Original research articles published in Nature Medicine range from basic findings that have clear implications for disease pathogenesis and therapy to the earliest phases of human investigation. Aiming to keep Ph.D. and M.D. readers informed of a wide range of biomedical research findings, the journal publishes the latest advances in cancer biology, vascular biology, neuroscience, inflammatory disease, infectious disease and metabolic disorders, among other fields. Reviews, Perspectives and other commissioned content clarify and give context to these biomedical research advances, and the News section reports on the latest developments in drug research and development. http://feeds.nature.com/nm/rss/current Nature Publishing Group en © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. Nature Medicine © 2026 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. permissions@nature.com https://www.nature.com/uploads/product/nm/rss.gif http://feeds.nature.com/nm/rss/current https://www.nature.com/articles/s41591-026-04555-8 Nature Medicine, Published online: 29 July 2026; doi:10.1038/s41591-026-04555-8

A new study reveals histidine as a readily measurable and potentially modifiable metabolic biomarker for cancer risk stratification and treatment optimization, but it also highlights the challenges of translating such associations into clinically usable interventions.]]> Feyza CansizAmanda N. PopeAlpaslan Tasdogan doi:10.1038/s41591-026-04555-8 Nature Medicine, Published online: 2026-07-29; | doi:10.1038/s41591-026-04555-8 2026-07-29 Nature Medicine 10.1038/s41591-026-04555-8 https://www.nature.com/articles/s41591-026-04555-8 https://www.nature.com/articles/s41591-026-04542-z Nature Medicine, Published online: 28 July 2026; doi:10.1038/s41591-026-04542-z

The timely detection of rare diseases is crucial, and using a range of approaches will be key to reducing the diagnostic odyssey.]]> Caroline F. WrightAmicia PhillipsSarah L. WynnNick MeadeEmma L. BapleAnneke M. LucassenLeigh Jackson doi:10.1038/s41591-026-04542-z Nature Medicine, Published online: 2026-07-28; | doi:10.1038/s41591-026-04542-z 2026-07-28 Nature Medicine 10.1038/s41591-026-04542-z https://www.nature.com/articles/s41591-026-04542-z https://www.nature.com/articles/s41591-026-04552-x Nature Medicine, Published online: 28 July 2026; doi:10.1038/s41591-026-04552-x

This cluster-randomized phase 3 trial examining the effectiveness of integrated care pathways comparing usual care with the addition of MRI imaging (Coverscan), or a digitally enabled rehabilitation platform app, or both (Coverscan + app), or neither, found specialist Long COVID care improved fatigue response in all arms.]]> Amitava BanerjeeGordon PrescottEmma WallCaroline L. WatkinsMelissa HeightmanAlison GibbonAl-Tahoor ButtAmanpreet SarnaAmir ManzelatAnand ViswanathanAndrea DennisAndrew CleggAndrew WilliamsAngela GreenAnnalisa ParabitaAntony LovelessAnu ChandraAshkan DashtbanCharles LatchfordCharlotte Adams-HeathChris RobsonChristina M. van der Feltz-CornelisChristopher BrownClaire HooperDan CuthbertsonDan WoottonWilliam David StrainDavid SunkersingDeepak RavindranDenise ForshawDonna ClutterbuckEamonn FoleyElena BaxElizabeth MurrayEmily AttreeEmily FraserEmma MiFauzia BegumFlorence MutesvaFrancesco GambinoGail AllsoppGregory Y. H. LipHakim-Moulay DehbiHan-I WangHelen GriceHenry GoodfellowHugh MontgomeryIleana L. SelejanJagdeep SahotaJai PrasharJanet ScottJasmine HayerJennifer SweetmanJoanna PeelJoanna WrightJonathan WaywellJosie NewtonKamlesh KhuntiKeri HildickKim HorstmanshofKiran KhanKumaran BalasundaramLaura PaseaLauren O’MahoneyLere FisherLyth HishmehMag LeahyManuel GomesMarija PantelicMark GabbayMatthew Robert BurnsMaya LeachMel RamasawmyMichael CrooksMichael ZandiMohamed MohamedNataliia KryvutenkoNatalie SmithNefyn WilliamsNisreen A. AlwanOndine SherwoodPablo Fernandez MedinaPaula LorgellyPhil CumberlidgeRachael A. EvansRachel BotellRachel HextRachel NyamRachel WilliamsRajarshi BanerjeeRebecca LivingstonRita MallinsonRobert BellRob SurianoSamantha EcclesSarah CleggSophie Burchell-KirkSophie EquiStephen ConeTerence Elliott-CooperToby HillmanTushy KailayanathanValerio BenedettoYi Mu doi:10.1038/s41591-026-04552-x Nature Medicine, Published online: 2026-07-28; | doi:10.1038/s41591-026-04552-x 2026-07-28 Nature Medicine 10.1038/s41591-026-04552-x https://www.nature.com/articles/s41591-026-04552-x https://www.nature.com/articles/s41591-026-04548-7 Nature Medicine, Published online: 28 July 2026; doi:10.1038/s41591-026-04548-7

A macroeconomic modeling analysis across 154 countries estimates that depression will impose a US$12 trillion global economic burden between 2025 and 2050, equivalent to around 0.5% of the annual global GDP.]]> Zhong CaoYuheng LuoLirui JiaoWenjin ChenKlaus PrettnerMichael KuhnDavid E. BloomDean T. JamisonTill Winfried BärnighausenSimiao Chen doi:10.1038/s41591-026-04548-7 Nature Medicine, Published online: 2026-07-28; | doi:10.1038/s41591-026-04548-7 2026-07-28 Nature Medicine 10.1038/s41591-026-04548-7 https://www.nature.com/articles/s41591-026-04548-7 https://www.nature.com/articles/s41591-026-04558-5 Nature Medicine, Published online: 28 July 2026; doi:10.1038/s41591-026-04558-5

A phase 1/2 study found maternal hexavalent 6 polysaccharide−protein conjugate group B Streptococcus vaccine (GBS6) to be safe and immunogenic and to have induced antibody responses to vaccine serotypes in infants whose parent was vaccinated while pregnant.]]> Streptococcus vaccine in non-pregnant and pregnant females: a randomized phase 1/2 trial]]> Shabir A. MadhiHasra SnaggsZahra SkogebyYe FengShaun BarnabasJeffrey BakerLee FairlieJohannes BeeslaarDavid RadleyHan-Qing JiangNatalie C. Silmon de MonerriRaphael SimonLindsay McLaughlinMichelle GaylordJulie SkinnerIona MunjalAnnaliesa S. AndersonAlejandra Gurtman doi:10.1038/s41591-026-04558-5 Nature Medicine, Published online: 2026-07-28; | doi:10.1038/s41591-026-04558-5 2026-07-28 Nature Medicine 10.1038/s41591-026-04558-5 https://www.nature.com/articles/s41591-026-04558-5 https://www.nature.com/articles/s41591-026-04492-6 Nature Medicine, Published online: 28 July 2026; doi:10.1038/s41591-026-04492-6

A multi-ancestry genome-wide association study meta-analysis across 2,563,755 individuals identifies 26 risk loci for fibromyalgia, including HTT, and finds genetic correlations with chronic pain and psychiatric and somatic disorders.]]> Isabel KerrebijnGyda BjornsdottirKeon ArbabiLea UrpaHele HaapaniemiGudmar ThorleifssonLilja StefansdottirStephan FrangakisJesse ValliereLovemore KunorozvaErik AbnerCaleb JiMarkus KangurBitten AagaardHenning BliddalSøren BrunakMie T. BruunMaria DidriksenChristian ErikstrupSarah FinerArni J. GeirssonDaniel F. GudbjartssonThomas F. HansenDavid van HeelIngileif JonsdottirStacey KnightKirk U. KnowltonChristina MikkelsenLincoln D. NadauldThorunn A. OlafsdottirSisse R. OstrowskiOle B. V. PedersenSaedis SaevarsdottirAstros T. SkuladottirErik SørensenHreinn StefanssonPatrick SulemOlafur A. SveinssonGudny E. ThorlaciusUnnur ThorsteinsdottirHenrik UllumArnor VikingssonThomas M. WergeFrances M. K. WilliamsDavid van HeelRicha SaxenaKari StefanssonChad M. BrummettBente GlintborgDaniel J. ClauwThorgeir E. ThorgeirssonFrances M. K. WilliamsNasa Sinnott-ArmstrongHanna M. OllilaMichael Wainberg doi:10.1038/s41591-026-04492-6 Nature Medicine, Published online: 2026-07-28; | doi:10.1038/s41591-026-04492-6 2026-07-28 Nature Medicine 10.1038/s41591-026-04492-6 https://www.nature.com/articles/s41591-026-04492-6 https://www.nature.com/articles/s41591-026-04539-8 Nature Medicine, Published online: 27 July 2026; doi:10.1038/s41591-026-04539-8

Researchers urgently need a rigorous, task-based framework to define and measure medical AI ‘superintelligence’, because existing benchmarks are misleading and insufficient.]]> Ethan GohDavid WuChase WaltonLiam G. McCoyAnastasia PerezLaura WegnerFateme Nateghi HaredashtLuyang LuoKathleen LacarThomas BuckleyAustin SchoefflerPeter BrodeurKameron C. BlackJohn HavlikYun LiuPo-Hsuan Cameron ChenMike SchaekermannJohn RumsfeldDaniel Lopez-MartinezPaxton Maeder-YorkKaran SinghalDavid GunningBon KuHaider WarraichShantanu NundyVishnu RaviArnold MilsteinJason HomKevin SchulmanPranav RajpurkarArjun K. ManraiRobert WachterEric TopolEric HorvitzAdam RodmanJonathan H. Chen doi:10.1038/s41591-026-04539-8 Nature Medicine, Published online: 2026-07-27; | doi:10.1038/s41591-026-04539-8 2026-07-27 Nature Medicine 10.1038/s41591-026-04539-8 https://www.nature.com/articles/s41591-026-04539-8 https://www.nature.com/articles/s41591-026-04528-x Nature Medicine, Published online: 27 July 2026; doi:10.1038/s41591-026-04528-x

Longitudinal proteomic analysis of plasma from unaffected carriers of ALS-associated pathogenic variants revealed early protein changes before ALS symptoms and enabled mapping of their trajectories as well as prediction of the timing of phenoconversion]]> Ximing RanJoanne WuuZhaohui S. QinMichael P. McDermottJohnathan Cooper-KnockYindi LiVolkan GranitAnne-Laure GrignonElizabeth LinMaria Catalina FernandezDanielle ColatoNathan CarberryChristina M. LillPaolo PiazzaAndrea MalaspinaMichael Benatar doi:10.1038/s41591-026-04528-x Nature Medicine, Published online: 2026-07-27; | doi:10.1038/s41591-026-04528-x 2026-07-27 Nature Medicine 10.1038/s41591-026-04528-x https://www.nature.com/articles/s41591-026-04528-x