Life Science Alliance | Immunology https://www.life-science-alliance.org/immunology Sun, 10 Jul 2022 18:05:53 GMT Feed43 Proxy/1.0 (www.feed43.com) 360 6a092713d95cd7ba5680777083e318e1 Sun, 10 Jul 2022 18:05:53 GMT The intracellular pathogen Francisella tularensis escapes from adaptive immunity by metabolic adaptation https://www.life-science-alliance.org/content/5/10/e202201441 The intracellular pathogen <em>Francisella tularensis</em> escapes from adaptive immunity by metabolic adaptation Kensuke Shibata, Takashi Shimizu, Mashio Nakahara, Emi Ito, Francois Legoux, Shotaro Fujii, Yuka Yamada, Makoto Furutani-Seiki, Olivier Lantz, Sho Yamasaki, Masahisa Watarai, Mutsunori Shirai

This study shows that metabolic adaptation allows the intracellular bacterial pathogen Francisella tularensis to escape recognition by the host adaptive immunity.

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]]> aa6a2cc3ca9ed920f0415d6325fcb006 Sun, 10 Jul 2022 18:05:52 GMT Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases https://www.life-science-alliance.org/content/5/10/e202101316 Workflow for high-dimensional flow cytometry analysis of T cells from tumor metastases Cristina Faccani, Gianluca Rotta, Francesca Clemente, Maya Fedeli, Danilo Abbati, Francesco Manfredi, Alessia Potenza, Achille Anselmo, Federica Pedica, Guido Fiorentini, Chiara Villa, Maria P Protti, Claudio Doglioni, Luca Aldrighetti, Chiara Bonini, Giulia Casorati, Paolo Dellabona, Claudia de Lalla

We describe an improved method for the high-dimensional flow cytometry analysis of conventional and rare unconventional T cells infiltrating tumor liver metastases.

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]]> cefb88eaf7960b032c03af9e30e0bc54 Sun, 10 Jul 2022 18:05:51 GMT OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection https://www.life-science-alliance.org/content/5/9/e202201476 OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection Elinor Hortle, Vi LT Tran, Kathryn Wright, Angela RM Fontaine, Natalia Pinello, Matthew B O’Rourke, Justin J-L Wong, Philip M Hansbro, Warwick J Britton, Stefan H Oehlers

Mycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.

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]]> 10b518ea0ca4aa9cc4229878afa309c7 Sun, 10 Jul 2022 18:05:50 GMT Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy https://www.life-science-alliance.org/content/5/9/e202101337 Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapy Tiffany C Blair, Shelly Bambina, Gwen F Kramer, Alexa K Dowdell, Alejandro F Alice, Jason R Baird, Amanda W Lund, Brian D Piening, Marka R Crittenden, Michael J Gough

Radiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.

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]]> a5f95b5dddceb7e5b66ebafd34ceb3e0 Sun, 10 Jul 2022 18:05:49 GMT The miR-26 family regulates early B cell development and transformation https://www.life-science-alliance.org/content/5/8/e202101303 The miR-26 family regulates early B cell development and transformation Katharina Hutter, Silke E Lindner, Constanze Kurschat, Thomas Rülicke, Andreas Villunger, Sebastian Herzog

We show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.

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]]> 07792d7587b4b4925d0fb83dfc4673b3 Sun, 10 Jul 2022 18:05:48 GMT mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients https://www.life-science-alliance.org/content/5/6/e202201381 mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patients Elena Azzolini, Chiara Pozzi, Luca Germagnoli, Bianca Oresta, Nicola Carriglio, Mariella Calleri, Carlo Selmi, Maria De Santis, Silvia Finazzi, Carmelo Carlo-Stella, Alexia Bertuzzi, Francesca Motta, Angela Ceribelli, Alberto Mantovani, Fabrizio Bonelli, Maria Rescigno

Immunocompromised patients poorly respond to two doses of SARS-CoV-2 mRNA vaccines. However, an additional booster dose elicits a strong humoral and cellular immune response in these subjects.

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]]> ddc48f276a6a1b959f97d03a4406f42a Sun, 10 Jul 2022 18:05:47 GMT Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells https://www.life-science-alliance.org/content/5/4/e202101272 Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cells Anthony Torres-Ruesta, Teck-Hui Teo, Yi-Hao Chan, Siti Naqiah Amrun, Nicholas Kim-Wah Yeo, Cheryl Yi-Pin Lee, Samantha Yee-Teng Nguee, Matthew Zirui Tay, Francois Nosten, Siew-Wai Fong, Fok-Moon Lum, Guillaume Carissimo, Laurent Renia, Lisa FP Ng

This study reveals that acute blood-stage malaria promotes resistance to ONNV infection by inducing IFNg-dependent antiviral status in human and murine nonimmune cells.

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]]> b4d69bc0b0ed6651b5330ffdfbe12375 Sun, 10 Jul 2022 18:05:46 GMT Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF https://www.life-science-alliance.org/content/5/4/e202101315 Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNF Stefanie Dichtl, David E Sanin, Carolin K Koss, Sebastian Willenborg, Andreas Petzold, Maria C Tanzer, Andreas Dahl, Agnieszka M Kabat, Laura Lindenthal, Leonie Zeitler, Sabrina Satzinger, Alexander Strasser, Matthias Mann, Axel Roers, Sabine A Eming, Karim C El Kasmi, Edward J Pearce, Peter J Murray

Pro-inflammatory TNF is a highly gene-selective inhibitor of the gene expression program of tissue repair and wound healing macrophages.

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]]> 7167303546bea3faf168a038b2548b18 Sun, 10 Jul 2022 18:05:45 GMT ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway https://www.life-science-alliance.org/content/5/3/e202101191 ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathway Xinfeng Guo, Silvia Liu, Rose Yan, Vy Nguyen, Mazen Zenati, Timothy R Billiar, Qingde Wang

Cellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway.

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]]> 66d162f4ef1efd51da8214903f55daca Sun, 10 Jul 2022 18:05:44 GMT Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting https://www.life-science-alliance.org/content/5/3/e202101285 Generation of human long-lived plasma cells by developmentally regulated epigenetic imprinting Chester J Joyner, Ariel M Ley, Doan C Nguyen, Mohammad Ali, Alessia Corrado, Christopher Tipton, Christopher D Scharer, Tian Mi, Matthew C Woodruff, Jennifer Hom, Jeremy M Boss, Meixue Duan, Greg Gibson, Danielle Roberts, Joel Andrews, Sagar Lonial, Inaki Sanz, F Eun-Hyung Lee

This study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.

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