Research Letter
Epigenetic Age among U.S. Adults with Chronic Respiratory Diseases: Results from NHANES 1999-2002Chronic respiratory diseases affect over 454 million people worldwide and rank as the third leading cause of mortality [1]. Increasing evidence suggests that ageing significantly contributes to their pathogenesis linked to epigenetic changes over the lifespan [2, 3]. DNA methylation markers, which capture gene-environment factors, may underly the development of…
Editorial | Podcast
ERJ Podcast May 2025: Efficacy and safety of the activin signalling inhibitor sotaterceptAs part of the May issue, the European Respiratory Journal presents the latest in its series of podcasts. Chief Editor James Chalmers interviews Associate Editor Marius Hoeper about the efficacy and safety of the activin signalling inhibitor sotatercept in a pooled analysis of the PULSAR and STELLAR studies.
Research Letter
Comparability, acceptability and longitudinal adherence with digital emPHasis-10 in pulmonary arterial hypertensionPulmonary hypertension (PH) affects 1% of the global population and significantly impacts health-related quality of life (HRQoL) [1, 2]. Patient reported outcome measures (PROMs) are standardised tools used in clinical practice and research to assess health outcomes from the patient's perspective. Routine measurement of HRQoL is supported by clinical guidelines,…
Original Research Article
How do people with COPD walk? A European study on digitally measured real-world gaitThe amount of walking that people with chronic obstructive pulmonary disease (COPD) do is reduced. However, data on their manner of walking (i.e., gait) is still lacking. We characterised real-world gait in COPD by assessing levels and distributions of gait parameters, and comparing them across…
Original Research Article
Impaired IgA Mucosal Immunity Following Lung Transplantation: A Potential Trigger for Bronchiolitis Obliterans SyndromeBronchiolitis obliterans syndrome (BOS) limits long-term survival after lung transplantation (LuTx) and may be triggered by infections. As immunoglobulin (Ig)A is crucial to ensure adequate mucosal immunity, we explored whether IgA-related mucosal immunity is impaired in BOS.
Original Research Article
Particulate matter–related ITIH4 deficiency is associated with an emphysema phenotype of chronic obstructive pulmonary disease through JNK-dependent and JNK-independent signaling: Prolonged exposure to airborne particulate matter (PM) is associated with emphysema and chronic obstructive pulmonary disease (COPD); however, the precise underlying mechanism remains unclear.
In a previous high-throughput screen, we identified…
Original Research Article
Renal dysfunction and outcomes in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension: an individual participant data meta-analysisPulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) cause right ventricular dysfunction with extrapulmonary sequalae including renal dysfunction. We sought to characterize renal dysfunction in PAH and CTEPH and to assess the effect of pulmonary hypertension treatment on renal function.
Original Research Article
Sputum metagenomics in bronchiectasis reveals pan-European variation: an EMBARC-BRIDGE studyThe EMBARC registry shows considerable variation in culturable microbes in sputum between different European countries. The additive role of next generation metagenomic sequencing remains unexplored and association with antimicrobial resistomes unknown.
We…
Editorial
Are systemic corticosteroids needed for all asthma exacerbations?Asthma exacerbations are potentially life-altering crises for many patients [1]. Despite this pivotal impact in the life cycle of asthma, the treatment for exacerbations has not changed in nearly 50 years. In particular, the therapeutic approach to exacerbations has not incorporated directions to identify which patient is most likely to benefit from the current…
Research Letter
Blood eosinophil counts, airway infections and inhaled antibiotic treatment in bronchiectasisBronchiectasis is a chronic airway disease characterised by recurrent airway infections, inflammation and structural remodelling [1]. Eosinophils contribute to its pathogenesis and progression, with blood eosinophil count (BEC) emerging as a key biomarker. BECs correlate with the disease severity and exacerbation risk, and they predict responsiveness to inhaled…
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