On this episode of Unsupervised Learning Razib talks to Brianna Wu. Wu is an American video game developer, programmer, and political activist best known as the co-founder and CEO of the independent game studio Giant Spacekat. Raised in Hattiesburg, Mississippi, she attended the University of Mississippi to study journalism and political science but withdrew in 2001 without earning a degree in order to pursue early entrepreneurial ventures. After establishing herself in the tech industry and leading the development of the 2014 indie game Revolution 60, Wu became a prominent advocate for marginalized groups in gaming, a role that expanded significantly after she was targeted during the Gamergate harassment campaign. She later transitioned into political organizing, running for the U.S. House of Representatives in Massachusetts as a Democrat in 2018 and 2020, and co-founding Rebellion PAC to support progressive political initiatives. In the last few years Wu has been pivoting more toward the center, expressing concerns about the power of the anti-Israel faction on the Left.

Razib and Wu discuss their political differences, he, being on the political Right his whole adult life, and, Wu, a partisan of the Left. Wu makes the affirmative case for a liberal Left vision of American politics, a welfare state without express support for socialism. They also discuss the excesses of both the woke Left and the MAGA Right, and Wu challenges Razib on the actions of state-level Republicans. She argues that for many Americans the Right presents no option, because it does not welcome many identity categories as the Left does.

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On this podcast, Razib and Yakovenko talk about the current top of the line "frontier labs," OpenAI, Anthropic, and Google's DeepMind, why xAI has faltered, and the reality that only DeepSeek in China seems up to challenging the American firms. Yakovenko notes that AI's transformative impact is mostly in the massive capital influx into the sector, as well as becoming a ubiquitous part of the software engineer's toolkit. They discuss how programming without an AI-assist is now likened to "raw dogging" coding, while artificial superintelligence seems a rather distant prospect. The technology is getting better, but predictions of the doomers seem not to have panned out.

On this episode of Unsupervised Learning Razib talks to geneticist Leonidas-Romanos Davranoglou about two papers, Ancient DNA evidence for the history of the Albanians and Uniparental analysis of Deep Maniot Greeks reveals genetic continuity from the pre-Medieval era. He is an entomologist and evolutionary biologist specializing in insect morphology, biomechanics, bioacoustics, systematics, and taxonomy. Born in Greece, Davranoglou earned a B.Sc. (Hons) in Zoology from Imperial College London (2012–2015) before completing a DPhil (2015–2020) in insect morphology and biomechanics at the University of Oxford under supervisors Graham Taylor and Beth Mortimer. He is currently a Leverhulme Trust Early Career Fellow at the Oxford University Museum of Natural History (with support from the John Fell OUP Fund), where he investigates the evolutionary origins of sound production in hemipteran insects. He also serves as Curator of Hemiptera and a senior researcher at the Steinhardt Museum of Natural History in Tel Aviv.

Over the course of the episode Razib and Davranoglou cover the intersection of history, archaeology and genetics. Who are the Greeks of the Mani peninsula, south of Sparta? Are they particularly “genetically pure” compared to other Greeks, and what is their connection to the ancient Greeks? How do Albanians differ from other Balkan populations and what are their deep origins? The podcast explores genetic results that demystify the demographic history of the southern Balkans, and two of the deeply indigenous peoples to the region.

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Razib and Rufo first discuss his California upbringing and the idyllic environment of the Golden State. They discuss what they both love about California and why it matters for the US as a whole. Razib brings up the contrast with Texas, where the weather and scenery are less attractive, but pro-business and pro-housing regulatory framework has attracted many migrants from California. Rufo then details exactly what he's uncovered about the poor governance in his home state under Gavin Newsom. They also discuss the prospects in the current governor's race, and whether California's pathologies can ever be fixed.

First, Razib and Cochran examine the controversy surrounding Ancient DNA reveals pervasive directional selection across West Eurasia, including Davide Piffer's complaint that the authors did not cite his work. Then, they review chapter-by-chapter the arguments in The 10,000 Year Explosion, from Cochran and John Hawks' prediction that Neanderthals likely admixed with modern humans, to the importance of agriculture in driving adaptation in human beings and the ecological context of the increase in Ashkenazi intelligence.

It’s been a minute since we’ve had Nikolai Yakovenko on the podcast. Yakovenko is a former professional poker player,and was a research scientist at Google, Twitter and Nvidia. With a decade in computer science, Yakovenko has been at the forefront of the large-language-model revolution that has driven to prominence companies like OpenAI, Anthropic, and DeepMind, and an ecosystem that has birthed hundreds of smaller startups. He is also the founder of DeepNewz, an AI-driven news startup.

Razib and Yakovenko have been discussing the Age of AI for about 4 years now, and it’s time for a temperature check. Nearly four years ago, Razib put in a “prompt” that generated the below image:

The same prompt now returns the image at the top of this post. It illustrates the strides that AI has made in the last four years.

On this podcast, Razib and Yakovenko talk about the current top of the line “frontier labs,” OpenAI, Anthropic, and Google’s DeepMind, why xAI has faltered, and the reality that only DeepSeek in China seems up to challenging the American firms. Yakovenko notes that AI’s transformative impact is mostly in the massive capital influx into the sector, as well as becoming a ubiquitous part of the software engineer’s toolkit. They discuss how programming without an AI-assist is now likened to “raw dogging” coding, while artificial superintelligence seems a rather distant prospect. The technology is getting better, but predictions of the doomers seem not to have panned out.

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Greene and Razib talk about the fiscal insolvency of Social Security in six years, and the shift of the federal budget to focus on transfers from younger generations to older ones. Greene also talks about the fiscal situation in the developed world more generally, out of the United States, and the general issues engendered by massive pension systems. They discuss the history of past changes to benefits programs for senior citizens, and how it puts the squeeze on all other areas of the budget.

On this episode of Unsupervised Learning Razib talks to Christopher Rufo. Rufo is a senior fellow at the Manhattan Institute for Policy Research. A contributing editor at City Journal, author of the New York Times bestseller America’s Cultural Revolution, and 2025 Bradley Prize recipient, he also serves as a New College of Florida board member and Distinguished Fellow at Hillsdale College. He is also co-host of the podcast Rufo and Lomez. Raised in Sacramento, California, Rufo graduated magna cum laude from Georgetown University’s Walsh School of Foreign Service in 2006 and a Master of Liberal Arts in Government from Harvard Extension School in 2022. He lives in the Pacific Northwest with his wife and children.

Razib and Rufo first discuss his California upbringing and the idyllic environment of the Golden State. They discuss what they both love about California and why it matters for the US as a whole. Razib brings up the contrast with Texas, where the weather and scenery are less attractive, but pro-business and pro-housing regulatory framework has attracted many migrants from California. Rufo then details exactly what he’s uncovered about the poor governance in his home state under Gavin Newsom. They also discuss the prospects in the current governor’s race, and whether California’s pathologies can ever be fixed.

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On this episode of Unsupervised Learning, Razib talks to physicist Gregory Cochran. Cochran is best known for his work in human evolution, often at the intersection of biology, anthropology, and history. Trained in physics, he later turned to population genetics and became widely known through collaborations with researchers like Henry Harpending, producing influential but controversial work on recent human evolution, including the idea that natural selection has accelerated in the Holocene. Cochran has also been a prominent public intellectual, co-authoring the book The 10,000 Year Explosion: How Civilization Accelerated Human Evolution. He writes at the blog West Hunt.

First, Razib and Cochran examine the controversy surrounding Ancient DNA reveals pervasive directional selection across West Eurasia, including Davide Piffer’s complaint that the authors did not cite his work. Then, they review chapter-by-chapter the arguments in The 10,000 Year Explosion, from Cochran and John Hawks’ prediction that Neanderthals likely admixed with modern humans, to the importance of agriculture in driving adaptation in human beings and the ecological context of the increase in Ashkenazi intelligence.

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Despite the preprint being out for two years, Akbari et al.'s Ancient DNA reveals pervasive directional selection across West Eurasia publication in Nature this week has resulted in a massive media response. Though Razib has discussed this work before, he thought it would be useful to review it, and put it in context in a new monologue.

First, they discuss Schmitz's piece in the Washington Post, The unreligious religiosity of Christian identity politics. Here Schmitz articulates the view that the nationalist-inflected Christianity exemplified by many MAGA and MAGA-adjacent figures is quite different from the sincere but earnest evangelicalism of the older religious right. Rather, it is more performative, more civilizational, and tied into white identity politics. Additionally, it turns away from the philo-Semitism that has been typical of the American religious landscape. Schmitz and Razib also address the rise and fall of the New Atheism over the last 20 years, from the decline of public Christian faith as the center of the body politic, the rationalist critique and the marginalization of both by woke social-justice political theology. They also discuss the difficulties and travails of religious pluralism in the US today, including the tensions caused by the arrival of large numbers of Hindus in places like Texas, where they erect statues to their gods, including the semi-monkey divinity Hanuman.

On this episode of Unsupervised Learning Razib talks to Russ Greene, who promoted the idea of “Total Boomer Luxury Communism.” Greene currently serves as the Executive Director of the Prime Mover Institute, a public interest organization and think tank he launched to advocate for American energy dominance. Previously, he was a Senior Fellow for the Economy at the Stand Together Trust. In this role, he managed a grantmaking portfolio centered on federal regulatory affairs and strategic litigation, with a strong focus on classical liberalism and critiques of Environmental, Social, and Governance (ESG) corporate frameworks. Greene also directed brand defense and government affairs for CrossFit Inc. He has a Bachelor of Science in International Politics from Georgetown University's Walsh School of Foreign Service.

Greene and Razib talk about the fiscal insolvency of Social Security in six years, and the shift of the federal budget to focus on transfers from younger generations to older ones. Greene also talks about the fiscal situation in the developed world more generally, out of the United States, and the general issues engendered by massive pension systems. They discuss the history of past changes to benefits programs for senior citizens, and how it puts the squeeze on all other areas of the budget.

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On this episode Razib talks about where we are when it comes to "Out-of-Africa," Neanderthal origins and the broader state of understanding the dynamics of Homo evolution.

Despite the preprint being out for two years, Akbari et al.’s Ancient DNA reveals pervasive directional selection across West Eurasia publication in Nature this week has resulted in a massive media response. Though Razib has discussed this work before, he thought it would be useful to review it, and put it in context in a new monologue.

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Today Razib talks to Matthew Schmitz, a journalist who previously served as an editor at the religious journal First Things. He is the cofounder of the online magazine Compact, alongside Edwin Aponte and Sohrab Ahmari. He currently serves as editor of Compact, religion editor of Washington Post Opinions, and co-host of the podcast Against the Grain. Compact His essays on politics and culture have appeared in The New York Times, The Wall Street Journal, and The Claremont Review of Books. A native of O’Neill, Nebraska, Schmitz is a graduate of Princeton University.

First, they discuss Schmitz’s piece in the Washington Post, The unreligious religiosity of Christian identity politics. Here Schmitz articulates the view that the nationalist-inflected Christianity exemplified by many MAGA and MAGA-adjacent figures is quite different from the sincere but earnest evangelicalism of the older religious right. Rather, it is more performative, more civilizational, and tied into white identity politics. Additionally, it turns away from the philo-Semitism that has been typical of the American religious landscape. Schmitz and Razib also address the rise and fall of the New Atheism over the last 20 years, from the decline of public Christian faith as the center of the body politic, the rationalist critique and the marginalization of both by woke social-justice political theology. They also discuss the difficulties and travails of religious pluralism in the US today, including the tensions caused by the arrival of large numbers of Hindus in places like Texas, where they erect statues to their gods, including the semi-monkey divinity Hanuman.

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The discussion first aims to focus on fundamental science concepts. What is genome integrity, and why does it matter? Bradley reviews the current state of the science to understand how errors creep into our genomic code over our lifetimes, and how it can lead to cancers and other pathologies. He points out that there is a wide variation in lifespan and cancer-risk across animal species, showing that in some ways nature may have "solved" the problem. In addition, Razib reiterates how complex and amazing any genome is, with billions of base pairs, and how incredible it is that our body's repair mechanisms function as well as they do.

Bradley then discusses the practical goals of Matter Bio as they begin their first clinical trials. Rather than just focusing on basic science, Bradley's long-term focus is to make a difference in human lives. He discusses how the drastic gain in human life expectancy over the last 150 years already shows that we can increase longevity. Ultimately, Matter Bio aims to push the frontier so that we are less and less surprised by centenarians. Bradley also addresses the reality that a lot of the innovation in biotech right now, including what Matter Bio wants to achieve, is limited by the regulatory state, rather than what can be done in terms of the science or funding environment.

The discussion first aims to focus on fundamental science concepts. What is genome integrity, and why does it matter? Bradley reviews the current state of the science to understand how errors creep into our genomic code over our lifetimes, and how it can lead to cancers and other pathologies. He points out that there is a wide variation in lifespan and cancer-risk across animal species, showing that in some ways nature may have "solved" the problem. In addition, Razib reiterates how complex and amazing any genome is, with billions of base pairs, and how incredible it is that our body's repair mechanisms function as well as they do.

Bradley then discusses the practical goals of Matter Bio as they begin their first clinical trials. Rather than just focusing on basic science, Bradley's long-term focus is to make a difference in human lives. He discusses how the drastic gain in human life expectancy over the last 150 years already shows that we can increase longevity. Ultimately, Matter Bio aims to push the frontier so that we are less and less surprised by centenarians. Bradley also addresses the reality that a lot of the innovation in biotech right now, including what Matter Bio wants to achieve, is limited by the regulatory state, rather than what can be done in terms of the science or funding environment.

On this episode of Unsupervised Learning Razib talks to returning guest Megan McArdle. She is the author of The Up Side of Down: Why Failing Well Is the Key to Success and a Washington Post columnist and op-ed board member. McArdle grew up in New York City and attended Riverdale Country School. She obtained an undergraduate degree in English from University of Pennsylvania and an MBA from the University of Chicago. McArdle’s previous positions were at The Economist, The Atlantic and Newsweek. She has a new podcast for the Washington Post, Reasonably Optimistic, and also contributes to Central Air and The Dispatch.

Razib and McArdle talk about the follies of populism, left and right, and the damage being done to America in the name of anti-elitism. Razib asks McArdle if there is any way out of a national debt crisis and fiscal insolvency (answer: probably not). Then they discuss the role high cost of living and confiscatory tax rates on the flight of capital and high-income individuals from blue states, and McArdle explains the historical-structural reasons that liberal cities cannot cut back on their top-heavy labor force. Razib and McArdle discuss immigration, trade and globalization, and the short-sightedness of MAGA-populism. Finally, they address AI, McArdle’s usage of it, and the promise it has in revolutionizing work and transforming our society.

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