Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation. Aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings, the journal publishes the latest advances in cancer biology, vascular biology, neuroscience, inflammatory disease, infectious disease and metabolic disorders, among other fields. Reviews, Perspectives and other commissioned content clarify and give context to these biomedical research advances, and the News section reports on the latest developments in drug research and development. http://feeds.nature.com/nm/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Medicine © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nm/rss.gif http://feeds.nature.com/nm/rss/current https://www.nature.com/articles/s41591-026-04621-1 Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04621-1

The International Consortium of Digital Twins in Healthcare and Medicine was established to advance medical digital twin technology as a new infrastructure for precision health.]]> Kang ZhangJiahong DongHang WongSian LiuKai WangWei WuKaixin ZhouKanmin XueEdward ZhangJonathan GootenbergOmar O. AbudayyehMichelle WilliamsXian ShenAlexandre LoupyTrey IdekerPatrick TanJoseph WuAkrit SodhiEric OermannTao XuGuang Ning doi:10.1038/s41591-026-04621-1 Nature Medicine, Published online: 2026-09-11; | doi:10.1038/s41591-026-04621-1 2026-09-11 Nature Medicine 10.1038/s41591-026-04621-1 https://www.nature.com/articles/s41591-026-04621-1 https://www.nature.com/articles/s41591-026-04642-w Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04642-w

In the randomized phase 2 ImmunoPRISM trial, patients with high-risk smoldering multiple myeloma (MM) showed higher rates of complete clinical responses in response to treatment with teclistamab compared with lenalidomide–dexamethasone, although longer follow-up is required to determine durable prevention of progression to MM.]]> Omar NadeemDavid M. Cordas dos SantosSophie MagidsonJeffrey MatousEva MedvedovaElizabeth O’DonnellRobert A. ReddYuxin LiuShonali MidhaAdam S. SperlingFrances ArtersChristine DavieCaroline RicciardiRosa ToengesNayda BidikianSubear HusseinJean-Baptiste AlbergeSungjae KimLorena Pantano-RubinoFrancesco CorradoHannah AshtonDaniel AddonizioSiham MohamedAshlee SturtevantMarjorie MartoAmy BergeronFrancesco MalfonaKevin PanaroPaul G. RichardsonJerome RitzLorenzo TrippaIrene M. Ghobrial doi:10.1038/s41591-026-04642-w Nature Medicine, Published online: 2026-09-11; | doi:10.1038/s41591-026-04642-w 2026-09-11 Nature Medicine 10.1038/s41591-026-04642-w https://www.nature.com/articles/s41591-026-04642-w https://www.nature.com/articles/s41591-026-04635-9 Nature Medicine, Published online: 11 September 2026; doi:10.1038/s41591-026-04635-9

A 15-year cohort study shows that Alzheimer’s dementia risk is jointly shaped by Alzheimer’s pathology and cognitive resilience, with high resilience linked to lower risk, even under greater pathology.]]> Zhibo WangShuheng WangYumei LiangXinlei ChenSimiao WangWei QinQi WangYan LiTan ZhaoYue WangFang LiGuoguang ZhaoJianping Jia doi:10.1038/s41591-026-04635-9 Nature Medicine, Published online: 2026-09-11; | doi:10.1038/s41591-026-04635-9 2026-09-11 Nature Medicine 10.1038/s41591-026-04635-9 https://www.nature.com/articles/s41591-026-04635-9 https://www.nature.com/articles/s41591-026-04703-0 Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04703-0

CRISP, a vision-based pathology foundation model developed exclusively from frozen section slides, supports treatment decision-making throughout the surgical workflow with superior performance to current foundation models and extensive validation, including in a prospective cohort.]]> Zihan ZhaoFengtao ZhouRonggang LiBing ChuXinke ZhangXueyi ZhengKe ZhengXiaobo WenJiabo MaYihui WangJiewei ChenChengyou ZhengJiangyu ZhangYongqin WenJiajia MengZiqi ZengXiaoqing LiJing LiDan XieYaping YeYu WangHao ChenMuyan Cai doi:10.1038/s41591-026-04703-0 Nature Medicine, Published online: 2026-09-10; | doi:10.1038/s41591-026-04703-0 2026-09-10 Nature Medicine 10.1038/s41591-026-04703-0 https://www.nature.com/articles/s41591-026-04703-0 https://www.nature.com/articles/s41591-026-04695-x Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04695-x

A suite of large pre-trained language models accurately extracts computable clinical data from unstructured electronic health records and integrates the findings into knowledge graphs that can facilitate understanding patient trajectories and treatment responses in the real world.]]> Edward KimRichard FotyAvnesh S. ThakorJay S. SkylerLucy F. RobinsonJames D. ParkMonica KraftCharles B. CairnsVicki Seyfert-Margolis doi:10.1038/s41591-026-04695-x Nature Medicine, Published online: 2026-09-10; | doi:10.1038/s41591-026-04695-x 2026-09-10 Nature Medicine 10.1038/s41591-026-04695-x https://www.nature.com/articles/s41591-026-04695-x https://www.nature.com/articles/s41591-026-04596-z Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04596-z

An early assessment of the UK’s Our Future Health project shows how national-scale cohorts may reshape population medicine by accelerating discovery and clinical recruitment, provided that selection and phenotyping biases are carefully measured and managed.]]> Zhonghan SunYan Zheng doi:10.1038/s41591-026-04596-z Nature Medicine, Published online: 2026-09-10; | doi:10.1038/s41591-026-04596-z 2026-09-10 Nature Medicine 10.1038/s41591-026-04596-z https://www.nature.com/articles/s41591-026-04596-z https://www.nature.com/articles/s41591-026-04702-1 Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04702-1

Author Correction: Colonoscopy and fecal immunochemical testing versus usual care in diagnostic colorectal cancer screening: the SCREESCO randomized controlled trial]]> Marcus WesterbergJonas F. LudvigssonChris MetcalfeUlf StrömbergJohannes BlomLars EngstrandMikael HellströmChristian LöwbeerRobert SteeleLars HolmbergAnna Forsberg doi:10.1038/s41591-026-04702-1 Nature Medicine, Published online: 2026-09-10; | doi:10.1038/s41591-026-04702-1 2026-09-10 Nature Medicine 10.1038/s41591-026-04702-1 https://www.nature.com/articles/s41591-026-04702-1 https://www.nature.com/articles/s41591-026-04634-w Nature Medicine, Published online: 10 September 2026; doi:10.1038/s41591-026-04634-w

The Value Cube: translating clinical benefit into realizable value in global oncology]]> Bibek AryalOphira GinsburgDario Trapani doi:10.1038/s41591-026-04634-w Nature Medicine, Published online: 2026-09-10; | doi:10.1038/s41591-026-04634-w 2026-09-10 Nature Medicine 10.1038/s41591-026-04634-w https://www.nature.com/articles/s41591-026-04634-w