603870123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis study establishes a pathogenic circuit framework to conceptualize the pathophysiology of nonlytic viral infections. Using hepatitis E virus (HEV) and macrophage-augmented organoids as an innovative experimental system, we delineate three ... Deciphering and targeting the pathogenic circuit of nonlytic hepatitis E virus infection using macrophage-augmented organoids doi:10.1073/pnas.2603870123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Kuan LiuYilan ZhaoYang WangTheano TsikariDewy Mae OffermansXincheng LiValeria V. OrlovaLuc J. W. van der LaanQiuwei PanaDepartment of Orthopaedics, Chongqing General Hospital, Chongqing University, Chongqing 401121, ChinabDepartment of Surgery, Erasmus MC Transplant Institute, Erasmus University Medical Center, Rotterdam 3015GD, The NetherlandscDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical Center, Rotterdam 3015GD, The NetherlandsdDepartment of Anatomy and Embryology, Leiden University Medical Center, Leiden 2333ZA, The NetherlandseThe Novo Nordisk Foundation Center for Stem Cell Medicine, reNEW, Leiden University Medical Center, Leiden 2333ZA, The NetherlandsfDepartment of Biomechanical Engineering, Faculty of Mechanical Engineering, Biomaterials and Tissue Biomechanics, Delft University of Technology, Delft 2628CD, the Netherlands Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2603870123 https://www.pnas.org/doi/abs/10.1073/pnas.2603870123?af=R NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma https://www.pnas.org/doi/abs/10.1073/pnas.2535550123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceEpstein–Barr virus (EBV) is associated with certain types of non-Hodgkin lymphoma (NHL). EBV-associated lymphomas are aggressive with limited treatment options, especially for patients whose disease becomes drug-resistant. Here, we ... NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma doi:10.1073/pnas.2535550123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Maria C. WhitePhilip T. LangeJessica StewartBlossom DamaniaaLineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599bhttps://ror.org/0130frc33Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535550123 https://www.pnas.org/doi/abs/10.1073/pnas.2535550123?af=R Ecological stability through nonlinear fluctuations and the portfolio effect https://www.pnas.org/doi/abs/10.1073/pnas.2535296123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceUnderstanding drivers of ecological stability is increasingly urgent amid global change. Despite ecological theory commonly assuming stable equilibria, populations in nature exhibit unstable and nonlinear dynamics, raising the question of how ... Ecological stability through nonlinear fluctuations and the portfolio effect doi:10.1073/pnas.2535296123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Robert M. HechlerMartin KrkosekaDepartment of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON M5S3B2, Canada Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535296123 https://www.pnas.org/doi/abs/10.1073/pnas.2535296123?af=R A broad-spectrum inhibitor of copper-exporting P1B-type ATPases https://www.pnas.org/doi/abs/10.1073/pnas.2604078123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceCopper (Cu)-transporting P1B-type ATPases are essential for copper homeostasis in all domains of life, yet have lacked pharmacological inhibitors. This work identifies MKV3 as the first small-molecule inhibitor of Cu+-ATPases in bacteria, ... A broad-spectrum inhibitor of copper-exporting P1B-type ATPases doi:10.1073/pnas.2604078123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Vinit C. ShanbhagSamuel Anakpeba-DinguyellaNikita GudekarKristyn ConradChiemerie AzubuoguCorinna ProbstMartina RalleMaría G. MediavillaJulia A. CriccoNatalie M. GarzaVishal M. GohilScott PeckSiddhartha KumarAmarnath NatarajanMadujika A. Horadigala-GamageGabriele MeloniKamal SinghMichael J. Petrisahttps://ror.org/02ymw8z06Bond Life Sciences Center, University of Missouri, Columbia, MO 65211bhttps://ror.org/02ymw8z06Department of Biochemistry, University of Missouri, Columbia, MO 65211cDepartment of Medicine, Duke University School of Medicine, Durham, NC 27710dDepartment of Molecular and Medical Genetics, School of Medicine, Oregon Health and Science University, Portland, OR 97239eLaboratorio de Cofactores Metálicos en Tripanosomátidos, Instituto de Biología Molecular y Celular de Rosario, Nacional de Investigaciones Científicas y Técnicas, Universidad Nacional de Rosario, Rosario 2000, Argentinafhttps://ror.org/01f5ytq51Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843gEppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198hhttps://ror.org/01e3m7079Division of Pharmaceutical Sciences, College of Pharmacy, University of Cincinnati, Cincinnati, OH 45267ihttps://ror.org/049emcs32Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080jhttps://ror.org/02ymw8z06Department of Pathobiology and Integrative Biomedical Sciences, University of Missouri, Columbia, MO 65211kDepartment of Ophthalmology, MU School of Medicine, University of Missouri, Columbia 65211, MO Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2604078123 https://www.pnas.org/doi/abs/10.1073/pnas.2604078123?af=R Streamlined optical training of large-scale modern deep learning architectures with direct feedback alignment https://www.pnas.org/doi/abs/10.1073/pnas.2532022123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceTraining today’s largest neural networks is limited by backpropagation’s sequential updates and Graphics Processing Unit (GPU) bound compute and energy, slowing scaling. We demonstrate a hybrid electronic–optics system that implements direct ... Streamlined optical training of large-scale modern deep learning architectures with direct feedback alignment doi:10.1073/pnas.2532022123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Ziao WangKilian MüllerMatthew FilipovichJulien LaunayRuben OhanaGustave ParienteSafa MokaadiCharles BrossolletFabien MoreauAlessandro CappelliIacopo PoliIgor CarronLaurent DaudetFlorent KrzakalaSylvain GiganaLaboratoire Kastler Brossel, École Normale Supérieure - Université Paris Sciences et Lettres, Sorbonne Université, Collège de France, CNRS, UMR 8552, Paris 75005, FrancebLightOn, Paris 75002, FrancecWelinq, Paris 75011, Francedhttps://ror.org/052gg0110Clarendon Laboratory, Department of Physics, University of Oxford, Oxford OX1 3PU, United Kingdomehttps://ror.org/00sekdz59Center for Computational Mathematics, Flatiron Institute, New York, NY 10010fhttps://ror.org/02s376052School of Engineering, École Polytechnique Fédérale de Lausanne, Information, Learning and Physics lab, Lausanne CH-1015, Switzerland Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2532022123 https://www.pnas.org/doi/abs/10.1073/pnas.2532022123?af=R Multiscale fatigue crack initiation in hierarchical additively manufactured alloys https://www.pnas.org/doi/abs/10.1073/pnas.2522790123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceA majority of mechanical failures are caused by fatigue, where damage progressively accumulates during cyclic loading. Hierarchical microstructures enabled by additive manufacturing offer a promising route to fatigue-resistant alloys. However, ... Multiscale fatigue crack initiation in hierarchical additively manufactured alloys doi:10.1073/pnas.2522790123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Luc N. CapaldiJamie FordSage FulcoRajeev K. RaiWuxian YangStephen ChingEric A. StachKevin T. TurnerWen ChenOttman A. TertulianoaMechanical Engineering and Applied Mechanics, University of Pennsylvania, Philadelphia, PA 19104bSingh Center for Nanotechnology, University of Pennsylvania, Philadelphia, PA 19104cMaterials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104dAerospace and Mechanical Engineering, University of Southern California, Los Angeles, CA 90089eBioengineering, University of Pennsylvania, Philadelphia, PA 19104 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2522790123 https://www.pnas.org/doi/abs/10.1073/pnas.2522790123?af=R Scientific authority cues increase the spread of misinformation https://www.pnas.org/doi/abs/10.1073/pnas.2535823123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMisinformation continues to circulate on social media, often because people unintentionally share posts without verifying their accuracy. We show that references to scientific entities, what we call Scientific Authority Cues, play an important ... Scientific authority cues increase the spread of misinformation doi:10.1073/pnas.2535823123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Ismail HarrandoRodrigo Reyes CordovaAchim EdelmannaMédialab, Sciences Po, Paris 75007, France Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2535823123 https://www.pnas.org/doi/abs/10.1073/pnas.2535823123?af=R PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model https://www.pnas.org/doi/abs/10.1073/pnas.2525028123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceOur study identifies poly(ADP-ribose) (PAR) as an elevated biomarker in the cerebrospinal fluid of patients with mild cognitive impairment and Alzheimer’s disease, correlating with established markers of amyloid pathology. We demonstrate that ... PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model doi:10.1073/pnas.2525028123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Aanishaa JhaldiyalManisha KumariLauren C. GuttmanTrupti TripathiMohammed Repon KhanJustin WangDevanik BiswasAbhishek PasupuletiAkansha AggarwalShraddha PandyaShih-Ching ChouNikhil PanickerAbhay MonghekarMarilyn AlbertLynn M. BekrisJames B. LeverenzTae-In KamTed M. DawsonValina L. DawsonaNeuroregeneration and Stem Cell Programs, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, MD 21205bDepartment of Neurology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205cDepartment of Physiology, Pharmacology and Therapeutics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205dDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University School of Medicine, Baltimore, MD 21205ehttps://ror.org/00cvxb145Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA 98104fhttps://ror.org/03xjacd83Lerner Research Institute, Genomic Medicine, Cleveland Clinic, Cleveland, OH 44195gLou Ruvo Center for Brain Health, Neurological Institute, Cleveland Clinic, Cleveland, OH 44195hhttps://ror.org/03xjacd83Department of Neurology, Cleveland Clinic, Cleveland, OH 44195ihttps://ror.org/01nh3sx96Geriatric Research Education and Clinical Center, Veteran Affairs Puget Sound Health Care System (S-182), Seattle, WA 98108jhttps://ror.org/00cvxb145Department of Neurology, University of Washington, Seattle, WA 98195kSolomon H. Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2525028123 https://www.pnas.org/doi/abs/10.1073/pnas.2525028123?af=R Blue- versus green-absorbing anion channelrhodopsins, essential tools in optogenetics, differ fundamentally in gating mechanisms https://www.pnas.org/doi/abs/10.1073/pnas.2519786123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceGuillardia thetaanion channelrhodopsins 1 and 2 (GtACR1 andGtACR2) are both widely used for optogenetic neuronal silencing, but onlyGtACR1 has been characterized in detail. This study focuses onGtACR2, which has a ~50-nm more blue-... Blue- versus green-absorbing anion channelrhodopsins, essential tools in optogenetics, differ fundamentally in gating mechanisms doi:10.1073/pnas.2519786123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Oleg A. SineshchekovElena G. GovorunovaHai LiYumei WangJohn L. Spudichahttps://ror.org/03gds6c39Center for Membrane Biology, Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston McGovern Medical School, Houston, TX 77030 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2519786123 https://www.pnas.org/doi/abs/10.1073/pnas.2519786123?af=R Regulated development of cannibalistic supergiant cells in the ciliate Euplotes gigatrox https://www.pnas.org/doi/abs/10.1073/pnas.2606891123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceDevelopment in microbial eukaryotes (protists), which can rival the morphological complexity of small animals, is largely unexplored. We report here on the finding that in clonal populations of the ciliateEuplotes gigatroxa small number of ... Regulated development of cannibalistic supergiant cells in the ciliate Euplotes gigatrox doi:10.1073/pnas.2606891123 Proceedings of the National Academy of Sciences 2026-05-14T07:00:00Z Ben T. LarsonDaniele GiannottiMahara MtawaliSamuel J. LordVittorio BoscaroPatrick J. Keelingahttps://ror.org/01rtyzb94Department of Biological Sciences, Center for Biotechnology and Interdisciplinary Studies, and Darrin Freshwater Institute, Rensselaer Polytechnic Institute, Troy, NY 12180bhttps://ror.org/03rmrcq20Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, CanadacDepartment of Cellular and Molecular Pharmacology and HHMI, University of California, San Francisco, CA 94143 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2606891123 https://www.pnas.org/doi/abs/10.1073/pnas.2606891123?af=R Discovering regularity and mechanisms of word sense acquisition in childhood https://www.pnas.org/doi/abs/10.1073/pnas.2525788123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceMany words in natural language have more than one meaning. For example, “stick” can refer to the senses of a thin piece, a thrusting motion, or the state of adhering. Children as language learners acquire these different senses of a word in ... Discovering regularity and mechanisms of word sense acquisition in childhood doi:10.1073/pnas.2525788123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Jiangtian LiBlair C. ArmstrongYang XuaDepartment of Psychology, University of Toronto Scarborough 1265 Military Trail Toronto, ON M1C 1A4, CanadabBasque Center on Cognition, Brain, and Language, Paseo Mikeletegi 69, 2°, Donostia - San Sebastián 20009, Gipuzkoa, SpaincDepartment of Computer Science, Cognitive Science Program, 6 King’s College Road, Toronto, ON M5S 3H5, Canada Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2525788123 https://www.pnas.org/doi/abs/10.1073/pnas.2525788123?af=R Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes https://www.pnas.org/doi/abs/10.1073/pnas.2536376123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe number of C4A gene copies is associated with the risk of schizophrenia in genome-wide association studies of individuals with European ancestry. Higher C4A gene expression is associated with higher levels of synaptic pruning in the brain. ... Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes doi:10.1073/pnas.2536376123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Agnieszka KalinowskiClaudia MacaubasHanmin GuoLauren A. AnkerDiane E. WakehamMarcus HoReenal PattniBatuhan BayramSurbhi SharmaJoanna LilientalJong H. YoonElizabeth D. MellinsLawrence SteinmanAlexander E. UrbanaDepartment of Psychiatry and Behavioral Sciences, Stanford University, School of Medicine, Stanford, CA 94305bDepartment of Pediatrics, Stanford University, School of Medicine, Stanford, CA 94304cDepartment of Genetics, Stanford University, School of Medicine, Stanford, CA 94304dTranslational Applications Service Center, Stanford University, School of Medicine, Department of Medicine, Division of Research and Education, Stanford, CA 94305eTranslational Research and Applied Medicine Center, Stanford University, School of Medicine, Department of Medicine, Division of Research and Education, Stanford, CA 94305fRepetitive Transcranial Magnetic Stimulation Neuromodulation Clinic, Palo Alto Veterans Healthcare System, Palo Alto, CA 94304gDepartment of Neurology and Neurological Sciences, Stanford University, School of Medicine, Stanford Multiple Sclerosis and Neuroimmunology Program, Stanford, CA 94305 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2536376123 https://www.pnas.org/doi/abs/10.1073/pnas.2536376123?af=R Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks https://www.pnas.org/doi/abs/10.1073/pnas.2602705123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceEarly cancer detection is crucial for improving patient survival, yet current diagnostic tools remain limited in their ability to comprehensively assess large, heterogeneous lesions at the cellular level in vivo. We introduce a compact and ... Deep-learning endomicroscope with large field-of-view and depth-of-field for real-time in vivo imaging of epithelial cancer hallmarks doi:10.1073/pnas.2602705123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Huayu HouJimin WuJinyun LiuVivek BoominathanArgaja ShendeKarthik GoliJennifer CarnsRichard A. SchwarzAnn M. GillenwaterPreetha RamalingamMila P. SalcedoKathleen M. SchmelerTomasz S. TkaczykJacob T. RobinsonAshok VeeraraghavanRebecca R. Richards-KortumaDepartment of Bioengineering, Rice University, Houston, TX 77005bDepartment of Electrical and Computer Engineering, Rice University, Houston, TX 77005cDepartment of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030dDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030eDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030fDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030gDepartment of Computer Science, Rice University, Houston, TX 77005 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2602705123 https://www.pnas.org/doi/abs/10.1073/pnas.2602705123?af=R The pig in the python: US decennial labor flows and economic opportunity, 1910–2040 https://www.pnas.org/doi/abs/10.1073/pnas.2601716123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe large size of the baby boom cohort depressed economic opportunities for that generation as it flooded the labor force in the 1970s. Contrary to the predictions of Richard Easterlin’s relative cohort size hypothesis, however, there was no ... The pig in the python: US decennial labor flows and economic opportunity, 1910–2040 doi:10.1073/pnas.2601716123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Steven RugglesaInstitute for Social Research and Data Innovation, University of Minnesota, Minneapolis, MN 55455bDepartment of History, University of Minnesota, Minneapolis, MN 55455 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2601716123 https://www.pnas.org/doi/abs/10.1073/pnas.2601716123?af=R Field data challenge predictions of universal crop pest proliferation under warming https://www.pnas.org/doi/abs/10.1073/pnas.2606726123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceClimate change is reshaping ecosystems worldwide, and agriculture faces particular scrutiny: Models consistently warn that warming will boost crop pest populations while decimating their natural enemies. These predictions, built largely from ... Field data challenge predictions of universal crop pest proliferation under warming doi:10.1073/pnas.2606726123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Mia K. LippeyJay A. RosenheimDaniel ParedesRichard SharpDaniel S. KarpRebecca Chaplin KramerSara E. EmeryColleen R. MillerEmily K. Meinekeahttps://ror.org/05rrcem69Department of Entomology and Nematology, University of California Davis, Davis, CA 95616bhttps://ror.org/0174shg90Department of Plant Biology, Ecology and Earth Sciences, University of Extremadura, Badajoz 06006, Spainchttps://ror.org/011590k05World Wildlife Fund, Global Science, San Francisco, CA 94105dhttps://ror.org/05rrcem69Department of Wildlife, Fish, and Conservation Biology, University of California Davis, Davis, CA 95616ehttps://ror.org/012qsrr25Department of Entomology, Cornell AgriTech, NY 14456fhttps://ror.org/017zqws13Natural Capital Project, Earth-Economy Modelers, University of Minnesota, Saint Paul, MN 55108 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2606726123 https://www.pnas.org/doi/abs/10.1073/pnas.2606726123?af=R Geometric ordering in bacterial communities https://www.pnas.org/doi/abs/10.1073/pnas.2526643123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThe general principles responsible for bacterial organization at the collective level are unclear. This work shows that large-scale pattern formation among diverse bacteria is explained by geometric ordering, which is also observed in ... Geometric ordering in bacterial communities doi:10.1073/pnas.2526643123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Melika GorgiSummer J. KasallisCalvin TrinhLizett Ortiz de OraTravis J. WilesAlbert Siryapornahttps://ror.org/04gyf1771Center for Complex Biological Systems, University of California Irvine, Irvine, CA 92697bhttps://ror.org/04gyf1771Department of Physics and Astronomy, University of California Irvine, Irvine, CA 92697chttps://ror.org/04gyf1771Department of Microbiology and Molecular Genetics, University of California Irvine, Irvine, CA 92697dhttps://ror.org/04gyf1771Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2526643123 https://www.pnas.org/doi/abs/10.1073/pnas.2526643123?af=R NEXT-FRET maps nonequilibrium rerouting of Escherichia coli maltose-binding protein folding by its signal peptide and chaperones https://www.pnas.org/doi/abs/10.1073/pnas.2529979123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceProteins and other biomolecules operate through transient, nonequilibrium intermediates that are crucial for function. Even folding, by which proteins reach native shapes despite astronomical possibilities posed by Levinthal’s paradox, ... NEXT-FRET maps nonequilibrium rerouting of Escherichia coli maltose-binding protein folding by its signal peptide and chaperones doi:10.1073/pnas.2529979123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Chara SarafoglouAndreas KofidisMarijn de BoerMikis MylonakisKostas MavrakisGiannis ZacharakisYannis PantazisGiorgos GouridisaLaboratory of Dynamic Structural Biology, Structural Biology and Biophysics Division, Institute of Molecular Biology and Biotechnology (IMBB-Foundation for Research and Technology-Hellas), Heraklion-Crete 70013, Greecebhttps://ror.org/00dr28g20Department of Biology, University of Crete, Heraklion-Crete 70013, GreececInstitute of Applied and Computational Mathematics, Foundation for Research and Technology—Hellas, Heraklion-Crete 70013, Greecedhttps://ror.org/00dr28g20Department of Computer Science, University of Crete, Heraklion-Crete 70013, Greeceehttps://ror.org/012p63287Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Groningen 9747 AG, The NetherlandsfLaboratory for Biophotonics and molecular imaging, Institute of Electronic Structure and Lasers (IESL-Foundation for Research and Technology-Hellas), Heraklion-Crete 70013, GreecegKymatonics Private Company, Heraklion-Crete 70013, Greece Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2529979123 https://www.pnas.org/doi/abs/10.1073/pnas.2529979123?af=R Bioinspired ultrasound-driven ultrafast soft microgripper https://www.pnas.org/doi/abs/10.1073/pnas.2537655123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceThis work introduces a paradigm for wireless, rapid, and precisely controllable artificial microcilia by uncovering how acoustic waves can drive biocompatible soft hydrogels at the microscale. Inspired by natural ciliary systems, the proposed ... Bioinspired ultrasound-driven ultrafast soft microgripper doi:10.1073/pnas.2537655123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Chengxi ZhongVincent WinderollKhemraj Gautam KshetriCornel DillingerTommaso BianchiZhan ShiJustus SchnermannMarco AmabiliSong LiuRaphael WittkowskiNitesh NamaDaniel AhmedaAcoustic Robotics Systems Lab, Institute of Robotics and Intelligent Systems, Department of Mechanical and Process Engineering, ETH Zurich, 8803 Rüschlikon, Switzerlandbhttps://ror.org/030bhh786School of Information Science and Technology, ShanghaiTech University, Shanghai 201210, Chinachttps://ror.org/043mer456Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588dhttps://ror.org/02k7v4d05Acoustic Robotics Systems Lab, ARTORG Center for Biomedical Engineering Research, Faculty of Medicine, University of Bern, Bern 3012, Switzerlandehttps://ror.org/05hfa4n20School of Engineering, Westlake University, 310030 Hangzhou, Chinafhttps://ror.org/04xfq0f34Department of Physics, RWTH Aachen University, 52074 Aachen, Germanyghttps://ror.org/0186h8060DWI – Leibniz Institute for Interactive Materials, 52074 Aachen, GermanyhInstitute of Theoretical Physics, Center for Soft Nanoscience, University of Münster, 48149 Münster, Germany Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2537655123 https://www.pnas.org/doi/abs/10.1073/pnas.2537655123?af=R Lineage-specific evolution of regulatory landscapes in a polyploid plant and its diploid progenitors https://www.pnas.org/doi/abs/10.1073/pnas.2530814123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceVariation withincis-regulatory element, controlling gene expression in a spatiotemporal manner, is a major source of phenotypic diversity and evolutionary innovation. Using polyploid peanut and its diploid progenitors as a framework, we ... Lineage-specific evolution of regulatory landscapes in a polyploid plant and its diploid progenitors doi:10.1073/pnas.2530814123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Xiang LiXuan ZhangZiliang LuoHao ZhangJohn Pablo MendietaRobert J. SchmitzaDepartment of Genetics, University of Georgia, Athens, GA 30602 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2530814123 https://www.pnas.org/doi/abs/10.1073/pnas.2530814123?af=R Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations https://www.pnas.org/doi/abs/10.1073/pnas.2521055123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceNormative models of brain structure are increasingly used to assess brain health, development, and aging by comparing an individual’s brain with age- and sex-expected patterns. Yet their performance across diverse populations is largely ... Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations doi:10.1073/pnas.2521055123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Ruiyang GeYuetong YuFaye NewShalaila S. HaasNicole SanfordKevin YuPaul AllenSeda ArslanMihai AvramStefan BorgwardtNicolas A. CrossleyCamilo de la Fuente-SandovalMasaki FukunagaJia-Hong GaoAlfonso Gonzalez-ValderramaRyota HashimotoFelice IasevoliDaniel KeeserKader KubatVeena KumariJunya MatsumotoUrvakhsh M. MehtaKiyotaka NemotoGiuseppe PontilloFlorian J. RaabeFrancisco Reyes-MadrigalNeelabja RoyDidenur Şahin-ÇevikTuba Sahin-IlikogluTimothea ToulopoulouElias WagnerGuoyuan YangMariana ZuritaPaul M. ThompsonSophia Frangouahttps://ror.org/03rmrcq20Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z3, Canadabhttps://ror.org/04a9tmd77Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY 10029cInstitute of Psychiatry, Psychology and Neuroscience, London SE5 8AF, United Kingdomdhttps://ror.org/02vh8a032Department of Psychology, Bilkent University, Ankara 06800, Türkiyeehttps://ror.org/02vh8a032National Magnetic Resonance Research Center, Bilkent University, Ankara 06800, Türkiyefhttps://ror.org/00t3r8h32Translational Psychiatry, Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck 23538, Germanyghttps://ror.org/04teye511Department of Psychiatry, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330077, Chilehhttps://ror.org/05k637k59Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México 14269, Mexicoihttps://ror.org/048v13307Section of Brain Function Information, National Institute for Physiological Sciences, Okazaki 444-8585, Japanjhttps://ror.org/02v51f717IDG McGovern Institute for Brain Research, Center for MRI Research, Peking University, Beijing 100871, Chinakhttps://ror.org/0225snd59School of Medicine, Universidad Finis Terrae, Santiago 7501015, ChilelPsychiatric Institute José Horwitz B., Santiago 8420000, ChilemDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187-8551, JapannDepartment of Neuroscience, University School of Naples “Federico II”, Naples 80131, ItalyoDepartment of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich 80336, GermanypNeuroImaging Core Unit Munich, LMU University Hospital, LMU Munich, Munich 80336, Germanyqhttps://ror.org/05591te55Munich Center for Neurosciences, Ludwig-Maximilians-Universität München, Munich 82152, Germanyrhttps://ror.org/02vh8a032Department of Neuroscience, Bilkent University Aysel Sabuncu Brain Research Center, Ankara 06800, Türkiyeshttps://ror.org/00dn4t376Centre for Cognitive and Clinical Neuroscience, Brunel University of London, Uxbridge UB8 3PH, United Kingdomthttps://ror.org/00dn4t376Department of Psychology, College of Health, Medicine and Life Sciences, Brunel University of London, Uxbridge UB8 3PH, United KingdomuDepartment of Pathology of Mental Diseases, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo 187–8551, JapanvDepartment of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore 560029, Indiawhttps://ror.org/02956yf07Department of Medical Informatics and Management and Psychiatry, Institute of Medicine, University of Tsukuba, Ibaraki 305-857, Japanxhttps://ror.org/05290cv24Department of Advanced Biomedical Sciences, University of Naples “Federico II”, Naples 80131, Italyyhttps://ror.org/04dq56617Max Planck Institute of Psychiatry, Munich 80804, Germanyzhttps://ror.org/04gnjpq42First Department of Psychiatry, National and Kapodistrian University of Athens, Athens 10679, Greeceaahttps://ror.org/03p14d497Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical Faculty University of Augsburg, Augsburg 86159, Germanybbhttps://ror.org/03p14d497Evidence-Based Psychiatry and Psychotherapy, Faculty of Medicine, University of Augsburg, Augsburg 86159, Germanycchttps://ror.org/01skt4w74Advanced Research Institute of Multidisciplinary Sciences, School of Medical Technology, School of Life Science, Beijing Institute of Technology, Beijing 100081, Chinaddhttps://ror.org/03taz7m60Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2521055123 https://www.pnas.org/doi/abs/10.1073/pnas.2521055123?af=R Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation https://www.pnas.org/doi/abs/10.1073/pnas.2602678123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceHow fleeting experiences are transformed into lasting emotional memories remains a fundamental question in neuroscience. Memories are encoded by small populations of neurons, but how these neurons are consolidated into a functional memory ... Temporally gated offline engram ensemble reverberation in the lateral amygdala is required for fear memory consolidation doi:10.1073/pnas.2602678123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Sungmo ParkBozhi WuSofiya ZbaranskaJoseph LeeAlexander D. JacobAnnelies HoornAndrew MocleAlessandro LuchettiMahe ChenJung Hoon JungPaul W. FranklandSheena A. JosselynaProgram in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, ON M5G 1X8, CanadabDepartment of Physiology, University of Toronto, Toronto, ON M5S 1A8, CanadacDepartment of Psychology, University of Toronto, Toronto, ON M5S 3G3, CanadadDepartment of Computer Science, University of Toronto, Toronto, ON M5S 2E4, CanadaeChild and Brain Development Program, Canadian Institute for Advanced Research, Toronto, ON M5G 1M1, Canada Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2602678123 https://www.pnas.org/doi/abs/10.1073/pnas.2602678123?af=R Correlating surface adsorbate configuration and electrochemical performance of IrO2 during seawater-relevant electrolysis https://www.pnas.org/doi/abs/10.1073/pnas.2529533123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceSeawater electrolysis offers a more promising solution for producing clean hydrogen than water electrolysis but is limited by the anodic competing reactions of oxygen and chlorine evolution. This study quantifies activity/selectivity ... Correlating surface adsorbate configuration and electrochemical performance of IrO2 during seawater-relevant electrolysis doi:10.1073/pnas.2529533123 Proceedings of the National Academy of Sciences 2026-05-12T07:00:00Z Tianyou MouDaniela A. BushiriDaniel V. EspositoJingguang G. ChenPing LiuaChemistry Division, Brookhaven National Laboratory, New York, NY 11973bhttps://ror.org/00hj8s172Department of Chemical Engineering, Columbia University, New York, NY 10027 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2529533123 https://www.pnas.org/doi/abs/10.1073/pnas.2529533123?af=R 2024 global temperature record is consistent with model-predicted warming https://www.pnas.org/doi/abs/10.1073/pnas.2600021123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceA number of recent articles and commentaries have argued that the record global temperatures of 2023–2024 cannot be explained by standard climate model simulations and infer that we are witnessing an unexpected surge in planetary warming. ... 2024 global temperature record is consistent with model-predicted warming doi:10.1073/pnas.2600021123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Michael E. MannByron A. SteinmanAlejandro FernandezShannon A. ChristiansenXueke LiaDepartment of Earth and Environmental Science, University of Pennsylvania, Philadelphia, PA 19104bDepartment of Earth and Environmental Sciences and Large Lakes Observatory, University of Minnesota Duluth, Duluth, MN 55812cDepartment of Earth and Environmental Sciences, University of Minnesota, Minneapolis MN 55405dGulf Coast Repository, Texas A&M University, College Station, TX 77845 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2600021123 https://www.pnas.org/doi/abs/10.1073/pnas.2600021123?af=R Sperm, egg, and embryo proteins critical for genetic adaptation of herring to low salinity in the Baltic Sea https://www.pnas.org/doi/abs/10.1073/pnas.2601861123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceIn species with external fertilization, sperm, eggs, and embryos are directly exposed to the environment and must therefore undergo genetic adaptation to the local conditions. Using genetic and functional analyses, we investigated how Atlantic ... Sperm, egg, and embryo proteins critical for genetic adaptation of herring to low salinity in the Baltic Sea doi:10.1073/pnas.2601861123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Cheng MaFahime Mohamadnejad SangdehiMari KawaguchiKaori SanoSvenja V. DannenbergMats E. PetterssonAndreas WallbergJoshua L. WortYumeng YanSergei MoshkovskiiFlorian BergArild FolkvordChristof LenzHenning UrlaubU. Benjamin KauppShigeki YasumasuLeif AnderssonaDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala 75123, SwedenbSciLifeLab, Uppsala University, Uppsala 75123, SwedencDepartment of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, Tokyo 102-8554, JapandDepartment of Chemistry and Biological Science, Faculty of Science, Josai University, Saitama 350-0295, JapaneBioanalytical Mass Spectrometry Research Group, Max Planck Institute for Multidisciplinary Sciences, Göttingen 37077, GermanyfLife & Medical Sciences Institute, Unit 4: Chemical Biology and Medicinal Chemistry, University of Bonn, Bonn 53115, GermanygBioanalytics, Department of Clinical Chemistry, University Medical Center, Göttingen 37075, GermanyhInstitute of Marine Research, Bergen N-5817, NorwayiDepartment of Biological Sciences, University of Bergen, Bergen N-5020, NorwayjBiophysics of Cellular Signal Transduction, Max-Planck-Institute for Multidisciplinary Sciences, Göttingen 37077, GermanykDepartment of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX 77843 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2601861123 https://www.pnas.org/doi/abs/10.1073/pnas.2601861123?af=R A brain circuit of bidirectional modulation of social and nonsocial cognition by androgens and estrogens in male mice https://www.pnas.org/doi/abs/10.1073/pnas.2600302123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceAndrogens and estrogens rapidly drive social recognition memory and social interactions, yet their mechanisms remain poorly understood. Here, we focused on the bed nucleus of the stria terminalis (BNST) to lateral septum (LS), a brain network ... A brain circuit of bidirectional modulation of social and nonsocial cognition by androgens and estrogens in male mice doi:10.1073/pnas.2600302123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Dario AspesiAnjana VaratharajahLucia CioffiSilvia DiviccaroDonatella CarusoNatalina BeckeJasmin LalondeMelissa L. PerreaultRoberto C. MelcangiNeil J. MacLuskyElena Cholerisahttps://ror.org/01r7awg59Department of Psychology and Neuroscience Program, University of Guelph, Guelph, ON N1G 2W1, Canadabhttps://ror.org/00wjc7c48Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milano 20133, Italychttps://ror.org/01r7awg59Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON N1G 2W1, Canadadhttps://ror.org/01r7awg59Department of Biomedical Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2600302123 https://www.pnas.org/doi/abs/10.1073/pnas.2600302123?af=R Structural and dynamic basis of indirect apoptosis inhibition by Bcl-xL: A case study with Bid https://www.pnas.org/doi/abs/10.1073/pnas.2527963123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>SignificanceProgrammed cell death, or apoptosis, is a fundamental process that eliminates damaged cells. However, cancer cells often evade this process by overexpressing antiapoptotic Bcl-2 family proteins, which neutralize their proapoptotic ... Structural and dynamic basis of indirect apoptosis inhibition by Bcl-xL: A case study with Bid doi:10.1073/pnas.2527963123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Christina ElsnerAnton HankeOscar VadasFrancesco Luigi GervasioEnrica BordignonaDepartment of Physical Chemistry, University of Geneva, Geneva 1211, SwitzerlandbDepartment of Pharmaceutical Sciences, University of Geneva, Geneva 1211, SwitzerlandcSwiss institute of Bioinformatics, University of GenevadDepartment of Microbiology and Molecular Medicine, University of GenevaeDepartment of Chemistry, University College London, London WC1E 6BT, United Kingdom Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2527963123 https://www.pnas.org/doi/abs/10.1073/pnas.2527963123?af=R ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E https://www.pnas.org/doi/abs/10.1073/pnas.2601795123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>Isoprenylcysteine carboxyl methyltransferase (ICMT) catalyzes C-terminal methylation of prenylated CAAX proteins, a final processing step promoting membrane association and signaling. Although ICMT has been pursued to disrupt RAS membrane targeting, its ... ICMT supports BRAFV600E-driven tumor growth by membrane targeting of the CAAX protein INPP5E doi:10.1073/pnas.2601795123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Xijie YangXi QiaoSarah SchmidtElla A. EklundCarolina Ebner-WalterEmil IvarssonMichelle Ann CrespoNadieh KersemakersJozefina J. DzananBjarni ThorissonChristine LundgrenHooi Ching LimSam ShkoukaniElin TüksammelXiufeng XuVolkan I. SayinMar Martín-FontechaSilvia Ortega-GutiérrezMartin DalinMartin O. Bergoahttps://ror.org/056d84691Department of Medicine, Huddinge, Karolinska Institutet, Huddinge SE-141 83, Swedenbhttps://ror.org/01tm6cn81Department of Surgery, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-413 45, Swedenchttps://ror.org/01tm6cn81Sahlgrenska Center for Cancer Research, University of Gothenburg, Gothenburg SE-405 30, Swedendhttps://ror.org/01tm6cn81Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg SE-405 30, Swedenehttps://ror.org/02p0gd045Organic Chemistry Department, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid 28040, Spainfhttps://ror.org/02p0gd045Organic Chemistry Department, Faculty of Chemical Sciences, Universidad Complutense de Madrid, Madrid 28040, Spainghttps://ror.org/01tm6cn81Department of Pediatrics, Institute of Clinical Sciences, University of Gothenburg, Gothenburg SE-416 85, Sweden Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2601795123 https://www.pnas.org/doi/abs/10.1073/pnas.2601795123?af=R Selective divergence between Grokipedia and Wikipedia articles https://www.pnas.org/doi/abs/10.1073/pnas.2603294123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/>The launch of Grokipedia, an AI-generated encyclopedia developed by xAI, was presented as a response to perceived ideological and structural biases in Wikipedia, with the goal of producing more “truthful” entries using the Grok large language model. ... Selective divergence between Grokipedia and Wikipedia articles doi:10.1073/pnas.2603294123 Proceedings of the National Academy of Sciences 2026-05-15T07:00:00Z Saeedeh MohammadiTaha YasseriaCentre for Sociology of Humans and Machines, Trinity College Dublin and Technological University Dublin, Dublin D02 PN40, IrelandbSchool of Mathematics and Statistics, University College Dublin, Dublin D04 V1W8, Ireland Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2603294123 https://www.pnas.org/doi/abs/10.1073/pnas.2603294123?af=R Hard and soft power in immigration enforcement https://www.pnas.org/doi/abs/10.1073/pnas.2609140123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Hard and soft power in immigration enforcement doi:10.1073/pnas.2609140123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Emily RyoaSchool of Law, Duke University, Durham, NC 27708bDepartment of Sociology, Duke University, Durham, NC 27708 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2609140123 https://www.pnas.org/doi/abs/10.1073/pnas.2609140123?af=R Energetic interactions of water around ions determine transport properties of electrolyte solutions https://www.pnas.org/doi/abs/10.1073/pnas.2611092123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Energetic interactions of water around ions determine transport properties of electrolyte solutions doi:10.1073/pnas.2611092123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Athanassios Z. PanagiotopoulosaDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08540 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2611092123 https://www.pnas.org/doi/abs/10.1073/pnas.2611092123?af=R A molecular lattice reinforces the sperm head–tail junction https://www.pnas.org/doi/abs/10.1073/pnas.2608469123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> A molecular lattice reinforces the sperm head–tail junction doi:10.1073/pnas.2608469123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Anna J. WoodPulan LiuShaogeng Tangahttps://ror.org/03v76x132Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520bhttps://ror.org/03v76x132Wu Tsai Institute, Yale University, New Haven, CT 06520 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2608469123 https://www.pnas.org/doi/abs/10.1073/pnas.2608469123?af=R Beyond antibodies in GAD65 autoimmunity: Reframing pathogenesis through intrathecal B–T cell cross-talk https://www.pnas.org/doi/abs/10.1073/pnas.2609144123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Beyond antibodies in GAD65 autoimmunity: Reframing pathogenesis through intrathecal B–T cell cross-talk doi:10.1073/pnas.2609144123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Simon FaissnerRalf GoldaRuhr University Bochum, St. Josef-Hospital, Department of Neurology, Bochum 44791, Germany Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2609144123 https://www.pnas.org/doi/abs/10.1073/pnas.2609144123?af=R Surrounding landscapes shape species persistence in fragmented forests https://www.pnas.org/doi/abs/10.1073/pnas.2609139123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Surrounding landscapes shape species persistence in fragmented forests doi:10.1073/pnas.2609139123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Juan Pablo Ramírez-DelgadoaDepartment of Ecosystem Science and Management, Natural Resources and Environmental Studies Institute, University of Northern British Columbia, Prince George, BC V2N 4Z9, Canada Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2609139123 https://www.pnas.org/doi/abs/10.1073/pnas.2609139123?af=R Do negative social ties accelerate aging in adults, or does aging erode social ties? https://www.pnas.org/doi/abs/10.1073/pnas.2608036123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Do negative social ties accelerate aging in adults, or does aging erode social ties? doi:10.1073/pnas.2608036123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Quan ZhangaDepartment of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813bDepartment of Economics, College of Social Sciences, University of Hawaii, Honolulu, HI 96822cUniversity of Hawaii Economic Research Organization, Honolulu, HI 96822 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2608036123 https://www.pnas.org/doi/abs/10.1073/pnas.2608036123?af=R Correction for Kuhlisch et al., Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers https://www.pnas.org/doi/abs/10.1073/pnas.2614660123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Correction for Kuhlisch et al., Mapping of the viral shunt across widespread coccolithophore blooms using metabolic biomarkers doi:10.1073/pnas.2614660123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2614660123 https://www.pnas.org/doi/abs/10.1073/pnas.2614660123?af=R Correction for Asimovic et al., Testing the effects of Facebook usage in an ethnically polarized setting https://www.pnas.org/doi/abs/10.1073/pnas.2614308123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Correction for Asimovic et al., Testing the effects of Facebook usage in an ethnically polarized setting doi:10.1073/pnas.2614308123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2614308123 https://www.pnas.org/doi/abs/10.1073/pnas.2614308123?af=R Reply to Zhang: Causal identification, social networks, and biological aging https://www.pnas.org/doi/abs/10.1073/pnas.2611082123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Reply to Zhang: Causal identification, social networks, and biological aging doi:10.1073/pnas.2611082123 Proceedings of the National Academy of Sciences 2026-05-11T07:00:00Z Byungkyu LeeGabriele CiciurkaiteSiyun PengColter MitchellBrea L. Perryahttps://ror.org/0190ak572Department of Sociology, New York University, New York, NY 10003bhttps://ror.org/00h6set76School of Social Sciences, Utah State University, Utah, UT 84112chttps://ror.org/032db5x82School of Aging Studies, University of South Florida, Florida, FL 33612dhttps://ror.org/00jmfr291Survey Research Center, University of Michigan – Ann Arbor, Michigan, MI 48104eDepartment of Sociology, Indiana University – Bloomington, Indiana, IN 47405fIrsay Institute for Sociomedical Sciences, Indiana University – Bloomington, Indiana, IN 47405 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2611082123 https://www.pnas.org/doi/abs/10.1073/pnas.2611082123?af=R Highlighting a science strategy for human exploration of Mars https://www.pnas.org/doi/abs/10.1073/pnas.2611962123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> Highlighting a science strategy for human exploration of Mars doi:10.1073/pnas.2611962123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Linda Elkins-TantonDava NewmanAbigail ShefferKelsie KraftonaDepartment of Earth and Planetary Science, University of California, Berkeley, CA 94720bhttps://ror.org/042nb2s44Department of Aeronautics and Astronautics, Massachusetts Institute of Technology, Cambridge, MA 02139chttps://ror.org/038mfx688National Academy of Sciences, Washington, DC 20001 Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2611962123 https://www.pnas.org/doi/abs/10.1073/pnas.2611962123?af=R QnAs with E. Dale Abel https://www.pnas.org/doi/abs/10.1073/pnas.2614006123?af=R Proceedings of the National Academy of Sciences, Volume 123, Issue 20, May 2026. <br/> QnAs with E. Dale Abel doi:10.1073/pnas.2614006123 Proceedings of the National Academy of Sciences 2026-05-13T07:00:00Z Sandeep Ravindran Proceedings of the National Academy of Sciences 123 20 2026-05-19T07:00:00Z 2026-05-19T07:00:00Z 10.1073/pnas.2614006123 https://www.pnas.org/doi/abs/10.1073/pnas.2614006123?af=R